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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WWTR1
Full Name:
WW domain-containing transcription regulator protein 1
Alias:
DKFZp586I1419; TAZ; Transcriptional coactivator with PDZ-binding motif; WW domain containing transcription regulator 1; WW domain containing transcription regulator protein 1
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
44101
Number AA:
400
UniProt ID:
Q9GZV5
International Prot ID:
IPI00180266
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005667
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003713
GO:0003713
GO:0003714
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
GO:0001649
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
H
V
T
Q
D
L
D
T
D
L
E
A
L
F
N
Site 2
S34
D
L
E
A
L
F
N
S
V
M
N
P
K
P
S
Site 3
S41
S
V
M
N
P
K
P
S
S
W
R
K
K
I
L
Site 4
S42
V
M
N
P
K
P
S
S
W
R
K
K
I
L
P
Site 5
S51
R
K
K
I
L
P
E
S
F
F
K
E
P
D
S
Site 6
S58
S
F
F
K
E
P
D
S
G
S
H
S
R
Q
S
Site 7
S60
F
K
E
P
D
S
G
S
H
S
R
Q
S
S
T
Site 8
S62
E
P
D
S
G
S
H
S
R
Q
S
S
T
D
S
Site 9
S65
S
G
S
H
S
R
Q
S
S
T
D
S
S
G
G
Site 10
S66
G
S
H
S
R
Q
S
S
T
D
S
S
G
G
H
Site 11
T67
S
H
S
R
Q
S
S
T
D
S
S
G
G
H
P
Site 12
S69
S
R
Q
S
S
T
D
S
S
G
G
H
P
G
P
Site 13
S70
R
Q
S
S
T
D
S
S
G
G
H
P
G
P
R
Site 14
S87
G
G
A
Q
H
V
R
S
H
S
S
P
A
S
L
Site 15
S89
A
Q
H
V
R
S
H
S
S
P
A
S
L
Q
L
Site 16
S90
Q
H
V
R
S
H
S
S
P
A
S
L
Q
L
G
Site 17
S93
R
S
H
S
S
P
A
S
L
Q
L
G
T
G
A
Site 18
T98
P
A
S
L
Q
L
G
T
G
A
G
A
A
G
S
Site 19
S105
T
G
A
G
A
A
G
S
P
A
Q
Q
H
A
H
Site 20
S117
H
A
H
L
R
Q
Q
S
Y
D
V
T
D
E
L
Site 21
T121
R
Q
Q
S
Y
D
V
T
D
E
L
P
L
P
P
Site 22
T133
L
P
P
G
W
E
M
T
F
T
A
T
G
Q
R
Site 23
Y141
F
T
A
T
G
Q
R
Y
F
L
N
H
I
E
K
Site 24
T151
N
H
I
E
K
I
T
T
W
Q
D
P
R
K
A
Site 25
S173
M
N
L
H
P
A
V
S
S
T
P
V
P
Q
R
Site 26
S174
N
L
H
P
A
V
S
S
T
P
V
P
Q
R
S
Site 27
T175
L
H
P
A
V
S
S
T
P
V
P
Q
R
S
M
Site 28
S181
S
T
P
V
P
Q
R
S
M
A
V
S
Q
P
N
Site 29
S185
P
Q
R
S
M
A
V
S
Q
P
N
L
V
M
N
Site 30
T203
Q
Q
Q
M
A
P
S
T
L
S
Q
Q
N
H
P
Site 31
S205
Q
M
A
P
S
T
L
S
Q
Q
N
H
P
T
Q
Site 32
T211
L
S
Q
Q
N
H
P
T
Q
N
P
P
A
G
L
Site 33
S220
N
P
P
A
G
L
M
S
M
P
N
A
L
T
T
Site 34
T283
Q
A
A
V
N
P
P
T
M
T
P
D
M
R
S
Site 35
T285
A
V
N
P
P
T
M
T
P
D
M
R
S
I
T
Site 36
S290
T
M
T
P
D
M
R
S
I
T
N
N
S
S
D
Site 37
T292
T
P
D
M
R
S
I
T
N
N
S
S
D
P
F
Site 38
S295
M
R
S
I
T
N
N
S
S
D
P
F
L
N
G
Site 39
S296
R
S
I
T
N
N
S
S
D
P
F
L
N
G
G
Site 40
Y305
P
F
L
N
G
G
P
Y
H
S
R
E
Q
S
T
Site 41
S307
L
N
G
G
P
Y
H
S
R
E
Q
S
T
D
S
Site 42
S311
P
Y
H
S
R
E
Q
S
T
D
S
G
L
G
L
Site 43
T312
Y
H
S
R
E
Q
S
T
D
S
G
L
G
L
G
Site 44
S314
S
R
E
Q
S
T
D
S
G
L
G
L
G
C
Y
Site 45
Y321
S
G
L
G
L
G
C
Y
S
V
P
T
T
P
E
Site 46
S322
G
L
G
L
G
C
Y
S
V
P
T
T
P
E
D
Site 47
T326
G
C
Y
S
V
P
T
T
P
E
D
F
L
S
N
Site 48
S332
T
T
P
E
D
F
L
S
N
V
D
E
M
D
T
Site 49
T339
S
N
V
D
E
M
D
T
G
E
N
A
G
Q
T
Site 50
T346
T
G
E
N
A
G
Q
T
P
M
N
I
N
P
Q
Site 51
T373
G
T
N
V
D
L
G
T
L
E
S
E
D
L
I
Site 52
S388
P
L
F
N
D
V
E
S
A
L
N
K
S
E
P
Site 53
S393
V
E
S
A
L
N
K
S
E
P
F
L
T
W
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation