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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPTBN4
Full Name:
Spectrin beta chain, brain 3
Alias:
Beta-IV spectrin; KIAA1642; Spectrin, beta, non-erythrocytic 4; Spectrin, non-erythroid beta chain 3; SPTBN3; SPTN4
Type:
Cytoskeletal protein
Mass (Da):
288985
Number AA:
2564
UniProt ID:
Q9H254
International Prot ID:
IPI00018829
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016605
GO:0005829
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0003779
GO:0030506
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
GO:0051693
GO:0007016
GO:0016192
Phosida
TranscriptoNet
STRING
Kinexus Products
Spectrin beta chain, non-erythrocytic 4 pan-specific antibody AB-NN329-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN329-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S27
N
P
A
A
R
W
E
S
P
D
R
G
W
E
R
Site 2
T66
R
E
A
V
Q
K
K
T
F
T
K
W
V
N
S
Site 3
T68
A
V
Q
K
K
T
F
T
K
W
V
N
S
H
L
Site 4
S103
T
R
L
L
E
V
L
S
G
E
Q
L
P
R
P
Site 5
T111
G
E
Q
L
P
R
P
T
R
G
R
M
R
I
H
Site 6
S119
R
G
R
M
R
I
H
S
L
E
N
V
D
K
A
Site 7
S142
V
H
L
E
N
V
G
S
H
D
I
V
D
G
N
Site 8
T179
E
T
E
D
N
R
E
T
R
S
A
K
D
A
L
Site 9
Y197
C
Q
M
K
T
A
G
Y
P
E
V
N
I
Q
N
Site 10
S230
R
P
D
L
V
D
F
S
K
L
T
K
S
N
A
Site 11
S235
D
F
S
K
L
T
K
S
N
A
N
Y
N
L
Q
Site 12
Y239
L
T
K
S
N
A
N
Y
N
L
Q
R
A
F
R
Site 13
S272
M
E
A
P
D
E
K
S
I
I
T
Y
V
V
S
Site 14
T275
P
D
E
K
S
I
I
T
Y
V
V
S
F
Y
H
Site 15
Y276
D
E
K
S
I
I
T
Y
V
V
S
F
Y
H
Y
Site 16
Y314
V
G
K
I
I
E
R
Y
E
E
L
A
A
E
L
Site 17
S333
H
R
T
V
G
L
I
S
N
Q
K
F
A
N
S
Site 18
S340
S
N
Q
K
F
A
N
S
L
S
G
V
Q
Q
Q
Site 19
S342
Q
K
F
A
N
S
L
S
G
V
Q
Q
Q
L
Q
Site 20
S453
N
E
N
Q
R
L
V
S
Q
D
N
F
G
Y
E
Site 21
Y459
V
S
Q
D
N
F
G
Y
E
L
P
A
V
E
A
Site 22
S512
R
V
A
A
Q
R
D
S
V
L
R
Q
W
A
L
Site 23
T529
G
L
V
G
A
R
R
T
R
L
E
Q
N
L
A
Site 24
S588
E
G
D
I
A
A
Q
S
E
R
V
E
A
L
N
Site 25
S602
N
A
A
A
L
R
F
S
Q
L
Q
G
Y
Q
P
Site 26
Y607
R
F
S
Q
L
Q
G
Y
Q
P
C
D
P
Q
V
Site 27
S643
R
R
A
E
L
E
A
S
R
S
L
W
A
L
L
Site 28
S645
A
E
L
E
A
S
R
S
L
W
A
L
L
Q
E
Site 29
S658
Q
E
L
E
E
A
E
S
W
A
R
D
K
E
R
Site 30
S693
G
G
A
H
D
L
S
S
T
A
R
L
L
A
Q
Site 31
S750
G
L
A
E
R
A
A
S
A
R
R
R
W
Q
R
Site 32
Y793
L
D
W
L
R
D
A
Y
R
L
A
A
A
G
D
Site 33
S807
D
F
G
H
D
E
A
S
S
R
R
L
A
R
Q
Site 34
S808
F
G
H
D
E
A
S
S
R
R
L
A
R
Q
H
Site 35
T819
A
R
Q
H
R
A
L
T
G
E
V
E
A
H
R
Site 36
S830
E
A
H
R
G
P
V
S
G
L
R
R
Q
L
A
Site 37
T838
G
L
R
R
Q
L
A
T
L
G
G
A
S
G
A
Site 38
T867
E
Q
L
F
A
E
V
T
E
V
A
A
L
R
R
Site 39
S906
E
K
E
Q
W
L
L
S
M
R
V
P
D
S
L
Site 40
S925
V
V
Q
H
R
F
E
S
L
D
Q
E
M
N
S
Site 41
S932
S
L
D
Q
E
M
N
S
L
M
G
R
V
L
D
Site 42
T943
R
V
L
D
V
N
H
T
V
Q
E
L
V
E
G
Site 43
S954
L
V
E
G
G
H
P
S
S
D
E
V
R
S
C
Site 44
S955
V
E
G
G
H
P
S
S
D
E
V
R
S
C
Q
Site 45
S960
P
S
S
D
E
V
R
S
C
Q
D
H
L
N
S
Site 46
S984
E
Q
R
K
E
E
M
S
A
V
L
L
V
E
N
Site 47
S1012
E
K
R
R
A
V
E
S
A
P
R
A
G
G
A
Site 48
S1121
S
E
G
P
L
P
N
S
L
E
E
A
D
A
L
Site 49
Y1146
V
D
Q
R
E
E
D
Y
A
R
I
V
A
A
S
Site 50
S1223
R
N
Q
E
M
A
L
S
G
A
E
L
P
G
T
Site 51
T1230
S
G
A
E
L
P
G
T
V
E
S
V
E
E
A
Site 52
S1233
E
L
P
G
T
V
E
S
V
E
E
A
L
K
Q
Site 53
T1246
K
Q
H
R
D
F
L
T
T
M
E
L
S
Q
Q
Site 54
T1247
Q
H
R
D
F
L
T
T
M
E
L
S
Q
Q
K
Site 55
S1251
F
L
T
T
M
E
L
S
Q
Q
K
M
Q
V
A
Site 56
Y1272
L
L
R
Q
G
N
I
Y
G
E
Q
A
Q
E
A
Site 57
T1332
M
L
M
A
R
D
G
T
R
E
D
N
H
K
L
Site 58
S1380
E
K
P
E
L
A
A
S
V
R
K
K
L
G
E
Site 59
S1418
K
A
D
Q
L
V
Q
S
F
A
E
L
D
K
K
Site 60
S1431
K
K
L
L
H
M
E
S
Q
L
Q
D
V
D
P
Site 61
T1444
D
P
G
G
D
L
A
T
V
N
S
Q
L
K
K
Site 62
S1447
G
D
L
A
T
V
N
S
Q
L
K
K
L
Q
S
Site 63
S1454
S
Q
L
K
K
L
Q
S
M
E
S
Q
V
E
E
Site 64
S1457
K
K
L
Q
S
M
E
S
Q
V
E
E
W
Y
R
Site 65
Y1463
E
S
Q
V
E
E
W
Y
R
E
V
G
E
L
Q
Site 66
S1482
A
L
P
L
E
P
A
S
K
E
L
V
G
E
R
Site 67
S1514
R
R
R
L
L
L
A
S
K
E
L
H
Q
V
A
Site 68
T1541
R
L
P
L
A
M
Q
T
E
R
G
N
G
L
Q
Site 69
S1583
E
R
A
G
A
L
A
S
L
R
S
P
E
A
E
Site 70
S1586
G
A
L
A
S
L
R
S
P
E
A
E
A
V
R
Site 71
S1601
R
G
L
E
Q
L
Q
S
A
W
A
G
L
R
E
Site 72
Y1627
A
F
Q
V
E
Q
Y
Y
F
D
V
A
E
V
E
Site 73
S1676
G
V
E
N
Y
E
E
S
I
A
Q
L
S
R
Q
Site 74
S1695
L
E
M
G
H
P
D
S
E
Q
I
S
R
R
Q
Site 75
S1699
H
P
D
S
E
Q
I
S
R
R
Q
S
Q
V
D
Site 76
S1703
E
Q
I
S
R
R
Q
S
Q
V
D
R
L
Y
V
Site 77
Y1709
Q
S
Q
V
D
R
L
Y
V
A
L
K
E
L
G
Site 78
Y1727
R
V
A
L
E
Q
Q
Y
W
L
Y
Q
L
S
R
Site 79
Y1730
L
E
Q
Q
Y
W
L
Y
Q
L
S
R
Q
V
S
Site 80
S1733
Q
Y
W
L
Y
Q
L
S
R
Q
V
S
E
L
E
Site 81
S1737
Y
Q
L
S
R
Q
V
S
E
L
E
H
W
I
A
Site 82
S1752
E
K
E
V
V
A
G
S
P
E
L
G
Q
D
F
Site 83
S1763
G
Q
D
F
E
H
V
S
V
L
Q
E
K
F
S
Site 84
S1770
S
V
L
Q
E
K
F
S
E
F
A
S
E
T
G
Site 85
S1774
E
K
F
S
E
F
A
S
E
T
G
M
A
G
R
Site 86
S1841
R
E
L
H
K
F
F
S
D
A
R
E
L
Q
G
Site 87
T1861
R
R
R
L
P
R
L
T
T
P
P
E
P
R
P
Site 88
T1862
R
R
L
P
R
L
T
T
P
P
E
P
R
P
S
Site 89
S1869
T
P
P
E
P
R
P
S
A
S
S
M
Q
R
T
Site 90
S1871
P
E
P
R
P
S
A
S
S
M
Q
R
T
L
R
Site 91
S1872
E
P
R
P
S
A
S
S
M
Q
R
T
L
R
A
Site 92
T1876
S
A
S
S
M
Q
R
T
L
R
A
F
E
H
D
Site 93
S1889
H
D
L
Q
L
L
V
S
Q
V
R
Q
L
Q
E
Site 94
T1903
E
G
A
A
Q
L
R
T
V
Y
A
G
E
H
A
Site 95
Y1905
A
A
Q
L
R
T
V
Y
A
G
E
H
A
E
A
Site 96
S1915
E
H
A
E
A
I
A
S
R
E
Q
E
V
L
Q
Site 97
S1939
E
D
A
R
L
H
V
S
S
T
A
D
A
L
R
Site 98
S1940
D
A
R
L
H
V
S
S
T
A
D
A
L
R
F
Site 99
S1949
A
D
A
L
R
F
H
S
Q
V
R
D
L
L
S
Site 100
S1956
S
Q
V
R
D
L
L
S
W
M
D
G
I
A
S
Site 101
S1963
S
W
M
D
G
I
A
S
Q
I
G
A
A
D
K
Site 102
S1975
A
D
K
P
R
D
V
S
S
V
E
V
L
M
N
Site 103
S1976
D
K
P
R
D
V
S
S
V
E
V
L
M
N
Y
Site 104
Y1983
S
V
E
V
L
M
N
Y
H
Q
G
L
K
T
E
Site 105
T1999
E
A
R
V
P
E
L
T
T
C
Q
E
L
G
R
Site 106
S2007
T
C
Q
E
L
G
R
S
L
L
L
N
K
S
A
Site 107
S2013
R
S
L
L
L
N
K
S
A
M
A
D
E
I
Q
Site 108
S2079
Q
S
R
E
L
G
S
S
V
D
E
V
E
Q
L
Site 109
S2105
A
A
W
E
E
R
F
S
S
L
R
R
L
T
T
Site 110
S2106
A
W
E
E
R
F
S
S
L
R
R
L
T
T
I
Site 111
T2111
F
S
S
L
R
R
L
T
T
I
E
K
I
K
A
Site 112
T2112
S
S
L
R
R
L
T
T
I
E
K
I
K
A
E
Site 113
S2121
E
K
I
K
A
E
Q
S
K
Q
P
P
T
P
L
Site 114
T2126
E
Q
S
K
Q
P
P
T
P
L
L
G
R
K
F
Site 115
T2138
R
K
F
F
G
D
P
T
E
L
A
A
K
A
A
Site 116
Y2153
P
L
L
R
P
G
G
Y
E
R
G
L
E
P
L
Site 117
S2165
E
P
L
A
R
R
A
S
D
T
L
S
A
E
V
Site 118
T2167
L
A
R
R
A
S
D
T
L
S
A
E
V
R
T
Site 119
S2169
R
R
A
S
D
T
L
S
A
E
V
R
T
R
V
Site 120
Y2178
E
V
R
T
R
V
G
Y
V
R
Q
E
L
K
P
Site 121
T2217
A
P
E
D
A
A
E
T
P
A
T
P
A
A
A
Site 122
T2220
D
A
A
E
T
P
A
T
P
A
A
A
E
Q
V
Site 123
S2236
P
R
P
E
R
Q
E
S
A
D
R
A
E
E
L
Site 124
S2254
R
R
P
E
R
Q
E
S
V
D
Q
S
E
E
A
Site 125
S2258
R
Q
E
S
V
D
Q
S
E
E
A
A
R
R
R
Site 126
S2272
R
R
P
E
R
Q
E
S
A
E
H
E
A
A
H
Site 127
S2280
A
E
H
E
A
A
H
S
L
T
L
G
R
Y
E
Site 128
Y2286
H
S
L
T
L
G
R
Y
E
Q
M
E
R
R
R
Site 129
S2305
R
R
L
E
R
Q
E
S
S
E
Q
E
M
P
I
Site 130
S2306
R
L
E
R
Q
E
S
S
E
Q
E
M
P
I
R
Site 131
S2344
P
G
L
P
A
G
P
S
L
P
Q
P
R
E
L
Site 132
T2366
G
L
E
L
P
E
R
T
P
R
P
D
R
P
R
Site 133
S2395
E
G
G
E
G
G
G
S
R
R
S
R
S
A
P
Site 134
S2398
E
G
G
G
S
R
R
S
R
S
A
P
A
Q
G
Site 135
S2400
G
G
S
R
R
S
R
S
A
P
A
Q
G
G
S
Site 136
S2407
S
A
P
A
Q
G
G
S
A
P
A
P
P
P
P
Site 137
T2416
P
A
P
P
P
P
P
T
H
T
V
Q
H
E
G
Site 138
T2418
P
P
P
P
P
T
H
T
V
Q
H
E
G
F
L
Site 139
S2437
E
L
D
A
N
R
K
S
S
N
R
S
W
V
S
Site 140
S2438
L
D
A
N
R
K
S
S
N
R
S
W
V
S
L
Site 141
S2441
N
R
K
S
S
N
R
S
W
V
S
L
Y
C
V
Site 142
S2444
S
S
N
R
S
W
V
S
L
Y
C
V
L
S
K
Site 143
Y2446
N
R
S
W
V
S
L
Y
C
V
L
S
K
G
E
Site 144
Y2457
S
K
G
E
L
G
F
Y
K
D
S
K
G
P
A
Site 145
S2460
E
L
G
F
Y
K
D
S
K
G
P
A
S
G
S
Site 146
S2465
K
D
S
K
G
P
A
S
G
S
T
H
G
G
E
Site 147
S2467
S
K
G
P
A
S
G
S
T
H
G
G
E
P
L
Site 148
S2476
H
G
G
E
P
L
L
S
L
H
K
A
T
S
E
Site 149
S2482
L
S
L
H
K
A
T
S
E
V
A
S
D
Y
K
Site 150
S2486
K
A
T
S
E
V
A
S
D
Y
K
K
K
K
H
Site 151
Y2488
T
S
E
V
A
S
D
Y
K
K
K
K
H
V
F
Site 152
T2499
K
H
V
F
K
L
Q
T
Q
D
G
S
E
F
L
Site 153
T2541
R
W
G
Q
T
L
P
T
T
S
S
T
D
E
G
Site 154
S2544
Q
T
L
P
T
T
S
S
T
D
E
G
N
P
K
Site 155
S2560
E
G
G
D
R
R
A
S
G
R
R
K
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation