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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TXNIP
Full Name:
Thioredoxin-interacting protein
Alias:
Thioredoxin-binding 2; Vitamin D3 up-regulated 1; Vitamin D3 up-regulated protein 1
Type:
Apoptosis protein
Mass (Da):
43661
Number AA:
391
UniProt ID:
Q9H3M7
International Prot ID:
IPI00007956
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0004857
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
D
P
E
K
V
Y
G
S
G
E
K
V
A
G
R
Site 2
S60
K
V
L
W
M
Q
G
S
Q
Q
C
K
Q
T
S
Site 3
Y69
Q
C
K
Q
T
S
E
Y
L
R
Y
E
D
T
L
Site 4
Y72
Q
T
S
E
Y
L
R
Y
E
D
T
L
L
L
E
Site 5
T75
E
Y
L
R
Y
E
D
T
L
L
L
E
D
Q
P
Site 6
T83
L
L
L
E
D
Q
P
T
G
E
N
E
M
V
I
Site 7
Y97
I
M
R
P
G
N
K
Y
E
Y
K
F
G
F
E
Site 8
Y99
R
P
G
N
K
Y
E
Y
K
F
G
F
E
L
P
Site 9
S113
P
Q
G
P
L
G
T
S
F
K
G
K
Y
G
C
Site 10
Y118
G
T
S
F
K
G
K
Y
G
C
V
D
Y
W
V
Site 11
Y123
G
K
Y
G
C
V
D
Y
W
V
K
A
F
L
D
Site 12
S133
K
A
F
L
D
R
P
S
Q
P
T
Q
E
T
K
Site 13
T136
L
D
R
P
S
Q
P
T
Q
E
T
K
K
N
F
Site 14
S161
P
D
L
M
A
P
V
S
A
K
K
E
K
K
V
Site 15
S179
F
I
P
D
G
R
V
S
V
S
A
R
I
D
R
Site 16
S181
P
D
G
R
V
S
V
S
A
R
I
D
R
K
G
Site 17
S206
A
D
F
E
N
T
C
S
R
I
V
V
P
K
A
Site 18
Y221
A
I
V
A
R
H
T
Y
L
A
N
G
Q
T
K
Site 19
T231
N
G
Q
T
K
V
L
T
Q
K
L
S
S
V
R
Site 20
S235
K
V
L
T
Q
K
L
S
S
V
R
G
N
H
I
Site 21
S249
I
I
S
G
T
C
A
S
W
R
G
K
S
L
R
Site 22
S254
C
A
S
W
R
G
K
S
L
R
V
Q
K
I
R
Site 23
S298
D
L
P
L
V
I
G
S
R
S
G
L
S
S
R
Site 24
S300
P
L
V
I
G
S
R
S
G
L
S
S
R
T
S
Site 25
S303
I
G
S
R
S
G
L
S
S
R
T
S
S
M
A
Site 26
S304
G
S
R
S
G
L
S
S
R
T
S
S
M
A
S
Site 27
S307
S
G
L
S
S
R
T
S
S
M
A
S
R
T
S
Site 28
S308
G
L
S
S
R
T
S
S
M
A
S
R
T
S
S
Site 29
S311
S
R
T
S
S
M
A
S
R
T
S
S
E
M
S
Site 30
T313
T
S
S
M
A
S
R
T
S
S
E
M
S
W
V
Site 31
S314
S
S
M
A
S
R
T
S
S
E
M
S
W
V
D
Site 32
S315
S
M
A
S
R
T
S
S
E
M
S
W
V
D
L
Site 33
S318
S
R
T
S
S
E
M
S
W
V
D
L
N
I
P
Site 34
T327
V
D
L
N
I
P
D
T
P
E
A
P
P
C
Y
Site 35
Y334
T
P
E
A
P
P
C
Y
M
D
V
I
P
E
D
Site 36
S346
P
E
D
H
R
L
E
S
P
T
T
P
L
L
D
Site 37
T348
D
H
R
L
E
S
P
T
T
P
L
L
D
D
M
Site 38
T349
H
R
L
E
S
P
T
T
P
L
L
D
D
M
D
Site 39
S358
L
L
D
D
M
D
G
S
Q
D
S
P
I
F
M
Site 40
S361
D
M
D
G
S
Q
D
S
P
I
F
M
Y
A
P
Site 41
Y366
Q
D
S
P
I
F
M
Y
A
P
E
F
K
F
M
Site 42
T377
F
K
F
M
P
P
P
T
Y
T
E
V
D
P
C
Site 43
Y378
K
F
M
P
P
P
T
Y
T
E
V
D
P
C
I
Site 44
T379
F
M
P
P
P
T
Y
T
E
V
D
P
C
I
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation