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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSARL
Full Name:
Presenilins-associated rhomboid-like protein, mitochondrial
Alias:
Mitochondrial intramembrane cleaving protease PARL; Mitochondrial intramembrane-cleaving protease PARL; PARL; P-beta; Presenilin associated, rhomboid-like; Presenilins-associated rhomboid-like protein, mitochondrial; PRO2207; PSARL1; PSENIP2; RHBDS1; Rhomboid 7 1; Rhomboid 7 homolog 1 (Drosophila)
Type:
Protease; Apoptosis; EC 3.4.21.105
Mass (Da):
42190
Number AA:
379
UniProt ID:
Q9H300
International Prot ID:
IPI00060545
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005743
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0008236
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
C
G
Q
A
W
G
A
S
V
G
G
R
S
C
E
Site 2
T30
G
R
S
C
E
E
L
T
A
V
L
T
P
P
Q
Site 3
S65
R
K
V
E
P
R
R
S
D
P
G
T
S
G
E
Site 4
T69
P
R
R
S
D
P
G
T
S
G
E
A
Y
K
R
Site 5
S70
R
R
S
D
P
G
T
S
G
E
A
Y
K
R
S
Site 6
Y74
P
G
T
S
G
E
A
Y
K
R
S
A
L
I
P
Site 7
Y89
P
V
E
E
T
V
F
Y
P
S
P
Y
P
I
R
Site 8
S91
E
E
T
V
F
Y
P
S
P
Y
P
I
R
S
L
Site 9
Y93
T
V
F
Y
P
S
P
Y
P
I
R
S
L
I
K
Site 10
Y121
G
S
A
A
I
W
Q
Y
E
S
L
K
S
R
V
Site 11
S123
A
A
I
W
Q
Y
E
S
L
K
S
R
V
Q
S
Site 12
S126
W
Q
Y
E
S
L
K
S
R
V
Q
S
Y
F
D
Site 13
S130
S
L
K
S
R
V
Q
S
Y
F
D
G
I
K
A
Site 14
Y131
L
K
S
R
V
Q
S
Y
F
D
G
I
K
A
D
Site 15
S142
I
K
A
D
W
L
D
S
I
R
P
Q
K
E
G
Site 16
T191
R
V
P
S
L
Q
R
T
M
I
R
Y
F
T
S
Site 17
Y195
L
Q
R
T
M
I
R
Y
F
T
S
N
P
A
S
Site 18
T197
R
T
M
I
R
Y
F
T
S
N
P
A
S
K
V
Site 19
S198
T
M
I
R
Y
F
T
S
N
P
A
S
K
V
L
Site 20
S202
Y
F
T
S
N
P
A
S
K
V
L
C
S
P
M
Site 21
T267
S
Y
V
G
K
V
A
T
G
R
Y
G
P
S
L
Site 22
T282
G
A
S
G
A
I
M
T
V
L
A
A
V
C
T
Site 23
T369
K
I
W
H
E
I
R
T
N
G
P
K
K
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation