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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCDC8
Full Name:
Coiled-coil domain-containing protein 8
Alias:
Coiled-coil domain containing 8; DKFZp564K0322
Type:
Unknown function
Mass (Da):
59374
Number AA:
538
UniProt ID:
Q9H0W5
International Prot ID:
IPI00290526
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
Q
I
G
E
D
V
D
Y
L
L
I
P
R
E
V
Site 2
S28
G
G
V
W
R
V
I
S
K
P
A
T
K
E
A
Site 3
T32
R
V
I
S
K
P
A
T
K
E
A
E
F
R
E
Site 4
T42
A
E
F
R
E
R
L
T
Q
F
L
E
E
E
G
Site 5
T51
F
L
E
E
E
G
R
T
L
E
D
V
A
R
I
Site 6
S62
V
A
R
I
M
E
K
S
T
P
H
P
P
Q
P
Site 7
T63
A
R
I
M
E
K
S
T
P
H
P
P
Q
P
P
Site 8
T87
R
R
V
Q
Q
M
V
T
P
P
P
R
L
V
V
Site 9
T96
P
P
R
L
V
V
G
T
Y
D
S
S
N
A
S
Site 10
Y97
P
R
L
V
V
G
T
Y
D
S
S
N
A
S
D
Site 11
S99
L
V
V
G
T
Y
D
S
S
N
A
S
D
S
E
Site 12
S100
V
V
G
T
Y
D
S
S
N
A
S
D
S
E
F
Site 13
S103
T
Y
D
S
S
N
A
S
D
S
E
F
S
D
F
Site 14
S105
D
S
S
N
A
S
D
S
E
F
S
D
F
E
T
Site 15
S108
N
A
S
D
S
E
F
S
D
F
E
T
S
R
D
Site 16
T112
S
E
F
S
D
F
E
T
S
R
D
K
S
R
Q
Site 17
S113
E
F
S
D
F
E
T
S
R
D
K
S
R
Q
G
Site 18
S117
F
E
T
S
R
D
K
S
R
Q
G
P
R
R
G
Site 19
S133
K
V
R
K
M
P
V
S
Y
L
G
S
K
F
L
Site 20
S142
L
G
S
K
F
L
G
S
D
L
E
S
E
D
D
Site 21
S146
F
L
G
S
D
L
E
S
E
D
D
E
E
L
V
Site 22
S165
R
R
Q
E
K
Q
P
S
A
P
P
A
R
R
R
Site 23
S189
D
N
L
G
P
Q
L
S
K
A
D
R
W
R
E
Site 24
Y197
K
A
D
R
W
R
E
Y
V
S
Q
V
S
W
G
Site 25
S199
D
R
W
R
E
Y
V
S
Q
V
S
W
G
K
L
Site 26
S237
A
V
E
S
A
G
V
S
S
A
P
E
G
T
S
Site 27
S238
V
E
S
A
G
V
S
S
A
P
E
G
T
S
P
Site 28
S244
S
S
A
P
E
G
T
S
P
G
D
R
L
G
N
Site 29
S261
D
V
C
V
P
Q
A
S
P
R
R
W
R
P
K
Site 30
S273
R
P
K
I
N
W
A
S
F
R
R
R
R
K
E
Site 31
T282
R
R
R
R
K
E
Q
T
A
P
T
G
Q
G
A
Site 32
S302
Q
G
G
E
A
A
D
S
Q
R
E
E
A
I
A
Site 33
S377
E
A
P
A
D
Q
R
S
Q
G
T
D
N
H
R
Site 34
S457
G
I
Q
E
A
E
V
S
A
A
Q
G
T
T
G
Site 35
T477
R
A
R
K
Q
V
K
T
V
R
F
Q
T
P
G
Site 36
T482
V
K
T
V
R
F
Q
T
P
G
R
F
S
W
F
Site 37
T499
R
R
R
A
F
W
H
T
P
R
L
P
T
L
P
Site 38
T504
W
H
T
P
R
L
P
T
L
P
K
R
V
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation