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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VPS11
Full Name:
Vacuolar protein sorting-associated protein 11 homolog
Alias:
END1; PEP5; RING finger 108; RING finger protein 108; RNF108; Vacuolar protein sorting 11
Type:
Mass (Da):
107837
Number AA:
941
UniProt ID:
Q9H270
International Prot ID:
IPI00300697
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030897
GO:0005764
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
E
L
V
K
E
P
L
S
N
D
G
A
A
P
G
Site 2
T32
D
G
A
A
P
G
A
T
P
A
S
G
S
A
A
Site 3
S35
A
P
G
A
T
P
A
S
G
S
A
A
S
K
F
Site 4
S58
V
C
D
S
G
R
G
S
L
V
F
G
D
M
E
Site 5
T78
L
P
R
S
L
Q
L
T
G
F
Q
A
Y
K
L
Site 6
T88
Q
A
Y
K
L
R
V
T
H
L
Y
Q
L
K
Q
Site 7
Y91
K
L
R
V
T
H
L
Y
Q
L
K
Q
H
N
I
Site 8
S101
K
Q
H
N
I
L
A
S
V
G
E
D
E
E
G
Site 9
S163
A
I
G
F
T
D
G
S
V
T
L
N
K
G
D
Site 10
T172
T
L
N
K
G
D
I
T
R
D
R
H
S
K
T
Site 11
S177
D
I
T
R
D
R
H
S
K
T
Q
I
L
H
K
Site 12
T179
T
R
D
R
H
S
K
T
Q
I
L
H
K
G
N
Site 13
S213
V
T
T
E
N
V
Q
S
Y
I
V
S
G
K
D
Site 14
Y214
T
T
E
N
V
Q
S
Y
I
V
S
G
K
D
Y
Site 15
S217
N
V
Q
S
Y
I
V
S
G
K
D
Y
P
R
V
Site 16
Y221
Y
I
V
S
G
K
D
Y
P
R
V
E
L
D
T
Site 17
T228
Y
P
R
V
E
L
D
T
H
G
C
G
L
R
C
Site 18
S236
H
G
C
G
L
R
C
S
A
L
S
D
P
S
Q
Site 19
S239
G
L
R
C
S
A
L
S
D
P
S
Q
D
L
Q
Site 20
Y256
V
A
G
D
E
C
V
Y
L
Y
Q
P
D
E
R
Site 21
Y258
G
D
E
C
V
Y
L
Y
Q
P
D
E
R
G
P
Site 22
S287
R
G
Y
L
I
I
V
S
R
D
R
K
V
S
P
Site 23
S293
V
S
R
D
R
K
V
S
P
K
S
E
F
T
S
Site 24
S296
D
R
K
V
S
P
K
S
E
F
T
S
R
D
S
Site 25
T299
V
S
P
K
S
E
F
T
S
R
D
S
Q
S
S
Site 26
S300
S
P
K
S
E
F
T
S
R
D
S
Q
S
S
D
Site 27
S303
S
E
F
T
S
R
D
S
Q
S
S
D
K
Q
I
Site 28
S305
F
T
S
R
D
S
Q
S
S
D
K
Q
I
L
N
Site 29
S306
T
S
R
D
S
Q
S
S
D
K
Q
I
L
N
I
Site 30
Y314
D
K
Q
I
L
N
I
Y
D
L
C
N
K
F
I
Site 31
Y341
L
A
E
W
G
S
L
Y
V
L
T
R
D
G
R
Site 32
T344
W
G
S
L
Y
V
L
T
R
D
G
R
V
H
A
Site 33
T357
H
A
L
Q
E
K
D
T
Q
T
K
L
E
M
L
Site 34
S379
M
A
I
N
L
A
K
S
Q
H
L
D
S
D
G
Site 35
S384
A
K
S
Q
H
L
D
S
D
G
L
A
Q
I
F
Site 36
Y399
M
Q
Y
G
D
H
L
Y
S
K
G
N
H
D
G
Site 37
Y411
H
D
G
A
V
Q
Q
Y
I
R
T
I
G
K
L
Site 38
Y422
I
G
K
L
E
P
S
Y
V
I
R
K
F
L
D
Site 39
T437
A
Q
R
I
H
N
L
T
A
Y
L
Q
T
L
H
Site 40
Y439
R
I
H
N
L
T
A
Y
L
Q
T
L
H
R
Q
Site 41
S447
L
Q
T
L
H
R
Q
S
L
A
N
A
D
H
T
Site 42
Y461
T
T
L
L
L
N
C
Y
T
K
L
K
D
S
S
Site 43
S468
Y
T
K
L
K
D
S
S
K
L
E
E
F
I
K
Site 44
S478
E
E
F
I
K
K
K
S
E
S
E
V
H
F
D
Site 45
S480
F
I
K
K
K
S
E
S
E
V
H
F
D
V
E
Site 46
T488
E
V
H
F
D
V
E
T
A
I
K
V
L
R
Q
Site 47
Y498
K
V
L
R
Q
A
G
Y
Y
S
H
A
L
Y
L
Site 48
Y504
G
Y
Y
S
H
A
L
Y
L
A
E
N
H
A
H
Site 49
Y515
N
H
A
H
H
E
W
Y
L
K
I
Q
L
E
D
Site 50
Y532
N
Y
Q
E
A
L
R
Y
I
G
K
L
P
F
E
Site 51
S543
L
P
F
E
Q
A
E
S
N
M
K
R
Y
G
K
Site 52
T569
Q
L
L
K
G
L
C
T
D
Y
R
P
S
L
E
Site 53
Y571
L
K
G
L
C
T
D
Y
R
P
S
L
E
G
R
Site 54
S574
L
C
T
D
Y
R
P
S
L
E
G
R
S
D
R
Site 55
S579
R
P
S
L
E
G
R
S
D
R
E
A
P
G
C
Site 56
S590
A
P
G
C
R
A
N
S
E
E
F
I
P
I
F
Site 57
S618
M
S
E
V
Q
P
D
S
P
Q
G
I
Y
D
T
Site 58
T625
S
P
Q
G
I
Y
D
T
L
L
E
L
R
L
Q
Site 59
S652
K
L
H
A
E
A
I
S
L
L
K
S
G
R
F
Site 60
Y681
D
F
Q
D
G
V
L
Y
L
Y
E
Q
G
K
L
Site 61
Y683
Q
D
G
V
L
Y
L
Y
E
Q
G
K
L
F
Q
Site 62
S707
E
Q
Y
R
Q
V
I
S
V
C
E
R
H
G
E
Site 63
S718
R
H
G
E
Q
D
P
S
L
W
E
Q
A
L
S
Site 64
S725
S
L
W
E
Q
A
L
S
Y
F
A
R
K
E
E
Site 65
Y726
L
W
E
Q
A
L
S
Y
F
A
R
K
E
E
D
Site 66
Y737
K
E
E
D
C
K
E
Y
V
A
A
V
L
K
H
Site 67
T765
Q
T
L
A
H
N
S
T
A
T
L
S
V
I
R
Site 68
Y774
T
L
S
V
I
R
D
Y
L
V
Q
K
L
Q
K
Site 69
Y796
D
E
L
R
V
R
R
Y
R
E
E
T
T
R
I
Site 70
T800
V
R
R
Y
R
E
E
T
T
R
I
R
Q
E
I
Site 71
S813
E
I
Q
E
L
K
A
S
P
K
I
F
Q
K
T
Site 72
T820
S
P
K
I
F
Q
K
T
K
C
S
I
C
N
S
Site 73
S851
Q
H
C
F
E
S
Y
S
E
S
D
A
D
C
P
Site 74
T859
E
S
D
A
D
C
P
T
C
L
P
E
N
R
K
Site 75
S891
F
Q
H
Q
L
R
C
S
N
D
S
F
S
V
I
Site 76
S894
Q
L
R
C
S
N
D
S
F
S
V
I
A
D
Y
Site 77
S896
R
C
S
N
D
S
F
S
V
I
A
D
Y
F
G
Site 78
T911
R
G
V
F
N
K
L
T
L
L
T
D
P
P
T
Site 79
T914
F
N
K
L
T
L
L
T
D
P
P
T
A
R
L
Site 80
T918
T
L
L
T
D
P
P
T
A
R
L
T
S
S
L
Site 81
T922
D
P
P
T
A
R
L
T
S
S
L
E
A
G
L
Site 82
S923
P
P
T
A
R
L
T
S
S
L
E
A
G
L
Q
Site 83
S924
P
T
A
R
L
T
S
S
L
E
A
G
L
Q
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation