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Updated November 2019
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Protein Info
Short Name:
ALX4
Full Name:
Homeobox protein aristaless-like 4
Alias:
Type:
Mass (Da):
44241
Number AA:
411
UniProt ID:
Q9H161
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
N
A
E
T
C
V
S
Y
C
E
S
P
A
A
Site 2
Y20
P
A
A
A
M
D
A
Y
Y
S
P
V
S
Q
S
Site 3
Y21
A
A
A
M
D
A
Y
Y
S
P
V
S
Q
S
R
Site 4
S22
A
A
M
D
A
Y
Y
S
P
V
S
Q
S
R
E
Site 5
S25
D
A
Y
Y
S
P
V
S
Q
S
R
E
G
S
S
Site 6
S27
Y
Y
S
P
V
S
Q
S
R
E
G
S
S
P
F
Site 7
S31
V
S
Q
S
R
E
G
S
S
P
F
R
A
F
P
Site 8
S32
S
Q
S
R
E
G
S
S
P
F
R
A
F
P
G
Site 9
T46
G
G
D
K
F
G
T
T
F
L
S
A
A
A
K
Site 10
S62
Q
G
F
G
D
A
K
S
R
A
R
Y
G
A
G
Site 11
Y66
D
A
K
S
R
A
R
Y
G
A
G
Q
Q
D
L
Site 12
T75
A
G
Q
Q
D
L
A
T
P
L
E
S
G
A
G
Site 13
S86
S
G
A
G
A
R
G
S
F
N
K
F
Q
P
Q
Site 14
S95
N
K
F
Q
P
Q
P
S
T
P
Q
P
Q
P
P
Site 15
T96
K
F
Q
P
Q
P
S
T
P
Q
P
Q
P
P
P
Site 16
Y123
P
P
A
Q
P
H
L
Y
L
Q
R
G
A
C
K
Site 17
T131
L
Q
R
G
A
C
K
T
P
P
D
G
S
L
K
Site 18
S143
S
L
K
L
Q
E
G
S
S
G
H
S
A
A
L
Site 19
S147
Q
E
G
S
S
G
H
S
A
A
L
Q
V
P
C
Site 20
S160
P
C
Y
A
K
E
S
S
L
G
E
P
E
L
P
Site 21
S170
E
P
E
L
P
P
D
S
D
T
V
G
M
D
S
Site 22
T172
E
L
P
P
D
S
D
T
V
G
M
D
S
S
Y
Site 23
S177
S
D
T
V
G
M
D
S
S
Y
L
S
V
K
E
Site 24
S178
D
T
V
G
M
D
S
S
Y
L
S
V
K
E
A
Site 25
Y179
T
V
G
M
D
S
S
Y
L
S
V
K
E
A
G
Site 26
S181
G
M
D
S
S
Y
L
S
V
K
E
A
G
V
K
Site 27
S195
K
G
P
Q
D
R
A
S
S
D
L
P
S
P
L
Site 28
S196
G
P
Q
D
R
A
S
S
D
L
P
S
P
L
E
Site 29
S200
R
A
S
S
D
L
P
S
P
L
E
K
A
D
S
Site 30
S207
S
P
L
E
K
A
D
S
E
S
N
K
G
K
K
Site 31
S209
L
E
K
A
D
S
E
S
N
K
G
K
K
R
R
Site 32
T219
G
K
K
R
R
N
R
T
T
F
T
S
Y
Q
L
Site 33
T220
K
K
R
R
N
R
T
T
F
T
S
Y
Q
L
E
Site 34
S223
R
N
R
T
T
F
T
S
Y
Q
L
E
E
L
E
Site 35
T236
L
E
K
V
F
Q
K
T
H
Y
P
D
V
Y
A
Site 36
Y238
K
V
F
Q
K
T
H
Y
P
D
V
Y
A
R
E
Site 37
Y242
K
T
H
Y
P
D
V
Y
A
R
E
Q
L
A
M
Site 38
T254
L
A
M
R
T
D
L
T
E
A
R
V
Q
V
W
Site 39
T287
Q
V
R
T
H
F
S
T
A
Y
E
L
P
L
L
Site 40
Y289
R
T
H
F
S
T
A
Y
E
L
P
L
L
T
R
Site 41
S333
D
P
V
P
A
C
M
S
P
H
A
H
P
P
G
Site 42
S341
P
H
A
H
P
P
G
S
G
A
S
S
V
T
D
Site 43
S357
L
S
V
S
G
A
G
S
H
V
G
Q
T
H
M
Site 44
T362
A
G
S
H
V
G
Q
T
H
M
G
S
L
F
G
Site 45
Y380
L
S
P
G
L
N
G
Y
E
L
N
G
E
P
D
Site 46
T390
N
G
E
P
D
R
K
T
S
S
I
A
A
L
R
Site 47
S391
G
E
P
D
R
K
T
S
S
I
A
A
L
R
M
Site 48
S392
E
P
D
R
K
T
S
S
I
A
A
L
R
M
K
Site 49
S404
R
M
K
A
K
E
H
S
A
A
I
S
W
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation