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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SIL1
Full Name:
Nucleotide exchange factor SIL1
Alias:
BiP-associated protein
Type:
Mass (Da):
52067
Number AA:
461
UniProt ID:
Q9H173
International Prot ID:
IPI00296197
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005788
GO:0031974
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0051082
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
GO:0006810
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
P
Q
S
L
P
S
S
R
M
A
P
L
G
Site 2
S9
A
P
Q
S
L
P
S
S
R
M
A
P
L
G
M
Site 3
T41
N
L
K
E
F
A
L
T
N
P
E
K
S
S
T
Site 4
S46
A
L
T
N
P
E
K
S
S
T
K
E
T
E
R
Site 5
T48
T
N
P
E
K
S
S
T
K
E
T
E
R
K
E
Site 6
T51
E
K
S
S
T
K
E
T
E
R
K
E
T
K
A
Site 7
T56
K
E
T
E
R
K
E
T
K
A
E
E
E
L
D
Site 8
S89
G
Q
A
V
P
A
G
S
H
V
R
L
N
L
Q
Site 9
T97
H
V
R
L
N
L
Q
T
G
E
R
E
A
K
L
Site 10
Y106
E
R
E
A
K
L
Q
Y
E
D
K
F
R
N
N
Site 11
T123
G
K
R
L
D
I
N
T
N
T
Y
T
S
Q
D
Site 12
S128
I
N
T
N
T
Y
T
S
Q
D
L
K
S
A
L
Site 13
S147
E
G
A
E
M
E
S
S
K
E
D
K
A
R
Q
Site 14
S194
R
L
I
N
K
F
N
S
S
S
S
S
L
E
E
Site 15
S195
L
I
N
K
F
N
S
S
S
S
S
L
E
E
K
Site 16
S196
I
N
K
F
N
S
S
S
S
S
L
E
E
K
I
Site 17
S198
K
F
N
S
S
S
S
S
L
E
E
K
I
A
A
Site 18
Y211
A
A
L
F
D
L
E
Y
Y
V
H
Q
M
D
N
Site 19
Y212
A
L
F
D
L
E
Y
Y
V
H
Q
M
D
N
A
Site 20
T284
L
A
T
E
Q
P
L
T
A
K
K
K
V
L
F
Site 21
Y302
S
L
L
R
H
F
P
Y
A
Q
R
Q
F
L
K
Site 22
T318
G
G
L
Q
V
L
R
T
L
V
Q
E
K
G
T
Site 23
T353
A
E
E
E
A
E
L
T
Q
E
M
S
P
E
K
Site 24
S357
A
E
L
T
Q
E
M
S
P
E
K
L
Q
Q
Y
Site 25
Y364
S
P
E
K
L
Q
Q
Y
R
Q
V
H
L
L
P
Site 26
T400
A
R
E
K
V
L
Q
T
L
G
V
L
L
T
T
Site 27
T406
Q
T
L
G
V
L
L
T
T
C
R
D
R
Y
R
Site 28
T407
T
L
G
V
L
L
T
T
C
R
D
R
Y
R
Q
Site 29
Y412
L
T
T
C
R
D
R
Y
R
Q
D
P
Q
L
G
Site 30
S434
A
E
Y
Q
V
L
A
S
L
E
L
Q
D
G
E
Site 31
Y445
Q
D
G
E
D
E
G
Y
F
Q
E
L
L
G
S
Site 32
S452
Y
F
Q
E
L
L
G
S
V
N
S
L
L
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation