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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UPF3A
Full Name:
Regulator of nonsense transcripts 3A
Alias:
HUpf3; Nonsense mRNA reducing factor 3A; RENT3A; UPF3; Up-frameshift suppressor 3 homologue A
Type:
RNA binding protein. RENT3 family.
Mass (Da):
54696
Number AA:
476
UniProt ID:
Q9H1J1
International Prot ID:
IPI00011138
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005487
GO:0000166
PhosphoSite+
KinaseNET
Biological Process:
GO:0051028
GO:0000184
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
A
V
A
A
R
G
P
S
G
R
E
K
L
S
A
Site 2
S27
P
S
G
R
E
K
L
S
A
L
E
V
Q
F
H
Site 3
S37
E
V
Q
F
H
R
D
S
Q
Q
Q
E
A
E
T
Site 4
T44
S
Q
Q
Q
E
A
E
T
P
P
T
S
S
S
G
Site 5
T47
Q
E
A
E
T
P
P
T
S
S
S
G
C
G
G
Site 6
S48
E
A
E
T
P
P
T
S
S
S
G
C
G
G
G
Site 7
S50
E
T
P
P
T
S
S
S
G
C
G
G
G
A
G
Site 8
T65
K
P
R
E
E
K
R
T
A
L
S
K
V
V
I
Site 9
S68
E
E
K
R
T
A
L
S
K
V
V
I
R
R
L
Site 10
Y96
R
P
L
P
A
H
D
Y
F
E
F
F
A
A
D
Site 11
Y115
P
H
L
Y
S
R
A
Y
I
N
F
R
N
P
D
Site 12
Y134
F
R
D
R
F
D
G
Y
I
F
L
D
S
K
G
Site 13
S139
D
G
Y
I
F
L
D
S
K
G
L
E
Y
P
A
Site 14
T168
L
R
K
K
D
A
K
T
G
S
I
E
D
D
P
Site 15
S170
K
K
D
A
K
T
G
S
I
E
D
D
P
E
Y
Site 16
Y177
S
I
E
D
D
P
E
Y
K
K
F
L
E
T
Y
Site 17
T191
Y
C
V
E
E
E
K
T
S
A
N
P
E
T
L
Site 18
S192
C
V
E
E
E
K
T
S
A
N
P
E
T
L
L
Site 19
T214
R
E
L
I
A
R
R
T
T
P
L
L
E
Y
I
Site 20
T215
E
L
I
A
R
R
T
T
P
L
L
E
Y
I
K
Site 21
T295
E
K
G
E
E
P
T
T
E
K
P
K
E
R
G
Site 22
T307
E
R
G
E
E
I
D
T
G
G
G
K
Q
E
S
Site 23
S314
T
G
G
G
K
Q
E
S
C
A
P
G
A
V
V
Site 24
S329
K
A
R
P
M
E
G
S
L
E
E
P
Q
E
T
Site 25
T336
S
L
E
E
P
Q
E
T
S
H
S
G
S
D
K
Site 26
S337
L
E
E
P
Q
E
T
S
H
S
G
S
D
K
E
Site 27
S339
E
P
Q
E
T
S
H
S
G
S
D
K
E
H
R
Site 28
S341
Q
E
T
S
H
S
G
S
D
K
E
H
R
D
V
Site 29
S351
E
H
R
D
V
E
R
S
Q
E
Q
E
S
E
A
Site 30
Y361
Q
E
S
E
A
Q
R
Y
H
V
D
D
G
R
R
Site 31
S379
H
H
E
P
E
R
L
S
R
R
S
E
D
E
Q
Site 32
S382
P
E
R
L
S
R
R
S
E
D
E
Q
R
W
G
Site 33
S401
Q
D
R
G
K
K
G
S
Q
D
S
G
A
P
G
Site 34
S404
G
K
K
G
S
Q
D
S
G
A
P
G
E
A
M
Site 35
S423
R
A
Q
R
C
D
D
S
P
A
P
R
K
E
R
Site 36
Y442
D
R
P
A
L
Q
L
Y
D
P
G
A
R
F
R
Site 37
S465
R
I
C
K
A
E
G
S
G
T
G
P
E
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation