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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KCNN2
Full Name:
Small conductance calcium-activated potassium channel protein 2
Alias:
KCa2.2; Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; SK2
Type:
Channel, potassium
Mass (Da):
63760
Number AA:
579
UniProt ID:
Q9H2S1
International Prot ID:
IPI00301072
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005516
GO:0016286
PhosphoSite+
KinaseNET
Biological Process:
GO:0006813
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y6
_
_
M
S
S
C
R
Y
N
G
G
V
M
R
P
Site 2
S15
G
G
V
M
R
P
L
S
N
L
S
A
S
R
R
Site 3
S18
M
R
P
L
S
N
L
S
A
S
R
R
N
L
H
Site 4
S20
P
L
S
N
L
S
A
S
R
R
N
L
H
E
M
Site 5
S29
R
N
L
H
E
M
D
S
E
A
Q
P
L
Q
P
Site 6
S39
Q
P
L
Q
P
P
A
S
V
G
G
G
G
G
A
Site 7
S60
A
A
A
A
A
A
V
S
S
S
A
P
E
I
V
Site 8
S69
S
A
P
E
I
V
V
S
K
P
E
H
N
N
S
Site 9
S76
S
K
P
E
H
N
N
S
N
N
L
A
L
Y
G
Site 10
Y82
N
S
N
N
L
A
L
Y
G
T
G
G
G
G
S
Site 11
S89
Y
G
T
G
G
G
G
S
T
G
G
G
G
G
G
Site 12
S99
G
G
G
G
G
G
G
S
G
H
G
S
S
S
G
Site 13
S103
G
G
G
S
G
H
G
S
S
S
G
T
K
S
S
Site 14
S104
G
G
S
G
H
G
S
S
S
G
T
K
S
S
K
Site 15
S105
G
S
G
H
G
S
S
S
G
T
K
S
S
K
K
Site 16
T107
G
H
G
S
S
S
G
T
K
S
S
K
K
K
N
Site 17
S109
G
S
S
S
G
T
K
S
S
K
K
K
N
Q
N
Site 18
S110
S
S
S
G
T
K
S
S
K
K
K
N
Q
N
I
Site 19
S135
F
E
K
R
K
R
L
S
D
Y
A
L
I
F
G
Site 20
Y137
K
R
K
R
L
S
D
Y
A
L
I
F
G
M
F
Site 21
S156
M
V
I
E
T
E
L
S
W
G
A
Y
D
K
A
Site 22
Y160
T
E
L
S
W
G
A
Y
D
K
A
S
L
Y
S
Site 23
S164
W
G
A
Y
D
K
A
S
L
Y
S
L
A
L
K
Site 24
S244
W
T
A
R
L
A
F
S
Y
A
P
S
T
T
T
Site 25
T281
L
L
H
S
K
L
F
T
D
A
S
S
R
S
I
Site 26
S284
S
K
L
F
T
D
A
S
S
R
S
I
G
A
L
Site 27
S285
K
L
F
T
D
A
S
S
R
S
I
G
A
L
N
Site 28
Y335
T
V
R
A
C
E
R
Y
H
D
Q
Q
D
V
T
Site 29
T400
V
A
R
K
L
E
L
T
K
A
E
K
H
V
H
Site 30
T416
F
M
M
D
T
Q
L
T
K
R
V
K
N
A
A
Site 31
T430
A
A
N
V
L
R
E
T
W
L
I
Y
K
N
T
Site 32
Y434
L
R
E
T
W
L
I
Y
K
N
T
K
L
V
K
Site 33
S464
Q
A
I
H
Q
L
R
S
V
K
M
E
Q
R
K
Site 34
Y490
A
K
T
Q
N
I
M
Y
D
M
I
S
D
L
N
Site 35
S494
N
I
M
Y
D
M
I
S
D
L
N
E
R
S
E
Site 36
S500
I
S
D
L
N
E
R
S
E
D
F
E
K
R
I
Site 37
T509
D
F
E
K
R
I
V
T
L
E
T
K
L
E
T
Site 38
T516
T
L
E
T
K
L
E
T
L
I
G
S
I
H
A
Site 39
S529
H
A
L
P
G
L
I
S
Q
T
I
R
Q
Q
Q
Site 40
T531
L
P
G
L
I
S
Q
T
I
R
Q
Q
Q
R
D
Site 41
Y553
S
Y
D
K
H
V
T
Y
N
A
E
R
S
R
S
Site 42
S558
V
T
Y
N
A
E
R
S
R
S
S
S
R
R
R
Site 43
S560
Y
N
A
E
R
S
R
S
S
S
R
R
R
R
S
Site 44
S561
N
A
E
R
S
R
S
S
S
R
R
R
R
S
S
Site 45
S562
A
E
R
S
R
S
S
S
R
R
R
R
S
S
S
Site 46
S567
S
S
S
R
R
R
R
S
S
S
T
A
P
P
T
Site 47
S568
S
S
R
R
R
R
S
S
S
T
A
P
P
T
S
Site 48
S569
S
R
R
R
R
S
S
S
T
A
P
P
T
S
S
Site 49
T570
R
R
R
R
S
S
S
T
A
P
P
T
S
S
E
Site 50
T574
S
S
S
T
A
P
P
T
S
S
E
S
S
_
_
Site 51
S575
S
S
T
A
P
P
T
S
S
E
S
S
_
_
_
Site 52
S576
S
T
A
P
P
T
S
S
E
S
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation