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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NUCKS1
Full Name:
Nuclear ubiquitous casein and cyclin-dependent kinases substrate
Alias:
Nuclear ubiquitous casein and cyclin-dependent kinases substrate: P1; P1
Type:
DNA binding protein
Mass (Da):
27296
Number AA:
243
UniProt ID:
Q9H1E3
International Prot ID:
IPI00022145
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0016301
GO:0016740
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
R
N
R
K
V
V
D
Y
S
Q
F
Q
E
S
D
Site 2
S14
N
R
K
V
V
D
Y
S
Q
F
Q
E
S
D
D
Site 3
S19
D
Y
S
Q
F
Q
E
S
D
D
A
D
E
D
Y
Site 4
Y26
S
D
D
A
D
E
D
Y
G
R
D
S
G
P
P
Site 5
S30
D
E
D
Y
G
R
D
S
G
P
P
T
K
K
I
Site 6
T34
G
R
D
S
G
P
P
T
K
K
I
R
S
S
P
Site 7
S39
P
P
T
K
K
I
R
S
S
P
R
E
A
K
N
Site 8
S40
P
T
K
K
I
R
S
S
P
R
E
A
K
N
K
Site 9
S50
E
A
K
N
K
R
R
S
G
K
N
S
Q
E
D
Site 10
S54
K
R
R
S
G
K
N
S
Q
E
D
S
E
D
S
Site 11
S58
G
K
N
S
Q
E
D
S
E
D
S
E
D
K
D
Site 12
S61
S
Q
E
D
S
E
D
S
E
D
K
D
V
K
T
Site 13
T68
S
E
D
K
D
V
K
T
K
K
D
D
S
H
S
Site 14
S73
V
K
T
K
K
D
D
S
H
S
A
E
D
S
E
Site 15
S75
T
K
K
D
D
S
H
S
A
E
D
S
E
D
E
Site 16
S79
D
S
H
S
A
E
D
S
E
D
E
K
E
D
H
Site 17
S97
R
Q
Q
R
Q
A
A
S
K
A
A
S
K
Q
R
Site 18
S101
Q
A
A
S
K
A
A
S
K
Q
R
E
M
L
M
Site 19
S113
M
L
M
E
D
V
G
S
E
E
E
Q
E
E
E
Site 20
S130
A
P
F
Q
E
K
D
S
G
S
D
E
D
F
L
Site 21
S132
F
Q
E
K
D
S
G
S
D
E
D
F
L
M
E
Site 22
S144
L
M
E
D
D
D
D
S
D
Y
G
S
S
K
K
Site 23
Y146
E
D
D
D
D
S
D
Y
G
S
S
K
K
K
N
Site 24
S148
D
D
D
S
D
Y
G
S
S
K
K
K
N
K
K
Site 25
S149
D
D
S
D
Y
G
S
S
K
K
K
N
K
K
M
Site 26
S160
N
K
K
M
V
K
K
S
K
P
E
R
K
E
K
Site 27
T177
P
K
P
R
L
K
A
T
V
T
P
S
P
V
K
Site 28
T179
P
R
L
K
A
T
V
T
P
S
P
V
K
G
K
Site 29
S181
L
K
A
T
V
T
P
S
P
V
K
G
K
G
K
Site 30
T193
K
G
K
V
G
R
P
T
A
S
K
A
S
K
E
Site 31
S198
R
P
T
A
S
K
A
S
K
E
K
T
P
S
P
Site 32
T202
S
K
A
S
K
E
K
T
P
S
P
K
E
E
D
Site 33
S204
A
S
K
E
K
T
P
S
P
K
E
E
D
E
E
Site 34
S214
E
E
D
E
E
P
E
S
P
P
E
K
K
T
S
Site 35
T220
E
S
P
P
E
K
K
T
S
T
S
P
P
P
E
Site 36
S221
S
P
P
E
K
K
T
S
T
S
P
P
P
E
K
Site 37
T222
P
P
E
K
K
T
S
T
S
P
P
P
E
K
S
Site 38
S223
P
E
K
K
T
S
T
S
P
P
P
E
K
S
G
Site 39
S229
T
S
P
P
P
E
K
S
G
D
E
G
S
E
D
Site 40
S234
E
K
S
G
D
E
G
S
E
D
E
A
P
S
G
Site 41
S240
G
S
E
D
E
A
P
S
G
E
D
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation