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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EAP1
Full Name:
Enhanced at puberty protein 1
Alias:
Chromosome 14 open reading frame 4; CN004; Enhanced at puberty 1; IRF2BPL; KIAA1865; Polyglutamine-containing protein
Type:
Mass (Da):
82659
Number AA:
796
UniProt ID:
Q9H1B7
International Prot ID:
IPI00019205
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
A
A
Q
V
S
S
S
Site 2
S7
_
M
S
A
A
Q
V
S
S
S
R
R
Q
S
C
Site 3
S8
M
S
A
A
Q
V
S
S
S
R
R
Q
S
C
Y
Site 4
S9
S
A
A
Q
V
S
S
S
R
R
Q
S
C
Y
L
Site 5
S13
V
S
S
S
R
R
Q
S
C
Y
L
C
D
L
P
Site 6
Y15
S
S
R
R
Q
S
C
Y
L
C
D
L
P
R
M
Site 7
Y41
V
C
R
G
C
V
N
Y
E
G
A
D
R
I
E
Site 8
S69
G
C
F
Q
D
G
R
S
P
G
P
P
P
P
V
Site 9
S134
Q
L
N
H
V
D
G
S
S
K
P
A
V
L
A
Site 10
S135
L
N
H
V
D
G
S
S
K
P
A
V
L
A
A
Site 11
Y173
E
Q
R
S
R
F
E
Y
P
P
P
P
V
S
L
Site 12
S179
E
Y
P
P
P
P
V
S
L
G
S
S
S
H
T
Site 13
S182
P
P
P
V
S
L
G
S
S
S
H
T
A
R
L
Site 14
S183
P
P
V
S
L
G
S
S
S
H
T
A
R
L
P
Site 15
S184
P
V
S
L
G
S
S
S
H
T
A
R
L
P
N
Site 16
T186
S
L
G
S
S
S
H
T
A
R
L
P
N
G
L
Site 17
T203
P
N
G
F
P
K
P
T
P
E
E
G
P
P
E
Site 18
S215
P
P
E
L
N
R
Q
S
P
N
S
S
S
A
A
Site 19
S218
L
N
R
Q
S
P
N
S
S
S
A
A
A
S
V
Site 20
S219
N
R
Q
S
P
N
S
S
S
A
A
A
S
V
A
Site 21
S220
R
Q
S
P
N
S
S
S
A
A
A
S
V
A
S
Site 22
S224
N
S
S
S
A
A
A
S
V
A
S
R
R
G
T
Site 23
S227
S
A
A
A
S
V
A
S
R
R
G
T
H
G
G
Site 24
T231
S
V
A
S
R
R
G
T
H
G
G
L
V
T
G
Site 25
T237
G
T
H
G
G
L
V
T
G
L
P
N
P
G
G
Site 26
T251
G
G
G
G
P
Q
L
T
V
P
P
N
L
L
P
Site 27
T260
P
P
N
L
L
P
Q
T
L
L
N
G
P
A
S
Site 28
S281
P
P
P
H
A
L
G
S
R
G
P
P
T
P
A
Site 29
T286
L
G
S
R
G
P
P
T
P
A
P
P
G
A
P
Site 30
S306
L
G
G
T
P
G
V
S
A
T
S
S
S
A
S
Site 31
T308
G
T
P
G
V
S
A
T
S
S
S
A
S
S
S
Site 32
S309
T
P
G
V
S
A
T
S
S
S
A
S
S
S
T
Site 33
S310
P
G
V
S
A
T
S
S
S
A
S
S
S
T
S
Site 34
S311
G
V
S
A
T
S
S
S
A
S
S
S
T
S
S
Site 35
S313
S
A
T
S
S
S
A
S
S
S
T
S
S
S
V
Site 36
S314
A
T
S
S
S
A
S
S
S
T
S
S
S
V
A
Site 37
S315
T
S
S
S
A
S
S
S
T
S
S
S
V
A
E
Site 38
S317
S
S
A
S
S
S
T
S
S
S
V
A
E
V
G
Site 39
S318
S
A
S
S
S
T
S
S
S
V
A
E
V
G
V
Site 40
S334
A
G
G
K
R
P
G
S
V
S
S
T
D
Q
E
Site 41
S336
G
K
R
P
G
S
V
S
S
T
D
Q
E
R
E
Site 42
S337
K
R
P
G
S
V
S
S
T
D
Q
E
R
E
L
Site 43
T338
R
P
G
S
V
S
S
T
D
Q
E
R
E
L
K
Site 44
S360
A
L
A
E
L
S
E
S
L
R
N
R
A
E
E
Site 45
S370
N
R
A
E
E
W
A
S
K
P
K
M
V
R
D
Site 46
Y388
T
L
A
G
C
T
P
Y
E
V
R
F
K
K
D
Site 47
S397
V
R
F
K
K
D
H
S
L
L
G
R
V
F
A
Site 48
Y415
V
S
K
P
G
M
D
Y
E
L
K
L
F
I
E
Site 49
Y423
E
L
K
L
F
I
E
Y
P
T
G
S
G
N
V
Site 50
Y431
P
T
G
S
G
N
V
Y
S
S
A
S
G
V
A
Site 51
S432
T
G
S
G
N
V
Y
S
S
A
S
G
V
A
K
Site 52
S433
G
S
G
N
V
Y
S
S
A
S
G
V
A
K
Q
Site 53
S435
G
N
V
Y
S
S
A
S
G
V
A
K
Q
M
Y
Site 54
Y442
S
G
V
A
K
Q
M
Y
Q
D
C
M
K
D
F
Site 55
S454
K
D
F
G
R
G
L
S
S
G
F
K
Y
L
E
Site 56
S455
D
F
G
R
G
L
S
S
G
F
K
Y
L
E
Y
Site 57
Y459
G
L
S
S
G
F
K
Y
L
E
Y
E
K
K
H
Site 58
Y462
S
G
F
K
Y
L
E
Y
E
K
K
H
G
S
G
Site 59
S468
E
Y
E
K
K
H
G
S
G
D
W
R
L
L
G
Site 60
Y499
A
D
M
L
P
Q
P
Y
L
D
A
S
C
P
M
Site 61
S503
P
Q
P
Y
L
D
A
S
C
P
M
L
P
T
A
Site 62
S519
V
S
L
S
R
A
P
S
A
P
P
G
T
G
A
Site 63
S540
S
G
R
G
A
A
A
S
L
R
K
R
K
A
S
Site 64
S547
S
L
R
K
R
K
A
S
P
E
P
P
D
S
A
Site 65
S553
A
S
P
E
P
P
D
S
A
E
G
A
L
K
L
Site 66
S607
P
P
P
L
G
P
H
S
N
R
T
T
P
P
E
Site 67
T610
L
G
P
H
S
N
R
T
T
P
P
E
S
A
P
Site 68
T611
G
P
H
S
N
R
T
T
P
P
E
S
A
P
Q
Site 69
S615
N
R
T
T
P
P
E
S
A
P
Q
N
G
P
S
Site 70
S622
S
A
P
Q
N
G
P
S
P
M
A
A
L
M
S
Site 71
T633
A
L
M
S
V
A
D
T
L
G
T
A
H
S
P
Site 72
T636
S
V
A
D
T
L
G
T
A
H
S
P
K
D
G
Site 73
S639
D
T
L
G
T
A
H
S
P
K
D
G
S
S
V
Site 74
S644
A
H
S
P
K
D
G
S
S
V
H
S
T
T
A
Site 75
S645
H
S
P
K
D
G
S
S
V
H
S
T
T
A
S
Site 76
S648
K
D
G
S
S
V
H
S
T
T
A
S
A
R
R
Site 77
T649
D
G
S
S
V
H
S
T
T
A
S
A
R
R
N
Site 78
S652
S
V
H
S
T
T
A
S
A
R
R
N
S
S
S
Site 79
S657
T
A
S
A
R
R
N
S
S
S
P
V
S
P
A
Site 80
S658
A
S
A
R
R
N
S
S
S
P
V
S
P
A
S
Site 81
S659
S
A
R
R
N
S
S
S
P
V
S
P
A
S
V
Site 82
S662
R
N
S
S
S
P
V
S
P
A
S
V
P
G
Q
Site 83
S665
S
S
P
V
S
P
A
S
V
P
G
Q
R
R
L
Site 84
S674
P
G
Q
R
R
L
A
S
R
N
G
D
L
N
L
Site 85
S689
Q
V
A
P
P
P
P
S
A
H
P
G
M
D
Q
Site 86
S705
H
P
Q
N
I
P
D
S
P
M
A
N
S
G
P
Site 87
S746
C
F
P
C
S
R
E
S
I
K
A
Q
G
A
T
Site 88
Y757
Q
G
A
T
G
E
V
Y
C
P
S
G
E
K
C
Site 89
S760
T
G
E
V
Y
C
P
S
G
E
K
C
P
L
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation