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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPA2
Full Name:
Inorganic pyrophosphatase 2, mitochondrial
Alias:
EC 3.6.1.1; HSPC124; IPYR2; PPase 2; Pyrophosphatase SID6-306; SID6-306
Type:
Enzyme, pyrophosphatase
Mass (Da):
37920
Number AA:
334
UniProt ID:
Q9H2U2
International Prot ID:
IPI00301109
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
Uniprot
OncoNet
Molecular Function:
GO:0004427
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006796
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
A
C
L
R
L
G
T
S
A
G
T
G
S
R
R
Site 2
S28
G
T
S
A
G
T
G
S
R
R
A
M
A
L
Y
Site 3
Y35
S
R
R
A
M
A
L
Y
H
T
E
E
R
G
Q
Site 4
S45
E
E
R
G
Q
P
C
S
Q
N
Y
R
L
F
F
Site 5
Y59
F
K
N
V
T
G
H
Y
I
S
P
F
H
D
I
Site 6
S61
N
V
T
G
H
Y
I
S
P
F
H
D
I
P
L
Site 7
S72
D
I
P
L
K
V
N
S
K
E
E
N
G
I
P
Site 8
Y88
K
K
A
R
N
D
E
Y
E
N
L
F
N
M
I
Site 9
Y120
P
M
N
P
I
K
Q
Y
V
K
D
G
K
L
R
Site 10
Y128
V
K
D
G
K
L
R
Y
V
A
N
I
F
P
Y
Site 11
Y138
N
I
F
P
Y
K
G
Y
I
W
N
Y
G
T
L
Site 12
T148
N
Y
G
T
L
P
Q
T
W
E
D
P
H
E
K
Site 13
Y230
V
K
K
F
K
P
G
Y
L
E
A
T
L
N
W
Site 14
T234
K
P
G
Y
L
E
A
T
L
N
W
F
R
L
Y
Site 15
Y241
T
L
N
W
F
R
L
Y
K
V
P
D
G
K
P
Site 16
S298
T
N
V
Q
I
S
D
S
P
F
R
C
T
Q
E
Site 17
T303
S
D
S
P
F
R
C
T
Q
E
E
A
R
S
L
Site 18
S309
C
T
Q
E
E
A
R
S
L
V
E
S
V
S
S
Site 19
S313
E
A
R
S
L
V
E
S
V
S
S
S
P
N
K
Site 20
S315
R
S
L
V
E
S
V
S
S
S
P
N
K
E
S
Site 21
S316
S
L
V
E
S
V
S
S
S
P
N
K
E
S
N
Site 22
S317
L
V
E
S
V
S
S
S
P
N
K
E
S
N
E
Site 23
S322
S
S
S
P
N
K
E
S
N
E
E
E
Q
V
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation