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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HRH4
Full Name:
Histamine H4 receptor
Alias:
AXOR35;G-protein coupled receptor 105;GPRv53;Pfi-013;SP9144
Type:
Mass (Da):
44496
Number AA:
390
UniProt ID:
Q9H3N8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
D
T
N
S
T
I
N
L
S
L
S
Site 2
T7
_
M
P
D
T
N
S
T
I
N
L
S
L
S
T
Site 3
S50
D
K
N
L
R
H
R
S
S
Y
F
F
L
N
L
Site 4
S51
K
N
L
R
H
R
S
S
Y
F
F
L
N
L
A
Site 5
Y52
N
L
R
H
R
S
S
Y
F
F
L
N
L
A
I
Site 6
S115
I
S
Y
D
R
Y
L
S
V
S
N
A
V
S
Y
Site 7
S117
Y
D
R
Y
L
S
V
S
N
A
V
S
Y
R
T
Site 8
S121
L
S
V
S
N
A
V
S
Y
R
T
Q
H
T
G
Site 9
S154
N
G
P
M
I
L
V
S
E
S
W
K
D
E
G
Site 10
S156
P
M
I
L
V
S
E
S
W
K
D
E
G
S
E
Site 11
S162
E
S
W
K
D
E
G
S
E
C
E
P
G
F
F
Site 12
S208
L
W
K
R
D
H
L
S
R
C
Q
S
H
P
G
Site 13
S212
D
H
L
S
R
C
Q
S
H
P
G
L
T
A
V
Site 14
S220
H
P
G
L
T
A
V
S
S
N
I
C
G
H
S
Site 15
S227
S
S
N
I
C
G
H
S
F
R
G
R
L
S
S
Site 16
S233
H
S
F
R
G
R
L
S
S
R
R
S
L
S
A
Site 17
S234
S
F
R
G
R
L
S
S
R
R
S
L
S
A
S
Site 18
S237
G
R
L
S
S
R
R
S
L
S
A
S
T
E
V
Site 19
S239
L
S
S
R
R
S
L
S
A
S
T
E
V
P
A
Site 20
S241
S
R
R
S
L
S
A
S
T
E
V
P
A
S
F
Site 21
T242
R
R
S
L
S
A
S
T
E
V
P
A
S
F
H
Site 22
S247
A
S
T
E
V
P
A
S
F
H
S
E
R
Q
R
Site 23
S250
E
V
P
A
S
F
H
S
E
R
Q
R
R
K
S
Site 24
S257
S
E
R
Q
R
R
K
S
S
L
M
F
S
S
R
Site 25
S258
E
R
Q
R
R
K
S
S
L
M
F
S
S
R
T
Site 26
S262
R
K
S
S
L
M
F
S
S
R
T
K
M
N
S
Site 27
S263
K
S
S
L
M
F
S
S
R
T
K
M
N
S
N
Site 28
S269
S
S
R
T
K
M
N
S
N
T
I
A
S
K
M
Site 29
S274
M
N
S
N
T
I
A
S
K
M
G
S
F
S
Q
Site 30
S278
T
I
A
S
K
M
G
S
F
S
Q
S
D
S
V
Site 31
S280
A
S
K
M
G
S
F
S
Q
S
D
S
V
A
L
Site 32
S282
K
M
G
S
F
S
Q
S
D
S
V
A
L
H
Q
Site 33
S284
G
S
F
S
Q
S
D
S
V
A
L
H
Q
R
E
Site 34
T333
L
S
F
Y
S
S
A
T
G
P
K
S
V
W
Y
Site 35
S337
S
S
A
T
G
P
K
S
V
W
Y
R
I
A
F
Site 36
Y340
T
G
P
K
S
V
W
Y
R
I
A
F
W
L
Q
Site 37
S382
I
K
K
Q
P
L
P
S
Q
H
S
R
S
V
S
Site 38
S385
Q
P
L
P
S
Q
H
S
R
S
V
S
S
_
_
Site 39
S387
L
P
S
Q
H
S
R
S
V
S
S
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation