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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PNN
Full Name:
Pinin
Alias:
140 kDa nuclear and cell adhesion-related phosphoprotein
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
81614
Number AA:
717
UniProt ID:
Q9H307
International Prot ID:
IPI00002649
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030057
GO:0005882
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0005515
GO:0005198
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0007155
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T30
D
E
N
I
R
K
L
T
G
R
D
P
N
D
V
Site 2
S48
Q
A
R
L
L
A
L
S
G
P
G
G
G
R
G
Site 3
S58
G
G
G
R
G
R
G
S
L
L
L
R
R
G
F
Site 4
S66
L
L
L
R
R
G
F
S
D
S
G
G
G
P
P
Site 5
S68
L
R
R
G
F
S
D
S
G
G
G
P
P
A
K
Site 6
S84
R
D
L
E
G
A
V
S
R
L
G
G
E
R
R
Site 7
T92
R
L
G
G
E
R
R
T
R
R
E
S
R
Q
E
Site 8
S96
E
R
R
T
R
R
E
S
R
Q
E
S
D
P
E
Site 9
S100
R
R
E
S
R
Q
E
S
D
P
E
D
D
D
V
Site 10
S114
V
K
K
P
A
L
Q
S
S
V
V
A
T
S
K
Site 11
S115
K
K
P
A
L
Q
S
S
V
V
A
T
S
K
E
Site 12
T124
V
A
T
S
K
E
R
T
R
R
D
L
I
Q
D
Site 13
S160
L
Q
K
F
K
Q
E
S
T
V
A
T
E
R
Q
Site 14
T161
Q
K
F
K
Q
E
S
T
V
A
T
E
R
Q
K
Site 15
T164
K
Q
E
S
T
V
A
T
E
R
Q
K
R
R
Q
Site 16
T204
E
E
R
R
A
K
Q
T
E
L
R
L
L
E
Q
Site 17
Y232
H
N
A
K
I
I
K
Y
I
R
T
K
T
K
P
Site 18
T237
I
K
Y
I
R
T
K
T
K
P
H
L
F
Y
I
Site 19
Y243
K
T
K
P
H
L
F
Y
I
P
G
R
M
C
P
Site 20
T252
P
G
R
M
C
P
A
T
Q
K
L
I
E
E
S
Site 21
S259
T
Q
K
L
I
E
E
S
Q
R
K
M
N
A
L
Site 22
S289
E
A
R
P
R
R
Q
S
M
K
E
K
E
H
Q
Site 23
T322
R
E
E
E
L
E
E
T
G
N
Q
H
N
D
V
Site 24
S347
K
E
I
A
I
V
H
S
D
A
E
K
E
Q
E
Site 25
S375
E
E
T
E
V
R
E
S
E
K
Q
Q
D
S
Q
Site 26
S381
E
S
E
K
Q
Q
D
S
Q
P
E
E
V
M
D
Site 27
T408
A
D
Q
E
V
M
E
T
N
R
V
E
S
V
E
Site 28
S413
M
E
T
N
R
V
E
S
V
E
P
S
E
N
E
Site 29
S417
R
V
E
S
V
E
P
S
E
N
E
A
S
K
E
Site 30
S422
E
P
S
E
N
E
A
S
K
E
L
E
P
E
M
Site 31
S441
E
P
D
K
E
C
K
S
L
S
P
G
K
E
N
Site 32
S443
D
K
E
C
K
S
L
S
P
G
K
E
N
V
S
Site 33
S450
S
P
G
K
E
N
V
S
A
L
D
M
E
K
E
Site 34
S466
E
E
K
E
E
K
E
S
E
P
Q
P
E
P
V
Site 35
S480
V
A
Q
P
Q
P
Q
S
Q
P
Q
L
Q
L
Q
Site 36
S488
Q
P
Q
L
Q
L
Q
S
Q
S
Q
P
V
L
Q
Site 37
S490
Q
L
Q
L
Q
S
Q
S
Q
P
V
L
Q
S
Q
Site 38
S496
Q
S
Q
P
V
L
Q
S
Q
P
P
S
Q
P
E
Site 39
S500
V
L
Q
S
Q
P
P
S
Q
P
E
D
L
S
L
Site 40
S506
P
S
Q
P
E
D
L
S
L
A
V
L
Q
P
T
Site 41
T513
S
L
A
V
L
Q
P
T
P
Q
V
T
Q
E
Q
Site 42
T547
V
P
V
E
P
V
L
T
V
H
P
E
S
K
S
Site 43
S552
V
L
T
V
H
P
E
S
K
S
K
T
K
T
R
Site 44
S554
T
V
H
P
E
S
K
S
K
T
K
T
R
S
R
Site 45
T556
H
P
E
S
K
S
K
T
K
T
R
S
R
S
R
Site 46
T558
E
S
K
S
K
T
K
T
R
S
R
S
R
G
R
Site 47
S560
K
S
K
T
K
T
R
S
R
S
R
G
R
A
R
Site 48
S562
K
T
K
T
R
S
R
S
R
G
R
A
R
N
K
Site 49
T570
R
G
R
A
R
N
K
T
S
K
S
R
S
R
S
Site 50
S571
G
R
A
R
N
K
T
S
K
S
R
S
R
S
S
Site 51
S573
A
R
N
K
T
S
K
S
R
S
R
S
S
S
S
Site 52
S575
N
K
T
S
K
S
R
S
R
S
S
S
S
S
S
Site 53
S577
T
S
K
S
R
S
R
S
S
S
S
S
S
S
S
Site 54
S578
S
K
S
R
S
R
S
S
S
S
S
S
S
S
S
Site 55
S579
K
S
R
S
R
S
S
S
S
S
S
S
S
S
S
Site 56
S580
S
R
S
R
S
S
S
S
S
S
S
S
S
S
S
Site 57
S581
R
S
R
S
S
S
S
S
S
S
S
S
S
S
T
Site 58
S582
S
R
S
S
S
S
S
S
S
S
S
S
S
T
S
Site 59
S583
R
S
S
S
S
S
S
S
S
S
S
S
T
S
S
Site 60
S584
S
S
S
S
S
S
S
S
S
S
S
T
S
S
S
Site 61
S585
S
S
S
S
S
S
S
S
S
S
T
S
S
S
S
Site 62
S586
S
S
S
S
S
S
S
S
S
T
S
S
S
S
G
Site 63
S587
S
S
S
S
S
S
S
S
T
S
S
S
S
G
S
Site 64
T588
S
S
S
S
S
S
S
T
S
S
S
S
G
S
S
Site 65
S589
S
S
S
S
S
S
T
S
S
S
S
G
S
S
S
Site 66
S590
S
S
S
S
S
T
S
S
S
S
G
S
S
S
S
Site 67
S591
S
S
S
S
T
S
S
S
S
G
S
S
S
S
S
Site 68
S592
S
S
S
T
S
S
S
S
G
S
S
S
S
S
G
Site 69
S594
S
T
S
S
S
S
G
S
S
S
S
S
G
S
S
Site 70
S595
T
S
S
S
S
G
S
S
S
S
S
G
S
S
S
Site 71
S596
S
S
S
S
G
S
S
S
S
S
G
S
S
S
S
Site 72
S597
S
S
S
G
S
S
S
S
S
G
S
S
S
S
R
Site 73
S598
S
S
G
S
S
S
S
S
G
S
S
S
S
R
S
Site 74
S600
G
S
S
S
S
S
G
S
S
S
S
R
S
S
S
Site 75
S601
S
S
S
S
S
G
S
S
S
S
R
S
S
S
S
Site 76
S602
S
S
S
S
G
S
S
S
S
R
S
S
S
S
S
Site 77
S603
S
S
S
G
S
S
S
S
R
S
S
S
S
S
S
Site 78
S605
S
G
S
S
S
S
R
S
S
S
S
S
S
S
S
Site 79
S606
G
S
S
S
S
R
S
S
S
S
S
S
S
S
T
Site 80
S607
S
S
S
S
R
S
S
S
S
S
S
S
S
T
S
Site 81
S608
S
S
S
R
S
S
S
S
S
S
S
S
T
S
G
Site 82
S609
S
S
R
S
S
S
S
S
S
S
S
T
S
G
S
Site 83
S610
S
R
S
S
S
S
S
S
S
S
T
S
G
S
S
Site 84
S611
R
S
S
S
S
S
S
S
S
T
S
G
S
S
S
Site 85
S612
S
S
S
S
S
S
S
S
T
S
G
S
S
S
R
Site 86
T613
S
S
S
S
S
S
S
T
S
G
S
S
S
R
D
Site 87
S614
S
S
S
S
S
S
T
S
G
S
S
S
R
D
S
Site 88
S616
S
S
S
S
T
S
G
S
S
S
R
D
S
S
S
Site 89
S617
S
S
S
T
S
G
S
S
S
R
D
S
S
S
S
Site 90
S618
S
S
T
S
G
S
S
S
R
D
S
S
S
S
T
Site 91
S621
S
G
S
S
S
R
D
S
S
S
S
T
S
S
S
Site 92
S622
G
S
S
S
R
D
S
S
S
S
T
S
S
S
S
Site 93
S623
S
S
S
R
D
S
S
S
S
T
S
S
S
S
E
Site 94
S624
S
S
R
D
S
S
S
S
T
S
S
S
S
E
S
Site 95
T625
S
R
D
S
S
S
S
T
S
S
S
S
E
S
R
Site 96
S626
R
D
S
S
S
S
T
S
S
S
S
E
S
R
S
Site 97
S627
D
S
S
S
S
T
S
S
S
S
E
S
R
S
R
Site 98
S628
S
S
S
S
T
S
S
S
S
E
S
R
S
R
S
Site 99
S629
S
S
S
T
S
S
S
S
E
S
R
S
R
S
R
Site 100
S631
S
T
S
S
S
S
E
S
R
S
R
S
R
G
R
Site 101
S633
S
S
S
S
E
S
R
S
R
S
R
G
R
G
H
Site 102
S635
S
S
E
S
R
S
R
S
R
G
R
G
H
N
R
Site 103
S649
R
D
R
K
H
R
R
S
V
D
R
K
R
R
D
Site 104
T657
V
D
R
K
R
R
D
T
S
G
L
E
R
S
H
Site 105
S658
D
R
K
R
R
D
T
S
G
L
E
R
S
H
K
Site 106
S663
D
T
S
G
L
E
R
S
H
K
S
S
K
G
G
Site 107
S666
G
L
E
R
S
H
K
S
S
K
G
G
S
S
R
Site 108
S667
L
E
R
S
H
K
S
S
K
G
G
S
S
R
D
Site 109
S671
H
K
S
S
K
G
G
S
S
R
D
T
K
G
S
Site 110
S672
K
S
S
K
G
G
S
S
R
D
T
K
G
S
K
Site 111
T675
K
G
G
S
S
R
D
T
K
G
S
K
D
K
N
Site 112
S678
S
S
R
D
T
K
G
S
K
D
K
N
S
R
S
Site 113
S683
K
G
S
K
D
K
N
S
R
S
D
R
K
R
S
Site 114
S685
S
K
D
K
N
S
R
S
D
R
K
R
S
I
S
Site 115
S690
S
R
S
D
R
K
R
S
I
S
E
S
S
R
S
Site 116
S692
S
D
R
K
R
S
I
S
E
S
S
R
S
G
K
Site 117
S694
R
K
R
S
I
S
E
S
S
R
S
G
K
R
S
Site 118
S695
K
R
S
I
S
E
S
S
R
S
G
K
R
S
S
Site 119
S697
S
I
S
E
S
S
R
S
G
K
R
S
S
R
S
Site 120
S701
S
S
R
S
G
K
R
S
S
R
S
E
R
D
R
Site 121
S702
S
R
S
G
K
R
S
S
R
S
E
R
D
R
K
Site 122
S704
S
G
K
R
S
S
R
S
E
R
D
R
K
S
D
Site 123
S710
R
S
E
R
D
R
K
S
D
R
K
D
K
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation