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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WWP1
Full Name:
NEDD4-like E3 ubiquitin-protein ligase WWP1
Alias:
AIP5; atropin-1-interacting protein 5; DKFZP434D2111; WW domain containing E3 ubiquitin protein ligase 1; WW domain-containing protein 1
Type:
EC 6.3.2.-; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Mass (Da):
105202
Number AA:
922
UniProt ID:
Q9H0M0
International Prot ID:
IPI00013009
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000151
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004842
PhosphoSite+
KinaseNET
Biological Process:
GO:0007417
GO:0046718
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
A
T
A
S
P
R
S
D
T
Site 2
S5
_
_
_
M
A
T
A
S
P
R
S
D
T
S
N
Site 3
S8
M
A
T
A
S
P
R
S
D
T
S
N
N
H
S
Site 4
T10
T
A
S
P
R
S
D
T
S
N
N
H
S
G
R
Site 5
S11
A
S
P
R
S
D
T
S
N
N
H
S
G
R
L
Site 6
S15
S
D
T
S
N
N
H
S
G
R
L
Q
L
Q
V
Site 7
T23
G
R
L
Q
L
Q
V
T
V
S
S
A
K
L
K
Site 8
S25
L
Q
L
Q
V
T
V
S
S
A
K
L
K
R
K
Site 9
T53
V
D
G
E
I
T
K
T
A
K
S
S
S
S
S
Site 10
S56
E
I
T
K
T
A
K
S
S
S
S
S
N
P
K
Site 11
S57
I
T
K
T
A
K
S
S
S
S
S
N
P
K
W
Site 12
S58
T
K
T
A
K
S
S
S
S
S
N
P
K
W
D
Site 13
S59
K
T
A
K
S
S
S
S
S
N
P
K
W
D
E
Site 14
S60
T
A
K
S
S
S
S
S
N
P
K
W
D
E
Q
Site 15
T69
P
K
W
D
E
Q
L
T
V
N
V
T
P
Q
T
Site 16
T73
E
Q
L
T
V
N
V
T
P
Q
T
T
L
E
F
Site 17
S84
T
L
E
F
Q
V
W
S
H
R
T
L
K
A
D
Site 18
S122
V
K
E
Q
L
K
L
S
L
E
N
K
N
G
I
Site 19
T150
V
I
E
Q
E
N
I
T
N
C
S
S
S
P
T
Site 20
S155
N
I
T
N
C
S
S
S
P
T
I
E
I
Q
E
Site 21
T157
T
N
C
S
S
S
P
T
I
E
I
Q
E
N
G
Site 22
S174
L
H
E
N
G
E
P
S
A
R
T
T
A
R
L
Site 23
T178
G
E
P
S
A
R
T
T
A
R
L
A
V
E
G
Site 24
T197
D
N
H
V
P
T
S
T
L
V
Q
N
S
C
C
Site 25
Y206
V
Q
N
S
C
C
S
Y
V
V
N
G
D
N
T
Site 26
T213
Y
V
V
N
G
D
N
T
P
S
S
P
S
Q
V
Site 27
S216
N
G
D
N
T
P
S
S
P
S
Q
V
A
A
R
Site 28
T227
V
A
A
R
P
K
N
T
P
A
P
K
P
L
A
Site 29
S235
P
A
P
K
P
L
A
S
E
P
A
D
D
T
V
Site 30
T241
A
S
E
P
A
D
D
T
V
N
G
E
S
S
S
Site 31
S248
T
V
N
G
E
S
S
S
F
A
P
T
D
N
A
Site 32
T252
E
S
S
S
F
A
P
T
D
N
A
S
V
T
G
Site 33
T258
P
T
D
N
A
S
V
T
G
T
P
V
V
S
E
Site 34
T260
D
N
A
S
V
T
G
T
P
V
V
S
E
E
N
Site 35
S270
V
S
E
E
N
A
L
S
P
N
C
T
S
T
T
Site 36
T274
N
A
L
S
P
N
C
T
S
T
T
V
E
D
P
Site 37
T276
L
S
P
N
C
T
S
T
T
V
E
D
P
P
V
Site 38
T277
S
P
N
C
T
S
T
T
V
E
D
P
P
V
Q
Site 39
S289
P
V
Q
E
I
L
T
S
S
E
N
N
E
C
I
Site 40
S298
E
N
N
E
C
I
P
S
T
S
A
E
L
E
S
Site 41
S300
N
E
C
I
P
S
T
S
A
E
L
E
S
E
A
Site 42
S305
S
T
S
A
E
L
E
S
E
A
R
S
I
L
E
Site 43
S309
E
L
E
S
E
A
R
S
I
L
E
P
D
T
S
Site 44
T315
R
S
I
L
E
P
D
T
S
N
S
R
S
S
S
Site 45
S316
S
I
L
E
P
D
T
S
N
S
R
S
S
S
A
Site 46
S318
L
E
P
D
T
S
N
S
R
S
S
S
A
F
E
Site 47
S320
P
D
T
S
N
S
R
S
S
S
A
F
E
A
A
Site 48
S321
D
T
S
N
S
R
S
S
S
A
F
E
A
A
K
Site 49
S322
T
S
N
S
R
S
S
S
A
F
E
A
A
K
S
Site 50
S329
S
A
F
E
A
A
K
S
R
Q
P
D
G
C
M
Site 51
S343
M
D
P
V
R
Q
Q
S
G
N
A
N
T
E
T
Site 52
T350
S
G
N
A
N
T
E
T
L
P
S
G
W
E
Q
Site 53
S353
A
N
T
E
T
L
P
S
G
W
E
Q
R
K
D
Site 54
Y366
K
D
P
H
G
R
T
Y
Y
V
D
H
N
T
R
Site 55
Y367
D
P
H
G
R
T
Y
Y
V
D
H
N
T
R
T
Site 56
T375
V
D
H
N
T
R
T
T
T
W
E
R
P
Q
P
Site 57
T376
D
H
N
T
R
T
T
T
W
E
R
P
Q
P
L
Site 58
Y398
V
D
D
R
R
R
V
Y
Y
V
D
H
N
T
R
Site 59
Y399
D
D
R
R
R
V
Y
Y
V
D
H
N
T
R
T
Site 60
T408
D
H
N
T
R
T
T
T
W
Q
R
P
T
M
E
Site 61
T413
T
T
T
W
Q
R
P
T
M
E
S
V
R
N
F
Site 62
Y441
M
Q
Q
F
N
Q
R
Y
L
Y
S
A
S
M
L
Site 63
Y443
Q
F
N
Q
R
Y
L
Y
S
A
S
M
L
A
A
Site 64
S444
F
N
Q
R
Y
L
Y
S
A
S
M
L
A
A
E
Site 65
S446
Q
R
Y
L
Y
S
A
S
M
L
A
A
E
N
D
Site 66
Y455
L
A
A
E
N
D
P
Y
G
P
L
P
P
G
W
Site 67
S468
G
W
E
K
R
V
D
S
T
D
R
V
Y
F
V
Site 68
Y473
V
D
S
T
D
R
V
Y
F
V
N
H
N
T
K
Site 69
T482
V
N
H
N
T
K
T
T
Q
W
E
D
P
R
T
Site 70
T489
T
Q
W
E
D
P
R
T
Q
G
L
Q
N
E
E
Site 71
Y506
P
E
G
W
E
I
R
Y
T
R
E
G
V
R
Y
Site 72
T507
E
G
W
E
I
R
Y
T
R
E
G
V
R
Y
F
Site 73
Y513
Y
T
R
E
G
V
R
Y
F
V
D
H
N
T
R
Site 74
T519
R
Y
F
V
D
H
N
T
R
T
T
T
F
K
D
Site 75
T522
V
D
H
N
T
R
T
T
T
F
K
D
P
R
N
Site 76
T523
D
H
N
T
R
T
T
T
F
K
D
P
R
N
G
Site 77
S532
K
D
P
R
N
G
K
S
S
V
T
K
G
G
P
Site 78
S533
D
P
R
N
G
K
S
S
V
T
K
G
G
P
Q
Site 79
Y543
K
G
G
P
Q
I
A
Y
E
R
G
F
R
W
K
Site 80
Y556
W
K
L
A
H
F
R
Y
L
C
Q
S
N
A
L
Site 81
T575
K
I
N
V
S
R
Q
T
L
F
E
D
S
F
Q
Site 82
S580
R
Q
T
L
F
E
D
S
F
Q
Q
I
M
A
L
Site 83
Y590
Q
I
M
A
L
K
P
Y
D
L
R
R
R
L
Y
Site 84
Y597
Y
D
L
R
R
R
L
Y
V
I
F
R
G
E
E
Site 85
Y608
R
G
E
E
G
L
D
Y
G
G
L
A
R
E
W
Site 86
Y639
E
Y
A
G
K
N
N
Y
C
L
Q
I
N
P
A
Site 87
S647
C
L
Q
I
N
P
A
S
T
I
N
P
D
H
L
Site 88
Y683
T
G
F
S
L
P
F
Y
K
R
M
L
S
K
K
Site 89
S688
P
F
Y
K
R
M
L
S
K
K
L
T
I
K
D
Site 90
T692
R
M
L
S
K
K
L
T
I
K
D
L
E
S
I
Site 91
T701
K
D
L
E
S
I
D
T
E
F
Y
N
S
L
I
Site 92
Y704
E
S
I
D
T
E
F
Y
N
S
L
I
W
I
R
Site 93
S736
E
I
L
G
K
V
T
S
H
D
L
K
L
G
G
Site 94
T749
G
G
S
N
I
L
V
T
E
E
N
K
D
E
Y
Site 95
Y756
T
E
E
N
K
D
E
Y
I
G
L
M
T
E
W
Site 96
S766
L
M
T
E
W
R
F
S
R
G
V
Q
E
Q
T
Site 97
Y791
V
P
L
Q
W
L
Q
Y
F
D
E
K
E
L
E
Site 98
Y821
R
N
T
V
Y
R
H
Y
T
R
N
S
K
Q
I
Site 99
T822
N
T
V
Y
R
H
Y
T
R
N
S
K
Q
I
I
Site 100
S867
G
F
A
E
L
M
G
S
N
G
P
Q
K
F
C
Site 101
T882
I
E
K
V
G
K
D
T
W
L
P
R
S
H
T
Site 102
T889
T
W
L
P
R
S
H
T
C
F
N
R
L
D
L
Site 103
Y899
N
R
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
Site 104
S901
L
D
L
P
P
Y
K
S
Y
E
Q
L
K
E
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation