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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WHSC2
Full Name:
Negative elongation factor A
Alias:
NELFA; NELF-A; NLFA; P/OKcl.15; Wolf-Hirschhorn syndrome candidate 2; Wolf-Hirschhorn syndrome candidate 2 protein; Wolf-Hirshhorn syndrome candidate 2 protein
Type:
Transcription, coactivator/corepressor
Mass (Da):
57277
Number AA:
528
UniProt ID:
Q9H3P2
International Prot ID:
IPI00394676
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003746
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
A
S
M
R
E
S
D
T
G
L
W
L
H
N
K
Site 2
T60
K
L
K
L
L
L
G
T
L
H
L
P
R
R
T
Site 3
T67
T
L
H
L
P
R
R
T
V
D
E
M
K
G
A
Site 4
S105
K
S
F
P
D
T
G
S
L
N
L
E
L
E
E
Site 5
T157
T
T
L
A
G
P
L
T
P
P
V
K
H
F
Q
Site 6
S171
Q
L
K
R
K
P
K
S
A
T
L
R
A
E
L
Site 7
T173
K
R
K
P
K
S
A
T
L
R
A
E
L
L
Q
Site 8
S182
R
A
E
L
L
Q
K
S
T
E
T
A
Q
Q
L
Site 9
T210
G
L
L
R
K
M
D
T
T
T
P
L
K
G
I
Site 10
T211
L
L
R
K
M
D
T
T
T
P
L
K
G
I
P
Site 11
T212
L
R
K
M
D
T
T
T
P
L
K
G
I
P
K
Site 12
S230
F
R
S
P
T
A
P
S
V
F
S
P
T
G
N
Site 13
S233
P
T
A
P
S
V
F
S
P
T
G
N
R
T
P
Site 14
T239
F
S
P
T
G
N
R
T
P
I
P
P
S
R
T
Site 15
S244
N
R
T
P
I
P
P
S
R
T
L
L
R
K
E
Site 16
T246
T
P
I
P
P
S
R
T
L
L
R
K
E
R
G
Site 17
T291
E
K
P
A
K
E
E
T
V
V
E
N
A
T
P
Site 18
T297
E
T
V
V
E
N
A
T
P
D
Y
A
A
G
L
Site 19
S312
V
S
T
Q
K
L
G
S
L
N
N
E
P
A
L
Site 20
S321
N
N
E
P
A
L
P
S
T
S
Y
L
P
S
T
Site 21
S323
E
P
A
L
P
S
T
S
Y
L
P
S
T
P
S
Site 22
Y324
P
A
L
P
S
T
S
Y
L
P
S
T
P
S
V
Site 23
S327
P
S
T
S
Y
L
P
S
T
P
S
V
V
P
A
Site 24
T328
S
T
S
Y
L
P
S
T
P
S
V
V
P
A
S
Site 25
S330
S
Y
L
P
S
T
P
S
V
V
P
A
S
S
Y
Site 26
S335
T
P
S
V
V
P
A
S
S
Y
I
P
S
S
E
Site 27
S336
P
S
V
V
P
A
S
S
Y
I
P
S
S
E
T
Site 28
Y337
S
V
V
P
A
S
S
Y
I
P
S
S
E
T
P
Site 29
S340
P
A
S
S
Y
I
P
S
S
E
T
P
P
A
P
Site 30
S341
A
S
S
Y
I
P
S
S
E
T
P
P
A
P
S
Site 31
T343
S
Y
I
P
S
S
E
T
P
P
A
P
S
S
R
Site 32
S348
S
E
T
P
P
A
P
S
S
R
E
A
S
R
P
Site 33
S349
E
T
P
P
A
P
S
S
R
E
A
S
R
P
P
Site 34
S353
A
P
S
S
R
E
A
S
R
P
P
E
E
P
S
Site 35
S360
S
R
P
P
E
E
P
S
A
P
S
P
T
L
P
Site 36
Y377
F
K
Q
R
A
P
M
Y
N
S
G
L
S
P
A
Site 37
S382
P
M
Y
N
S
G
L
S
P
A
T
P
T
P
A
Site 38
T385
N
S
G
L
S
P
A
T
P
T
P
A
A
P
T
Site 39
T387
G
L
S
P
A
T
P
T
P
A
A
P
T
S
P
Site 40
S393
P
T
P
A
A
P
T
S
P
L
T
P
T
T
P
Site 41
T398
P
T
S
P
L
T
P
T
T
P
P
A
V
A
P
Site 42
T399
T
S
P
L
T
P
T
T
P
P
A
V
A
P
T
Site 43
T419
V
A
M
V
A
P
Q
T
Q
A
P
A
Q
Q
Q
Site 44
S432
Q
Q
P
K
K
N
L
S
L
T
R
E
Q
M
F
Site 45
T447
A
A
Q
E
M
F
K
T
A
N
K
V
T
R
P
Site 46
Y510
D
T
V
F
E
M
N
Y
A
T
G
Q
W
T
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation