KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IKZF4
Full Name:
Zinc finger protein Eos
Alias:
Ikaros family zinc finger protein 4
Type:
Mass (Da):
64106
Number AA:
585
UniProt ID:
Q9H2S9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T19
Q
G
G
G
R
V
R
T
P
G
S
H
R
Q
G
Site 2
S22
G
R
V
R
T
P
G
S
H
R
Q
G
K
D
N
Site 3
S35
D
N
L
E
R
D
P
S
G
G
C
V
P
D
F
Site 4
S56
S
N
H
F
I
M
E
S
L
F
C
E
S
S
G
Site 5
S62
E
S
L
F
C
E
S
S
G
D
S
S
L
E
K
Site 6
S65
F
C
E
S
S
G
D
S
S
L
E
K
E
F
L
Site 7
S66
C
E
S
S
G
D
S
S
L
E
K
E
F
L
G
Site 8
S79
L
G
A
P
V
G
P
S
V
S
T
P
N
S
Q
Site 9
S81
A
P
V
G
P
S
V
S
T
P
N
S
Q
H
S
Site 10
T82
P
V
G
P
S
V
S
T
P
N
S
Q
H
S
S
Site 11
S85
P
S
V
S
T
P
N
S
Q
H
S
S
P
S
R
Site 12
S88
S
T
P
N
S
Q
H
S
S
P
S
R
S
L
S
Site 13
S89
T
P
N
S
Q
H
S
S
P
S
R
S
L
S
A
Site 14
S91
N
S
Q
H
S
S
P
S
R
S
L
S
A
N
S
Site 15
S93
Q
H
S
S
P
S
R
S
L
S
A
N
S
I
K
Site 16
S95
S
S
P
S
R
S
L
S
A
N
S
I
K
V
E
Site 17
S98
S
R
S
L
S
A
N
S
I
K
V
E
M
Y
S
Site 18
Y104
N
S
I
K
V
E
M
Y
S
D
E
E
S
S
R
Site 19
S105
S
I
K
V
E
M
Y
S
D
E
E
S
S
R
L
Site 20
S109
E
M
Y
S
D
E
E
S
S
R
L
L
G
P
D
Site 21
S125
R
L
L
E
K
D
D
S
V
I
V
E
D
S
L
Site 22
S131
D
S
V
I
V
E
D
S
L
S
E
P
L
G
Y
Site 23
Y138
S
L
S
E
P
L
G
Y
C
D
G
S
G
P
E
Site 24
S142
P
L
G
Y
C
D
G
S
G
P
E
P
H
S
P
Site 25
S148
G
S
G
P
E
P
H
S
P
G
G
I
R
L
P
Site 26
T182
M
V
H
K
R
S
H
T
G
E
R
P
F
H
C
Site 27
T231
C
R
R
R
D
A
L
T
G
H
L
R
T
H
S
Site 28
T236
A
L
T
G
H
L
R
T
H
S
V
S
S
P
T
Site 29
S238
T
G
H
L
R
T
H
S
V
S
S
P
T
V
G
Site 30
S240
H
L
R
T
H
S
V
S
S
P
T
V
G
K
P
Site 31
S241
L
R
T
H
S
V
S
S
P
T
V
G
K
P
Y
Site 32
T243
T
H
S
V
S
S
P
T
V
G
K
P
Y
K
C
Site 33
Y248
S
P
T
V
G
K
P
Y
K
C
N
Y
C
G
R
Site 34
Y252
G
K
P
Y
K
C
N
Y
C
G
R
S
Y
K
Q
Site 35
Y257
C
N
Y
C
G
R
S
Y
K
Q
Q
S
T
L
E
Site 36
Y273
H
K
E
R
C
H
N
Y
L
Q
S
L
S
T
E
Site 37
S276
R
C
H
N
Y
L
Q
S
L
S
T
E
A
Q
A
Site 38
S278
H
N
Y
L
Q
S
L
S
T
E
A
Q
A
L
A
Site 39
S301
D
L
E
M
V
P
D
S
M
L
H
S
S
S
E
Site 40
S305
V
P
D
S
M
L
H
S
S
S
E
R
P
T
F
Site 41
S307
D
S
M
L
H
S
S
S
E
R
P
T
F
I
D
Site 42
T311
H
S
S
S
E
R
P
T
F
I
D
R
L
A
N
Site 43
S319
F
I
D
R
L
A
N
S
L
T
K
R
K
R
S
Site 44
T321
D
R
L
A
N
S
L
T
K
R
K
R
S
T
P
Site 45
S326
S
L
T
K
R
K
R
S
T
P
Q
K
F
V
G
Site 46
T327
L
T
K
R
K
R
S
T
P
Q
K
F
V
G
E
Site 47
S340
G
E
K
Q
M
R
F
S
L
S
D
L
P
Y
D
Site 48
S342
K
Q
M
R
F
S
L
S
D
L
P
Y
D
V
N
Site 49
Y346
F
S
L
S
D
L
P
Y
D
V
N
S
G
G
Y
Site 50
T389
R
P
L
R
L
P
P
T
N
C
I
S
E
L
T
Site 51
S400
S
E
L
T
P
V
I
S
S
V
Y
T
Q
M
Q
Site 52
S418
G
R
L
E
L
P
G
S
R
E
A
G
E
G
P
Site 53
Y436
A
D
G
G
P
L
L
Y
R
P
R
G
P
L
T
Site 54
T443
Y
R
P
R
G
P
L
T
D
P
G
A
S
P
S
Site 55
S448
P
L
T
D
P
G
A
S
P
S
N
G
C
Q
D
Site 56
S450
T
D
P
G
A
S
P
S
N
G
C
Q
D
S
T
Site 57
S456
P
S
N
G
C
Q
D
S
T
D
T
E
S
N
H
Site 58
T457
S
N
G
C
Q
D
S
T
D
T
E
S
N
H
E
Site 59
S472
D
R
V
A
G
V
V
S
L
P
Q
G
P
P
P
Site 60
T484
P
P
P
Q
P
P
P
T
I
V
V
G
R
H
S
Site 61
S491
T
I
V
V
G
R
H
S
P
A
Y
A
K
E
D
Site 62
Y494
V
G
R
H
S
P
A
Y
A
K
E
D
P
K
P
Site 63
T509
Q
E
G
L
L
R
G
T
P
G
P
S
K
E
V
Site 64
Y571
G
Y
H
S
Q
D
R
Y
E
F
S
S
H
I
V
Site 65
S575
Q
D
R
Y
E
F
S
S
H
I
V
R
G
E
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation