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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
JMJD2C
Full Name:
Lysine-specific demethylase 4C
Alias:
EC 1.14.11.-; GASC1; GASC-1; Gene amplified in squamous cell carcinoma 1; JHD3C; JHDM3C; Jumonji domain-containing protein 2C
Type:
Nucleus protein
Mass (Da):
119982
Number AA:
1056
UniProt ID:
Q9H3R0
International Prot ID:
IPI00027642
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005506
GO:0003676
GO:0016702
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0055114
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
V
A
E
V
E
S
P
L
N
P
S
C
K
Site 2
S13
V
E
S
P
L
N
P
S
C
K
I
M
T
F
R
Site 3
T18
N
P
S
C
K
I
M
T
F
R
P
S
M
E
E
Site 4
S22
K
I
M
T
F
R
P
S
M
E
E
F
R
E
F
Site 5
Y32
E
F
R
E
F
N
K
Y
L
A
Y
M
E
S
K
Site 6
Y35
E
F
N
K
Y
L
A
Y
M
E
S
K
G
A
H
Site 7
S38
K
Y
L
A
Y
M
E
S
K
G
A
H
R
A
G
Site 8
Y61
E
W
K
P
R
Q
C
Y
D
D
I
D
N
L
L
Site 9
T85
T
G
Q
S
G
L
F
T
Q
Y
N
I
Q
K
K
Site 10
S105
E
F
R
Q
L
A
N
S
G
K
Y
C
T
P
R
Site 11
Y108
Q
L
A
N
S
G
K
Y
C
T
P
R
Y
L
D
Site 12
T110
A
N
S
G
K
Y
C
T
P
R
Y
L
D
Y
E
Site 13
Y113
G
K
Y
C
T
P
R
Y
L
D
Y
E
D
L
E
Site 14
Y116
C
T
P
R
Y
L
D
Y
E
D
L
E
R
K
Y
Site 15
Y123
Y
E
D
L
E
R
K
Y
W
K
N
L
T
F
V
Site 16
S141
Y
G
A
D
I
N
G
S
I
Y
D
E
G
V
D
Site 17
Y143
A
D
I
N
G
S
I
Y
D
E
G
V
D
E
W
Site 18
S169
V
E
E
E
C
G
I
S
I
E
G
V
N
T
P
Site 19
Y177
I
E
G
V
N
T
P
Y
L
Y
F
G
M
W
K
Site 20
Y179
G
V
N
T
P
Y
L
Y
F
G
M
W
K
T
T
Site 21
Y197
H
T
E
D
M
D
L
Y
S
I
N
Y
L
H
F
Site 22
Y201
M
D
L
Y
S
I
N
Y
L
H
F
G
E
P
K
Site 23
S209
L
H
F
G
E
P
K
S
W
Y
A
I
P
P
E
Site 24
Y211
F
G
E
P
K
S
W
Y
A
I
P
P
E
H
G
Site 25
S231
L
A
Q
G
F
F
P
S
S
S
Q
G
C
D
A
Site 26
S232
A
Q
G
F
F
P
S
S
S
Q
G
C
D
A
F
Site 27
S233
Q
G
F
F
P
S
S
S
Q
G
C
D
A
F
L
Site 28
S248
R
H
K
M
T
L
I
S
P
S
V
L
K
K
Y
Site 29
S250
K
M
T
L
I
S
P
S
V
L
K
K
Y
G
I
Site 30
Y255
S
P
S
V
L
K
K
Y
G
I
P
F
D
K
I
Site 31
T263
G
I
P
F
D
K
I
T
Q
E
A
G
E
F
M
Site 32
T272
E
A
G
E
F
M
I
T
F
P
Y
G
Y
H
A
Site 33
T295
A
E
S
T
N
F
A
T
V
R
W
I
D
Y
G
Site 34
T309
G
K
V
A
K
L
C
T
C
R
K
D
M
V
K
Site 35
Y331
R
K
F
Q
P
D
R
Y
Q
L
W
K
Q
G
K
Site 36
Y341
W
K
Q
G
K
D
I
Y
T
I
D
H
T
K
P
Site 37
T342
K
Q
G
K
D
I
Y
T
I
D
H
T
K
P
T
Site 38
T349
T
I
D
H
T
K
P
T
P
A
S
T
P
E
V
Site 39
S352
H
T
K
P
T
P
A
S
T
P
E
V
K
A
W
Site 40
T353
T
K
P
T
P
A
S
T
P
E
V
K
A
W
L
Site 41
S370
R
R
K
V
R
K
A
S
R
S
F
Q
C
A
R
Site 42
S372
K
V
R
K
A
S
R
S
F
Q
C
A
R
S
T
Site 43
S378
R
S
F
Q
C
A
R
S
T
S
K
R
P
K
A
Site 44
T379
S
F
Q
C
A
R
S
T
S
K
R
P
K
A
D
Site 45
S380
F
Q
C
A
R
S
T
S
K
R
P
K
A
D
E
Site 46
S392
A
D
E
E
E
E
V
S
D
E
V
D
G
A
E
Site 47
S405
A
E
V
P
N
P
D
S
V
T
D
D
L
K
V
Site 48
S416
D
L
K
V
S
E
K
S
E
A
A
V
K
L
R
Site 49
T425
A
A
V
K
L
R
N
T
E
A
S
S
E
E
E
Site 50
S428
K
L
R
N
T
E
A
S
S
E
E
E
S
S
A
Site 51
S429
L
R
N
T
E
A
S
S
E
E
E
S
S
A
S
Site 52
S433
E
A
S
S
E
E
E
S
S
A
S
R
M
Q
V
Site 53
S434
A
S
S
E
E
E
S
S
A
S
R
M
Q
V
E
Site 54
S436
S
E
E
E
S
S
A
S
R
M
Q
V
E
Q
N
Site 55
S445
M
Q
V
E
Q
N
L
S
D
H
I
K
L
S
G
Site 56
S451
L
S
D
H
I
K
L
S
G
N
S
C
L
S
T
Site 57
S457
L
S
G
N
S
C
L
S
T
S
V
T
E
D
I
Site 58
T458
S
G
N
S
C
L
S
T
S
V
T
E
D
I
K
Site 59
T461
S
C
L
S
T
S
V
T
E
D
I
K
T
E
D
Site 60
T466
S
V
T
E
D
I
K
T
E
D
D
K
A
Y
A
Site 61
Y472
K
T
E
D
D
K
A
Y
A
Y
R
S
V
P
S
Site 62
Y474
E
D
D
K
A
Y
A
Y
R
S
V
P
S
I
S
Site 63
S476
D
K
A
Y
A
Y
R
S
V
P
S
I
S
S
E
Site 64
S479
Y
A
Y
R
S
V
P
S
I
S
S
E
A
D
D
Site 65
S482
R
S
V
P
S
I
S
S
E
A
D
D
S
I
P
Site 66
S487
I
S
S
E
A
D
D
S
I
P
L
S
S
G
Y
Site 67
S491
A
D
D
S
I
P
L
S
S
G
Y
E
K
P
E
Site 68
S492
D
D
S
I
P
L
S
S
G
Y
E
K
P
E
K
Site 69
Y494
S
I
P
L
S
S
G
Y
E
K
P
E
K
S
D
Site 70
S500
G
Y
E
K
P
E
K
S
D
P
S
E
L
S
W
Site 71
S503
K
P
E
K
S
D
P
S
E
L
S
W
P
K
S
Site 72
S506
K
S
D
P
S
E
L
S
W
P
K
S
P
E
S
Site 73
S510
S
E
L
S
W
P
K
S
P
E
S
C
S
S
V
Site 74
S513
S
W
P
K
S
P
E
S
C
S
S
V
A
E
S
Site 75
S515
P
K
S
P
E
S
C
S
S
V
A
E
S
N
G
Site 76
S516
K
S
P
E
S
C
S
S
V
A
E
S
N
G
V
Site 77
S520
S
C
S
S
V
A
E
S
N
G
V
L
T
E
G
Site 78
S530
V
L
T
E
G
E
E
S
D
V
E
S
H
G
N
Site 79
S534
G
E
E
S
D
V
E
S
H
G
N
G
L
E
P
Site 80
S549
G
E
I
P
A
V
P
S
G
E
R
N
S
F
K
Site 81
S554
V
P
S
G
E
R
N
S
F
K
V
P
S
I
A
Site 82
S559
R
N
S
F
K
V
P
S
I
A
E
G
E
N
K
Site 83
S568
A
E
G
E
N
K
T
S
K
S
W
R
H
P
L
Site 84
S570
G
E
N
K
T
S
K
S
W
R
H
P
L
S
R
Site 85
S576
K
S
W
R
H
P
L
S
R
P
P
A
R
S
P
Site 86
S582
L
S
R
P
P
A
R
S
P
M
T
L
V
K
Q
Site 87
T585
P
P
A
R
S
P
M
T
L
V
K
Q
Q
A
P
Site 88
S593
L
V
K
Q
Q
A
P
S
D
E
E
L
P
E
V
Site 89
S602
E
E
L
P
E
V
L
S
I
E
E
E
V
E
E
Site 90
T610
I
E
E
E
V
E
E
T
E
S
W
A
K
P
L
Site 91
S612
E
E
V
E
E
T
E
S
W
A
K
P
L
I
H
Site 92
S625
I
H
L
W
Q
T
K
S
P
N
F
A
A
E
Q
Site 93
T637
A
E
Q
E
Y
N
A
T
V
A
R
M
K
P
H
Site 94
Y654
I
C
T
L
L
M
P
Y
H
K
P
D
S
S
N
Site 95
S659
M
P
Y
H
K
P
D
S
S
N
E
E
N
D
A
Site 96
S660
P
Y
H
K
P
D
S
S
N
E
E
N
D
A
R
Site 97
T670
E
N
D
A
R
W
E
T
K
L
D
E
V
V
T
Site 98
T682
V
V
T
S
E
G
K
T
K
P
L
I
P
E
M
Site 99
Y700
Y
S
E
E
N
I
E
Y
S
P
P
N
A
F
L
Site 100
S701
S
E
E
N
I
E
Y
S
P
P
N
A
F
L
E
Site 101
T768
R
G
G
A
L
K
Q
T
K
N
N
K
W
A
H
Site 102
T788
A
V
P
E
V
R
F
T
N
V
P
E
R
T
Q
Site 103
S821
R
H
R
V
K
R
V
S
G
A
C
I
Q
C
S
Site 104
S872
K
V
N
P
N
V
K
S
K
A
C
E
K
V
I
Site 105
T884
K
V
I
S
V
G
Q
T
V
I
T
K
H
R
N
Site 106
T887
S
V
G
Q
T
V
I
T
K
H
R
N
T
R
Y
Site 107
Y894
T
K
H
R
N
T
R
Y
Y
S
C
R
V
M
A
Site 108
Y895
K
H
R
N
T
R
Y
Y
S
C
R
V
M
A
V
Site 109
T903
S
C
R
V
M
A
V
T
S
Q
T
F
Y
E
V
Site 110
T906
V
M
A
V
T
S
Q
T
F
Y
E
V
M
F
D
Site 111
Y908
A
V
T
S
Q
T
F
Y
E
V
M
F
D
D
G
Site 112
S916
E
V
M
F
D
D
G
S
F
S
R
D
T
F
P
Site 113
S918
M
F
D
D
G
S
F
S
R
D
T
F
P
E
D
Site 114
T921
D
G
S
F
S
R
D
T
F
P
E
D
I
V
S
Site 115
S928
T
F
P
E
D
I
V
S
R
D
C
L
K
L
G
Site 116
Y953
K
W
P
D
G
K
L
Y
G
A
K
Y
F
G
S
Site 117
Y957
G
K
L
Y
G
A
K
Y
F
G
S
N
I
A
H
Site 118
Y966
G
S
N
I
A
H
M
Y
Q
V
E
F
E
D
G
Site 119
S974
Q
V
E
F
E
D
G
S
Q
I
A
M
K
R
E
Site 120
Y984
A
M
K
R
E
D
I
Y
T
L
D
E
E
L
P
Site 121
T985
M
K
R
E
D
I
Y
T
L
D
E
E
L
P
K
Site 122
S999
K
R
V
K
A
R
F
S
T
A
S
D
M
R
F
Site 123
T1000
R
V
K
A
R
F
S
T
A
S
D
M
R
F
E
Site 124
S1002
K
A
R
F
S
T
A
S
D
M
R
F
E
D
T
Site 125
T1009
S
D
M
R
F
E
D
T
F
Y
G
A
D
I
I
Site 126
Y1011
M
R
F
E
D
T
F
Y
G
A
D
I
I
Q
G
Site 127
S1027
R
K
R
Q
R
V
L
S
S
R
F
K
N
E
Y
Site 128
Y1034
S
S
R
F
K
N
E
Y
V
A
D
P
V
Y
R
Site 129
Y1040
E
Y
V
A
D
P
V
Y
R
T
F
L
K
S
S
Site 130
T1042
V
A
D
P
V
Y
R
T
F
L
K
S
S
F
Q
Site 131
S1046
V
Y
R
T
F
L
K
S
S
F
Q
K
K
C
Q
Site 132
S1047
Y
R
T
F
L
K
S
S
F
Q
K
K
C
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation