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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
epsin 3
Full Name:
Epsin-3
Alias:
EPN3; EPS-15 interacting protein 3; EPS-15-interacting protein 3; Epsin 3; FLJ20778; MGC129899
Type:
Vesicle protein
Mass (Da):
68222
Number AA:
632
UniProt ID:
Q9H201
International Prot ID:
IPI00300584
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030136
GO:0005634
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0008289
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
V
K
N
I
V
H
N
Y
S
E
A
E
I
K
V
Site 2
S18
K
N
I
V
H
N
Y
S
E
A
E
I
K
V
R
Site 3
T28
E
I
K
V
R
E
A
T
S
N
D
P
W
G
P
Site 4
S37
N
D
P
W
G
P
P
S
S
L
M
S
E
I
A
Site 5
S38
D
P
W
G
P
P
S
S
L
M
S
E
I
A
D
Site 6
Y75
G
K
N
W
R
H
V
Y
K
A
L
T
L
L
D
Site 7
Y83
K
A
L
T
L
L
D
Y
L
L
K
T
G
S
E
Site 8
T87
L
L
D
Y
L
L
K
T
G
S
E
R
V
A
H
Site 9
S89
D
Y
L
L
K
T
G
S
E
R
V
A
H
Q
C
Site 10
Y101
H
Q
C
R
E
N
L
Y
T
I
Q
T
L
K
D
Site 11
T102
Q
C
R
E
N
L
Y
T
I
Q
T
L
K
D
F
Site 12
T105
E
N
L
Y
T
I
Q
T
L
K
D
F
Q
Y
I
Site 13
Y111
Q
T
L
K
D
F
Q
Y
I
D
R
D
G
K
D
Site 14
S169
G
S
G
Q
L
G
F
S
R
R
Y
G
E
D
Y
Site 15
Y172
Q
L
G
F
S
R
R
Y
G
E
D
Y
S
R
S
Site 16
Y176
S
R
R
Y
G
E
D
Y
S
R
S
R
G
S
P
Site 17
S177
R
R
Y
G
E
D
Y
S
R
S
R
G
S
P
S
Site 18
S179
Y
G
E
D
Y
S
R
S
R
G
S
P
S
S
Y
Site 19
S182
D
Y
S
R
S
R
G
S
P
S
S
Y
N
S
S
Site 20
S184
S
R
S
R
G
S
P
S
S
Y
N
S
S
S
S
Site 21
S185
R
S
R
G
S
P
S
S
Y
N
S
S
S
S
S
Site 22
Y186
S
R
G
S
P
S
S
Y
N
S
S
S
S
S
P
Site 23
S188
G
S
P
S
S
Y
N
S
S
S
S
S
P
R
Y
Site 24
S189
S
P
S
S
Y
N
S
S
S
S
S
P
R
Y
T
Site 25
S190
P
S
S
Y
N
S
S
S
S
S
P
R
Y
T
S
Site 26
S191
S
S
Y
N
S
S
S
S
S
P
R
Y
T
S
D
Site 27
S192
S
Y
N
S
S
S
S
S
P
R
Y
T
S
D
L
Site 28
Y195
S
S
S
S
S
P
R
Y
T
S
D
L
E
Q
A
Site 29
T196
S
S
S
S
P
R
Y
T
S
D
L
E
Q
A
R
Site 30
S197
S
S
S
P
R
Y
T
S
D
L
E
Q
A
R
P
Site 31
T206
L
E
Q
A
R
P
Q
T
S
G
E
E
E
L
Q
Site 32
S207
E
Q
A
R
P
Q
T
S
G
E
E
E
L
Q
L
Site 33
S233
E
K
P
V
P
P
A
S
H
R
D
E
D
L
Q
Site 34
S248
L
Q
L
A
L
R
L
S
R
Q
E
H
E
K
E
Site 35
S264
R
S
W
Q
G
D
G
S
P
M
A
N
G
A
G
Site 36
T295
K
E
E
E
K
L
K
T
S
Q
S
S
I
L
D
Site 37
S296
E
E
E
K
L
K
T
S
Q
S
S
I
L
D
L
Site 38
S298
E
K
L
K
T
S
Q
S
S
I
L
D
L
A
D
Site 39
S299
K
L
K
T
S
Q
S
S
I
L
D
L
A
D
I
Site 40
S315
V
P
A
L
A
P
P
S
T
H
C
S
A
D
P
Site 41
T316
P
A
L
A
P
P
S
T
H
C
S
A
D
P
W
Site 42
S319
A
P
P
S
T
H
C
S
A
D
P
W
D
I
P
Site 43
T332
I
P
G
F
R
P
N
T
E
A
S
G
S
S
W
Site 44
S335
F
R
P
N
T
E
A
S
G
S
S
W
G
P
S
Site 45
S337
P
N
T
E
A
S
G
S
S
W
G
P
S
A
D
Site 46
S338
N
T
E
A
S
G
S
S
W
G
P
S
A
D
P
Site 47
S342
S
G
S
S
W
G
P
S
A
D
P
W
S
P
I
Site 48
S347
G
P
S
A
D
P
W
S
P
I
P
S
G
T
V
Site 49
S351
D
P
W
S
P
I
P
S
G
T
V
L
S
R
S
Site 50
T353
W
S
P
I
P
S
G
T
V
L
S
R
S
Q
P
Site 51
S356
I
P
S
G
T
V
L
S
R
S
Q
P
W
D
L
Site 52
S358
S
G
T
V
L
S
R
S
Q
P
W
D
L
T
P
Site 53
T364
R
S
Q
P
W
D
L
T
P
M
L
S
S
S
E
Site 54
S368
W
D
L
T
P
M
L
S
S
S
E
P
W
G
R
Site 55
S370
L
T
P
M
L
S
S
S
E
P
W
G
R
T
P
Site 56
T376
S
S
E
P
W
G
R
T
P
V
L
P
A
G
P
Site 57
T385
V
L
P
A
G
P
P
T
T
D
P
W
A
L
N
Site 58
T386
L
P
A
G
P
P
T
T
D
P
W
A
L
N
S
Site 59
S393
T
D
P
W
A
L
N
S
P
H
H
K
L
P
S
Site 60
S400
S
P
H
H
K
L
P
S
T
G
A
D
P
W
G
Site 61
T401
P
H
H
K
L
P
S
T
G
A
D
P
W
G
A
Site 62
S409
G
A
D
P
W
G
A
S
L
E
T
S
D
T
P
Site 63
S413
W
G
A
S
L
E
T
S
D
T
P
G
G
A
S
Site 64
T415
A
S
L
E
T
S
D
T
P
G
G
A
S
T
F
Site 65
T421
D
T
P
G
G
A
S
T
F
D
P
F
A
K
P
Site 66
S431
P
F
A
K
P
P
E
S
T
E
T
K
E
G
L
Site 67
T434
K
P
P
E
S
T
E
T
K
E
G
L
E
Q
A
Site 68
S444
G
L
E
Q
A
L
P
S
G
K
P
S
S
P
V
Site 69
S448
A
L
P
S
G
K
P
S
S
P
V
E
L
D
L
Site 70
S449
L
P
S
G
K
P
S
S
P
V
E
L
D
L
F
Site 71
S460
L
D
L
F
G
D
P
S
P
S
S
K
Q
N
G
Site 72
S462
L
F
G
D
P
S
P
S
S
K
Q
N
G
T
K
Site 73
S463
F
G
D
P
S
P
S
S
K
Q
N
G
T
K
E
Site 74
T484
G
I
L
G
E
A
L
T
Q
P
S
K
E
A
R
Site 75
T495
K
E
A
R
A
C
R
T
P
E
S
F
L
G
P
Site 76
S498
R
A
C
R
T
P
E
S
F
L
G
P
S
A
S
Site 77
T522
K
A
P
Q
V
A
K
T
R
N
P
F
L
T
G
Site 78
T528
K
T
R
N
P
F
L
T
G
L
S
A
P
S
P
Site 79
S531
N
P
F
L
T
G
L
S
A
P
S
P
T
N
P
Site 80
S534
L
T
G
L
S
A
P
S
P
T
N
P
F
G
A
Site 81
T548
A
G
E
P
G
R
P
T
L
N
Q
M
R
T
G
Site 82
T554
P
T
L
N
Q
M
R
T
G
S
P
A
L
G
L
Site 83
S556
L
N
Q
M
R
T
G
S
P
A
L
G
L
A
G
Site 84
T613
A
P
Q
P
L
L
P
T
P
S
S
A
G
P
R
Site 85
S615
Q
P
L
L
P
T
P
S
S
A
G
P
R
P
P
Site 86
S616
P
L
L
P
T
P
S
S
A
G
P
R
P
P
P
Site 87
T626
P
R
P
P
P
P
Q
T
G
T
N
P
F
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation