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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PARP12
Full Name:
Poly [ADP-ribose] polymerase 12
Alias:
FLJ22693; PAR12; PARP-12; Poly (ADP-ribose) polymerase family, member 12; ZC3H1; ZC3HDC1; Zinc finger CCCH domain-containing 1; Zinc finger CCCH domain-containing protein 1
Type:
Transferase; EC 2.4.2.30
Mass (Da):
79064
Number AA:
701
UniProt ID:
Q9H0J9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003950
GO:0003676
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S35
R
R
L
R
M
G
L
S
A
D
A
L
E
R
L
Site 2
S81
L
C
R
A
H
Q
G
S
K
P
G
C
V
G
L
Site 3
S115
A
G
K
N
C
R
N
S
H
S
L
T
T
E
H
Site 4
S117
K
N
C
R
N
S
H
S
L
T
T
E
H
N
L
Site 5
T119
C
R
N
S
H
S
L
T
T
E
H
N
L
S
V
Site 6
S125
L
T
T
E
H
N
L
S
V
L
R
T
H
G
V
Site 7
T129
H
N
L
S
V
L
R
T
H
G
V
D
H
L
S
Site 8
Y137
H
G
V
D
H
L
S
Y
N
E
L
C
Q
L
L
Site 9
Y159
L
P
E
I
C
Q
H
Y
N
K
G
D
G
P
H
Site 10
Y183
I
K
L
H
I
C
Q
Y
F
L
Q
G
E
C
K
Site 11
T193
Q
G
E
C
K
F
G
T
S
C
K
R
S
H
D
Site 12
S198
F
G
T
S
C
K
R
S
H
D
F
S
N
S
E
Site 13
S202
C
K
R
S
H
D
F
S
N
S
E
N
L
E
K
Site 14
S204
R
S
H
D
F
S
N
S
E
N
L
E
K
L
E
Site 15
S216
K
L
E
K
L
G
M
S
S
D
L
V
S
R
L
Site 16
S217
L
E
K
L
G
M
S
S
D
L
V
S
R
L
P
Site 17
S221
G
M
S
S
D
L
V
S
R
L
P
T
I
Y
R
Site 18
T225
D
L
V
S
R
L
P
T
I
Y
R
N
A
H
D
Site 19
Y227
V
S
R
L
P
T
I
Y
R
N
A
H
D
I
K
Site 20
S237
A
H
D
I
K
N
K
S
S
A
P
S
R
V
P
Site 21
S241
K
N
K
S
S
A
P
S
R
V
P
P
L
F
V
Site 22
S253
L
F
V
P
Q
G
T
S
E
R
K
D
S
S
G
Site 23
S258
G
T
S
E
R
K
D
S
S
G
S
V
S
P
N
Site 24
S259
T
S
E
R
K
D
S
S
G
S
V
S
P
N
T
Site 25
S261
E
R
K
D
S
S
G
S
V
S
P
N
T
L
S
Site 26
S263
K
D
S
S
G
S
V
S
P
N
T
L
S
Q
E
Site 27
T266
S
G
S
V
S
P
N
T
L
S
Q
E
E
G
D
Site 28
S268
S
V
S
P
N
T
L
S
Q
E
E
G
D
Q
I
Site 29
Y278
E
G
D
Q
I
C
L
Y
H
I
R
K
S
C
S
Site 30
S285
Y
H
I
R
K
S
C
S
F
Q
D
K
C
H
R
Site 31
Y322
M
E
L
I
E
E
A
Y
C
N
P
K
I
E
R
Site 32
S333
K
I
E
R
I
L
C
S
E
S
A
S
T
F
H
Site 33
S335
E
R
I
L
C
S
E
S
A
S
T
F
H
S
H
Site 34
T338
L
C
S
E
S
A
S
T
F
H
S
H
C
L
N
Site 35
S360
A
T
Q
A
R
R
L
S
T
A
S
S
V
T
K
Site 36
T361
T
Q
A
R
R
L
S
T
A
S
S
V
T
K
P
Site 37
S363
A
R
R
L
S
T
A
S
S
V
T
K
P
P
H
Site 38
S364
R
R
L
S
T
A
S
S
V
T
K
P
P
H
F
Site 39
T366
L
S
T
A
S
S
V
T
K
P
P
H
F
I
L
Site 40
Y391
E
F
G
S
W
Q
E
Y
G
R
Q
G
T
V
H
Site 41
T396
Q
E
Y
G
R
Q
G
T
V
H
P
V
T
T
V
Site 42
T401
Q
G
T
V
H
P
V
T
T
V
S
S
S
D
V
Site 43
T402
G
T
V
H
P
V
T
T
V
S
S
S
D
V
E
Site 44
S404
V
H
P
V
T
T
V
S
S
S
D
V
E
K
A
Site 45
S406
P
V
T
T
V
S
S
S
D
V
E
K
A
Y
L
Site 46
Y412
S
S
D
V
E
K
A
Y
L
A
Y
C
T
P
G
Site 47
Y415
V
E
K
A
Y
L
A
Y
C
T
P
G
S
D
G
Site 48
T417
K
A
Y
L
A
Y
C
T
P
G
S
D
G
Q
A
Site 49
Y436
F
Q
A
G
K
H
N
Y
E
L
D
F
K
A
F
Site 50
Y462
K
V
C
R
R
P
K
Y
V
S
P
Q
D
V
T
Site 51
S464
C
R
R
P
K
Y
V
S
P
Q
D
V
T
T
M
Site 52
T476
T
T
M
Q
T
C
N
T
K
F
P
G
P
K
S
Site 53
S483
T
K
F
P
G
P
K
S
I
P
D
Y
W
D
S
Site 54
Y487
G
P
K
S
I
P
D
Y
W
D
S
S
A
L
P
Site 55
S490
S
I
P
D
Y
W
D
S
S
A
L
P
D
P
G
Site 56
S491
I
P
D
Y
W
D
S
S
A
L
P
D
P
G
F
Site 57
T502
D
P
G
F
Q
K
I
T
L
S
S
S
S
E
E
Site 58
S504
G
F
Q
K
I
T
L
S
S
S
S
E
E
Y
Q
Site 59
S506
Q
K
I
T
L
S
S
S
S
E
E
Y
Q
K
V
Site 60
S507
K
I
T
L
S
S
S
S
E
E
Y
Q
K
V
W
Site 61
Y510
L
S
S
S
S
E
E
Y
Q
K
V
W
N
L
F
Site 62
Y524
F
N
R
T
L
P
F
Y
F
V
Q
K
I
E
R
Site 63
Y541
N
L
A
L
W
E
V
Y
Q
W
Q
K
G
Q
M
Site 64
T589
R
V
C
G
V
H
G
T
S
Y
G
K
G
S
Y
Site 65
Y591
C
G
V
H
G
T
S
Y
G
K
G
S
Y
F
A
Site 66
Y596
T
S
Y
G
K
G
S
Y
F
A
R
D
A
A
Y
Site 67
Y603
Y
F
A
R
D
A
A
Y
S
H
H
Y
S
K
S
Site 68
S604
F
A
R
D
A
A
Y
S
H
H
Y
S
K
S
D
Site 69
S608
A
A
Y
S
H
H
Y
S
K
S
D
T
Q
T
H
Site 70
T614
Y
S
K
S
D
T
Q
T
H
T
M
F
L
A
R
Site 71
S633
E
F
V
R
G
N
A
S
F
V
R
P
P
A
K
Site 72
Y648
E
G
W
S
N
A
F
Y
D
S
C
V
N
S
V
Site 73
Y670
I
F
E
K
H
Q
V
Y
P
E
Y
V
I
Q
Y
Site 74
Y673
K
H
Q
V
Y
P
E
Y
V
I
Q
Y
T
T
S
Site 75
Y677
Y
P
E
Y
V
I
Q
Y
T
T
S
S
K
P
S
Site 76
T678
P
E
Y
V
I
Q
Y
T
T
S
S
K
P
S
V
Site 77
S680
Y
V
I
Q
Y
T
T
S
S
K
P
S
V
T
P
Site 78
S681
V
I
Q
Y
T
T
S
S
K
P
S
V
T
P
S
Site 79
S684
Y
T
T
S
S
K
P
S
V
T
P
S
I
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation