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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LSG1
Full Name:
Large subunit GTPase 1 homolog
Alias:
FLJ11301; large subunit GTPase 1
Type:
Endoplasmic reticulum; Hydrolase; EC 3.6.1.-; G protein, monomeric (non-Rab)
Mass (Da):
75225
Number AA:
658
UniProt ID:
Q9H089
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0005783
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0016787
PhosphoSite+
KinaseNET
Biological Process:
GO:0051168
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
R
R
A
P
A
G
G
S
L
G
R
A
L
M
R
Site 2
T21
R
A
L
M
R
H
Q
T
Q
R
S
R
S
H
R
Site 3
S26
H
Q
T
Q
R
S
R
S
H
R
H
T
D
S
W
Site 4
T30
R
S
R
S
H
R
H
T
D
S
W
L
H
T
S
Site 5
S32
R
S
H
R
H
T
D
S
W
L
H
T
S
E
L
Site 6
T36
H
T
D
S
W
L
H
T
S
E
L
N
D
G
Y
Site 7
Y43
T
S
E
L
N
D
G
Y
D
W
G
R
L
N
L
Site 8
S52
W
G
R
L
N
L
Q
S
V
T
E
Q
S
S
L
Site 9
T54
R
L
N
L
Q
S
V
T
E
Q
S
S
L
D
D
Site 10
S58
Q
S
V
T
E
Q
S
S
L
D
D
F
L
A
T
Site 11
S93
E
A
R
T
G
L
L
S
F
E
E
S
Q
R
I
Site 12
S97
G
L
L
S
F
E
E
S
Q
R
I
K
K
L
H
Site 13
T124
P
N
W
N
Q
N
T
T
P
E
E
L
K
Q
A
Site 14
T155
E
E
Q
K
L
I
L
T
P
F
E
R
N
L
D
Site 15
Y197
R
C
E
D
L
E
C
Y
V
K
E
M
D
A
N
Site 16
T218
I
N
K
A
D
L
L
T
A
E
Q
R
S
A
W
Site 17
Y228
Q
R
S
A
W
A
M
Y
F
E
K
E
D
V
K
Site 18
S252
A
I
P
L
N
G
D
S
E
E
E
A
N
R
D
Site 19
S263
A
N
R
D
D
R
Q
S
N
T
T
K
F
G
H
Site 20
T265
R
D
D
R
Q
S
N
T
T
K
F
G
H
S
S
Site 21
T266
D
D
R
Q
S
N
T
T
K
F
G
H
S
S
F
Site 22
S272
T
T
K
F
G
H
S
S
F
D
Q
A
E
I
S
Site 23
S279
S
F
D
Q
A
E
I
S
H
S
E
S
E
H
L
Site 24
S281
D
Q
A
E
I
S
H
S
E
S
E
H
L
P
A
Site 25
S283
A
E
I
S
H
S
E
S
E
H
L
P
A
R
D
Site 26
S291
E
H
L
P
A
R
D
S
P
S
L
S
E
N
P
Site 27
S293
L
P
A
R
D
S
P
S
L
S
E
N
P
T
T
Site 28
S295
A
R
D
S
P
S
L
S
E
N
P
T
T
D
E
Site 29
T299
P
S
L
S
E
N
P
T
T
D
E
D
D
S
E
Site 30
T300
S
L
S
E
N
P
T
T
D
E
D
D
S
E
Y
Site 31
S305
P
T
T
D
E
D
D
S
E
Y
E
D
C
P
E
Site 32
Y307
T
D
E
D
D
S
E
Y
E
D
C
P
E
E
E
Site 33
T320
E
E
E
D
D
W
Q
T
C
S
E
E
D
G
P
Site 34
S322
E
D
D
W
Q
T
C
S
E
E
D
G
P
K
E
Site 35
S333
G
P
K
E
E
D
C
S
Q
D
W
K
E
S
S
Site 36
S340
S
Q
D
W
K
E
S
S
T
A
D
S
E
A
R
Site 37
S344
K
E
S
S
T
A
D
S
E
A
R
S
R
K
T
Site 38
S348
T
A
D
S
E
A
R
S
R
K
T
P
Q
K
R
Site 39
T351
S
E
A
R
S
R
K
T
P
Q
K
R
Q
I
H
Site 40
S361
K
R
Q
I
H
N
F
S
H
L
V
S
K
Q
E
Site 41
S365
H
N
F
S
H
L
V
S
K
Q
E
L
L
E
L
Site 42
S400
G
Y
P
N
V
G
K
S
S
T
I
N
T
I
M
Site 43
T405
G
K
S
S
T
I
N
T
I
M
G
N
K
K
V
Site 44
S413
I
M
G
N
K
K
V
S
V
S
A
T
P
G
H
Site 45
S415
G
N
K
K
V
S
V
S
A
T
P
G
H
T
K
Site 46
T417
K
K
V
S
V
S
A
T
P
G
H
T
K
H
F
Site 47
T421
V
S
A
T
P
G
H
T
K
H
F
Q
T
L
Y
Site 48
T426
G
H
T
K
H
F
Q
T
L
Y
V
E
P
G
L
Site 49
S445
C
P
G
L
V
M
P
S
F
V
S
T
K
A
E
Site 50
S472
R
D
H
V
P
P
V
S
L
V
C
Q
N
I
P
Site 51
T493
T
Y
G
I
N
I
I
T
P
R
E
D
E
D
P
Site 52
T505
E
D
P
H
R
P
P
T
S
E
E
L
L
T
A
Site 53
S506
D
P
H
R
P
P
T
S
E
E
L
L
T
A
Y
Site 54
T511
P
T
S
E
E
L
L
T
A
Y
G
Y
M
R
G
Site 55
Y513
S
E
E
L
L
T
A
Y
G
Y
M
R
G
F
M
Site 56
S531
G
Q
P
D
Q
P
R
S
A
R
Y
I
L
K
D
Site 57
Y539
A
R
Y
I
L
K
D
Y
V
S
G
K
L
L
Y
Site 58
Y546
Y
V
S
G
K
L
L
Y
C
H
P
P
P
G
R
Site 59
T557
P
P
G
R
D
P
V
T
F
Q
H
Q
H
Q
R
Site 60
S572
L
L
E
N
K
M
N
S
D
E
I
K
M
Q
L
Site 61
T606
Q
E
N
V
R
A
L
T
K
G
V
Q
A
V
M
Site 62
Y615
G
V
Q
A
V
M
G
Y
K
P
G
S
G
V
V
Site 63
T623
K
P
G
S
G
V
V
T
A
S
T
A
S
S
E
Site 64
S625
G
S
G
V
V
T
A
S
T
A
S
S
E
N
G
Site 65
T626
S
G
V
V
T
A
S
T
A
S
S
E
N
G
A
Site 66
S629
V
T
A
S
T
A
S
S
E
N
G
A
G
K
P
Site 67
S649
N
R
N
K
K
E
K
S
R
R
L
Y
K
H
L
Site 68
Y653
K
E
K
S
R
R
L
Y
K
H
L
D
M
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation