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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EHM2
Full Name:
Band 4.1-like protein 4B
Alias:
E41LB; E4LB; EHM2 protein; EPB41L4B; FERM-containing protein CG1
Type:
Extrinsic membrane, Cytoplasm, Cytoskeleton protein
Mass (Da):
99712
Number AA:
900
UniProt ID:
Q9H329
International Prot ID:
IPI00152953
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0008092
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
L
R
F
L
R
R
T
F
G
R
R
S
M
Q
Site 2
S13
R
R
T
F
G
R
R
S
M
Q
R
Y
A
R
G
Site 3
Y17
G
R
R
S
M
Q
R
Y
A
R
G
A
A
G
R
Site 4
S76
G
G
A
A
V
H
I
S
A
A
G
A
A
K
A
Site 5
S98
L
L
D
G
T
E
V
S
V
D
L
P
K
H
A
Site 6
Y156
Q
M
K
I
G
P
A
Y
A
L
H
F
R
V
K
Site 7
Y164
A
L
H
F
R
V
K
Y
Y
S
S
E
P
N
N
Site 8
Y165
L
H
F
R
V
K
Y
Y
S
S
E
P
N
N
L
Site 9
S166
H
F
R
V
K
Y
Y
S
S
E
P
N
N
L
R
Site 10
S167
F
R
V
K
Y
Y
S
S
E
P
N
N
L
R
E
Site 11
Y179
L
R
E
E
F
T
R
Y
L
F
V
L
Q
L
R
Site 12
S191
Q
L
R
H
D
I
L
S
G
K
L
K
C
P
Y
Site 13
Y198
S
G
K
L
K
C
P
Y
E
T
A
V
E
L
A
Site 14
T222
E
C
E
L
P
E
H
T
P
E
L
V
S
E
F
Site 15
S227
E
H
T
P
E
L
V
S
E
F
R
F
I
P
N
Site 16
S254
W
K
E
C
R
G
K
S
P
A
Q
A
E
L
S
Site 17
S261
S
P
A
Q
A
E
L
S
Y
L
N
K
A
K
W
Site 18
Y287
R
G
R
D
G
C
E
Y
S
L
G
L
T
P
T
Site 19
S288
G
R
D
G
C
E
Y
S
L
G
L
T
P
T
G
Site 20
T340
Q
G
R
E
Q
E
H
T
F
V
F
R
L
D
S
Site 21
S347
T
F
V
F
R
L
D
S
A
R
T
C
K
H
L
Site 22
T369
H
A
F
F
R
L
R
T
P
G
N
S
K
S
N
Site 23
S373
R
L
R
T
P
G
N
S
K
S
N
R
S
D
F
Site 24
S375
R
T
P
G
N
S
K
S
N
R
S
D
F
I
R
Site 25
S378
G
N
S
K
S
N
R
S
D
F
I
R
L
G
S
Site 26
S385
S
D
F
I
R
L
G
S
R
F
R
F
S
G
R
Site 27
S390
L
G
S
R
F
R
F
S
G
R
T
E
Y
Q
A
Site 28
T393
R
F
R
F
S
G
R
T
E
Y
Q
A
T
H
G
Site 29
Y395
R
F
S
G
R
T
E
Y
Q
A
T
H
G
S
R
Site 30
T398
G
R
T
E
Y
Q
A
T
H
G
S
R
L
R
R
Site 31
S401
E
Y
Q
A
T
H
G
S
R
L
R
R
T
S
T
Site 32
T406
H
G
S
R
L
R
R
T
S
T
F
E
R
K
P
Site 33
S407
G
S
R
L
R
R
T
S
T
F
E
R
K
P
S
Site 34
T408
S
R
L
R
R
T
S
T
F
E
R
K
P
S
K
Site 35
S414
S
T
F
E
R
K
P
S
K
R
Y
P
S
R
R
Site 36
Y417
E
R
K
P
S
K
R
Y
P
S
R
R
H
S
T
Site 37
S419
K
P
S
K
R
Y
P
S
R
R
H
S
T
F
K
Site 38
S423
R
Y
P
S
R
R
H
S
T
F
K
A
S
N
P
Site 39
T424
Y
P
S
R
R
H
S
T
F
K
A
S
N
P
V
Site 40
S428
R
H
S
T
F
K
A
S
N
P
V
I
A
A
Q
Site 41
S438
V
I
A
A
Q
L
C
S
K
T
N
P
E
V
H
Site 42
T440
A
A
Q
L
C
S
K
T
N
P
E
V
H
N
Y
Site 43
Y447
T
N
P
E
V
H
N
Y
Q
P
Q
Y
H
P
N
Site 44
Y451
V
H
N
Y
Q
P
Q
Y
H
P
N
I
H
P
S
Site 45
S466
Q
P
R
W
H
P
H
S
P
N
V
S
Y
P
L
Site 46
S470
H
P
H
S
P
N
V
S
Y
P
L
P
S
P
V
Site 47
Y471
P
H
S
P
N
V
S
Y
P
L
P
S
P
V
L
Site 48
S475
N
V
S
Y
P
L
P
S
P
V
L
S
S
S
D
Site 49
S479
P
L
P
S
P
V
L
S
S
S
D
R
L
P
F
Site 50
S480
L
P
S
P
V
L
S
S
S
D
R
L
P
F
G
Site 51
S481
P
S
P
V
L
S
S
S
D
R
L
P
F
G
I
Site 52
T494
G
I
E
E
N
G
G
T
P
F
L
T
A
A
S
Site 53
T498
N
G
G
T
P
F
L
T
A
A
S
G
R
H
H
Site 54
S521
H
Q
H
H
S
N
Y
S
L
S
L
T
L
E
N
Site 55
S523
H
H
S
N
Y
S
L
S
L
T
L
E
N
K
E
Site 56
T525
S
N
Y
S
L
S
L
T
L
E
N
K
E
G
P
Site 57
S535
N
K
E
G
P
L
R
S
P
N
S
S
S
K
S
Site 58
S538
G
P
L
R
S
P
N
S
S
S
K
S
L
T
K
Site 59
S539
P
L
R
S
P
N
S
S
S
K
S
L
T
K
L
Site 60
S540
L
R
S
P
N
S
S
S
K
S
L
T
K
L
S
Site 61
S542
S
P
N
S
S
S
K
S
L
T
K
L
S
P
G
Site 62
T544
N
S
S
S
K
S
L
T
K
L
S
P
G
T
P
Site 63
S547
S
K
S
L
T
K
L
S
P
G
T
P
A
L
F
Site 64
S591
K
A
E
E
K
K
V
S
E
K
T
L
Q
T
P
Site 65
T597
V
S
E
K
T
L
Q
T
P
L
L
P
S
P
V
Site 66
S602
L
Q
T
P
L
L
P
S
P
V
A
D
H
V
K
Site 67
S632
I
Q
G
G
K
E
E
S
P
F
V
N
I
N
K
Site 68
S647
K
S
S
L
Q
D
A
S
V
R
S
P
I
P
I
Site 69
S650
L
Q
D
A
S
V
R
S
P
I
P
I
R
V
E
Site 70
T658
P
I
P
I
R
V
E
T
A
Q
P
A
V
E
K
Site 71
T677
P
P
R
V
R
K
L
T
R
Q
Y
S
F
D
E
Site 72
Y680
V
R
K
L
T
R
Q
Y
S
F
D
E
D
D
L
Site 73
S681
R
K
L
T
R
Q
Y
S
F
D
E
D
D
L
P
Site 74
S713
T
T
A
A
T
Q
V
S
V
P
L
P
S
P
K
Site 75
S718
Q
V
S
V
P
L
P
S
P
K
V
Q
N
V
S
Site 76
S725
S
P
K
V
Q
N
V
S
S
P
H
K
S
E
G
Site 77
S726
P
K
V
Q
N
V
S
S
P
H
K
S
E
G
K
Site 78
S730
N
V
S
S
P
H
K
S
E
G
K
G
L
L
S
Site 79
S737
S
E
G
K
G
L
L
S
P
G
A
K
S
P
S
Site 80
S742
L
L
S
P
G
A
K
S
P
S
D
R
G
G
A
Site 81
S744
S
P
G
A
K
S
P
S
D
R
G
G
A
F
T
Site 82
T751
S
D
R
G
G
A
F
T
L
E
P
G
D
L
L
Site 83
S772
T
P
L
A
E
P
A
S
N
P
H
C
A
H
S
Site 84
S779
S
N
P
H
C
A
H
S
R
C
S
P
P
L
S
Site 85
S782
H
C
A
H
S
R
C
S
P
P
L
S
L
P
M
Site 86
S786
S
R
C
S
P
P
L
S
L
P
M
K
E
E
T
Site 87
Y799
E
T
T
G
V
C
M
Y
P
P
I
K
T
R
L
Site 88
T809
I
K
T
R
L
I
K
T
F
P
V
D
T
M
N
Site 89
T814
I
K
T
F
P
V
D
T
M
N
P
F
P
D
T
Site 90
T821
T
M
N
P
F
P
D
T
F
T
T
G
P
Q
F
Site 91
T823
N
P
F
P
D
T
F
T
T
G
P
Q
F
T
A
Site 92
T859
T
L
R
P
L
T
E
T
V
S
T
V
Q
T
I
Site 93
S861
R
P
L
T
E
T
V
S
T
V
Q
T
I
Y
T
Site 94
T865
E
T
V
S
T
V
Q
T
I
Y
T
T
R
K
P
Site 95
Y867
V
S
T
V
Q
T
I
Y
T
T
R
K
P
V
S
Site 96
S874
Y
T
T
R
K
P
V
S
L
A
A
S
A
E
T
Site 97
S878
K
P
V
S
L
A
A
S
A
E
T
L
R
Q
E
Site 98
T881
S
L
A
A
S
A
E
T
L
R
Q
E
L
E
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation