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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPC1
Full Name:
Enhancer of polycomb homolog 1
Alias:
Epl1
Type:
Mass (Da):
93463
Number AA:
836
UniProt ID:
Q9H2F5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035267
GO:0032777
GO:0031965
Uniprot
OncoNet
Molecular Function:
GO:0016563
GO:0016564
PhosphoSite+
KinaseNET
Biological Process:
GO:0043968
GO:0043967
GO:0045814
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
K
L
S
F
R
A
R
Site 2
S14
R
A
R
A
L
D
A
S
K
P
L
P
V
F
R
Site 3
Y31
D
L
P
D
L
H
E
Y
A
S
I
N
R
A
V
Site 4
S33
P
D
L
H
E
Y
A
S
I
N
R
A
V
P
Q
Site 5
S60
H
H
L
Q
R
A
I
S
A
Q
Q
V
Y
G
E
Site 6
Y85
E
A
E
S
N
I
A
Y
Y
E
S
I
Y
P
G
Site 7
Y86
A
E
S
N
I
A
Y
Y
E
S
I
Y
P
G
E
Site 8
Y90
I
A
Y
Y
E
S
I
Y
P
G
E
F
K
M
P
Site 9
S107
L
I
H
I
Q
P
F
S
L
D
A
E
Q
P
D
Site 10
Y115
L
D
A
E
Q
P
D
Y
D
L
D
S
E
D
E
Site 11
S119
Q
P
D
Y
D
L
D
S
E
D
E
V
F
V
N
Site 12
S150
I
D
R
L
E
K
G
S
G
Q
Q
P
V
S
L
Site 13
S156
G
S
G
Q
Q
P
V
S
L
Q
E
A
K
L
L
Site 14
Y175
D
E
L
I
R
E
V
Y
E
Y
W
I
K
K
R
Site 15
Y177
L
I
R
E
V
Y
E
Y
W
I
K
K
R
K
N
Site 16
S189
R
K
N
C
R
G
P
S
L
I
P
S
V
K
Q
Site 17
S193
R
G
P
S
L
I
P
S
V
K
Q
E
K
R
D
Site 18
S202
K
Q
E
K
R
D
G
S
S
T
N
D
P
Y
V
Site 19
T204
E
K
R
D
G
S
S
T
N
D
P
Y
V
A
F
Site 20
Y208
G
S
S
T
N
D
P
Y
V
A
F
R
R
R
T
Site 21
T215
Y
V
A
F
R
R
R
T
E
K
M
Q
T
R
K
Site 22
T220
R
R
T
E
K
M
Q
T
R
K
N
R
K
N
D
Site 23
S230
N
R
K
N
D
E
A
S
Y
E
K
M
L
K
L
Site 24
S242
L
K
L
R
R
D
L
S
R
A
V
T
I
L
E
Site 25
T246
R
D
L
S
R
A
V
T
I
L
E
M
I
K
R
Site 26
S257
M
I
K
R
R
E
K
S
K
R
E
L
L
H
L
Site 27
T265
K
R
E
L
L
H
L
T
L
E
I
M
E
K
R
Site 28
Y278
K
R
Y
N
L
G
D
Y
N
G
E
I
M
S
E
Site 29
S307
P
I
I
P
I
T
N
S
S
Q
F
K
H
Q
E
Site 30
S308
I
I
P
I
T
N
S
S
Q
F
K
H
Q
E
A
Site 31
Y338
L
I
R
P
K
R
K
Y
E
K
K
P
K
V
L
Site 32
S347
K
K
P
K
V
L
P
S
S
A
A
A
T
P
Q
Site 33
S348
K
P
K
V
L
P
S
S
A
A
A
T
P
Q
Q
Site 34
T352
L
P
S
S
A
A
A
T
P
Q
Q
T
S
P
A
Site 35
S357
A
A
T
P
Q
Q
T
S
P
A
A
L
P
V
F
Site 36
Y372
N
A
K
D
L
N
Q
Y
D
F
P
S
S
D
E
Site 37
S376
L
N
Q
Y
D
F
P
S
S
D
E
E
P
L
S
Site 38
S377
N
Q
Y
D
F
P
S
S
D
E
E
P
L
S
Q
Site 39
S383
S
S
D
E
E
P
L
S
Q
V
L
S
G
S
S
Site 40
S387
E
P
L
S
Q
V
L
S
G
S
S
E
A
E
E
Site 41
Y412
R
R
K
A
G
C
Q
Y
Y
A
P
H
L
D
Q
Site 42
Y413
R
K
A
G
C
Q
Y
Y
A
P
H
L
D
Q
T
Site 43
T426
Q
T
G
N
W
P
W
T
S
P
K
D
G
G
L
Site 44
S427
T
G
N
W
P
W
T
S
P
K
D
G
G
L
G
Site 45
Y438
G
G
L
G
D
V
R
Y
R
Y
C
L
T
T
L
Site 46
T443
V
R
Y
R
Y
C
L
T
T
L
T
V
P
Q
R
Site 47
T444
R
Y
R
Y
C
L
T
T
L
T
V
P
Q
R
C
Site 48
S472
V
L
L
D
R
A
H
S
D
Y
D
S
V
F
H
Site 49
Y474
L
D
R
A
H
S
D
Y
D
S
V
F
H
H
L
Site 50
S476
R
A
H
S
D
Y
D
S
V
F
H
H
L
D
L
Site 51
S487
H
L
D
L
E
M
L
S
S
P
Q
H
S
P
V
Site 52
S488
L
D
L
E
M
L
S
S
P
Q
H
S
P
V
N
Site 53
S492
M
L
S
S
P
Q
H
S
P
V
N
Q
F
A
N
Site 54
S501
V
N
Q
F
A
N
T
S
E
T
N
T
S
D
K
Site 55
T505
A
N
T
S
E
T
N
T
S
D
K
S
F
S
K
Site 56
S506
N
T
S
E
T
N
T
S
D
K
S
F
S
K
D
Site 57
S509
E
T
N
T
S
D
K
S
F
S
K
D
L
S
Q
Site 58
S511
N
T
S
D
K
S
F
S
K
D
L
S
Q
I
L
Site 59
S515
K
S
F
S
K
D
L
S
Q
I
L
V
N
I
K
Site 60
T533
W
R
H
F
R
P
R
T
P
S
L
H
D
S
D
Site 61
S535
H
F
R
P
R
T
P
S
L
H
D
S
D
N
D
Site 62
S539
R
T
P
S
L
H
D
S
D
N
D
E
L
S
C
Site 63
S545
D
S
D
N
D
E
L
S
C
R
K
L
Y
R
S
Site 64
Y550
E
L
S
C
R
K
L
Y
R
S
I
N
R
T
G
Site 65
S552
S
C
R
K
L
Y
R
S
I
N
R
T
G
T
A
Site 66
T556
L
Y
R
S
I
N
R
T
G
T
A
Q
P
G
T
Site 67
T558
R
S
I
N
R
T
G
T
A
Q
P
G
T
Q
T
Site 68
T563
T
G
T
A
Q
P
G
T
Q
T
C
S
T
S
T
Site 69
T565
T
A
Q
P
G
T
Q
T
C
S
T
S
T
Q
S
Site 70
S567
Q
P
G
T
Q
T
C
S
T
S
T
Q
S
K
S
Site 71
T568
P
G
T
Q
T
C
S
T
S
T
Q
S
K
S
S
Site 72
S569
G
T
Q
T
C
S
T
S
T
Q
S
K
S
S
S
Site 73
T570
T
Q
T
C
S
T
S
T
Q
S
K
S
S
S
G
Site 74
S572
T
C
S
T
S
T
Q
S
K
S
S
S
G
S
A
Site 75
S574
S
T
S
T
Q
S
K
S
S
S
G
S
A
H
F
Site 76
S576
S
T
Q
S
K
S
S
S
G
S
A
H
F
A
F
Site 77
S578
Q
S
K
S
S
S
G
S
A
H
F
A
F
T
A
Site 78
S613
I
Q
Q
Q
Q
A
N
S
N
S
S
T
N
T
S
Site 79
S615
Q
Q
Q
A
N
S
N
S
S
T
N
T
S
Q
N
Site 80
S616
Q
Q
A
N
S
N
S
S
T
N
T
S
Q
N
L
Site 81
T617
Q
A
N
S
N
S
S
T
N
T
S
Q
N
L
A
Site 82
T619
N
S
N
S
S
T
N
T
S
Q
N
L
A
S
N
Site 83
S620
S
N
S
S
T
N
T
S
Q
N
L
A
S
N
Q
Site 84
S625
N
T
S
Q
N
L
A
S
N
Q
Q
K
S
G
F
Site 85
S630
L
A
S
N
Q
Q
K
S
G
F
R
L
N
I
Q
Site 86
S648
R
T
L
Q
G
F
V
S
K
T
L
D
S
A
S
Site 87
T650
L
Q
G
F
V
S
K
T
L
D
S
A
S
A
Q
Site 88
S655
S
K
T
L
D
S
A
S
A
Q
F
A
A
S
A
Site 89
T702
K
G
L
H
L
S
S
T
T
P
T
A
L
V
H
Site 90
T705
H
L
S
S
T
T
P
T
A
L
V
H
T
S
P
Site 91
S711
P
T
A
L
V
H
T
S
P
S
T
A
G
S
A
Site 92
S717
T
S
P
S
T
A
G
S
A
L
L
Q
P
S
N
Site 93
S723
G
S
A
L
L
Q
P
S
N
I
T
Q
T
S
S
Site 94
T726
L
L
Q
P
S
N
I
T
Q
T
S
S
S
H
S
Site 95
T728
Q
P
S
N
I
T
Q
T
S
S
S
H
S
A
L
Site 96
S729
P
S
N
I
T
Q
T
S
S
S
H
S
A
L
S
Site 97
S730
S
N
I
T
Q
T
S
S
S
H
S
A
L
S
H
Site 98
S731
N
I
T
Q
T
S
S
S
H
S
A
L
S
H
Q
Site 99
S733
T
Q
T
S
S
S
H
S
A
L
S
H
Q
V
T
Site 100
S736
S
S
S
H
S
A
L
S
H
Q
V
T
A
A
N
Site 101
T740
S
A
L
S
H
Q
V
T
A
A
N
S
A
T
T
Site 102
T780
N
A
R
H
I
P
R
T
L
S
A
V
P
S
S
Site 103
S782
R
H
I
P
R
T
L
S
A
V
P
S
S
A
L
Site 104
S800
A
A
A
N
C
Q
V
S
K
V
P
S
S
S
S
Site 105
S804
C
Q
V
S
K
V
P
S
S
S
S
V
D
S
V
Site 106
S805
Q
V
S
K
V
P
S
S
S
S
V
D
S
V
P
Site 107
S806
V
S
K
V
P
S
S
S
S
V
D
S
V
P
R
Site 108
S807
S
K
V
P
S
S
S
S
V
D
S
V
P
R
E
Site 109
S810
P
S
S
S
S
V
D
S
V
P
R
E
N
H
E
Site 110
S818
V
P
R
E
N
H
E
S
E
K
P
A
L
N
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation