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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHX36
Full Name:
Probable ATP-dependent RNA helicase DHX36
Alias:
DDX36; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36; DEAH (Asp-Glu-Ala-His) box polypeptide 36; KIAA1488; MLEL1
Type:
Helicase; EC 3.6.1.-
Mass (Da):
114776
Number AA:
1008
UniProt ID:
Q9H2U1
International Prot ID:
IPI00027415
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
Y
D
Y
H
Q
N
W
Site 2
Y5
_
_
_
M
S
Y
D
Y
H
Q
N
W
G
R
D
Site 3
S17
G
R
D
G
G
P
R
S
S
G
G
G
Y
G
G
Site 4
S18
R
D
G
G
P
R
S
S
G
G
G
Y
G
G
G
Site 5
Y22
P
R
S
S
G
G
G
Y
G
G
G
P
A
G
G
Site 6
S36
G
H
G
G
N
R
G
S
G
G
G
G
G
G
G
Site 7
Y66
G
R
E
I
G
M
W
Y
A
K
K
Q
G
Q
K
Site 8
S110
Q
A
K
N
D
K
E
S
E
A
Q
I
S
W
F
Site 9
S115
K
E
S
E
A
Q
I
S
W
F
A
P
E
D
H
Site 10
Y124
F
A
P
E
D
H
G
Y
G
T
E
V
S
T
K
Site 11
S129
H
G
Y
G
T
E
V
S
T
K
N
T
P
C
S
Site 12
T133
T
E
V
S
T
K
N
T
P
C
S
E
N
K
L
Site 13
S136
S
T
K
N
T
P
C
S
E
N
K
L
D
I
Q
Site 14
S161
M
F
R
I
R
N
R
S
Y
I
D
R
D
S
E
Site 15
Y162
F
R
I
R
N
R
S
Y
I
D
R
D
S
E
Y
Site 16
S167
R
S
Y
I
D
R
D
S
E
Y
L
L
Q
E
N
Site 17
Y169
Y
I
D
R
D
S
E
Y
L
L
Q
E
N
E
P
Site 18
T179
Q
E
N
E
P
D
G
T
L
D
Q
K
L
L
E
Site 19
Y197
K
K
K
N
D
L
R
Y
I
E
M
Q
H
F
R
Site 20
S209
H
F
R
E
K
L
P
S
Y
G
M
Q
K
E
L
Site 21
Y210
F
R
E
K
L
P
S
Y
G
M
Q
K
E
L
V
Site 22
T226
L
I
D
N
H
Q
V
T
V
I
S
G
E
T
G
Site 23
S229
N
H
Q
V
T
V
I
S
G
E
T
G
C
G
K
Site 24
Y248
T
Q
F
I
L
D
N
Y
I
E
R
G
K
G
S
Site 25
T262
S
A
C
R
I
V
C
T
Q
P
R
R
I
S
A
Site 26
S268
C
T
Q
P
R
R
I
S
A
I
S
V
A
E
R
Site 27
S271
P
R
R
I
S
A
I
S
V
A
E
R
V
A
A
Site 28
S283
V
A
A
E
R
A
E
S
C
G
S
G
N
S
T
Site 29
S286
E
R
A
E
S
C
G
S
G
N
S
T
G
Y
Q
Site 30
T290
S
C
G
S
G
N
S
T
G
Y
Q
I
R
L
Q
Site 31
Y292
G
S
G
N
S
T
G
Y
Q
I
R
L
Q
S
R
Site 32
S298
G
Y
Q
I
R
L
Q
S
R
L
P
R
K
Q
G
Site 33
S306
R
L
P
R
K
Q
G
S
I
L
Y
C
T
T
G
Site 34
Y324
Q
W
L
Q
S
D
P
Y
L
S
S
V
S
H
I
Site 35
S327
Q
S
D
P
Y
L
S
S
V
S
H
I
V
L
D
Site 36
Y377
N
A
E
K
F
S
E
Y
F
G
N
C
P
M
I
Site 37
Y407
D
V
I
E
K
I
R
Y
V
P
E
Q
K
E
H
Site 38
Y439
K
E
E
K
E
A
I
Y
K
E
R
W
P
D
Y
Site 39
Y446
Y
K
E
R
W
P
D
Y
V
R
E
L
R
R
R
Site 40
Y454
V
R
E
L
R
R
R
Y
S
A
S
T
V
D
V
Site 41
S455
R
E
L
R
R
R
Y
S
A
S
T
V
D
V
I
Site 42
S457
L
R
R
R
Y
S
A
S
T
V
D
V
I
E
M
Site 43
T458
R
R
R
Y
S
A
S
T
V
D
V
I
E
M
M
Site 44
T503
P
G
W
D
N
I
S
T
L
H
D
L
L
M
S
Site 45
T534
L
M
P
T
V
N
Q
T
Q
V
F
K
R
T
P
Site 46
T540
Q
T
Q
V
F
K
R
T
P
P
G
V
R
K
I
Site 47
T579
I
K
E
T
H
F
D
T
Q
N
N
I
S
T
M
Site 48
Y612
R
V
Q
P
G
H
C
Y
H
L
Y
N
G
L
R
Site 49
Y615
P
G
H
C
Y
H
L
Y
N
G
L
R
A
S
L
Site 50
S621
L
Y
N
G
L
R
A
S
L
L
D
D
Y
Q
L
Site 51
Y626
R
A
S
L
L
D
D
Y
Q
L
P
E
I
L
R
Site 52
S663
S
R
L
M
D
P
P
S
N
E
A
V
L
L
S
Site 53
T687
L
D
K
Q
E
E
L
T
P
L
G
V
H
L
A
Site 54
T752
R
K
E
L
A
K
D
T
R
S
D
H
L
T
V
Site 55
S754
E
L
A
K
D
T
R
S
D
H
L
T
V
V
N
Site 56
T758
D
T
R
S
D
H
L
T
V
V
N
A
F
E
G
Site 57
Y776
A
R
R
R
G
F
R
Y
E
K
D
Y
C
W
E
Site 58
Y780
G
F
R
Y
E
K
D
Y
C
W
E
Y
F
L
S
Site 59
Y784
E
K
D
Y
C
W
E
Y
F
L
S
S
N
T
L
Site 60
S812
L
L
G
A
G
F
V
S
S
R
N
P
K
D
P
Site 61
S813
L
G
A
G
F
V
S
S
R
N
P
K
D
P
E
Site 62
S821
R
N
P
K
D
P
E
S
N
I
N
S
D
N
E
Site 63
S825
D
P
E
S
N
I
N
S
D
N
E
K
I
I
K
Site 64
Y860
K
R
K
M
V
K
V
Y
T
K
T
D
G
L
V
Site 65
S873
L
V
A
V
H
P
K
S
V
N
V
E
Q
T
D
Site 66
Y898
K
M
R
T
S
S
I
Y
L
Y
D
C
T
E
V
Site 67
Y900
R
T
S
S
I
Y
L
Y
D
C
T
E
V
S
P
Site 68
S918
L
F
F
G
G
D
I
S
I
Q
K
D
N
D
Q
Site 69
S963
L
L
Q
E
K
I
E
S
P
H
P
V
D
W
N
Site 70
S974
V
D
W
N
D
T
K
S
R
D
C
A
V
L
S
Site 71
T989
A
I
I
D
L
I
K
T
Q
E
K
A
T
P
R
Site 72
T994
I
K
T
Q
E
K
A
T
P
R
N
F
P
P
R
Site 73
Y1006
P
P
R
F
Q
D
G
Y
Y
S
_
_
_
_
_
Site 74
Y1007
P
R
F
Q
D
G
Y
Y
S
_
_
_
_
_
_
Site 75
S1008
R
F
Q
D
G
Y
Y
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation