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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
XRN2
Full Name:
5'-3' exoribonuclease 2
Alias:
5'-3' exoribonuclease 2; DHM1-like protein; XRN2_HUMAN
Type:
RNA processing; EC 3.1.13.-; Ribonuclease; Cell development/differentiation; RNA binding protein
Mass (Da):
108582
Number AA:
950
UniProt ID:
Q9H0D6
International Prot ID:
IPI00100151
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003824
GO:0004518
PhosphoSite+
KinaseNET
Biological Process:
GO:0000003
GO:0000738
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
A
F
F
R
W
L
S
R
K
Y
P
S
I
I
Site 2
Y14
F
R
W
L
S
R
K
Y
P
S
I
I
V
N
C
Site 3
T63
N
G
I
I
H
P
C
T
H
P
E
D
K
P
A
Site 4
S90
E
Y
I
D
R
L
F
S
I
V
R
P
R
R
L
Site 5
Y99
V
R
P
R
R
L
L
Y
M
A
I
D
G
V
A
Site 6
S116
A
K
M
N
Q
Q
R
S
R
R
F
R
A
S
K
Site 7
S122
R
S
R
R
F
R
A
S
K
E
G
M
E
A
A
Site 8
S157
E
I
K
E
R
F
D
S
N
C
I
T
P
G
T
Site 9
T161
R
F
D
S
N
C
I
T
P
G
T
E
F
M
D
Site 10
Y176
N
L
A
K
C
L
R
Y
Y
I
A
D
R
L
N
Site 11
Y177
L
A
K
C
L
R
Y
Y
I
A
D
R
L
N
N
Site 12
T192
D
P
G
W
K
N
L
T
V
I
L
S
D
A
S
Site 13
S196
K
N
L
T
V
I
L
S
D
A
S
A
P
G
E
Site 14
S199
T
V
I
L
S
D
A
S
A
P
G
E
G
E
H
Site 15
Y211
G
E
H
K
I
M
D
Y
I
R
R
Q
R
A
Q
Site 16
T249
A
T
H
E
P
N
F
T
I
I
R
E
E
F
K
Site 17
S293
K
H
D
E
L
A
D
S
L
P
C
A
E
G
E
Site 18
Y312
R
L
N
V
L
R
E
Y
L
E
R
E
L
T
M
Site 19
T318
E
Y
L
E
R
E
L
T
M
A
S
L
P
F
T
Site 20
S352
D
F
L
P
H
L
P
S
L
E
I
R
E
N
A
Site 21
Y367
I
D
R
L
V
N
I
Y
K
N
V
V
H
K
T
Site 22
Y377
V
V
H
K
T
G
G
Y
L
T
E
S
G
Y
V
Site 23
T379
H
K
T
G
G
Y
L
T
E
S
G
Y
V
N
L
Site 24
S381
T
G
G
Y
L
T
E
S
G
Y
V
N
L
Q
R
Site 25
Y383
G
Y
L
T
E
S
G
Y
V
N
L
Q
R
V
Q
Site 26
S402
A
V
G
E
V
E
D
S
I
F
K
K
R
K
D
Site 27
S413
K
R
K
D
D
E
D
S
F
R
R
R
Q
K
E
Site 28
T433
K
R
D
Q
P
A
F
T
P
S
G
I
L
T
P
Site 29
S435
D
Q
P
A
F
T
P
S
G
I
L
T
P
H
A
Site 30
T439
F
T
P
S
G
I
L
T
P
H
A
L
G
S
R
Site 31
S445
L
T
P
H
A
L
G
S
R
N
S
P
G
S
Q
Site 32
S448
H
A
L
G
S
R
N
S
P
G
S
Q
V
A
S
Site 33
S451
G
S
R
N
S
P
G
S
Q
V
A
S
N
P
R
Site 34
S455
S
P
G
S
Q
V
A
S
N
P
R
Q
A
A
Y
Site 35
Y462
S
N
P
R
Q
A
A
Y
E
M
R
M
Q
N
N
Site 36
S470
E
M
R
M
Q
N
N
S
S
P
S
I
S
P
N
Site 37
S471
M
R
M
Q
N
N
S
S
P
S
I
S
P
N
T
Site 38
S473
M
Q
N
N
S
S
P
S
I
S
P
N
T
S
F
Site 39
S475
N
N
S
S
P
S
I
S
P
N
T
S
F
T
S
Site 40
T478
S
P
S
I
S
P
N
T
S
F
T
S
D
G
S
Site 41
S479
P
S
I
S
P
N
T
S
F
T
S
D
G
S
P
Site 42
T481
I
S
P
N
T
S
F
T
S
D
G
S
P
S
P
Site 43
S482
S
P
N
T
S
F
T
S
D
G
S
P
S
P
L
Site 44
S485
T
S
F
T
S
D
G
S
P
S
P
L
G
G
I
Site 45
S487
F
T
S
D
G
S
P
S
P
L
G
G
I
K
R
Site 46
S499
I
K
R
K
A
E
D
S
D
S
E
P
E
P
E
Site 47
S501
R
K
A
E
D
S
D
S
E
P
E
P
E
D
N
Site 48
Y520
E
A
G
W
K
Q
R
Y
Y
K
N
K
F
D
V
Site 49
Y521
A
G
W
K
Q
R
Y
Y
K
N
K
F
D
V
D
Site 50
Y542
R
R
K
V
V
Q
S
Y
V
E
G
L
C
W
V
Site 51
S573
F
H
Y
A
P
F
A
S
D
F
E
G
I
A
D
Site 52
S583
E
G
I
A
D
M
P
S
D
F
E
K
G
T
K
Site 53
S613
S
G
N
F
L
P
P
S
W
R
K
L
M
S
D
Site 54
S619
P
S
W
R
K
L
M
S
D
P
D
S
S
I
I
Site 55
S623
K
L
M
S
D
P
D
S
S
I
I
D
F
Y
P
Site 56
S624
L
M
S
D
P
D
S
S
I
I
D
F
Y
P
E
Site 57
Y629
D
S
S
I
I
D
F
Y
P
E
D
F
A
I
D
Site 58
Y642
I
D
L
N
G
K
K
Y
A
W
Q
G
V
A
L
Site 59
Y666
R
A
A
L
E
E
V
Y
P
D
L
T
P
E
E
Site 60
T670
E
E
V
Y
P
D
L
T
P
E
E
T
R
R
N
Site 61
T674
P
D
L
T
P
E
E
T
R
R
N
S
L
G
G
Site 62
S678
P
E
E
T
R
R
N
S
L
G
G
D
V
L
F
Site 63
Y700
H
D
F
I
L
E
L
Y
Q
T
G
S
T
E
P
Site 64
T702
F
I
L
E
L
Y
Q
T
G
S
T
E
P
V
E
Site 65
S704
L
E
L
Y
Q
T
G
S
T
E
P
V
E
V
P
Site 66
S723
H
G
I
Q
G
K
F
S
L
D
E
E
A
I
L
Site 67
T749
L
R
D
L
T
Q
N
T
V
V
S
I
N
F
K
Site 68
S784
P
A
A
V
L
K
P
S
D
W
E
K
S
S
N
Site 69
S789
K
P
S
D
W
E
K
S
S
N
G
R
Q
W
K
Site 70
S790
P
S
D
W
E
K
S
S
N
G
R
Q
W
K
P
Site 71
S826
G
H
V
M
P
R
G
S
G
T
G
I
Y
S
N
Site 72
T828
V
M
P
R
G
S
G
T
G
I
Y
S
N
A
A
Site 73
Y831
R
G
S
G
T
G
I
Y
S
N
A
A
P
P
P
Site 74
S832
G
S
G
T
G
I
Y
S
N
A
A
P
P
P
V
Site 75
T840
N
A
A
P
P
P
V
T
Y
Q
G
N
L
Y
R
Site 76
Y846
V
T
Y
Q
G
N
L
Y
R
P
L
L
R
G
Q
Site 77
S861
A
Q
I
P
K
L
M
S
N
M
R
P
Q
D
S
Site 78
S868
S
N
M
R
P
Q
D
S
W
R
G
P
P
P
L
Site 79
Y909
A
A
F
Q
P
N
Q
Y
Q
M
L
A
G
P
G
Site 80
Y931
D
R
G
G
R
Q
G
Y
P
R
E
G
R
K
Y
Site 81
Y938
Y
P
R
E
G
R
K
Y
P
L
P
P
P
S
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation