KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
p63
Full Name:
Tumor protein 63
Alias:
EEC3; KET; LMS; NBP; OFC8; p51; p53CP; p63; p73H; p73L; SHFM4; TA p63 alpha; TP53CP; TP53L; TP63; TP73L; tumor protein p63
Type:
Transcription factor
Mass (Da):
76785
Number AA:
680
UniProt ID:
Q9H3D4
International Prot ID:
IPI00301360
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0042802
GO:0016563
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0007219
GO:0030308
GO:0045747
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
F
E
T
S
R
C
A
T
L
Q
Y
C
P
D
P
Site 2
Y13
S
R
C
A
T
L
Q
Y
C
P
D
P
Y
I
Q
Site 3
Y18
L
Q
Y
C
P
D
P
Y
I
Q
R
F
V
E
T
Site 4
Y35
H
F
S
W
K
E
S
Y
Y
R
S
T
M
S
Q
Site 5
Y36
F
S
W
K
E
S
Y
Y
R
S
T
M
S
Q
S
Site 6
S38
W
K
E
S
Y
Y
R
S
T
M
S
Q
S
T
Q
Site 7
T39
K
E
S
Y
Y
R
S
T
M
S
Q
S
T
Q
T
Site 8
S41
S
Y
Y
R
S
T
M
S
Q
S
T
Q
T
N
E
Site 9
S51
T
Q
T
N
E
F
L
S
P
E
V
F
Q
H
I
Site 10
S81
L
N
F
V
D
E
P
S
E
D
G
A
T
N
K
Site 11
T86
E
P
S
E
D
G
A
T
N
K
I
E
I
S
M
Site 12
Y111
S
D
P
M
W
P
Q
Y
T
N
L
G
L
L
N
Site 13
S119
T
N
L
G
L
L
N
S
M
D
Q
Q
I
Q
N
Site 14
S128
D
Q
Q
I
Q
N
G
S
S
S
T
S
P
Y
N
Site 15
S130
Q
I
Q
N
G
S
S
S
T
S
P
Y
N
T
D
Site 16
S132
Q
N
G
S
S
S
T
S
P
Y
N
T
D
H
A
Site 17
T136
S
S
T
S
P
Y
N
T
D
H
A
Q
N
S
V
Site 18
S142
N
T
D
H
A
Q
N
S
V
T
A
P
S
P
Y
Site 19
S147
Q
N
S
V
T
A
P
S
P
Y
A
Q
P
S
S
Site 20
Y149
S
V
T
A
P
S
P
Y
A
Q
P
S
S
T
F
Site 21
S153
P
S
P
Y
A
Q
P
S
S
T
F
D
A
L
S
Site 22
S154
S
P
Y
A
Q
P
S
S
T
F
D
A
L
S
P
Site 23
T155
P
Y
A
Q
P
S
S
T
F
D
A
L
S
P
S
Site 24
S160
S
S
T
F
D
A
L
S
P
S
P
A
I
P
S
Site 25
S162
T
F
D
A
L
S
P
S
P
A
I
P
S
N
T
Site 26
S167
S
P
S
P
A
I
P
S
N
T
D
Y
P
G
P
Site 27
T169
S
P
A
I
P
S
N
T
D
Y
P
G
P
H
S
Site 28
Y171
A
I
P
S
N
T
D
Y
P
G
P
H
S
F
D
Site 29
S176
T
D
Y
P
G
P
H
S
F
D
V
S
F
Q
Q
Site 30
S180
G
P
H
S
F
D
V
S
F
Q
Q
S
S
T
A
Site 31
S184
F
D
V
S
F
Q
Q
S
S
T
A
K
S
A
T
Site 32
S185
D
V
S
F
Q
Q
S
S
T
A
K
S
A
T
W
Site 33
S189
Q
Q
S
S
T
A
K
S
A
T
W
T
Y
S
T
Site 34
T191
S
S
T
A
K
S
A
T
W
T
Y
S
T
E
L
Site 35
T193
T
A
K
S
A
T
W
T
Y
S
T
E
L
K
K
Site 36
S195
K
S
A
T
W
T
Y
S
T
E
L
K
K
L
Y
Site 37
T196
S
A
T
W
T
Y
S
T
E
L
K
K
L
Y
C
Site 38
Y202
S
T
E
L
K
K
L
Y
C
Q
I
A
K
T
C
Site 39
Y231
V
I
R
A
M
P
V
Y
K
K
A
E
H
V
T
Site 40
S250
R
C
P
N
H
E
L
S
R
E
F
N
E
G
Q
Site 41
S262
E
G
Q
I
A
P
P
S
H
L
I
R
V
E
G
Site 42
S271
L
I
R
V
E
G
N
S
H
A
Q
Y
V
E
D
Site 43
Y275
E
G
N
S
H
A
Q
Y
V
E
D
P
I
T
G
Site 44
T281
Q
Y
V
E
D
P
I
T
G
R
Q
S
V
L
V
Site 45
S285
D
P
I
T
G
R
Q
S
V
L
V
P
Y
E
P
Site 46
Y290
R
Q
S
V
L
V
P
Y
E
P
P
Q
V
G
T
Site 47
S358
D
R
K
A
D
E
D
S
I
R
K
Q
Q
V
S
Site 48
S365
S
I
R
K
Q
Q
V
S
D
S
T
K
N
G
D
Site 49
S367
R
K
Q
Q
V
S
D
S
T
K
N
G
D
G
T
Site 50
T368
K
Q
Q
V
S
D
S
T
K
N
G
D
G
T
K
Site 51
T374
S
T
K
N
G
D
G
T
K
R
P
F
R
Q
N
Site 52
T382
K
R
P
F
R
Q
N
T
H
G
I
Q
M
T
S
Site 53
S389
T
H
G
I
Q
M
T
S
I
K
K
R
R
S
P
Site 54
S395
T
S
I
K
K
R
R
S
P
D
D
E
L
L
Y
Site 55
Y402
S
P
D
D
E
L
L
Y
L
P
V
R
G
R
E
Site 56
T410
L
P
V
R
G
R
E
T
Y
E
M
L
L
K
I
Site 57
Y411
P
V
R
G
R
E
T
Y
E
M
L
L
K
I
K
Site 58
Y426
E
S
L
E
L
M
Q
Y
L
P
Q
H
T
I
E
Site 59
T451
Q
H
L
L
Q
K
Q
T
S
I
Q
S
P
S
S
Site 60
S452
H
L
L
Q
K
Q
T
S
I
Q
S
P
S
S
Y
Site 61
S455
Q
K
Q
T
S
I
Q
S
P
S
S
Y
G
N
S
Site 62
S457
Q
T
S
I
Q
S
P
S
S
Y
G
N
S
S
P
Site 63
S458
T
S
I
Q
S
P
S
S
Y
G
N
S
S
P
P
Site 64
Y459
S
I
Q
S
P
S
S
Y
G
N
S
S
P
P
L
Site 65
S462
S
P
S
S
Y
G
N
S
S
P
P
L
N
K
M
Site 66
S463
P
S
S
Y
G
N
S
S
P
P
L
N
K
M
N
Site 67
S471
P
P
L
N
K
M
N
S
M
N
K
L
P
S
V
Site 68
S477
N
S
M
N
K
L
P
S
V
S
Q
L
I
N
P
Site 69
S479
M
N
K
L
P
S
V
S
Q
L
I
N
P
Q
Q
Site 70
T491
P
Q
Q
R
N
A
L
T
P
T
T
I
P
D
G
Site 71
T493
Q
R
N
A
L
T
P
T
T
I
P
D
G
M
G
Site 72
T494
R
N
A
L
T
P
T
T
I
P
D
G
M
G
A
Site 73
S520
A
G
D
M
N
G
L
S
P
T
Q
A
L
P
P
Site 74
T522
D
M
N
G
L
S
P
T
Q
A
L
P
P
P
L
Site 75
S530
Q
A
L
P
P
P
L
S
M
P
S
T
S
H
C
Site 76
S533
P
P
P
L
S
M
P
S
T
S
H
C
T
P
P
Site 77
T534
P
P
L
S
M
P
S
T
S
H
C
T
P
P
P
Site 78
S535
P
L
S
M
P
S
T
S
H
C
T
P
P
P
P
Site 79
T538
M
P
S
T
S
H
C
T
P
P
P
P
Y
P
T
Site 80
Y543
H
C
T
P
P
P
P
Y
P
T
D
C
S
I
V
Site 81
T545
T
P
P
P
P
Y
P
T
D
C
S
I
V
S
F
Site 82
S560
L
A
R
L
G
C
S
S
C
L
D
Y
F
T
T
Site 83
T567
S
C
L
D
Y
F
T
T
Q
G
L
T
T
I
Y
Site 84
Y574
T
Q
G
L
T
T
I
Y
Q
I
E
H
Y
S
M
Site 85
S586
Y
S
M
D
D
L
A
S
L
K
I
P
E
Q
F
Site 86
S611
H
R
Q
L
H
E
F
S
S
P
S
H
L
L
R
Site 87
S612
R
Q
L
H
E
F
S
S
P
S
H
L
L
R
T
Site 88
T619
S
P
S
H
L
L
R
T
P
S
S
A
S
T
V
Site 89
S621
S
H
L
L
R
T
P
S
S
A
S
T
V
S
V
Site 90
S622
H
L
L
R
T
P
S
S
A
S
T
V
S
V
G
Site 91
S624
L
R
T
P
S
S
A
S
T
V
S
V
G
S
S
Site 92
T625
R
T
P
S
S
A
S
T
V
S
V
G
S
S
E
Site 93
S627
P
S
S
A
S
T
V
S
V
G
S
S
E
T
R
Site 94
S631
S
T
V
S
V
G
S
S
E
T
R
G
E
R
V
Site 95
T649
V
R
F
T
L
R
Q
T
I
S
F
P
P
R
D
Site 96
S651
F
T
L
R
Q
T
I
S
F
P
P
R
D
E
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation