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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKRN2
Full Name:
Probable E3 ubiquitin-protein ligase makorin-2
Alias:
RING finger protein 62
Type:
Mass (Da):
46940
Number AA:
416
UniProt ID:
Q9H000
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
H
G
V
C
R
E
G
S
Q
C
L
F
S
H
D
Site 2
S31
F
S
H
D
L
A
N
S
K
P
S
T
I
C
K
Site 3
T35
L
A
N
S
K
P
S
T
I
C
K
Y
Y
Q
K
Site 4
Y39
K
P
S
T
I
C
K
Y
Y
Q
K
G
Y
C
A
Site 5
Y40
P
S
T
I
C
K
Y
Y
Q
K
G
Y
C
A
Y
Site 6
T49
K
G
Y
C
A
Y
G
T
R
C
R
Y
D
H
T
Site 7
Y53
A
Y
G
T
R
C
R
Y
D
H
T
R
P
S
A
Site 8
T56
T
R
C
R
Y
D
H
T
R
P
S
A
A
A
G
Site 9
S59
R
Y
D
H
T
R
P
S
A
A
A
G
G
A
V
Site 10
S75
T
M
A
H
S
V
P
S
P
A
F
H
S
P
H
Site 11
S80
V
P
S
P
A
F
H
S
P
H
P
P
S
E
V
Site 12
S85
F
H
S
P
H
P
P
S
E
V
T
A
S
I
V
Site 13
S90
P
P
S
E
V
T
A
S
I
V
K
T
N
S
H
Site 14
T94
V
T
A
S
I
V
K
T
N
S
H
E
P
G
K
Site 15
S115
V
L
R
D
R
N
L
S
G
M
A
E
R
K
T
Site 16
T122
S
G
M
A
E
R
K
T
Q
P
S
M
V
S
N
Site 17
S125
A
E
R
K
T
Q
P
S
M
V
S
N
P
G
S
Site 18
S128
K
T
Q
P
S
M
V
S
N
P
G
S
C
S
D
Site 19
S132
S
M
V
S
N
P
G
S
C
S
D
P
Q
P
S
Site 20
S134
V
S
N
P
G
S
C
S
D
P
Q
P
S
P
E
Site 21
S139
S
C
S
D
P
Q
P
S
P
E
M
K
P
H
S
Site 22
S146
S
P
E
M
K
P
H
S
Y
L
D
A
I
R
S
Site 23
Y147
P
E
M
K
P
H
S
Y
L
D
A
I
R
S
G
Site 24
S153
S
Y
L
D
A
I
R
S
G
L
D
D
V
E
A
Site 25
S161
G
L
D
D
V
E
A
S
S
S
Y
S
N
E
Q
Site 26
S163
D
D
V
E
A
S
S
S
Y
S
N
E
Q
Q
L
Site 27
Y164
D
V
E
A
S
S
S
Y
S
N
E
Q
Q
L
C
Site 28
S165
V
E
A
S
S
S
Y
S
N
E
Q
Q
L
C
P
Site 29
Y173
N
E
Q
Q
L
C
P
Y
A
A
A
G
E
C
R
Site 30
S252
I
L
E
K
A
S
A
S
E
R
R
F
G
I
L
Site 31
Y303
E
F
V
I
P
S
V
Y
W
V
E
D
Q
N
K
Site 32
Y329
M
G
K
K
A
C
K
Y
F
E
Q
G
K
G
T
Site 33
Y345
P
F
G
S
K
C
L
Y
R
H
A
Y
P
D
G
Site 34
Y349
K
C
L
Y
R
H
A
Y
P
D
G
R
L
A
E
Site 35
S365
E
K
P
R
K
Q
L
S
S
Q
G
T
V
R
F
Site 36
S366
K
P
R
K
Q
L
S
S
Q
G
T
V
R
F
F
Site 37
T369
K
Q
L
S
S
Q
G
T
V
R
F
F
N
S
V
Site 38
S387
D
F
I
E
N
R
E
S
R
H
V
P
N
N
E
Site 39
T399
N
N
E
D
V
D
M
T
E
L
G
D
L
F
M
Site 40
S409
G
D
L
F
M
H
L
S
G
V
E
S
S
E
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation