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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NuaK2
Full Name:
NUAK family SNF1-like kinase 2
Alias:
DKFZp434J037; EC 2.7.11.1; FLJ90349; NUAK family, SNF1-like kinase, 2; SNARK; SNF1/AMP activated protein kinase
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
CAMK
group; CAMKL family; NuaK subfamily
Mass (Da):
69612
Number AA:
628
UniProt ID:
Q9H093
International Prot ID:
IPI00008883
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0006915
GO:0042149
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
L
V
F
A
R
R
S
G
P
T
P
S
A
A
Site 2
T13
F
A
R
R
S
G
P
T
P
S
A
A
E
L
A
Site 3
S15
R
R
S
G
P
T
P
S
A
A
E
L
A
R
P
Site 4
S30
L
A
E
G
L
I
K
S
P
K
P
L
M
K
K
Site 5
Y53
K
H
N
L
R
H
R
Y
E
F
L
E
T
L
G
Site 6
T58
H
R
Y
E
F
L
E
T
L
G
K
G
T
Y
G
Site 7
Y64
E
T
L
G
K
G
T
Y
G
K
V
K
K
A
R
Site 8
S73
K
V
K
K
A
R
E
S
S
G
R
L
V
A
I
Site 9
S74
V
K
K
A
R
E
S
S
G
R
L
V
A
I
K
Site 10
S82
G
R
L
V
A
I
K
S
I
R
K
D
K
I
K
Site 11
S106
R
E
I
E
I
M
S
S
L
N
H
P
H
I
I
Site 12
Y131
K
I
V
I
V
M
E
Y
A
S
R
G
D
L
Y
Site 13
Y138
Y
A
S
R
G
D
L
Y
D
Y
I
S
E
R
Q
Site 14
Y140
S
R
G
D
L
Y
D
Y
I
S
E
R
Q
Q
L
Site 15
S142
G
D
L
Y
D
Y
I
S
E
R
Q
Q
L
S
E
Site 16
S148
I
S
E
R
Q
Q
L
S
E
R
E
A
R
H
F
Site 17
Y200
D
F
G
L
S
N
L
Y
H
Q
G
K
F
L
Q
Site 18
T208
H
Q
G
K
F
L
Q
T
F
C
G
S
P
L
Y
Site 19
S217
C
G
S
P
L
Y
A
S
P
E
I
V
N
G
K
Site 20
Y226
E
I
V
N
G
K
P
Y
T
G
P
E
V
D
S
Site 21
S263
K
I
L
V
K
Q
I
S
N
G
A
Y
R
E
P
Site 22
Y267
K
Q
I
S
N
G
A
Y
R
E
P
P
K
P
S
Site 23
T289
W
L
L
M
V
N
P
T
R
R
A
T
L
E
D
Site 24
T293
V
N
P
T
R
R
A
T
L
E
D
V
A
S
H
Site 25
S325
H
E
G
G
H
P
G
S
D
S
A
R
A
S
M
Site 26
S327
G
G
H
P
G
S
D
S
A
R
A
S
M
A
D
Site 27
S331
G
S
D
S
A
R
A
S
M
A
D
W
L
R
R
Site 28
S339
M
A
D
W
L
R
R
S
S
R
P
L
L
E
N
Site 29
S340
A
D
W
L
R
R
S
S
R
P
L
L
E
N
G
Site 30
S352
E
N
G
A
K
V
C
S
F
F
K
Q
H
A
P
Site 31
S363
Q
H
A
P
G
G
G
S
T
T
P
G
L
E
R
Site 32
T365
A
P
G
G
G
S
T
T
P
G
L
E
R
Q
H
Site 33
S373
P
G
L
E
R
Q
H
S
L
K
K
S
R
K
E
Site 34
S377
R
Q
H
S
L
K
K
S
R
K
E
N
D
M
A
Site 35
S386
K
E
N
D
M
A
Q
S
L
H
S
D
T
A
D
Site 36
T395
H
S
D
T
A
D
D
T
A
H
R
P
G
K
S
Site 37
S402
T
A
H
R
P
G
K
S
N
L
K
L
P
K
G
Site 38
S416
G
I
L
K
K
K
V
S
A
S
A
E
G
V
Q
Site 39
S418
L
K
K
K
V
S
A
S
A
E
G
V
Q
E
D
Site 40
S430
Q
E
D
P
P
E
L
S
P
I
P
A
S
P
G
Site 41
S435
E
L
S
P
I
P
A
S
P
G
Q
A
A
P
L
Site 42
S457
K
K
P
R
Q
R
E
S
G
Y
Y
S
S
P
E
Site 43
Y459
P
R
Q
R
E
S
G
Y
Y
S
S
P
E
P
S
Site 44
Y460
R
Q
R
E
S
G
Y
Y
S
S
P
E
P
S
E
Site 45
S461
Q
R
E
S
G
Y
Y
S
S
P
E
P
S
E
S
Site 46
S462
R
E
S
G
Y
Y
S
S
P
E
P
S
E
S
G
Site 47
S466
Y
Y
S
S
P
E
P
S
E
S
G
E
L
L
D
Site 48
S468
S
S
P
E
P
S
E
S
G
E
L
L
D
A
G
Site 49
S480
D
A
G
D
V
F
V
S
G
D
P
K
E
Q
K
Site 50
S523
A
A
P
T
T
F
G
S
L
D
E
L
A
P
P
Site 51
S537
P
R
P
L
A
R
A
S
R
P
S
G
A
V
S
Site 52
S540
L
A
R
A
S
R
P
S
G
A
V
S
E
D
S
Site 53
S544
S
R
P
S
G
A
V
S
E
D
S
I
L
S
S
Site 54
S547
S
G
A
V
S
E
D
S
I
L
S
S
E
S
F
Site 55
S550
V
S
E
D
S
I
L
S
S
E
S
F
D
Q
L
Site 56
S551
S
E
D
S
I
L
S
S
E
S
F
D
Q
L
D
Site 57
S553
D
S
I
L
S
S
E
S
F
D
Q
L
D
L
P
Site 58
S573
P
P
L
R
G
C
V
S
V
D
N
L
T
G
L
Site 59
T578
C
V
S
V
D
N
L
T
G
L
E
E
P
P
S
Site 60
S585
T
G
L
E
E
P
P
S
E
G
P
G
S
C
L
Site 61
S590
P
P
S
E
G
P
G
S
C
L
R
R
W
R
Q
Site 62
S603
R
Q
D
P
L
G
D
S
C
F
S
L
T
D
C
Site 63
S606
P
L
G
D
S
C
F
S
L
T
D
C
Q
E
V
Site 64
T608
G
D
S
C
F
S
L
T
D
C
Q
E
V
T
A
Site 65
T616
D
C
Q
E
V
T
A
T
Y
R
Q
A
L
R
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation