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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNH6
Full Name:
Potassium voltage-gated channel subfamily H member 6
Alias:
Ether-a-go-go-related gene potassium channel 2;Voltage-gated potassium channel subunit Kv11.2
Type:
Mass (Da):
109925
Number AA:
994
UniProt ID:
Q9H252
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T17
P
Q
N
T
Y
L
D
T
I
I
R
K
F
E
G
Site 2
T70
P
C
T
C
D
F
L
T
G
P
N
T
P
S
S
Site 3
T74
D
F
L
T
G
P
N
T
P
S
S
A
V
S
R
Site 4
S76
L
T
G
P
N
T
P
S
S
A
V
S
R
L
A
Site 5
S77
T
G
P
N
T
P
S
S
A
V
S
R
L
A
Q
Site 6
Y98
E
C
K
V
D
I
L
Y
Y
R
K
D
A
S
S
Site 7
Y99
C
K
V
D
I
L
Y
Y
R
K
D
A
S
S
F
Site 8
S104
L
Y
Y
R
K
D
A
S
S
F
R
C
L
V
D
Site 9
S105
Y
Y
R
K
D
A
S
S
F
R
C
L
V
D
V
Site 10
S140
A
Q
L
L
A
K
C
S
S
R
S
L
S
Q
R
Site 11
S141
Q
L
L
A
K
C
S
S
R
S
L
S
Q
R
L
Site 12
S143
L
A
K
C
S
S
R
S
L
S
Q
R
L
L
S
Site 13
S145
K
C
S
S
R
S
L
S
Q
R
L
L
S
Q
S
Site 14
S150
S
L
S
Q
R
L
L
S
Q
S
F
L
G
S
E
Site 15
S152
S
Q
R
L
L
S
Q
S
F
L
G
S
E
G
S
Site 16
S156
L
S
Q
S
F
L
G
S
E
G
S
H
G
R
P
Site 17
S159
S
F
L
G
S
E
G
S
H
G
R
P
G
G
P
Site 18
T170
P
G
G
P
G
P
G
T
G
R
G
K
Y
R
T
Site 19
Y175
P
G
T
G
R
G
K
Y
R
T
I
S
Q
I
P
Site 20
T177
T
G
R
G
K
Y
R
T
I
S
Q
I
P
Q
F
Site 21
S179
R
G
K
Y
R
T
I
S
Q
I
P
Q
F
T
L
Site 22
S198
F
N
L
E
K
H
R
S
S
S
T
T
E
I
E
Site 23
S199
N
L
E
K
H
R
S
S
S
T
T
E
I
E
I
Site 24
S200
L
E
K
H
R
S
S
S
T
T
E
I
E
I
I
Site 25
T202
K
H
R
S
S
S
T
T
E
I
E
I
I
A
P
Site 26
T220
V
E
R
T
Q
N
V
T
E
K
V
T
Q
V
L
Site 27
Y237
G
A
D
V
L
P
E
Y
K
L
Q
A
P
R
I
Site 28
S283
Y
S
A
A
F
L
L
S
D
Q
D
E
S
R
R
Site 29
S288
L
L
S
D
Q
D
E
S
R
R
G
A
C
S
Y
Site 30
S294
E
S
R
R
G
A
C
S
Y
T
C
S
P
L
T
Site 31
Y295
S
R
R
G
A
C
S
Y
T
C
S
P
L
T
V
Site 32
Y323
V
I
N
F
R
T
T
Y
V
N
T
N
D
E
V
Site 33
T369
R
T
G
S
D
E
T
T
T
L
I
G
L
L
K
Site 34
Y393
V
A
R
K
L
D
R
Y
S
E
Y
G
A
A
V
Site 35
S394
A
R
K
L
D
R
Y
S
E
Y
G
A
A
V
L
Site 36
Y429
I
G
N
V
E
R
P
Y
L
E
H
K
I
G
W
Site 37
S439
H
K
I
G
W
L
D
S
L
G
V
Q
L
G
K
Site 38
S451
L
G
K
R
Y
N
G
S
D
P
A
S
G
P
S
Site 39
S455
Y
N
G
S
D
P
A
S
G
P
S
V
Q
D
K
Site 40
Y463
G
P
S
V
Q
D
K
Y
V
T
A
L
Y
F
T
Site 41
S483
S
V
G
F
G
N
V
S
P
N
T
N
S
E
K
Site 42
T486
F
G
N
V
S
P
N
T
N
S
E
K
V
F
S
Site 43
S488
N
V
S
P
N
T
N
S
E
K
V
F
S
I
C
Site 44
Y519
S
A
I
I
Q
R
L
Y
S
G
T
A
R
Y
H
Site 45
S520
A
I
I
Q
R
L
Y
S
G
T
A
R
Y
H
T
Site 46
T522
I
Q
R
L
Y
S
G
T
A
R
Y
H
T
Q
M
Site 47
T527
S
G
T
A
R
Y
H
T
Q
M
L
R
V
K
E
Site 48
Y552
L
R
Q
R
L
E
E
Y
F
Q
H
A
W
S
Y
Site 49
T612
A
L
A
V
K
F
K
T
T
H
A
P
P
G
D
Site 50
T620
T
H
A
P
P
G
D
T
L
V
H
L
G
D
V
Site 51
S638
L
Y
F
I
S
R
G
S
I
E
I
L
R
D
D
Site 52
S662
D
I
F
G
E
P
V
S
L
H
A
Q
P
G
K
Site 53
S670
L
H
A
Q
P
G
K
S
S
A
D
V
R
A
L
Site 54
T678
S
A
D
V
R
A
L
T
Y
C
D
L
H
K
I
Site 55
T711
F
W
S
K
L
E
V
T
F
N
L
R
D
A
A
Site 56
S723
D
A
A
G
G
L
H
S
S
P
R
Q
A
P
G
Site 57
S724
A
A
G
G
L
H
S
S
P
R
Q
A
P
G
S
Site 58
S731
S
P
R
Q
A
P
G
S
Q
D
H
Q
G
F
F
Site 59
S740
D
H
Q
G
F
F
L
S
D
N
Q
S
G
S
P
Site 60
S744
F
F
L
S
D
N
Q
S
G
S
P
H
E
L
G
Site 61
S746
L
S
D
N
Q
S
G
S
P
H
E
L
G
P
Q
Site 62
S756
E
L
G
P
Q
F
P
S
K
G
Y
S
L
L
G
Site 63
S760
Q
F
P
S
K
G
Y
S
L
L
G
P
G
S
Q
Site 64
S766
Y
S
L
L
G
P
G
S
Q
N
S
M
G
A
G
Site 65
S769
L
G
P
G
S
Q
N
S
M
G
A
G
P
C
A
Site 66
S787
P
D
A
A
P
P
L
S
I
S
D
A
S
G
L
Site 67
S807
Q
E
M
P
P
R
H
S
P
Q
S
P
Q
E
D
Site 68
S810
P
P
R
H
S
P
Q
S
P
Q
E
D
P
D
C
Site 69
S824
C
W
P
L
K
L
G
S
R
L
E
Q
L
Q
A
Site 70
S838
A
Q
M
N
R
L
E
S
R
V
S
S
D
L
S
Site 71
S841
N
R
L
E
S
R
V
S
S
D
L
S
R
I
L
Site 72
S842
R
L
E
S
R
V
S
S
D
L
S
R
I
L
Q
Site 73
S845
S
R
V
S
S
D
L
S
R
I
L
Q
L
L
Q
Site 74
T881
L
V
P
I
A
S
E
T
T
S
P
G
P
R
L
Site 75
S883
P
I
A
S
E
T
T
S
P
G
P
R
L
P
Q
Site 76
T898
G
F
L
P
P
A
Q
T
P
S
Y
G
D
L
D
Site 77
S900
L
P
P
A
Q
T
P
S
Y
G
D
L
D
D
C
Site 78
Y901
P
P
A
Q
T
P
S
Y
G
D
L
D
D
C
S
Site 79
S908
Y
G
D
L
D
D
C
S
P
K
H
R
N
S
S
Site 80
S914
C
S
P
K
H
R
N
S
S
P
R
M
P
H
L
Site 81
S915
S
P
K
H
R
N
S
S
P
R
M
P
H
L
A
Site 82
T928
L
A
V
A
T
D
K
T
L
A
P
S
S
E
Q
Site 83
S933
D
K
T
L
A
P
S
S
E
Q
E
Q
P
E
G
Site 84
S972
S
L
P
E
H
L
G
S
V
P
K
Q
L
D
F
Site 85
S984
L
D
F
Q
R
H
G
S
D
P
G
F
A
G
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation