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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SAP130
Full Name:
Histone deacetylase complex subunit SAP130
Alias:
FLJ12761; Histone deacetylase complex subunit SAP130: 130 kDa Sin3-associated polypeptide: Sin3-associated polypeptide p130: Histone deacetylase complex subunit SAP130: 130 kDa Sin3-associated polypeptide: Sin3-associated polypeptide p130; SIN3A-associated protein 130; Sin3A-associated protein, 130kDa; SP130
Type:
Transcription, coactivator/corepressor
Mass (Da):
110324
Number AA:
1048
UniProt ID:
Q9H0E3
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030914
Uniprot
OncoNet
Molecular Function:
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0043966
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
R
R
L
Q
V
E
M
S
S
Q
Q
F
P
R
L
Site 2
S29
R
L
Q
V
E
M
S
S
Q
Q
F
P
R
L
G
Site 3
S39
F
P
R
L
G
A
P
S
T
G
L
S
Q
A
P
Site 4
T40
P
R
L
G
A
P
S
T
G
L
S
Q
A
P
S
Site 5
S43
G
A
P
S
T
G
L
S
Q
A
P
S
Q
I
A
Site 6
S47
T
G
L
S
Q
A
P
S
Q
I
A
N
S
G
S
Site 7
S52
A
P
S
Q
I
A
N
S
G
S
A
G
L
I
N
Site 8
T63
G
L
I
N
P
A
A
T
V
N
D
E
S
G
R
Site 9
S68
A
A
T
V
N
D
E
S
G
R
D
S
E
V
S
Site 10
S72
N
D
E
S
G
R
D
S
E
V
S
A
R
E
H
Site 11
S75
S
G
R
D
S
E
V
S
A
R
E
H
M
S
S
Site 12
S81
V
S
A
R
E
H
M
S
S
S
S
S
L
Q
S
Site 13
S82
S
A
R
E
H
M
S
S
S
S
S
L
Q
S
R
Site 14
S83
A
R
E
H
M
S
S
S
S
S
L
Q
S
R
E
Site 15
S84
R
E
H
M
S
S
S
S
S
L
Q
S
R
E
E
Site 16
S85
E
H
M
S
S
S
S
S
L
Q
S
R
E
E
K
Site 17
S88
S
S
S
S
S
L
Q
S
R
E
E
K
Q
E
P
Site 18
Y101
E
P
V
V
V
R
P
Y
P
Q
V
Q
M
L
S
Site 19
S108
Y
P
Q
V
Q
M
L
S
T
H
H
A
V
A
S
Site 20
T148
M
K
P
P
P
K
P
T
M
P
S
R
P
I
A
Site 21
S151
P
P
K
P
T
M
P
S
R
P
I
A
P
A
P
Site 22
S160
P
I
A
P
A
P
P
S
T
L
S
L
P
P
K
Site 23
S163
P
A
P
P
S
T
L
S
L
P
P
K
V
P
G
Site 24
T173
P
K
V
P
G
Q
V
T
V
T
M
E
S
S
I
Site 25
T175
V
P
G
Q
V
T
V
T
M
E
S
S
I
P
Q
Site 26
S212
M
T
T
N
V
Q
M
S
I
I
R
S
N
A
P
Site 27
S228
P
P
L
H
I
G
A
S
H
L
P
R
G
A
A
Site 28
T246
V
M
S
S
S
K
V
T
T
V
L
R
P
T
S
Site 29
T247
M
S
S
S
K
V
T
T
V
L
R
P
T
S
Q
Site 30
S253
T
T
V
L
R
P
T
S
Q
L
P
N
A
A
T
Site 31
S275
I
I
H
Q
P
I
Q
S
R
P
P
V
T
T
S
Site 32
T281
Q
S
R
P
P
V
T
T
S
N
A
I
P
P
A
Site 33
S282
S
R
P
P
V
T
T
S
N
A
I
P
P
A
V
Site 34
S300
V
S
A
T
R
A
Q
S
P
V
I
T
T
T
A
Site 35
T304
R
A
Q
S
P
V
I
T
T
T
A
A
H
A
T
Site 36
S313
T
A
A
H
A
T
D
S
A
L
S
R
P
T
L
Site 37
T319
D
S
A
L
S
R
P
T
L
S
I
Q
H
P
P
Site 38
S321
A
L
S
R
P
T
L
S
I
Q
H
P
P
S
A
Site 39
S327
L
S
I
Q
H
P
P
S
A
A
I
S
I
Q
R
Site 40
S331
H
P
P
S
A
A
I
S
I
Q
R
P
A
Q
S
Site 41
T342
P
A
Q
S
R
D
V
T
T
R
I
T
L
P
S
Site 42
T346
R
D
V
T
T
R
I
T
L
P
S
H
P
A
L
Site 43
S349
T
T
R
I
T
L
P
S
H
P
A
L
G
T
P
Site 44
T355
P
S
H
P
A
L
G
T
P
K
Q
Q
L
H
T
Site 45
T393
T
N
T
I
P
S
A
T
T
A
G
S
V
S
H
Site 46
S397
P
S
A
T
T
A
G
S
V
S
H
T
Q
A
P
Site 47
T401
T
A
G
S
V
S
H
T
Q
A
P
T
S
T
I
Site 48
T412
T
S
T
I
V
T
M
T
V
P
S
H
S
S
H
Site 49
T421
P
S
H
S
S
H
A
T
A
V
T
T
S
N
I
Site 50
T439
K
V
V
P
Q
Q
I
T
H
T
S
P
R
I
Q
Site 51
S442
P
Q
Q
I
T
H
T
S
P
R
I
Q
P
D
Y
Site 52
Y449
S
P
R
I
Q
P
D
Y
P
A
E
R
S
S
L
Site 53
S454
P
D
Y
P
A
E
R
S
S
L
I
P
I
S
G
Site 54
S455
D
Y
P
A
E
R
S
S
L
I
P
I
S
G
H
Site 55
S460
R
S
S
L
I
P
I
S
G
H
R
A
S
P
N
Site 56
S465
P
I
S
G
H
R
A
S
P
N
P
V
A
M
E
Site 57
S475
P
V
A
M
E
T
R
S
D
N
R
P
S
V
P
Site 58
S480
T
R
S
D
N
R
P
S
V
P
V
Q
F
Q
Y
Site 59
Y487
S
V
P
V
Q
F
Q
Y
F
L
P
T
Y
P
P
Site 60
T491
Q
F
Q
Y
F
L
P
T
Y
P
P
S
A
Y
P
Site 61
Y492
F
Q
Y
F
L
P
T
Y
P
P
S
A
Y
P
L
Site 62
T503
A
Y
P
L
A
A
H
T
Y
T
P
I
T
S
S
Site 63
T508
A
H
T
Y
T
P
I
T
S
S
V
S
T
I
R
Site 64
S510
T
Y
T
P
I
T
S
S
V
S
T
I
R
Q
Y
Site 65
T513
P
I
T
S
S
V
S
T
I
R
Q
Y
P
V
S
Site 66
Y517
S
V
S
T
I
R
Q
Y
P
V
S
A
Q
A
P
Site 67
S520
T
I
R
Q
Y
P
V
S
A
Q
A
P
N
S
A
Site 68
S526
V
S
A
Q
A
P
N
S
A
I
T
A
Q
T
G
Site 69
T549
L
N
P
M
Q
L
M
T
V
D
A
S
H
A
R
Site 70
S567
G
I
Q
P
A
P
I
S
T
Q
G
I
Q
P
A
Site 71
S593
L
G
T
Q
G
I
H
S
A
T
P
I
N
T
Q
Site 72
T595
T
Q
G
I
H
S
A
T
P
I
N
T
Q
G
L
Site 73
T609
L
Q
P
A
P
M
G
T
Q
Q
P
Q
P
E
G
Site 74
S619
P
Q
P
E
G
K
T
S
A
V
V
L
A
D
G
Site 75
S639
N
P
I
S
N
P
F
S
A
A
P
A
A
T
T
Site 76
S652
T
T
V
V
Q
T
H
S
Q
S
A
S
T
N
A
Site 77
S656
Q
T
H
S
Q
S
A
S
T
N
A
P
A
Q
G
Site 78
S664
T
N
A
P
A
Q
G
S
S
P
R
P
S
I
L
Site 79
S665
N
A
P
A
Q
G
S
S
P
R
P
S
I
L
R
Site 80
S669
Q
G
S
S
P
R
P
S
I
L
R
K
K
P
A
Site 81
T677
I
L
R
K
K
P
A
T
D
G
A
K
P
K
S
Site 82
S684
T
D
G
A
K
P
K
S
E
I
H
V
S
M
A
Site 83
T692
E
I
H
V
S
M
A
T
P
V
T
V
S
M
E
Site 84
T710
N
Q
N
N
D
Q
P
T
I
A
V
P
P
T
A
Site 85
T716
P
T
I
A
V
P
P
T
A
Q
Q
P
P
P
T
Site 86
S798
M
D
I
M
R
P
V
S
A
V
P
P
L
A
T
Site 87
S824
N
N
L
S
M
P
T
S
D
L
P
P
G
A
S
Site 88
S831
S
D
L
P
P
G
A
S
P
R
K
K
P
R
K
Site 89
S844
R
K
Q
Q
H
V
I
S
T
E
E
G
D
M
M
Site 90
T853
E
E
G
D
M
M
E
T
N
S
T
D
D
E
K
Site 91
S855
G
D
M
M
E
T
N
S
T
D
D
E
K
S
T
Site 92
T856
D
M
M
E
T
N
S
T
D
D
E
K
S
T
A
Site 93
S861
N
S
T
D
D
E
K
S
T
A
K
S
L
L
V
Site 94
S865
D
E
K
S
T
A
K
S
L
L
V
K
A
E
K
Site 95
S875
V
K
A
E
K
R
K
S
P
P
K
E
Y
I
D
Site 96
Y880
R
K
S
P
P
K
E
Y
I
D
E
E
G
V
R
Site 97
Y888
I
D
E
E
G
V
R
Y
V
P
V
R
P
R
P
Site 98
T898
V
R
P
R
P
P
I
T
L
L
R
H
Y
R
N
Site 99
Y903
P
I
T
L
L
R
H
Y
R
N
P
W
K
A
A
Site 100
Y966
T
N
L
E
H
D
V
Y
E
R
L
T
N
L
Q
Site 101
T970
H
D
V
Y
E
R
L
T
N
L
Q
E
G
I
I
Site 102
S1010
K
L
V
M
D
Q
I
S
E
A
R
D
S
M
L
Site 103
S1015
Q
I
S
E
A
R
D
S
M
L
K
V
L
D
H
Site 104
T1035
K
L
L
N
K
N
G
T
V
K
K
V
S
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation