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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EHD4
Full Name:
EH domain-containing protein 4
Alias:
EH domain-containing protein FKSG7; EH-domain containing 4; EH-domain containing protein 4; FKSG7; HCA10; HCA11; Hepatocellular carcinoma-associated protein 10/11; MPAST2; PAST2; PAST4
Type:
Extracellular matrix
Mass (Da):
61175
Number AA:
541
UniProt ID:
Q9H223
International Prot ID:
IPI00005578
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0005768
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005525
GO:0003924
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
G
G
A
D
A
V
Q
T
V
T
G
G
L
R
S
Site 2
S50
Y
R
F
H
E
F
H
S
P
A
L
E
D
A
D
Site 3
T75
G
Q
Y
S
T
G
K
T
T
F
I
R
Y
L
L
Site 4
T76
Q
Y
S
T
G
K
T
T
F
I
R
Y
L
L
E
Site 5
S99
G
P
E
P
T
T
D
S
F
I
A
V
M
Y
G
Site 6
Y105
D
S
F
I
A
V
M
Y
G
E
T
E
G
S
T
Site 7
S111
M
Y
G
E
T
E
G
S
T
P
G
N
A
L
V
Site 8
T112
Y
G
E
T
E
G
S
T
P
G
N
A
L
V
V
Site 9
S129
K
K
P
F
R
K
L
S
R
F
G
N
A
F
L
Site 10
S162
I
D
S
P
G
I
L
S
G
E
K
Q
R
I
S
Site 11
S169
S
G
E
K
Q
R
I
S
R
G
Y
D
F
C
Q
Site 12
Y172
K
Q
R
I
S
R
G
Y
D
F
C
Q
V
L
Q
Site 13
S200
D
A
H
K
L
D
I
S
D
E
F
S
E
A
I
Site 14
S204
L
D
I
S
D
E
F
S
E
A
I
K
A
F
R
Site 15
T249
S
L
G
K
V
I
N
T
P
E
V
L
R
V
Y
Site 16
S287
D
L
F
R
D
I
Q
S
L
P
Q
K
A
A
V
Site 17
Y312
R
L
A
K
V
H
A
Y
I
I
S
Y
L
K
K
Site 18
Y316
V
H
A
Y
I
I
S
Y
L
K
K
E
M
P
S
Site 19
S336
N
K
K
R
E
L
I
S
R
L
P
E
I
Y
I
Site 20
Y342
I
S
R
L
P
E
I
Y
I
Q
L
Q
R
E
Y
Site 21
Y349
Y
I
Q
L
Q
R
E
Y
Q
I
S
A
G
D
F
Site 22
S352
L
Q
R
E
Y
Q
I
S
A
G
D
F
P
E
V
Site 23
Y369
M
Q
E
Q
L
E
N
Y
D
F
T
K
F
H
S
Site 24
T372
Q
L
E
N
Y
D
F
T
K
F
H
S
L
K
P
Site 25
S376
Y
D
F
T
K
F
H
S
L
K
P
K
L
I
E
Site 26
S390
E
A
V
D
N
M
L
S
N
K
I
S
P
L
M
Site 27
S401
S
P
L
M
N
L
I
S
Q
E
E
T
S
T
P
Site 28
T405
N
L
I
S
Q
E
E
T
S
T
P
T
Q
L
V
Site 29
S406
L
I
S
Q
E
E
T
S
T
P
T
Q
L
V
Q
Site 30
T407
I
S
Q
E
E
T
S
T
P
T
Q
L
V
Q
G
Site 31
T420
Q
G
G
A
F
D
G
T
T
E
G
P
F
N
Q
Site 32
T421
G
G
A
F
D
G
T
T
E
G
P
F
N
Q
G
Site 33
Y429
E
G
P
F
N
Q
G
Y
G
E
G
A
K
E
G
Site 34
Y451
V
A
K
D
K
P
V
Y
D
E
L
F
Y
T
L
Site 35
Y456
P
V
Y
D
E
L
F
Y
T
L
S
P
I
N
G
Site 36
T457
V
Y
D
E
L
F
Y
T
L
S
P
I
N
G
K
Site 37
S459
D
E
L
F
Y
T
L
S
P
I
N
G
K
I
S
Site 38
S477
A
K
K
E
M
V
T
S
K
L
P
N
S
V
L
Site 39
S482
V
T
S
K
L
P
N
S
V
L
G
K
I
W
K
Site 40
Y518
I
K
I
K
L
D
G
Y
E
L
P
S
S
L
P
Site 41
S523
D
G
Y
E
L
P
S
S
L
P
P
H
L
V
P
Site 42
S532
P
P
H
L
V
P
P
S
H
R
K
S
L
P
K
Site 43
S536
V
P
P
S
H
R
K
S
L
P
K
A
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation