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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BRD8
Full Name:
Bromodomain-containing protein 8
Alias:
Bromodomain containing 8; P120; SMAP; Thyroid hormone receptor coactivating protein
Type:
Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Mass (Da):
135364
Number AA:
1235
UniProt ID:
Q9H0E9
International Prot ID:
IPI00019226
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035267
GO:0005739
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004887
GO:0003700
GO:0003713
PhosphoSite+
KinaseNET
Biological Process:
GO:0007166
GO:0043968
GO:0043967
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
T
G
K
H
K
L
L
S
T
G
P
T
E
P
W
Site 2
T13
G
K
H
K
L
L
S
T
G
P
T
E
P
W
S
Site 3
T16
K
L
L
S
T
G
P
T
E
P
W
S
I
R
E
Site 4
S20
T
G
P
T
E
P
W
S
I
R
E
K
L
C
L
Site 5
S29
R
E
K
L
C
L
A
S
S
V
M
R
S
G
D
Site 6
S30
E
K
L
C
L
A
S
S
V
M
R
S
G
D
Q
Site 7
S34
L
A
S
S
V
M
R
S
G
D
Q
N
W
V
S
Site 8
S41
S
G
D
Q
N
W
V
S
V
S
R
A
I
K
P
Site 9
S66
F
S
Q
K
H
C
A
S
Q
Y
S
E
L
L
E
Site 10
T74
Q
Y
S
E
L
L
E
T
T
E
T
P
K
R
K
Site 11
T77
E
L
L
E
T
T
E
T
P
K
R
K
R
G
E
Site 12
T91
E
K
G
E
V
V
E
T
V
E
D
V
I
V
R
Site 13
T101
D
V
I
V
R
K
L
T
A
E
R
V
E
E
L
Site 14
S136
I
Q
A
G
H
M
D
S
R
L
D
E
L
C
N
Site 15
T163
A
E
V
K
R
K
A
T
D
A
A
Y
Q
A
R
Site 16
Y167
R
K
A
T
D
A
A
Y
Q
A
R
Q
A
V
K
Site 17
T175
Q
A
R
Q
A
V
K
T
P
P
R
R
L
P
T
Site 18
T182
T
P
P
R
R
L
P
T
V
M
V
R
S
P
I
Site 19
S191
M
V
R
S
P
I
D
S
A
S
P
G
G
D
Y
Site 20
S193
R
S
P
I
D
S
A
S
P
G
G
D
Y
P
L
Site 21
Y198
S
A
S
P
G
G
D
Y
P
L
G
D
L
T
P
Site 22
T204
D
Y
P
L
G
D
L
T
P
T
T
M
E
E
A
Site 23
T207
L
G
D
L
T
P
T
T
M
E
E
A
T
S
G
Site 24
S213
T
T
M
E
E
A
T
S
G
V
N
E
S
E
M
Site 25
S218
A
T
S
G
V
N
E
S
E
M
A
V
A
S
G
Site 26
S224
E
S
E
M
A
V
A
S
G
H
L
N
S
T
G
Site 27
T251
H
G
G
E
I
Q
Q
T
P
N
T
V
A
A
S
Site 28
T254
E
I
Q
Q
T
P
N
T
V
A
A
S
P
A
A
Site 29
S258
T
P
N
T
V
A
A
S
P
A
A
S
G
A
P
Site 30
T286
T
T
P
L
A
S
F
T
T
V
A
S
E
P
P
Site 31
S325
P
S
S
A
P
A
V
S
T
T
E
S
V
A
P
Site 32
S329
P
A
V
S
T
T
E
S
V
A
P
V
S
Q
P
Site 33
S334
T
E
S
V
A
P
V
S
Q
P
D
N
C
V
P
Site 34
T350
E
A
V
G
D
P
H
T
V
T
V
S
M
D
S
Site 35
T352
V
G
D
P
H
T
V
T
V
S
M
D
S
S
E
Site 36
S354
D
P
H
T
V
T
V
S
M
D
S
S
E
I
S
Site 37
S361
S
M
D
S
S
E
I
S
M
I
I
N
S
I
K
Site 38
S374
I
K
E
E
C
F
R
S
G
V
A
E
A
P
V
Site 39
S383
V
A
E
A
P
V
G
S
K
A
P
S
I
D
G
Site 40
S387
P
V
G
S
K
A
P
S
I
D
G
K
E
E
L
Site 41
S405
E
K
M
D
I
A
V
S
Y
T
G
E
E
L
D
Site 42
S444
A
A
V
E
A
A
L
S
F
C
E
E
N
D
D
Site 43
S454
E
E
N
D
D
P
Q
S
L
P
G
P
W
E
H
Site 44
T479
P
L
P
A
P
E
M
T
V
K
Q
E
R
L
D
Site 45
T490
E
R
L
D
F
E
E
T
E
N
K
G
I
H
E
Site 46
S505
L
V
D
I
R
E
P
S
A
E
I
K
V
E
P
Site 47
S533
A
G
V
V
P
A
T
S
M
E
P
P
E
L
R
Site 48
S550
D
L
D
E
E
L
G
S
T
A
A
G
E
I
V
Site 49
T551
L
D
E
E
L
G
S
T
A
A
G
E
I
V
E
Site 50
T569
A
I
G
K
G
D
E
T
P
L
T
N
V
K
T
Site 51
T572
K
G
D
E
T
P
L
T
N
V
K
T
E
A
S
Site 52
T576
T
P
L
T
N
V
K
T
E
A
S
P
E
S
M
Site 53
S579
T
N
V
K
T
E
A
S
P
E
S
M
L
S
P
Site 54
S582
K
T
E
A
S
P
E
S
M
L
S
P
S
H
G
Site 55
S585
A
S
P
E
S
M
L
S
P
S
H
G
S
N
P
Site 56
S587
P
E
S
M
L
S
P
S
H
G
S
N
P
I
E
Site 57
S590
M
L
S
P
S
H
G
S
N
P
I
E
D
P
L
Site 58
S608
T
Q
H
K
F
E
M
S
D
S
L
K
E
E
S
Site 59
S610
H
K
F
E
M
S
D
S
L
K
E
E
S
G
T
Site 60
S615
S
D
S
L
K
E
E
S
G
T
I
F
G
S
Q
Site 61
T617
S
L
K
E
E
S
G
T
I
F
G
S
Q
I
K
Site 62
S621
E
S
G
T
I
F
G
S
Q
I
K
D
A
P
G
Site 63
S637
D
E
E
E
D
G
V
S
E
A
A
S
L
E
E
Site 64
S641
D
G
V
S
E
A
A
S
L
E
E
P
K
E
E
Site 65
Y654
E
E
D
Q
G
E
G
Y
L
S
E
M
D
N
E
Site 66
S656
D
Q
G
E
G
Y
L
S
E
M
D
N
E
P
P
Site 67
S665
M
D
N
E
P
P
V
S
E
S
D
D
G
F
S
Site 68
S667
N
E
P
P
V
S
E
S
D
D
G
F
S
I
H
Site 69
T682
N
A
T
L
Q
S
H
T
L
A
D
S
I
P
S
Site 70
S686
Q
S
H
T
L
A
D
S
I
P
S
S
P
A
S
Site 71
S689
T
L
A
D
S
I
P
S
S
P
A
S
S
Q
F
Site 72
S690
L
A
D
S
I
P
S
S
P
A
S
S
Q
F
S
Site 73
S693
S
I
P
S
S
P
A
S
S
Q
F
S
V
C
S
Site 74
S694
I
P
S
S
P
A
S
S
Q
F
S
V
C
S
E
Site 75
S697
S
P
A
S
S
Q
F
S
V
C
S
E
D
Q
E
Site 76
S700
S
S
Q
F
S
V
C
S
E
D
Q
E
A
I
Q
Site 77
Y728
R
A
A
A
N
H
R
Y
A
N
V
F
L
Q
P
Site 78
Y744
T
D
D
I
A
P
G
Y
H
S
I
V
Q
R
P
Site 79
S746
D
I
A
P
G
Y
H
S
I
V
Q
R
P
M
D
Site 80
S755
V
Q
R
P
M
D
L
S
T
I
K
K
N
I
E
Site 81
T769
E
N
G
L
I
R
S
T
A
E
F
Q
R
D
I
Site 82
Y794
N
S
S
D
H
D
V
Y
H
M
A
V
E
M
Q
Site 83
S821
T
Q
L
I
M
Q
T
S
E
S
G
I
S
A
K
Site 84
S826
Q
T
S
E
S
G
I
S
A
K
S
L
R
G
R
Site 85
S829
E
S
G
I
S
A
K
S
L
R
G
R
D
S
T
Site 86
S835
K
S
L
R
G
R
D
S
T
R
K
Q
D
A
S
Site 87
T836
S
L
R
G
R
D
S
T
R
K
Q
D
A
S
E
Site 88
S842
S
T
R
K
Q
D
A
S
E
K
D
S
V
P
M
Site 89
S846
Q
D
A
S
E
K
D
S
V
P
M
G
S
P
A
Site 90
S877
E
Q
D
H
P
N
D
S
E
L
S
N
D
C
R
Site 91
S880
H
P
N
D
S
E
L
S
N
D
C
R
S
L
F
Site 92
S885
E
L
S
N
D
C
R
S
L
F
S
S
W
D
S
Site 93
S888
N
D
C
R
S
L
F
S
S
W
D
S
S
L
D
Site 94
S889
D
C
R
S
L
F
S
S
W
D
S
S
L
D
L
Site 95
S892
S
L
F
S
S
W
D
S
S
L
D
L
D
V
G
Site 96
S893
L
F
S
S
W
D
S
S
L
D
L
D
V
G
N
Site 97
T904
D
V
G
N
W
R
E
T
E
D
P
E
A
E
E
Site 98
S915
E
A
E
E
L
E
E
S
S
P
E
R
E
P
S
Site 99
S916
A
E
E
L
E
E
S
S
P
E
R
E
P
S
E
Site 100
S922
S
S
P
E
R
E
P
S
E
L
L
V
G
D
G
Site 101
S931
L
L
V
G
D
G
G
S
E
E
S
Q
E
A
A
Site 102
S942
Q
E
A
A
R
K
A
S
H
Q
N
L
L
H
F
Site 103
S963
L
M
E
P
L
C
I
S
S
N
E
S
S
E
G
Site 104
S964
M
E
P
L
C
I
S
S
N
E
S
S
E
G
C
Site 105
S967
L
C
I
S
S
N
E
S
S
E
G
C
C
P
P
Site 106
S968
C
I
S
S
N
E
S
S
E
G
C
C
P
P
S
Site 107
S975
S
E
G
C
C
P
P
S
G
T
R
Q
E
G
R
Site 108
S987
E
G
R
E
I
K
A
S
E
G
E
R
E
L
C
Site 109
T997
E
R
E
L
C
R
E
T
E
E
L
S
A
K
G
Site 110
S1001
C
R
E
T
E
E
L
S
A
K
G
D
P
L
V
Site 111
T1030
S
A
P
S
V
I
C
T
V
Q
G
L
L
T
E
Site 112
S1038
V
Q
G
L
L
T
E
S
E
E
G
E
A
Q
Q
Site 113
Y1056
G
E
D
Q
G
E
V
Y
V
S
E
M
E
D
Q
Site 114
S1058
D
Q
G
E
V
Y
V
S
E
M
E
D
Q
P
P
Site 115
S1066
E
M
E
D
Q
P
P
S
G
E
C
D
D
A
F
Site 116
T1083
K
E
T
P
L
V
D
T
L
F
S
H
A
T
S
Site 117
S1090
T
L
F
S
H
A
T
S
S
K
L
T
D
L
S
Site 118
T1094
H
A
T
S
S
K
L
T
D
L
S
Q
D
D
P
Site 119
S1097
S
S
K
L
T
D
L
S
Q
D
D
P
V
Q
D
Site 120
S1126
I
A
S
H
R
F
S
S
P
F
L
K
P
V
S
Site 121
S1133
S
P
F
L
K
P
V
S
E
R
Q
A
P
G
Y
Site 122
Y1140
S
E
R
Q
A
P
G
Y
K
D
V
V
K
R
P
Site 123
T1151
V
K
R
P
M
D
L
T
S
L
K
R
N
L
S
Site 124
S1152
K
R
P
M
D
L
T
S
L
K
R
N
L
S
K
Site 125
S1158
T
S
L
K
R
N
L
S
K
G
R
I
R
T
M
Site 126
T1164
L
S
K
G
R
I
R
T
M
A
Q
F
L
R
D
Site 127
S1217
W
L
D
K
R
K
G
S
S
S
L
E
G
E
P
Site 128
S1219
D
K
R
K
G
S
S
S
L
E
G
E
P
A
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation