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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SNX25
Full Name:
Sorting nexin-25
Alias:
SBBI31; Sorting nexin 25
Type:
Vesicle protein
Mass (Da):
97945
Number AA:
840
UniProt ID:
Q9H3E2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0035091
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y11
A
L
K
E
V
F
D
Y
S
Y
R
D
Y
I
L
Site 2
S12
L
K
E
V
F
D
Y
S
Y
R
D
Y
I
L
S
Site 3
Y13
K
E
V
F
D
Y
S
Y
R
D
Y
I
L
S
W
Site 4
Y16
F
D
Y
S
Y
R
D
Y
I
L
S
W
Y
G
N
Site 5
S19
S
Y
R
D
Y
I
L
S
W
Y
G
N
L
S
R
Site 6
Y21
R
D
Y
I
L
S
W
Y
G
N
L
S
R
D
E
Site 7
S25
L
S
W
Y
G
N
L
S
R
D
E
G
Q
L
Y
Site 8
Y32
S
R
D
E
G
Q
L
Y
H
L
L
L
E
D
F
Site 9
S51
R
Q
L
H
H
R
L
S
H
V
D
V
V
K
V
Site 10
S97
L
H
A
C
L
R
N
S
D
D
E
V
R
F
L
Site 11
S125
S
K
D
V
Q
S
L
S
L
R
I
M
L
A
E
Site 12
T135
I
M
L
A
E
I
L
T
T
K
V
L
K
P
V
Site 13
T136
M
L
A
E
I
L
T
T
K
V
L
K
P
V
V
Site 14
S147
K
P
V
V
E
L
L
S
N
P
D
Y
I
N
Q
Site 15
Y151
E
L
L
S
N
P
D
Y
I
N
Q
M
L
L
A
Site 16
Y162
M
L
L
A
Q
L
A
Y
R
E
Q
M
N
E
H
Site 17
Y174
N
E
H
H
K
R
A
Y
T
Y
A
P
S
Y
E
Site 18
T175
E
H
H
K
R
A
Y
T
Y
A
P
S
Y
E
D
Site 19
S179
R
A
Y
T
Y
A
P
S
Y
E
D
F
I
K
L
Site 20
Y180
A
Y
T
Y
A
P
S
Y
E
D
F
I
K
L
I
Site 21
S191
I
K
L
I
N
S
N
S
D
V
E
F
L
K
Q
Site 22
S215
I
Q
A
T
T
I
S
S
F
P
Q
L
K
R
H
Site 23
Y243
R
A
R
N
M
K
R
Y
I
N
Q
L
T
V
A
Site 24
T248
K
R
Y
I
N
Q
L
T
V
A
K
K
Q
C
E
Site 25
Y266
R
I
L
G
G
P
A
Y
D
Q
Q
E
D
G
A
Site 26
S282
D
E
G
E
G
P
Q
S
Q
K
I
L
Q
F
E
Site 27
Y297
D
I
L
A
N
T
F
Y
R
E
H
F
G
M
Y
Site 28
Y304
Y
R
E
H
F
G
M
Y
M
E
R
M
D
K
R
Site 29
S315
M
D
K
R
A
L
I
S
F
W
E
S
V
E
H
Site 30
Y339
P
Q
L
V
G
E
I
Y
Q
N
F
F
V
E
S
Site 31
S350
F
V
E
S
K
E
I
S
V
E
K
S
L
Y
K
Site 32
S354
K
E
I
S
V
E
K
S
L
Y
K
E
I
Q
Q
Site 33
Y356
I
S
V
E
K
S
L
Y
K
E
I
Q
Q
C
L
Site 34
Y380
Y
K
I
Q
E
D
V
Y
E
T
L
K
D
R
Y
Site 35
Y387
Y
E
T
L
K
D
R
Y
Y
P
S
F
I
V
S
Site 36
Y388
E
T
L
K
D
R
Y
Y
P
S
F
I
V
S
D
Site 37
S390
L
K
D
R
Y
Y
P
S
F
I
V
S
D
L
Y
Site 38
S410
K
E
E
E
K
H
A
S
Q
M
I
S
N
K
D
Site 39
S414
K
H
A
S
Q
M
I
S
N
K
D
E
M
G
P
Site 40
T434
E
E
A
V
D
D
G
T
N
Q
I
N
E
Q
A
Site 41
S442
N
Q
I
N
E
Q
A
S
F
A
V
N
K
L
R
Site 42
Y457
E
L
N
E
K
L
E
Y
K
R
Q
A
L
N
S
Site 43
S464
Y
K
R
Q
A
L
N
S
I
Q
N
A
P
K
P
Site 44
T491
I
L
I
E
K
E
R
T
D
L
Q
L
H
M
A
Site 45
T520
S
I
T
S
G
E
V
T
E
E
N
G
E
Q
L
Site 46
T548
G
V
E
T
K
N
W
T
V
P
R
R
L
S
E
Site 47
S554
W
T
V
P
R
R
L
S
E
F
Q
N
L
H
R
Site 48
S564
Q
N
L
H
R
K
L
S
E
C
V
P
S
L
K
Site 49
S569
K
L
S
E
C
V
P
S
L
K
K
V
Q
L
P
Site 50
S577
L
K
K
V
Q
L
P
S
L
S
K
L
P
F
K
Site 51
S579
K
V
Q
L
P
S
L
S
K
L
P
F
K
S
I
Site 52
S585
L
S
K
L
P
F
K
S
I
D
Q
K
F
M
E
Site 53
S607
K
F
L
Q
N
L
L
S
D
E
R
L
C
Q
S
Site 54
S622
E
A
L
Y
A
F
L
S
P
S
P
D
Y
L
K
Site 55
S639
D
V
Q
G
K
K
N
S
F
S
L
S
S
F
L
Site 56
S641
Q
G
K
K
N
S
F
S
L
S
S
F
L
E
R
Site 57
S643
K
K
N
S
F
S
L
S
S
F
L
E
R
L
P
Site 58
S644
K
N
S
F
S
L
S
S
F
L
E
R
L
P
R
Site 59
S655
R
L
P
R
D
F
F
S
H
Q
E
E
E
T
E
Site 60
S665
E
E
E
T
E
E
D
S
D
L
S
D
Y
G
D
Site 61
S668
T
E
E
D
S
D
L
S
D
Y
G
D
D
V
D
Site 62
Y670
E
D
S
D
L
S
D
Y
G
D
D
V
D
G
R
Site 63
T725
I
N
K
Q
I
R
D
T
V
S
W
I
F
S
E
Site 64
Y737
F
S
E
Q
M
L
V
Y
Y
I
N
I
F
R
D
Site 65
T756
N
G
K
L
A
P
P
T
T
I
R
S
K
E
Q
Site 66
T757
G
K
L
A
P
P
T
T
I
R
S
K
E
Q
S
Site 67
S760
A
P
P
T
T
I
R
S
K
E
Q
S
Q
E
T
Site 68
S764
T
I
R
S
K
E
Q
S
Q
E
T
K
Q
R
A
Site 69
S785
N
I
P
D
M
L
Q
S
L
V
G
Q
Q
N
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation