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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZNF541
Full Name:
Zinc finger protein 541
Alias:
DKFZp434I1930; Zinc finger 541; Zn541; Znf541
Type:
Mass (Da):
147810
Number AA:
UniProt ID:
Q9H0D2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007275
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
G
D
E
G
A
L
P
S
E
M
H
L
P
S
F
Site 2
S20
P
S
E
M
H
L
P
S
F
S
E
S
Q
G
L
Site 3
S22
E
M
H
L
P
S
F
S
E
S
Q
G
L
N
C
Site 4
S24
H
L
P
S
F
S
E
S
Q
G
L
N
C
S
D
Site 5
S30
E
S
Q
G
L
N
C
S
D
T
L
N
R
D
L
Site 6
T32
Q
G
L
N
C
S
D
T
L
N
R
D
L
G
P
Site 7
Y46
P
N
T
R
G
F
L
Y
A
G
L
S
G
L
D
Site 8
S50
G
F
L
Y
A
G
L
S
G
L
D
P
D
P
S
Site 9
S57
S
G
L
D
P
D
P
S
L
P
T
P
D
M
S
Site 10
T60
D
P
D
P
S
L
P
T
P
D
M
S
S
E
V
Site 11
S64
S
L
P
T
P
D
M
S
S
E
V
L
E
D
N
Site 12
T74
V
L
E
D
N
L
D
T
L
S
L
Y
S
G
K
Site 13
S76
E
D
N
L
D
T
L
S
L
Y
S
G
K
D
S
Site 14
Y78
N
L
D
T
L
S
L
Y
S
G
K
D
S
D
S
Site 15
S79
L
D
T
L
S
L
Y
S
G
K
D
S
D
S
V
Site 16
S83
S
L
Y
S
G
K
D
S
D
S
V
K
L
L
E
Site 17
S85
Y
S
G
K
D
S
D
S
V
K
L
L
E
E
Y
Site 18
Y92
S
V
K
L
L
E
E
Y
A
D
S
E
S
Q
A
Site 19
S95
L
L
E
E
Y
A
D
S
E
S
Q
A
S
L
Q
Site 20
S97
E
E
Y
A
D
S
E
S
Q
A
S
L
Q
D
L
Site 21
S100
A
D
S
E
S
Q
A
S
L
Q
D
L
G
L
G
Site 22
T121
A
D
E
G
G
R
A
T
S
G
S
A
R
K
G
Site 23
S122
D
E
G
G
R
A
T
S
G
S
A
R
K
G
K
Site 24
S124
G
G
R
A
T
S
G
S
A
R
K
G
K
R
Q
Site 25
S133
R
K
G
K
R
Q
H
S
S
P
Q
N
P
L
L
Site 26
S134
K
G
K
R
Q
H
S
S
P
Q
N
P
L
L
D
Site 27
S151
L
C
G
K
V
F
S
S
A
S
S
L
S
K
H
Site 28
S153
G
K
V
F
S
S
A
S
S
L
S
K
H
Y
L
Site 29
S154
K
V
F
S
S
A
S
S
L
S
K
H
Y
L
T
Site 30
S156
F
S
S
A
S
S
L
S
K
H
Y
L
T
H
S
Site 31
Y159
A
S
S
L
S
K
H
Y
L
T
H
S
Q
E
R
Site 32
T161
S
L
S
K
H
Y
L
T
H
S
Q
E
R
K
H
Site 33
S163
S
K
H
Y
L
T
H
S
Q
E
R
K
H
V
C
Site 34
S206
I
E
Q
G
C
S
K
S
Y
C
D
Y
R
S
L
Site 35
Y207
E
Q
G
C
S
K
S
Y
C
D
Y
R
S
L
R
Site 36
Y210
C
S
K
S
Y
C
D
Y
R
S
L
R
R
H
Y
Site 37
Y217
Y
R
S
L
R
R
H
Y
E
V
H
H
G
L
C
Site 38
S239
E
E
E
A
C
G
D
S
P
H
A
H
E
S
A
Site 39
S245
D
S
P
H
A
H
E
S
A
G
Q
P
P
P
S
Site 40
S252
S
A
G
Q
P
P
P
S
S
L
R
S
L
V
P
Site 41
S253
A
G
Q
P
P
P
S
S
L
R
S
L
V
P
P
Site 42
S256
P
P
P
S
S
L
R
S
L
V
P
P
E
A
R
Site 43
S264
L
V
P
P
E
A
R
S
P
G
S
L
L
P
H
Site 44
S267
P
E
A
R
S
P
G
S
L
L
P
H
R
D
L
Site 45
S280
D
L
L
R
R
I
V
S
S
I
V
H
Q
K
T
Site 46
S281
L
L
R
R
I
V
S
S
I
V
H
Q
K
T
P
Site 47
T287
S
S
I
V
H
Q
K
T
P
S
P
G
P
A
P
Site 48
S289
I
V
H
Q
K
T
P
S
P
G
P
A
P
A
G
Site 49
S298
G
P
A
P
A
G
A
S
D
S
E
G
R
N
T
Site 50
S300
A
P
A
G
A
S
D
S
E
G
R
N
T
A
C
Site 51
T305
S
D
S
E
G
R
N
T
A
C
P
C
P
A
S
Site 52
S312
T
A
C
P
C
P
A
S
S
G
S
S
S
C
T
Site 53
S313
A
C
P
C
P
A
S
S
G
S
S
S
C
T
P
Site 54
S315
P
C
P
A
S
S
G
S
S
S
C
T
P
A
G
Site 55
S316
C
P
A
S
S
G
S
S
S
C
T
P
A
G
P
Site 56
S317
P
A
S
S
G
S
S
S
C
T
P
A
G
P
H
Site 57
T319
S
S
G
S
S
S
C
T
P
A
G
P
H
A
A
Site 58
T332
A
A
P
A
A
L
D
T
E
L
P
E
E
P
C
Site 59
T351
E
P
A
T
D
V
F
T
A
P
N
S
R
A
A
Site 60
T372
P
P
E
P
E
P
D
T
A
L
L
Q
A
R
S
Site 61
S379
T
A
L
L
Q
A
R
S
T
A
E
C
W
P
E
Site 62
T380
A
L
L
Q
A
R
S
T
A
E
C
W
P
E
G
Site 63
T401
L
P
L
F
R
G
Q
T
V
P
A
S
S
Q
P
Site 64
S405
R
G
Q
T
V
P
A
S
S
Q
P
S
S
H
S
Site 65
S406
G
Q
T
V
P
A
S
S
Q
P
S
S
H
S
F
Site 66
S409
V
P
A
S
S
Q
P
S
S
H
S
F
Q
W
L
Site 67
S410
P
A
S
S
Q
P
S
S
H
S
F
Q
W
L
R
Site 68
S412
S
S
Q
P
S
S
H
S
F
Q
W
L
R
N
L
Site 69
S425
N
L
P
G
C
P
K
S
K
G
N
N
V
F
V
Site 70
S437
V
F
V
V
H
K
P
S
A
V
P
S
R
E
G
Site 71
S441
H
K
P
S
A
V
P
S
R
E
G
S
E
S
G
Site 72
S445
A
V
P
S
R
E
G
S
E
S
G
P
G
P
S
Site 73
S447
P
S
R
E
G
S
E
S
G
P
G
P
S
S
G
Site 74
S453
E
S
G
P
G
P
S
S
G
S
P
S
E
E
S
Site 75
S455
G
P
G
P
S
S
G
S
P
S
E
E
S
P
P
Site 76
S457
G
P
S
S
G
S
P
S
E
E
S
P
P
G
P
Site 77
S460
S
G
S
P
S
E
E
S
P
P
G
P
G
G
G
Site 78
S487
R
V
P
A
E
A
P
S
D
P
R
S
A
S
G
Site 79
S491
E
A
P
S
D
P
R
S
A
S
G
E
D
D
P
Site 80
S493
P
S
D
P
R
S
A
S
G
E
D
D
P
C
A
Site 81
S510
K
V
K
V
D
C
D
S
F
L
C
Q
N
P
G
Site 82
S545
F
R
Q
L
F
L
K
S
Q
E
P
L
V
S
H
Site 83
S551
K
S
Q
E
P
L
V
S
H
E
Q
M
Q
V
F
Site 84
S569
T
K
S
Q
R
I
F
S
H
A
Q
V
A
A
V
Site 85
S610
P
L
A
P
A
V
D
S
L
H
A
G
P
G
N
Site 86
S623
G
N
P
E
A
E
G
S
P
A
R
R
R
K
T
Site 87
T630
S
P
A
R
R
R
K
T
T
P
G
V
P
R
E
Site 88
T631
P
A
R
R
R
K
T
T
P
G
V
P
R
E
A
Site 89
S639
P
G
V
P
R
E
A
S
P
G
S
T
R
R
D
Site 90
S642
P
R
E
A
S
P
G
S
T
R
R
D
A
K
G
Site 91
T643
R
E
A
S
P
G
S
T
R
R
D
A
K
G
G
Site 92
T658
L
K
V
A
A
V
P
T
P
L
A
A
P
S
L
Site 93
S664
P
T
P
L
A
A
P
S
L
D
P
S
R
N
P
Site 94
S668
A
A
P
S
L
D
P
S
R
N
P
D
I
S
S
Site 95
S674
P
S
R
N
P
D
I
S
S
L
A
K
Q
L
R
Site 96
S675
S
R
N
P
D
I
S
S
L
A
K
Q
L
R
S
Site 97
S682
S
L
A
K
Q
L
R
S
S
K
G
T
L
D
L
Site 98
S683
L
A
K
Q
L
R
S
S
K
G
T
L
D
L
E
Site 99
T686
Q
L
R
S
S
K
G
T
L
D
L
E
D
I
F
Site 100
T696
L
E
D
I
F
P
S
T
G
Q
R
Q
T
Q
L
Site 101
T701
P
S
T
G
Q
R
Q
T
Q
L
G
G
E
E
P
Site 102
S712
G
E
E
P
P
G
A
S
L
P
G
K
Q
A
P
Site 103
T729
N
G
A
A
S
R
I
T
K
G
E
K
G
P
A
Site 104
S755
N
P
R
A
P
R
F
S
G
F
R
K
E
K
A
Site 105
S779
P
S
Q
V
A
M
A
S
F
S
S
A
G
P
P
Site 106
S790
A
G
P
P
A
D
P
S
K
S
K
L
T
I
F
Site 107
S792
P
P
A
D
P
S
K
S
K
L
T
I
F
S
R
Site 108
S798
K
S
K
L
T
I
F
S
R
I
Q
G
G
N
I
Site 109
Y806
R
I
Q
G
G
N
I
Y
R
L
P
H
P
V
K
Site 110
S827
R
G
N
Q
Q
N
G
S
P
T
D
W
T
K
P
Site 111
T832
N
G
S
P
T
D
W
T
K
P
R
S
T
F
V
Site 112
Y848
K
N
C
S
Q
M
F
Y
T
E
K
G
L
S
S
Site 113
T849
N
C
S
Q
M
F
Y
T
E
K
G
L
S
S
H
Site 114
S866
F
H
S
D
Q
W
P
S
P
R
G
K
Q
E
P
Site 115
S896
R
P
E
G
D
R
H
S
P
P
G
T
K
K
P
Site 116
T900
D
R
H
S
P
P
G
T
K
K
P
L
D
P
T
Site 117
T943
C
S
R
W
L
Q
A
T
T
C
G
S
K
L
L
Site 118
S962
K
D
G
E
E
R
D
S
K
E
S
S
Q
Q
R
Site 119
S965
E
E
R
D
S
K
E
S
S
Q
Q
R
K
R
K
Site 120
S966
E
R
D
S
K
E
S
S
Q
Q
R
K
R
K
K
Site 121
S978
R
K
K
R
P
P
P
S
T
A
G
E
P
G
P
Site 122
T979
K
K
R
P
P
P
S
T
A
G
E
P
G
P
A
Site 123
S991
G
P
A
G
C
H
Q
S
R
L
R
S
P
M
F
Site 124
S995
C
H
Q
S
R
L
R
S
P
M
F
L
V
D
C
Site 125
S1011
L
K
G
L
F
Q
C
S
P
Y
T
P
P
P
M
Site 126
Y1013
G
L
F
Q
C
S
P
Y
T
P
P
P
M
L
S
Site 127
T1014
L
F
Q
C
S
P
Y
T
P
P
P
M
L
S
P
Site 128
S1020
Y
T
P
P
P
M
L
S
P
I
R
E
G
S
G
Site 129
S1026
L
S
P
I
R
E
G
S
G
V
Y
F
N
T
L
Site 130
Y1029
I
R
E
G
S
G
V
Y
F
N
T
L
C
S
T
Site 131
T1032
G
S
G
V
Y
F
N
T
L
C
S
T
S
T
Q
Site 132
S1035
V
Y
F
N
T
L
C
S
T
S
T
Q
A
S
P
Site 133
S1037
F
N
T
L
C
S
T
S
T
Q
A
S
P
D
Q
Site 134
S1041
C
S
T
S
T
Q
A
S
P
D
Q
L
I
S
S
Site 135
S1048
S
P
D
Q
L
I
S
S
M
L
D
Q
V
D
G
Site 136
T1066
I
C
V
V
K
D
D
T
K
I
S
I
E
P
H
Site 137
S1069
V
K
D
D
T
K
I
S
I
E
P
H
I
N
I
Site 138
S1091
I
P
E
L
Q
E
R
S
L
A
G
T
D
E
H
Site 139
T1095
Q
E
R
S
L
A
G
T
D
E
H
V
A
S
L
Site 140
T1121
S
E
T
Q
D
R
V
T
E
L
C
N
V
A
C
Site 141
T1170
R
G
P
H
K
P
R
T
H
L
L
A
D
Y
R
Site 142
Y1176
R
T
H
L
L
A
D
Y
R
Y
T
G
S
D
V
Site 143
Y1178
H
L
L
A
D
Y
R
Y
T
G
S
D
V
W
T
Site 144
T1179
L
L
A
D
Y
R
Y
T
G
S
D
V
W
T
P
Site 145
S1181
A
D
Y
R
Y
T
G
S
D
V
W
T
P
I
E
Site 146
T1185
Y
T
G
S
D
V
W
T
P
I
E
K
R
L
F
Site 147
Y1204
Y
A
H
K
K
D
F
Y
L
I
H
K
M
I
Q
Site 148
T1214
H
K
M
I
Q
T
K
T
V
A
Q
C
V
E
Y
Site 149
T1253
E
P
E
E
V
E
R
T
E
E
K
V
P
C
S
Site 150
S1260
T
E
E
K
V
P
C
S
P
R
E
R
P
S
H
Site 151
S1266
C
S
P
R
E
R
P
S
H
H
P
T
P
K
L
Site 152
T1270
E
R
P
S
H
H
P
T
P
K
L
K
T
K
S
Site 153
S1277
T
P
K
L
K
T
K
S
Y
R
R
E
S
I
L
Site 154
Y1278
P
K
L
K
T
K
S
Y
R
R
E
S
I
L
S
Site 155
S1282
T
K
S
Y
R
R
E
S
I
L
S
S
S
P
N
Site 156
S1285
Y
R
R
E
S
I
L
S
S
S
P
N
A
G
S
Site 157
S1286
R
R
E
S
I
L
S
S
S
P
N
A
G
S
K
Site 158
S1287
R
E
S
I
L
S
S
S
P
N
A
G
S
K
R
Site 159
S1292
S
S
S
P
N
A
G
S
K
R
T
P
E
L
L
Site 160
T1295
P
N
A
G
S
K
R
T
P
E
L
L
G
S
A
Site 161
S1301
R
T
P
E
L
L
G
S
A
E
S
Q
G
I
F
Site 162
S1304
E
L
L
G
S
A
E
S
Q
G
I
F
P
C
R
Site 163
S1322
R
V
F
D
K
I
K
S
R
N
A
H
M
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation