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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OSBPL5
Full Name:
Oxysterol-binding protein-related protein 5
Alias:
KIAA1534; OBPH1; ORP5; ORP-5; OSBL5; OSBP-related 5; Oxysterol binding protein-like 5; Oxysterol-binding protein-related 5
Type:
Lipid binding protein
Mass (Da):
98616
Number AA:
879
UniProt ID:
Q9H0X9
International Prot ID:
IPI00784269
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0008142
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006893
GO:0008203
GO:0030301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
A
F
L
R
R
R
F
S
L
C
P
P
S
S
T
Site 2
S17
R
F
S
L
C
P
P
S
S
T
P
Q
K
V
D
Site 3
S18
F
S
L
C
P
P
S
S
T
P
Q
K
V
D
P
Site 4
T19
S
L
C
P
P
S
S
T
P
Q
K
V
D
P
R
Site 5
T29
K
V
D
P
R
K
L
T
R
N
L
L
L
S
G
Site 6
S35
L
T
R
N
L
L
L
S
G
D
N
E
L
Y
P
Site 7
Y41
L
S
G
D
N
E
L
Y
P
L
S
P
G
K
D
Site 8
S44
D
N
E
L
Y
P
L
S
P
G
K
D
M
E
P
Site 9
S55
D
M
E
P
N
G
P
S
L
P
R
D
E
G
P
Site 10
T64
P
R
D
E
G
P
P
T
P
S
S
A
T
K
V
Site 11
S67
E
G
P
P
T
P
S
S
A
T
K
V
P
P
A
Site 12
S82
E
Y
R
L
C
N
G
S
D
K
E
C
V
S
P
Site 13
S88
G
S
D
K
E
C
V
S
P
T
A
R
V
T
K
Site 14
T94
V
S
P
T
A
R
V
T
K
K
E
T
L
K
A
Site 15
T114
R
Q
E
K
K
R
A
T
R
Q
L
L
S
A
L
Site 16
S119
R
A
T
R
Q
L
L
S
A
L
T
D
P
S
V
Site 17
S132
S
V
V
I
M
A
D
S
L
K
I
R
G
T
L
Site 18
T138
D
S
L
K
I
R
G
T
L
K
S
W
T
K
L
Site 19
Y157
K
P
G
V
L
L
I
Y
K
T
P
K
V
G
Q
Site 20
S197
L
F
H
P
L
D
Q
S
V
W
A
V
K
G
P
Site 21
S211
P
K
G
E
S
V
G
S
I
T
Q
P
L
P
S
Site 22
T213
G
E
S
V
G
S
I
T
Q
P
L
P
S
S
Y
Site 23
S227
Y
L
I
F
R
A
A
S
E
S
D
G
R
C
W
Site 24
S229
I
F
R
A
A
S
E
S
D
G
R
C
W
L
D
Site 25
T252
S
S
L
L
R
L
G
T
C
K
P
G
R
D
G
Site 26
T263
G
R
D
G
E
P
G
T
S
P
D
A
S
P
S
Site 27
S264
R
D
G
E
P
G
T
S
P
D
A
S
P
S
S
Site 28
S268
P
G
T
S
P
D
A
S
P
S
S
L
C
G
L
Site 29
S270
T
S
P
D
A
S
P
S
S
L
C
G
L
P
A
Site 30
S271
S
P
D
A
S
P
S
S
L
C
G
L
P
A
S
Site 31
S278
S
L
C
G
L
P
A
S
A
T
V
H
P
D
Q
Site 32
T280
C
G
L
P
A
S
A
T
V
H
P
D
Q
D
L
Site 33
S294
L
F
P
L
N
G
S
S
L
E
N
D
A
F
S
Site 34
S301
S
L
E
N
D
A
F
S
D
K
S
E
R
E
N
Site 35
S304
N
D
A
F
S
D
K
S
E
R
E
N
P
E
E
Site 36
T314
E
N
P
E
E
S
D
T
E
T
Q
D
H
S
R
Site 37
T316
P
E
E
S
D
T
E
T
Q
D
H
S
R
K
T
Site 38
S320
D
T
E
T
Q
D
H
S
R
K
T
E
S
G
S
Site 39
T323
T
Q
D
H
S
R
K
T
E
S
G
S
D
Q
S
Site 40
S325
D
H
S
R
K
T
E
S
G
S
D
Q
S
E
T
Site 41
S327
S
R
K
T
E
S
G
S
D
Q
S
E
T
P
G
Site 42
S330
T
E
S
G
S
D
Q
S
E
T
P
G
A
P
V
Site 43
T332
S
G
S
D
Q
S
E
T
P
G
A
P
V
R
R
Site 44
T341
G
A
P
V
R
R
G
T
T
Y
V
E
Q
V
Q
Site 45
T342
A
P
V
R
R
G
T
T
Y
V
E
Q
V
Q
E
Site 46
Y343
P
V
R
R
G
T
T
Y
V
E
Q
V
Q
E
E
Site 47
S358
L
G
E
L
G
E
A
S
Q
V
E
T
V
S
E
Site 48
T362
G
E
A
S
Q
V
E
T
V
S
E
E
N
K
S
Site 49
S369
T
V
S
E
E
N
K
S
L
M
W
T
L
L
K
Site 50
T373
E
N
K
S
L
M
W
T
L
L
K
Q
L
R
P
Site 51
S398
T
F
V
L
E
P
R
S
F
L
N
K
L
S
D
Site 52
S404
R
S
F
L
N
K
L
S
D
Y
Y
Y
H
A
D
Site 53
Y406
F
L
N
K
L
S
D
Y
Y
Y
H
A
D
L
L
Site 54
Y407
L
N
K
L
S
D
Y
Y
Y
H
A
D
L
L
S
Site 55
Y408
N
K
L
S
D
Y
Y
Y
H
A
D
L
L
S
R
Site 56
S414
Y
Y
H
A
D
L
L
S
R
A
A
V
E
E
D
Site 57
S424
A
V
E
E
D
A
Y
S
R
M
K
L
V
L
R
Site 58
Y433
M
K
L
V
L
R
W
Y
L
S
G
F
Y
K
K
Site 59
S435
L
V
L
R
W
Y
L
S
G
F
Y
K
K
P
K
Site 60
Y438
R
W
Y
L
S
G
F
Y
K
K
P
K
G
I
K
Site 61
Y448
P
K
G
I
K
K
P
Y
N
P
I
L
G
E
T
Site 62
T469
H
P
Q
T
D
S
R
T
F
Y
I
A
E
Q
V
Site 63
Y471
Q
T
D
S
R
T
F
Y
I
A
E
Q
V
S
H
Site 64
S477
F
Y
I
A
E
Q
V
S
H
H
P
P
V
S
A
Site 65
S483
V
S
H
H
P
P
V
S
A
F
H
V
S
N
R
Site 66
S497
R
K
D
G
F
C
I
S
G
S
I
T
A
K
S
Site 67
S504
S
G
S
I
T
A
K
S
R
F
Y
G
N
S
L
Site 68
Y507
I
T
A
K
S
R
F
Y
G
N
S
L
S
A
L
Site 69
S510
K
S
R
F
Y
G
N
S
L
S
A
L
L
D
G
Site 70
S512
R
F
Y
G
N
S
L
S
A
L
L
D
G
K
A
Site 71
T522
L
D
G
K
A
T
L
T
F
L
N
R
A
E
D
Site 72
Y530
F
L
N
R
A
E
D
Y
T
L
T
M
P
Y
A
Site 73
T531
L
N
R
A
E
D
Y
T
L
T
M
P
Y
A
H
Site 74
S579
L
K
P
F
F
G
G
S
T
S
I
N
Q
I
S
Site 75
S581
P
F
F
G
G
S
T
S
I
N
Q
I
S
G
K
Site 76
S591
Q
I
S
G
K
I
T
S
G
E
E
V
L
A
S
Site 77
S598
S
G
E
E
V
L
A
S
L
S
G
H
W
D
R
Site 78
S600
E
E
V
L
A
S
L
S
G
H
W
D
R
D
V
Site 79
S616
I
K
E
E
G
S
G
S
S
A
L
F
W
T
P
Site 80
T622
G
S
S
A
L
F
W
T
P
S
G
E
V
R
R
Site 81
S624
S
A
L
F
W
T
P
S
G
E
V
R
R
Q
R
Site 82
T636
R
Q
R
L
R
Q
H
T
V
P
L
E
E
Q
T
Site 83
S647
E
E
Q
T
E
L
E
S
E
R
L
W
Q
H
V
Site 84
T655
E
R
L
W
Q
H
V
T
R
A
I
S
K
G
D
Site 85
S659
Q
H
V
T
R
A
I
S
K
G
D
Q
H
R
A
Site 86
T667
K
G
D
Q
H
R
A
T
Q
E
K
F
A
L
E
Site 87
S687
R
A
R
E
R
Q
E
S
L
M
P
W
K
P
Q
Site 88
T702
L
F
H
L
D
P
I
T
Q
E
W
H
Y
R
Y
Site 89
Y709
T
Q
E
W
H
Y
R
Y
E
D
H
S
P
W
D
Site 90
T742
Q
E
A
V
A
R
Q
T
T
F
L
G
S
P
G
Site 91
T743
E
A
V
A
R
Q
T
T
F
L
G
S
P
G
P
Site 92
S747
R
Q
T
T
F
L
G
S
P
G
P
R
H
E
R
Site 93
S755
P
G
P
R
H
E
R
S
G
P
D
Q
R
L
R
Site 94
S765
D
Q
R
L
R
K
A
S
D
Q
P
S
G
H
S
Site 95
S769
R
K
A
S
D
Q
P
S
G
H
S
Q
A
T
E
Site 96
S772
S
D
Q
P
S
G
H
S
Q
A
T
E
S
S
G
Site 97
T775
P
S
G
H
S
Q
A
T
E
S
S
G
S
T
P
Site 98
S777
G
H
S
Q
A
T
E
S
S
G
S
T
P
E
S
Site 99
S778
H
S
Q
A
T
E
S
S
G
S
T
P
E
S
C
Site 100
S780
Q
A
T
E
S
S
G
S
T
P
E
S
C
P
E
Site 101
T781
A
T
E
S
S
G
S
T
P
E
S
C
P
E
L
Site 102
S784
S
S
G
S
T
P
E
S
C
P
E
L
S
D
E
Site 103
S789
P
E
S
C
P
E
L
S
D
E
E
Q
D
G
D
Site 104
S803
D
F
V
P
G
G
E
S
P
C
P
R
C
R
K
Site 105
S824
A
L
H
E
A
I
L
S
I
R
E
A
Q
Q
E
Site 106
S837
Q
E
L
H
R
H
L
S
A
M
L
S
S
T
A
Site 107
S841
R
H
L
S
A
M
L
S
S
T
A
R
A
A
Q
Site 108
T851
A
R
A
A
Q
A
P
T
P
G
L
L
Q
S
P
Site 109
S857
P
T
P
G
L
L
Q
S
P
R
S
W
F
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation