KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SLK
Full Name:
STE20-like serine/threonine-protein kinase
Alias:
CTCL tumor antigen se20-9; CTCL tumour antigen se20-9; EC 2.7.11.1; KIAA0204; Se20-9; STE20-like kinase; STK2
Type:
Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1;
STE
group; STE20 family; SLK subfamily
Mass (Da):
142695
Number AA:
1235
UniProt ID:
Q9H2G2
International Prot ID:
IPI00022827
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0004518
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0006289
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
STE20-like serine/threonine-protein kinase; CTCL tumour antigen se20-9 S189 phosphosite-specific antibody AB-PK816#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK816#STE20-like serine/threonine-protein kinase / CTCL tumour antigen se20-9 (R186-G192, human) pS189 phosphopeptide - Powder PE-04ALC99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALC99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
F
F
N
F
R
K
I
Site 2
S14
R
K
I
F
K
L
G
S
E
K
K
K
K
Q
Y
Site 3
Y21
S
E
K
K
K
K
Q
Y
E
H
V
K
R
D
L
Site 4
Y49
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
Site 5
S57
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
Site 6
S69
A
K
V
I
D
T
K
S
E
E
E
L
E
D
Y
Site 7
Y76
S
E
E
E
L
E
D
Y
M
V
E
I
D
I
L
Site 8
T128
L
E
L
E
R
P
L
T
E
S
Q
I
Q
V
V
Site 9
S130
L
E
R
P
L
T
E
S
Q
I
Q
V
V
C
K
Site 10
T139
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
Site 11
Y145
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
Site 12
S177
K
L
A
D
F
G
V
S
A
K
N
T
R
T
I
Site 13
T181
F
G
V
S
A
K
N
T
R
T
I
Q
R
R
D
Site 14
T183
V
S
A
K
N
T
R
T
I
Q
R
R
D
S
F
Site 15
S189
R
T
I
Q
R
R
D
S
F
I
G
T
P
Y
W
STE20-like serine/threonine-protein kinase; CTCL tumour antigen se20-9 S189 phosphosite-specific antibody AB-PK816#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK816#STE20-like serine/threonine-protein kinase / CTCL tumour antigen se20-9 (R186-G192, human) pS189 phosphopeptide - Powder PE-04ALC99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ALC99
Site 16
T193
R
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
Site 17
Y195
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
Site 18
Y212
E
T
S
K
D
R
P
Y
D
Y
K
A
D
V
W
Site 19
Y214
S
K
D
R
P
Y
D
Y
K
A
D
V
W
S
L
Site 20
T254
I
A
K
S
E
P
P
T
L
A
Q
P
S
R
W
Site 21
S259
P
P
T
L
A
Q
P
S
R
W
S
S
N
F
K
Site 22
S262
L
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
Site 23
S263
A
Q
P
S
R
W
S
S
N
F
K
D
F
L
K
Site 24
T282
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
Site 25
T283
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
Site 26
S284
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
Site 27
S296
H
P
F
V
T
V
D
S
N
K
P
I
R
E
L
Site 28
T327
E
E
D
E
E
E
E
T
E
N
S
L
P
I
P
Site 29
S330
E
E
E
E
T
E
N
S
L
P
I
P
A
S
K
Site 30
S336
N
S
L
P
I
P
A
S
K
R
A
S
S
D
L
Site 31
S340
I
P
A
S
K
R
A
S
S
D
L
S
I
A
S
Site 32
S341
P
A
S
K
R
A
S
S
D
L
S
I
A
S
S
Site 33
S344
K
R
A
S
S
D
L
S
I
A
S
S
E
E
D
Site 34
S347
S
S
D
L
S
I
A
S
S
E
E
D
K
L
S
Site 35
S348
S
D
L
S
I
A
S
S
E
E
D
K
L
S
Q
Site 36
S354
S
S
E
E
D
K
L
S
Q
N
A
C
I
L
E
Site 37
S362
Q
N
A
C
I
L
E
S
V
S
E
K
T
E
R
Site 38
S364
A
C
I
L
E
S
V
S
E
K
T
E
R
S
N
Site 39
T367
L
E
S
V
S
E
K
T
E
R
S
N
S
E
D
Site 40
S370
V
S
E
K
T
E
R
S
N
S
E
D
K
L
N
Site 41
S372
E
K
T
E
R
S
N
S
E
D
K
L
N
S
K
Site 42
T387
I
L
N
E
K
P
T
T
D
E
P
E
K
A
V
Site 43
T436
K
L
E
N
L
P
D
T
E
D
Q
E
T
V
D
Site 44
T441
P
D
T
E
D
Q
E
T
V
D
I
N
S
V
S
Site 45
S446
Q
E
T
V
D
I
N
S
V
S
E
G
K
E
N
Site 46
S448
T
V
D
I
N
S
V
S
E
G
K
E
N
N
I
Site 47
S469
N
I
E
H
N
L
K
S
E
E
E
K
D
Q
E
Site 48
S488
F
E
N
K
L
I
K
S
E
E
I
K
D
T
I
Site 49
T494
K
S
E
E
I
K
D
T
I
L
Q
T
V
D
L
Site 50
S503
L
Q
T
V
D
L
V
S
Q
E
T
G
E
K
E
Site 51
S518
A
N
I
Q
A
V
D
S
E
V
G
L
T
K
E
Site 52
T523
V
D
S
E
V
G
L
T
K
E
D
T
Q
E
K
Site 53
T527
V
G
L
T
K
E
D
T
Q
E
K
L
G
E
D
Site 54
T537
K
L
G
E
D
D
K
T
Q
K
D
V
I
S
N
Site 55
S543
K
T
Q
K
D
V
I
S
N
T
S
D
V
I
G
Site 56
T545
Q
K
D
V
I
S
N
T
S
D
V
I
G
T
C
Site 57
S546
K
D
V
I
S
N
T
S
D
V
I
G
T
C
E
Site 58
T551
N
T
S
D
V
I
G
T
C
E
A
A
D
V
A
Site 59
S565
A
Q
K
V
D
E
D
S
A
E
D
T
Q
S
N
Site 60
T569
D
E
D
S
A
E
D
T
Q
S
N
D
G
K
E
Site 61
S571
D
S
A
E
D
T
Q
S
N
D
G
K
E
V
V
Site 62
T597
V
G
P
E
A
G
G
T
K
E
V
P
I
K
E
Site 63
S623
N
K
E
Q
A
I
N
S
S
E
N
I
M
D
I
Site 64
T636
D
I
N
E
E
P
G
T
T
E
G
E
E
I
T
Site 65
T637
I
N
E
E
P
G
T
T
E
G
E
E
I
T
E
Site 66
T643
T
T
E
G
E
E
I
T
E
S
S
S
T
E
E
Site 67
S645
E
G
E
E
I
T
E
S
S
S
T
E
E
M
E
Site 68
S646
G
E
E
I
T
E
S
S
S
T
E
E
M
E
V
Site 69
S647
E
E
I
T
E
S
S
S
T
E
E
M
E
V
R
Site 70
T648
E
I
T
E
S
S
S
T
E
E
M
E
V
R
S
Site 71
S655
T
E
E
M
E
V
R
S
V
V
A
D
T
D
Q
Site 72
T660
V
R
S
V
V
A
D
T
D
Q
K
A
L
G
S
Site 73
S667
T
D
Q
K
A
L
G
S
E
V
Q
D
A
S
K
Site 74
T676
V
Q
D
A
S
K
V
T
T
Q
I
D
K
E
K
Site 75
T677
Q
D
A
S
K
V
T
T
Q
I
D
K
E
K
K
Site 76
S689
E
K
K
E
I
P
V
S
I
K
K
E
P
E
V
Site 77
T697
I
K
K
E
P
E
V
T
V
V
S
Q
P
T
E
Site 78
S700
E
P
E
V
T
V
V
S
Q
P
T
E
P
Q
P
Site 79
S712
P
Q
P
V
L
I
P
S
I
N
I
N
S
D
S
Site 80
S717
I
P
S
I
N
I
N
S
D
S
G
E
N
K
E
Site 81
S719
S
I
N
I
N
S
D
S
G
E
N
K
E
E
I
Site 82
S728
E
N
K
E
E
I
G
S
L
S
K
T
E
T
I
Site 83
S730
K
E
E
I
G
S
L
S
K
T
E
T
I
L
P
Site 84
T732
E
I
G
S
L
S
K
T
E
T
I
L
P
P
E
Site 85
T734
G
S
L
S
K
T
E
T
I
L
P
P
E
S
E
Site 86
S740
E
T
I
L
P
P
E
S
E
N
P
K
E
N
D
Site 87
S750
P
K
E
N
D
N
D
S
G
T
G
S
T
A
D
Site 88
T752
E
N
D
N
D
S
G
T
G
S
T
A
D
T
S
Site 89
S754
D
N
D
S
G
T
G
S
T
A
D
T
S
S
I
Site 90
T755
N
D
S
G
T
G
S
T
A
D
T
S
S
I
D
Site 91
T758
G
T
G
S
T
A
D
T
S
S
I
D
L
N
L
Site 92
S759
T
G
S
T
A
D
T
S
S
I
D
L
N
L
S
Site 93
S760
G
S
T
A
D
T
S
S
I
D
L
N
L
S
I
Site 94
S769
D
L
N
L
S
I
S
S
F
L
S
K
T
K
D
Site 95
S772
L
S
I
S
S
F
L
S
K
T
K
D
S
G
S
Site 96
T774
I
S
S
F
L
S
K
T
K
D
S
G
S
I
S
Site 97
S777
F
L
S
K
T
K
D
S
G
S
I
S
L
Q
E
Site 98
S779
S
K
T
K
D
S
G
S
I
S
L
Q
E
T
R
Site 99
S781
T
K
D
S
G
S
I
S
L
Q
E
T
R
R
Q
Site 100
T785
G
S
I
S
L
Q
E
T
R
R
Q
K
K
T
L
Site 101
T791
E
T
R
R
Q
K
K
T
L
K
K
T
R
K
F
Site 102
T808
D
G
V
E
V
S
V
T
T
S
K
I
V
T
D
Site 103
S810
V
E
V
S
V
T
T
S
K
I
V
T
D
S
D
Site 104
T814
V
T
T
S
K
I
V
T
D
S
D
S
K
T
E
Site 105
S816
T
S
K
I
V
T
D
S
D
S
K
T
E
E
L
Site 106
S818
K
I
V
T
D
S
D
S
K
T
E
E
L
R
F
Site 107
T820
V
T
D
S
D
S
K
T
E
E
L
R
F
L
R
Site 108
Y874
M
M
S
K
K
R
Q
Y
D
Q
E
I
E
N
L
Site 109
T897
E
R
L
E
Q
E
H
T
N
R
L
R
D
E
A
Site 110
S916
G
E
Q
E
K
E
L
S
K
F
Q
N
M
L
K
Site 111
S955
R
K
E
E
L
A
Q
S
Q
H
A
Q
E
Q
E
Site 112
S974
Q
Q
Q
E
L
D
G
S
L
K
K
I
I
Q
Q
Site 113
Y1031
K
Q
Q
L
K
D
Q
Y
F
M
Q
R
H
Q
L
Site 114
T1046
L
K
R
H
E
K
E
T
E
Q
M
Q
R
Y
N
Site 115
Y1052
E
T
E
Q
M
Q
R
Y
N
Q
R
L
I
E
E
Site 116
T1065
E
E
L
K
N
R
Q
T
Q
E
R
A
R
L
P
Site 117
S1077
R
L
P
K
I
Q
R
S
E
A
K
T
R
M
A
Site 118
T1081
I
Q
R
S
E
A
K
T
R
M
A
M
F
K
K
Site 119
S1089
R
M
A
M
F
K
K
S
L
R
I
N
S
T
A
Site 120
S1094
K
K
S
L
R
I
N
S
T
A
T
P
D
Q
D
Site 121
T1095
K
S
L
R
I
N
S
T
A
T
P
D
Q
D
R
Site 122
T1097
L
R
I
N
S
T
A
T
P
D
Q
D
R
D
K
Site 123
S1172
K
E
L
D
E
E
H
S
Q
E
L
K
E
W
R
Site 124
T1188
K
L
R
P
R
K
K
T
L
E
E
E
F
A
R
Site 125
S1216
E
S
E
C
L
N
P
S
T
Q
S
R
I
S
K
Site 126
T1217
S
E
C
L
N
P
S
T
Q
S
R
I
S
K
F
Site 127
S1219
C
L
N
P
S
T
Q
S
R
I
S
K
F
Y
P
Site 128
S1222
P
S
T
Q
S
R
I
S
K
F
Y
P
I
P
S
Site 129
Y1225
Q
S
R
I
S
K
F
Y
P
I
P
S
L
H
S
Site 130
S1229
S
K
F
Y
P
I
P
S
L
H
S
T
G
S
_
Site 131
S1232
Y
P
I
P
S
L
H
S
T
G
S
_
_
_
_
Site 132
T1233
P
I
P
S
L
H
S
T
G
S
_
_
_
_
_
Site 133
S1235
P
S
L
H
S
T
G
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation