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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRIOBP
Full Name:
TRIO and F-actin-binding protein
Alias:
DFNB28; HRIHFB2122; KIAA1662; Protein Tara; Tara; Trio and F-actin binding protein; Trio-associated repeat on actin
Type:
Cytoskeletal protein
Mass (Da):
261376
Number AA:
2365
UniProt ID:
Q9H2D6
International Prot ID:
IPI00148768
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015629
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0017049
GO:0003779
GO:0045159
PhosphoSite+
KinaseNET
Biological Process:
GO:0030047
GO:0051016
GO:0007600
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y37
E
E
A
H
G
A
R
Y
Q
E
L
R
S
P
S
Site 2
S42
A
R
Y
Q
E
L
R
S
P
S
G
A
E
V
P
Site 3
S44
Y
Q
E
L
R
S
P
S
G
A
E
V
P
Y
C
Site 4
S65
P
A
P
E
D
P
L
S
A
S
T
S
G
C
Q
Site 5
S67
P
E
D
P
L
S
A
S
T
S
G
C
Q
S
V
Site 6
S69
D
P
L
S
A
S
T
S
G
C
Q
S
V
V
D
Site 7
S73
A
S
T
S
G
C
Q
S
V
V
D
P
G
L
R
Site 8
S88
P
G
P
K
R
G
P
S
P
S
A
G
L
P
E
Site 9
S90
P
K
R
G
P
S
P
S
A
G
L
P
E
E
G
Site 10
T99
G
L
P
E
E
G
P
T
A
A
P
R
S
R
S
Site 11
S104
G
P
T
A
A
P
R
S
R
S
R
E
L
E
A
Site 12
S106
T
A
A
P
R
S
R
S
R
E
L
E
A
V
P
Site 13
Y114
R
E
L
E
A
V
P
Y
L
E
G
L
T
T
S
Site 14
S121
Y
L
E
G
L
T
T
S
L
C
G
S
C
N
E
Site 15
S125
L
T
T
S
L
C
G
S
C
N
E
D
P
G
S
Site 16
S132
S
C
N
E
D
P
G
S
D
P
T
S
S
P
D
Site 17
T135
E
D
P
G
S
D
P
T
S
S
P
D
S
A
T
Site 18
S136
D
P
G
S
D
P
T
S
S
P
D
S
A
T
P
Site 19
S137
P
G
S
D
P
T
S
S
P
D
S
A
T
P
D
Site 20
S140
D
P
T
S
S
P
D
S
A
T
P
D
D
T
S
Site 21
T142
T
S
S
P
D
S
A
T
P
D
D
T
S
N
S
Site 22
T146
D
S
A
T
P
D
D
T
S
N
S
S
S
V
D
Site 23
S147
S
A
T
P
D
D
T
S
N
S
S
S
V
D
W
Site 24
S149
T
P
D
D
T
S
N
S
S
S
V
D
W
D
T
Site 25
S151
D
D
T
S
N
S
S
S
V
D
W
D
T
V
E
Site 26
T156
S
S
S
V
D
W
D
T
V
E
R
Q
E
E
E
Site 27
S166
R
Q
E
E
E
A
P
S
W
D
E
L
A
V
M
Site 28
S186
R
E
G
P
R
A
D
S
S
Q
R
A
P
S
L
Site 29
S187
E
G
P
R
A
D
S
S
Q
R
A
P
S
L
L
Site 30
S192
D
S
S
Q
R
A
P
S
L
L
T
R
S
P
V
Site 31
T195
Q
R
A
P
S
L
L
T
R
S
P
V
G
G
D
Site 32
T211
A
G
Q
K
K
E
D
T
G
G
G
G
R
S
A
Site 33
S229
W
A
R
L
R
G
E
S
G
L
S
L
E
R
H
Site 34
S232
L
R
G
E
S
G
L
S
L
E
R
H
R
S
T
Site 35
S238
L
S
L
E
R
H
R
S
T
L
T
Q
A
S
S
Site 36
T239
S
L
E
R
H
R
S
T
L
T
Q
A
S
S
M
Site 37
T241
E
R
H
R
S
T
L
T
Q
A
S
S
M
T
P
Site 38
S244
R
S
T
L
T
Q
A
S
S
M
T
P
H
S
G
Site 39
S245
S
T
L
T
Q
A
S
S
M
T
P
H
S
G
P
Site 40
T247
L
T
Q
A
S
S
M
T
P
H
S
G
P
R
S
Site 41
S250
A
S
S
M
T
P
H
S
G
P
R
S
T
T
S
Site 42
S254
T
P
H
S
G
P
R
S
T
T
S
Q
A
S
P
Site 43
T255
P
H
S
G
P
R
S
T
T
S
Q
A
S
P
A
Site 44
T256
H
S
G
P
R
S
T
T
S
Q
A
S
P
A
Q
Site 45
S257
S
G
P
R
S
T
T
S
Q
A
S
P
A
Q
R
Site 46
S260
R
S
T
T
S
Q
A
S
P
A
Q
R
D
T
A
Site 47
T266
A
S
P
A
Q
R
D
T
A
Q
A
A
S
T
R
Site 48
S271
R
D
T
A
Q
A
A
S
T
R
E
I
P
R
A
Site 49
S279
T
R
E
I
P
R
A
S
S
P
H
R
I
T
Q
Site 50
S280
R
E
I
P
R
A
S
S
P
H
R
I
T
Q
R
Site 51
T285
A
S
S
P
H
R
I
T
Q
R
D
T
S
R
A
Site 52
T289
H
R
I
T
Q
R
D
T
S
R
A
S
S
T
Q
Site 53
S290
R
I
T
Q
R
D
T
S
R
A
S
S
T
Q
Q
Site 54
S293
Q
R
D
T
S
R
A
S
S
T
Q
Q
E
I
S
Site 55
S294
R
D
T
S
R
A
S
S
T
Q
Q
E
I
S
R
Site 56
S300
S
S
T
Q
Q
E
I
S
R
A
S
S
T
Q
Q
Site 57
S303
Q
Q
E
I
S
R
A
S
S
T
Q
Q
E
T
S
Site 58
S304
Q
E
I
S
R
A
S
S
T
Q
Q
E
T
S
R
Site 59
T309
A
S
S
T
Q
Q
E
T
S
R
A
S
S
T
Q
Site 60
S310
S
S
T
Q
Q
E
T
S
R
A
S
S
T
Q
E
Site 61
S313
Q
Q
E
T
S
R
A
S
S
T
Q
E
D
T
P
Site 62
S314
Q
E
T
S
R
A
S
S
T
Q
E
D
T
P
R
Site 63
T315
E
T
S
R
A
S
S
T
Q
E
D
T
P
R
A
Site 64
T319
A
S
S
T
Q
E
D
T
P
R
A
S
S
T
Q
Site 65
S323
Q
E
D
T
P
R
A
S
S
T
Q
E
D
T
P
Site 66
S324
E
D
T
P
R
A
S
S
T
Q
E
D
T
P
R
Site 67
T325
D
T
P
R
A
S
S
T
Q
E
D
T
P
R
A
Site 68
S333
Q
E
D
T
P
R
A
S
S
T
Q
W
N
T
P
Site 69
S334
E
D
T
P
R
A
S
S
T
Q
W
N
T
P
R
Site 70
T335
D
T
P
R
A
S
S
T
Q
W
N
T
P
R
A
Site 71
T339
A
S
S
T
Q
W
N
T
P
R
A
S
S
P
S
Site 72
S343
Q
W
N
T
P
R
A
S
S
P
S
R
S
T
Q
Site 73
S344
W
N
T
P
R
A
S
S
P
S
R
S
T
Q
L
Site 74
S346
T
P
R
A
S
S
P
S
R
S
T
Q
L
D
N
Site 75
S348
R
A
S
S
P
S
R
S
T
Q
L
D
N
P
R
Site 76
T349
A
S
S
P
S
R
S
T
Q
L
D
N
P
R
T
Site 77
S357
Q
L
D
N
P
R
T
S
S
T
Q
Q
D
N
P
Site 78
S358
L
D
N
P
R
T
S
S
T
Q
Q
D
N
P
Q
Site 79
T366
T
Q
Q
D
N
P
Q
T
S
F
P
T
C
T
P
Site 80
S367
Q
Q
D
N
P
Q
T
S
F
P
T
C
T
P
Q
Site 81
T372
Q
T
S
F
P
T
C
T
P
Q
R
E
N
P
R
Site 82
T380
P
Q
R
E
N
P
R
T
P
C
V
Q
Q
D
D
Site 83
S391
Q
Q
D
D
P
R
A
S
S
P
N
R
T
T
Q
Site 84
S392
Q
D
D
P
R
A
S
S
P
N
R
T
T
Q
R
Site 85
T396
R
A
S
S
P
N
R
T
T
Q
R
E
N
S
R
Site 86
T397
A
S
S
P
N
R
T
T
Q
R
E
N
S
R
T
Site 87
S402
R
T
T
Q
R
E
N
S
R
T
S
C
A
Q
R
Site 88
T404
T
Q
R
E
N
S
R
T
S
C
A
Q
R
D
N
Site 89
S405
Q
R
E
N
S
R
T
S
C
A
Q
R
D
N
P
Site 90
S415
Q
R
D
N
P
K
A
S
R
T
S
S
P
N
R
Site 91
T417
D
N
P
K
A
S
R
T
S
S
P
N
R
A
T
Site 92
S418
N
P
K
A
S
R
T
S
S
P
N
R
A
T
R
Site 93
S419
P
K
A
S
R
T
S
S
P
N
R
A
T
R
D
Site 94
T424
T
S
S
P
N
R
A
T
R
D
N
P
R
T
S
Site 95
T430
A
T
R
D
N
P
R
T
S
C
A
Q
R
D
N
Site 96
S431
T
R
D
N
P
R
T
S
C
A
Q
R
D
N
P
Site 97
S441
Q
R
D
N
P
R
A
S
S
P
S
R
A
T
R
Site 98
S442
R
D
N
P
R
A
S
S
P
S
R
A
T
R
D
Site 99
S444
N
P
R
A
S
S
P
S
R
A
T
R
D
N
P
Site 100
T447
A
S
S
P
S
R
A
T
R
D
N
P
T
T
S
Site 101
T452
R
A
T
R
D
N
P
T
T
S
C
A
Q
R
D
Site 102
T453
A
T
R
D
N
P
T
T
S
C
A
Q
R
D
N
Site 103
S464
Q
R
D
N
P
R
A
S
R
T
S
S
P
N
R
Site 104
T466
D
N
P
R
A
S
R
T
S
S
P
N
R
A
T
Site 105
S467
N
P
R
A
S
R
T
S
S
P
N
R
A
T
R
Site 106
S468
P
R
A
S
R
T
S
S
P
N
R
A
T
R
D
Site 107
S539
Q
R
D
N
P
R
A
S
S
P
N
R
A
A
R
Site 108
S540
R
D
N
P
R
A
S
S
P
N
R
A
A
R
D
Site 109
T550
R
A
A
R
D
N
P
T
T
S
C
A
Q
R
D
Site 110
T551
A
A
R
D
N
P
T
T
S
C
A
Q
R
D
N
Site 111
S588
Q
R
D
N
P
R
A
S
S
P
N
R
A
T
R
Site 112
S589
R
D
N
P
R
A
S
S
P
N
R
A
T
R
D
Site 113
T594
A
S
S
P
N
R
A
T
R
D
N
P
T
T
S
Site 114
S637
Q
R
D
N
P
R
A
S
S
P
N
R
T
T
Q
Site 115
S638
R
D
N
P
R
A
S
S
P
N
R
T
T
Q
Q
Site 116
T642
R
A
S
S
P
N
R
T
T
Q
Q
D
S
P
R
Site 117
T643
A
S
S
P
N
R
T
T
Q
Q
D
S
P
R
T
Site 118
S647
N
R
T
T
Q
Q
D
S
P
R
T
S
C
A
R
Site 119
S651
Q
Q
D
S
P
R
T
S
C
A
R
R
D
D
P
Site 120
S661
R
R
D
D
P
R
A
S
S
P
N
R
T
I
Q
Site 121
S662
R
D
D
P
R
A
S
S
P
N
R
T
I
Q
Q
Site 122
T666
R
A
S
S
P
N
R
T
I
Q
Q
E
N
P
R
Site 123
T674
I
Q
Q
E
N
P
R
T
S
C
A
L
R
D
N
Site 124
S675
Q
Q
E
N
P
R
T
S
C
A
L
R
D
N
P
Site 125
S685
L
R
D
N
P
R
A
S
S
P
S
R
T
I
Q
Site 126
S686
R
D
N
P
R
A
S
S
P
S
R
T
I
Q
Q
Site 127
S688
N
P
R
A
S
S
P
S
R
T
I
Q
Q
E
N
Site 128
T690
R
A
S
S
P
S
R
T
I
Q
Q
E
N
P
R
Site 129
T698
I
Q
Q
E
N
P
R
T
S
C
A
Q
R
D
D
Site 130
S699
Q
Q
E
N
P
R
T
S
C
A
Q
R
D
D
P
Site 131
S709
Q
R
D
D
P
R
A
S
S
P
N
R
T
T
Q
Site 132
S710
R
D
D
P
R
A
S
S
P
N
R
T
T
Q
Q
Site 133
T714
R
A
S
S
P
N
R
T
T
Q
Q
E
N
P
R
Site 134
T715
A
S
S
P
N
R
T
T
Q
Q
E
N
P
R
T
Site 135
T722
T
Q
Q
E
N
P
R
T
S
C
A
R
R
D
N
Site 136
S723
Q
Q
E
N
P
R
T
S
C
A
R
R
D
N
P
Site 137
S733
R
R
D
N
P
R
A
S
S
R
N
R
T
I
Q
Site 138
S734
R
D
N
P
R
A
S
S
R
N
R
T
I
Q
R
Site 139
T738
R
A
S
S
R
N
R
T
I
Q
R
D
N
P
R
Site 140
T746
I
Q
R
D
N
P
R
T
S
C
A
Q
R
D
N
Site 141
S747
Q
R
D
N
P
R
T
S
C
A
Q
R
D
N
P
Site 142
S757
Q
R
D
N
P
R
A
S
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Site 295
T1662
P
S
P
A
C
T
S
T
Q
W
P
K
I
K
V
Site 296
T1684
T
L
A
G
L
E
Q
T
G
P
L
G
S
R
S
Site 297
S1689
E
Q
T
G
P
L
G
S
R
S
T
A
K
G
P
Site 298
S1691
T
G
P
L
G
S
R
S
T
A
K
G
P
S
L
Site 299
T1692
G
P
L
G
S
R
S
T
A
K
G
P
S
L
P
Site 300
S1697
R
S
T
A
K
G
P
S
L
P
E
L
Q
F
Q
Site 301
S1711
Q
P
E
E
P
E
E
S
E
P
S
R
G
Q
D
Site 302
S1714
E
P
E
E
S
E
P
S
R
G
Q
D
P
L
T
Site 303
T1721
S
R
G
Q
D
P
L
T
D
Q
K
Q
A
D
S
Site 304
S1728
T
D
Q
K
Q
A
D
S
A
D
K
R
P
A
E
Site 305
S1740
P
A
E
G
K
A
G
S
P
L
K
G
R
L
V
Site 306
T1748
P
L
K
G
R
L
V
T
S
W
R
M
P
G
D
Site 307
S1749
L
K
G
R
L
V
T
S
W
R
M
P
G
D
R
Site 308
T1758
R
M
P
G
D
R
P
T
L
F
N
P
F
L
L
Site 309
S1786
N
F
K
K
G
W
M
S
I
L
D
E
P
G
E
Site 310
S1796
D
E
P
G
E
P
P
S
P
S
L
T
T
T
S
Site 311
S1798
P
G
E
P
P
S
P
S
L
T
T
T
S
T
S
Site 312
T1800
E
P
P
S
P
S
L
T
T
T
S
T
S
Q
W
Site 313
T1801
P
P
S
P
S
L
T
T
T
S
T
S
Q
W
K
Site 314
T1802
P
S
P
S
L
T
T
T
S
T
S
Q
W
K
K
Site 315
T1804
P
S
L
T
T
T
S
T
S
Q
W
K
K
H
W
Site 316
T1815
K
K
H
W
F
V
L
T
D
S
S
L
K
Y
Y
Site 317
S1818
W
F
V
L
T
D
S
S
L
K
Y
Y
R
D
S
Site 318
Y1821
L
T
D
S
S
L
K
Y
Y
R
D
S
T
A
E
Site 319
Y1822
T
D
S
S
L
K
Y
Y
R
D
S
T
A
E
E
Site 320
S1825
S
L
K
Y
Y
R
D
S
T
A
E
E
A
D
E
Site 321
T1826
L
K
Y
Y
R
D
S
T
A
E
E
A
D
E
L
Site 322
S1841
D
G
E
I
D
L
R
S
C
T
D
V
T
E
Y
Site 323
T1843
E
I
D
L
R
S
C
T
D
V
T
E
Y
A
V
Site 324
T1846
L
R
S
C
T
D
V
T
E
Y
A
V
Q
R
N
Site 325
Y1848
S
C
T
D
V
T
E
Y
A
V
Q
R
N
Y
G
Site 326
Y1854
E
Y
A
V
Q
R
N
Y
G
F
Q
I
H
T
K
Site 327
T1866
H
T
K
D
A
V
Y
T
L
S
A
M
T
S
G
Site 328
S1868
K
D
A
V
Y
T
L
S
A
M
T
S
G
I
R
Site 329
T1885
W
I
E
A
L
R
K
T
V
R
P
T
S
A
P
Site 330
T1889
L
R
K
T
V
R
P
T
S
A
P
D
V
T
K
Site 331
S1890
R
K
T
V
R
P
T
S
A
P
D
V
T
K
L
Site 332
T1895
P
T
S
A
P
D
V
T
K
L
S
D
S
N
K
Site 333
S1898
A
P
D
V
T
K
L
S
D
S
N
K
E
N
A
Site 334
S1908
N
K
E
N
A
L
H
S
Y
S
T
Q
K
G
P
Site 335
S1910
E
N
A
L
H
S
Y
S
T
Q
K
G
P
L
K
Site 336
T1911
N
A
L
H
S
Y
S
T
Q
K
G
P
L
K
A
Site 337
S1925
A
G
E
Q
R
A
G
S
E
V
I
S
R
G
G
Site 338
S1929
R
A
G
S
E
V
I
S
R
G
G
P
R
K
A
Site 339
Y1945
G
Q
R
Q
A
L
D
Y
V
E
L
S
P
L
T
Site 340
S1949
A
L
D
Y
V
E
L
S
P
L
T
Q
A
S
P
Site 341
S1955
L
S
P
L
T
Q
A
S
P
Q
R
A
R
T
P
Site 342
T1961
A
S
P
Q
R
A
R
T
P
A
R
T
P
D
R
Site 343
T1965
R
A
R
T
P
A
R
T
P
D
R
L
A
K
Q
Site 344
S1983
E
R
D
L
A
Q
R
S
E
E
R
R
K
W
F
Site 345
T1993
R
R
K
W
F
E
A
T
D
S
R
T
P
E
V
Site 346
S1995
K
W
F
E
A
T
D
S
R
T
P
E
V
P
A
Site 347
T1997
F
E
A
T
D
S
R
T
P
E
V
P
A
G
E
Site 348
T2015
R
G
L
G
A
P
L
T
E
D
Q
Q
N
R
L
Site 349
S2023
E
D
Q
Q
N
R
L
S
E
E
I
E
K
K
W
Site 350
T2047
E
N
K
R
V
P
L
T
A
L
L
N
Q
S
R
Site 351
S2062
G
E
R
R
G
P
P
S
D
G
H
E
A
L
E
Site 352
S2091
L
Q
G
E
A
P
Q
S
A
L
R
S
Q
E
D
Site 353
S2095
A
P
Q
S
A
L
R
S
Q
E
D
G
H
I
P
Site 354
Y2105
D
G
H
I
P
P
G
Y
I
S
Q
E
A
C
E
Site 355
S2107
H
I
P
P
G
Y
I
S
Q
E
A
C
E
R
S
Site 356
S2114
S
Q
E
A
C
E
R
S
L
A
E
M
E
S
S
Site 357
S2120
R
S
L
A
E
M
E
S
S
H
Q
Q
V
M
E
Site 358
S2121
S
L
A
E
M
E
S
S
H
Q
Q
V
M
E
E
Site 359
S2171
K
A
Y
Q
E
E
L
S
R
E
L
S
K
T
R
Site 360
S2175
E
E
L
S
R
E
L
S
K
T
R
S
L
Q
Q
Site 361
T2177
L
S
R
E
L
S
K
T
R
S
L
Q
Q
G
P
Site 362
S2179
R
E
L
S
K
T
R
S
L
Q
Q
G
P
D
G
Site 363
S2193
G
L
R
K
Q
H
Q
S
D
V
E
A
L
K
R
Site 364
S2206
K
R
E
L
Q
V
L
S
E
Q
Y
S
Q
K
C
Site 365
S2210
Q
V
L
S
E
Q
Y
S
Q
K
C
L
E
I
G
Site 366
T2229
Q
A
E
E
R
E
H
T
L
R
R
C
Q
Q
E
Site 367
S2252
Q
E
L
H
G
R
L
S
E
E
I
D
Q
L
R
Site 368
S2264
Q
L
R
G
F
I
A
S
Q
G
M
G
N
G
C
Site 369
S2274
M
G
N
G
C
G
R
S
N
E
R
S
S
C
E
Site 370
S2278
C
G
R
S
N
E
R
S
S
C
E
L
E
V
L
Site 371
S2279
G
R
S
N
E
R
S
S
C
E
L
E
V
L
L
Site 372
Y2295
V
K
E
N
E
L
Q
Y
L
K
K
E
V
Q
C
Site 373
T2317
M
Q
K
D
K
R
F
T
S
G
K
Y
Q
D
V
Site 374
S2318
Q
K
D
K
R
F
T
S
G
K
Y
Q
D
V
Y
Site 375
Y2321
K
R
F
T
S
G
K
Y
Q
D
V
Y
V
E
L
Site 376
Y2325
S
G
K
Y
Q
D
V
Y
V
E
L
S
H
I
K
Site 377
S2329
Q
D
V
Y
V
E
L
S
H
I
K
T
R
S
E
Site 378
T2333
V
E
L
S
H
I
K
T
R
S
E
R
E
I
E
Site 379
S2335
L
S
H
I
K
T
R
S
E
R
E
I
E
Q
L
Site 380
S2358
A
A
L
Q
E
K
E
S
M
R
N
S
L
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation