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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
INTS2
Full Name:
Integrator complex subunit 2
Alias:
INT2; KIAA1287
Type:
Mass (Da):
134346
Number AA:
1204
UniProt ID:
Q9H0H0
International Prot ID:
IPI00477759
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0032039
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016180
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
D
Q
Q
T
V
I
M
T
E
C
T
S
L
Q
F
Site 2
S61
L
C
A
P
A
D
Q
S
Q
S
W
A
Q
D
K
Site 3
S100
H
A
L
E
Q
D
A
S
K
E
Q
Q
L
R
H
Site 4
S120
S
G
E
S
I
L
V
S
Q
L
Q
H
G
L
T
Site 5
T127
S
Q
L
Q
H
G
L
T
L
E
F
E
H
S
D
Site 6
S133
L
T
L
E
F
E
H
S
D
S
P
R
R
L
R
Site 7
S135
L
E
F
E
H
S
D
S
P
R
R
L
R
L
V
Site 8
S164
N
G
E
F
F
F
K
S
S
E
L
F
E
S
P
Site 9
S165
G
E
F
F
F
K
S
S
E
L
F
E
S
P
V
Site 10
S170
K
S
S
E
L
F
E
S
P
V
Y
L
E
E
A
Site 11
Y173
E
L
F
E
S
P
V
Y
L
E
E
A
A
D
V
Site 12
S240
G
E
R
Q
D
E
E
S
L
G
G
R
R
R
T
Site 13
T247
S
L
G
G
R
R
R
T
D
A
L
R
F
L
C
Site 14
S259
F
L
C
K
M
N
P
S
Q
A
L
K
V
R
G
Site 15
T282
P
G
L
G
V
A
L
T
L
D
H
T
K
N
E
Site 16
T286
V
A
L
T
L
D
H
T
K
N
E
A
C
E
D
Site 17
T331
G
Q
Q
R
K
R
E
T
S
S
S
V
L
W
Q
Site 18
S332
Q
Q
R
K
R
E
T
S
S
S
V
L
W
Q
M
Site 19
S334
R
K
R
E
T
S
S
S
V
L
W
Q
M
R
R
Site 20
T353
E
L
M
G
I
L
P
T
V
R
S
T
R
I
V
Site 21
T357
I
L
P
T
V
R
S
T
R
I
V
E
E
A
D
Site 22
S372
V
D
M
E
P
N
V
S
V
Y
S
G
L
K
E
Site 23
S375
E
P
N
V
S
V
Y
S
G
L
K
E
E
H
V
Site 24
T416
E
Q
L
L
Q
L
M
T
S
R
P
P
A
T
P
Site 25
S417
Q
L
L
Q
L
M
T
S
R
P
P
A
T
P
A
Site 26
T422
M
T
S
R
P
P
A
T
P
A
G
V
R
F
V
Site 27
S444
L
A
F
S
T
L
V
S
T
P
E
Q
E
Q
L
Site 28
T445
A
F
S
T
L
V
S
T
P
E
Q
E
Q
L
M
Site 29
Y465
W
M
I
K
E
E
A
Y
F
E
S
T
S
G
V
Site 30
S468
K
E
E
A
Y
F
E
S
T
S
G
V
S
A
S
Site 31
S470
E
A
Y
F
E
S
T
S
G
V
S
A
S
F
G
Site 32
S513
K
I
V
I
K
P
S
S
L
S
R
M
K
T
I
Site 33
T519
S
S
L
S
R
M
K
T
I
F
T
Q
E
I
F
Site 34
T522
S
R
M
K
T
I
F
T
Q
E
I
F
T
E
Q
Site 35
S565
Y
Q
L
L
R
S
R
S
F
T
K
H
K
V
S
Site 36
T567
L
L
R
S
R
S
F
T
K
H
K
V
S
I
K
Site 37
Y578
V
S
I
K
D
W
I
Y
R
Q
L
C
E
T
S
Site 38
T584
I
Y
R
Q
L
C
E
T
S
T
P
L
H
P
Q
Site 39
T586
R
Q
L
C
E
T
S
T
P
L
H
P
Q
L
L
Site 40
T605
V
Y
I
N
S
I
L
T
P
A
S
K
S
N
P
Site 41
S608
N
S
I
L
T
P
A
S
K
S
N
P
E
A
T
Site 42
S610
I
L
T
P
A
S
K
S
N
P
E
A
T
N
Q
Site 43
T668
A
L
L
A
N
T
K
T
L
A
A
M
Q
R
K
Site 44
S678
A
M
Q
R
K
P
K
S
Y
S
S
S
L
M
D
Site 45
S680
Q
R
K
P
K
S
Y
S
S
S
L
M
D
Q
I
Site 46
S682
K
P
K
S
Y
S
S
S
L
M
D
Q
I
P
I
Site 47
T734
W
I
C
E
E
E
I
T
G
T
D
A
L
L
R
Site 48
T736
C
E
E
E
I
T
G
T
D
A
L
L
R
R
M
Site 49
T746
L
L
R
R
M
L
L
T
N
N
A
K
N
H
S
Site 50
S753
T
N
N
A
K
N
H
S
P
K
Q
L
Q
E
A
Site 51
S762
K
Q
L
Q
E
A
F
S
A
V
P
V
N
H
T
Site 52
S795
P
Y
A
E
V
L
T
S
N
M
S
Q
L
L
N
Site 53
T832
P
R
R
L
W
V
M
T
V
N
A
L
Q
P
S
Site 54
Y848
K
F
V
R
Q
Q
K
Y
T
Q
N
D
L
M
I
Site 55
T849
F
V
R
Q
Q
K
Y
T
Q
N
D
L
M
I
D
Site 56
S893
L
A
S
K
A
Y
L
S
A
H
L
K
E
T
E
Site 57
S905
E
T
E
Q
D
R
P
S
Q
N
N
T
I
G
L
Site 58
T909
D
R
P
S
Q
N
N
T
I
G
L
V
G
Q
T
Site 59
S961
A
N
G
V
N
P
D
S
L
L
R
N
V
Q
S
Site 60
T972
N
V
Q
S
V
I
T
T
S
A
P
N
K
G
M
Site 61
S1075
Y
A
L
P
K
S
L
S
V
A
R
L
A
V
N
Site 62
T1086
L
A
V
N
V
M
G
T
L
L
T
V
L
T
Q
Site 63
T1092
G
T
L
L
T
V
L
T
Q
A
K
R
Y
A
F
Site 64
S1134
Q
I
G
Q
V
C
A
S
D
V
A
T
Q
T
R
Site 65
T1138
V
C
A
S
D
V
A
T
Q
T
R
D
I
D
P
Site 66
S1167
W
S
Q
I
C
K
D
S
S
Y
K
N
G
S
R
Site 67
S1168
S
Q
I
C
K
D
S
S
Y
K
N
G
S
R
D
Site 68
Y1169
Q
I
C
K
D
S
S
Y
K
N
G
S
R
D
T
Site 69
T1176
Y
K
N
G
S
R
D
T
G
S
M
D
P
D
V
Site 70
S1178
N
G
S
R
D
T
G
S
M
D
P
D
V
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation