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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN23
Full Name:
Tyrosine-protein phosphatase non-receptor type 23
Alias:
DKFZP564F0923; EC 3.1.3.48; HDPTP; HD-PTP; His-domain protein tyrosine phosphatase; His-domain-containing protein tyrosine phosphatase; KIAA1471; Protein tyrosine phosphatase TD14; Protein tyrosine phosphatase, non-receptor type 23; PTN23; PTP-TD14; Tyrosine-protein phosphatase non-receptor type 23
Type:
Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48
Mass (Da):
178974
Number AA:
1636
UniProt ID:
Q9H3S7
International Prot ID:
IPI00034006
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016023
GO:0031982
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0004725
GO:0004721
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
GO:0006470
GO:0006793
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y34
K
K
F
V
L
K
N
Y
G
E
N
P
E
A
Y
Site 2
Y41
Y
G
E
N
P
E
A
Y
N
E
E
L
K
K
L
Site 3
S66
P
R
D
F
E
G
C
S
V
L
R
K
Y
L
G
Site 4
Y77
K
Y
L
G
Q
L
H
Y
L
Q
S
R
V
P
M
Site 5
S80
G
Q
L
H
Y
L
Q
S
R
V
P
M
G
S
G
Site 6
S86
Q
S
R
V
P
M
G
S
G
Q
E
A
A
V
P
Site 7
S104
T
E
I
F
S
G
K
S
V
A
H
E
D
I
K
Site 8
Y112
V
A
H
E
D
I
K
Y
E
Q
A
C
I
L
Y
Site 9
S136
G
A
M
D
K
R
V
S
E
E
G
M
K
V
S
Site 10
Y165
R
E
H
F
P
Q
A
Y
S
V
D
M
S
R
Q
Site 11
S166
E
H
F
P
Q
A
Y
S
V
D
M
S
R
Q
I
Site 12
S170
Q
A
Y
S
V
D
M
S
R
Q
I
L
T
L
N
Site 13
S193
Q
E
C
L
L
E
K
S
M
L
D
N
R
K
S
Site 14
S200
S
M
L
D
N
R
K
S
F
L
V
A
R
I
S
Site 15
Y213
I
S
A
Q
V
V
D
Y
Y
K
E
A
C
R
A
Site 16
Y214
S
A
Q
V
V
D
Y
Y
K
E
A
C
R
A
L
Site 17
T226
R
A
L
E
N
P
D
T
A
S
L
L
G
R
I
Site 18
S228
L
E
N
P
D
T
A
S
L
L
G
R
I
Q
K
Site 19
Y272
K
F
G
E
R
V
A
Y
F
Q
S
A
L
D
K
Site 20
T293
L
A
K
G
Q
P
D
T
V
Q
D
A
L
R
F
Site 21
S311
V
I
G
G
K
Y
N
S
A
K
K
D
N
D
F
Site 22
Y320
K
K
D
N
D
F
I
Y
H
E
A
V
P
A
L
Site 23
S369
P
M
A
A
H
E
A
S
S
L
Y
S
E
E
K
Site 24
S370
M
A
A
H
E
A
S
S
L
Y
S
E
E
K
A
Site 25
S373
H
E
A
S
S
L
Y
S
E
E
K
A
K
L
L
Site 26
S400
V
L
D
Q
F
M
D
S
M
Q
L
D
P
E
T
Site 27
T407
S
M
Q
L
D
P
E
T
V
D
N
L
D
A
Y
Site 28
Y414
T
V
D
N
L
D
A
Y
S
H
I
P
P
Q
L
Site 29
S429
M
E
K
C
A
A
L
S
V
R
P
D
T
V
R
Site 30
T434
A
L
S
V
R
P
D
T
V
R
N
L
V
Q
S
Site 31
S455
V
F
T
D
V
E
A
S
L
K
D
I
R
D
L
Site 32
Y501
V
R
R
E
W
A
K
Y
M
E
V
H
E
K
A
Site 33
S509
M
E
V
H
E
K
A
S
F
T
N
S
E
L
H
Site 34
T511
V
H
E
K
A
S
F
T
N
S
E
L
H
R
A
Site 35
S513
E
K
A
S
F
T
N
S
E
L
H
R
A
M
N
Site 36
S530
V
G
N
L
R
L
L
S
G
P
L
D
Q
V
R
Site 37
T542
Q
V
R
A
A
L
P
T
P
A
L
S
P
E
D
Site 38
S572
E
M
R
D
Q
R
V
S
L
E
Q
Q
L
R
E
Site 39
T587
L
I
Q
K
D
D
I
T
A
S
L
V
T
T
D
Site 40
S589
Q
K
D
D
I
T
A
S
L
V
T
T
D
H
S
Site 41
T593
I
T
A
S
L
V
T
T
D
H
S
E
M
K
K
Site 42
S596
S
L
V
T
T
D
H
S
E
M
K
K
L
F
E
Site 43
Y609
F
E
E
Q
L
K
K
Y
D
Q
L
K
V
Y
L
Site 44
Y615
K
Y
D
Q
L
K
V
Y
L
E
Q
N
L
A
A
Site 45
S645
A
A
V
R
R
V
L
S
D
L
D
Q
K
W
N
Site 46
S653
D
L
D
Q
K
W
N
S
T
L
Q
T
L
V
A
Site 47
T657
K
W
N
S
T
L
Q
T
L
V
A
S
Y
E
A
Site 48
Y665
L
V
A
S
Y
E
A
Y
E
D
L
M
K
K
S
Site 49
S672
Y
E
D
L
M
K
K
S
Q
E
G
R
D
F
Y
Site 50
Y679
S
Q
E
G
R
D
F
Y
A
D
L
E
S
K
V
Site 51
T693
V
A
A
L
L
E
R
T
Q
S
T
C
Q
A
R
Site 52
S695
A
L
L
E
R
T
Q
S
T
C
Q
A
R
E
A
Site 53
T696
L
L
E
R
T
Q
S
T
C
Q
A
R
E
A
A
Site 54
T721
K
K
P
P
P
R
P
T
A
P
K
P
L
L
P
Site 55
S733
L
L
P
R
R
E
E
S
E
A
V
E
A
G
D
Site 56
S747
D
P
P
E
E
L
R
S
L
P
P
D
M
V
A
Site 57
T761
A
G
P
R
L
P
D
T
F
L
G
S
A
T
P
Site 58
T767
D
T
F
L
G
S
A
T
P
L
H
F
P
P
S
Site 59
S774
T
P
L
H
F
P
P
S
P
F
P
S
S
T
G
Site 60
S778
F
P
P
S
P
F
P
S
S
T
G
P
G
P
H
Site 61
S779
P
P
S
P
F
P
S
S
T
G
P
G
P
H
Y
Site 62
T780
P
S
P
F
P
S
S
T
G
P
G
P
H
Y
L
Site 63
Y786
S
T
G
P
G
P
H
Y
L
S
G
P
L
P
P
Site 64
S788
G
P
G
P
H
Y
L
S
G
P
L
P
P
G
T
Site 65
T795
S
G
P
L
P
P
G
T
Y
S
G
P
T
Q
L
Site 66
Y796
G
P
L
P
P
G
T
Y
S
G
P
T
Q
L
I
Site 67
S797
P
L
P
P
G
T
Y
S
G
P
T
Q
L
I
Q
Site 68
S837
E
L
G
L
V
P
R
S
S
P
Q
H
G
V
V
Site 69
S838
L
G
L
V
P
R
S
S
P
Q
H
G
V
V
S
Site 70
S845
S
P
Q
H
G
V
V
S
S
P
Y
V
G
V
G
Site 71
S846
P
Q
H
G
V
V
S
S
P
Y
V
G
V
G
P
Site 72
S862
P
P
V
A
G
L
P
S
A
P
P
P
Q
F
S
Site 73
S869
S
A
P
P
P
Q
F
S
G
P
E
L
A
M
A
Site 74
T883
A
V
R
P
A
T
T
T
V
D
S
I
Q
A
P
Site 75
S886
P
A
T
T
T
V
D
S
I
Q
A
P
I
P
S
Site 76
S893
S
I
Q
A
P
I
P
S
H
T
A
P
R
P
N
Site 77
T902
T
A
P
R
P
N
P
T
P
A
P
P
P
P
C
Site 78
T920
P
P
P
Q
P
L
P
T
P
Y
T
Y
P
A
G
Site 79
Y922
P
Q
P
L
P
T
P
Y
T
Y
P
A
G
A
K
Site 80
T923
Q
P
L
P
T
P
Y
T
Y
P
A
G
A
K
Q
Site 81
S964
P
H
P
Q
P
H
P
S
Q
A
F
G
P
Q
P
Site 82
S996
P
G
L
L
P
P
Q
S
P
Y
P
Y
A
P
Q
Site 83
Y998
L
L
P
P
Q
S
P
Y
P
Y
A
P
Q
P
G
Site 84
Y1000
P
P
Q
S
P
Y
P
Y
A
P
Q
P
G
V
L
Site 85
Y1019
P
P
L
H
T
Q
L
Y
P
G
P
A
Q
D
P
Site 86
S1038
S
G
A
L
P
F
P
S
P
G
P
P
Q
P
P
Site 87
S1056
L
A
Y
G
P
A
P
S
T
R
P
M
G
P
Q
Site 88
T1057
A
Y
G
P
A
P
S
T
R
P
M
G
P
Q
A
Site 89
T1068
G
P
Q
A
A
P
L
T
I
R
G
P
S
S
A
Site 90
S1073
P
L
T
I
R
G
P
S
S
A
G
Q
S
T
P
Site 91
S1074
L
T
I
R
G
P
S
S
A
G
Q
S
T
P
S
Site 92
S1078
G
P
S
S
A
G
Q
S
T
P
S
P
H
L
V
Site 93
T1079
P
S
S
A
G
Q
S
T
P
S
P
H
L
V
P
Site 94
S1081
S
A
G
Q
S
T
P
S
P
H
L
V
P
S
P
Site 95
S1087
P
S
P
H
L
V
P
S
P
A
P
S
P
G
P
Site 96
S1091
L
V
P
S
P
A
P
S
P
G
P
G
P
V
P
Site 97
S1121
A
A
A
A
D
L
L
S
S
S
P
E
S
Q
H
Site 98
S1122
A
A
A
D
L
L
S
S
S
P
E
S
Q
H
G
Site 99
S1123
A
A
D
L
L
S
S
S
P
E
S
Q
H
G
G
Site 100
S1126
L
L
S
S
S
P
E
S
Q
H
G
G
T
Q
S
Site 101
T1131
P
E
S
Q
H
G
G
T
Q
S
P
G
G
G
Q
Site 102
S1133
S
Q
H
G
G
T
Q
S
P
G
G
G
Q
P
L
Site 103
Y1165
R
L
I
E
R
D
P
Y
E
H
P
E
R
L
R
Site 104
T1193
G
D
V
G
A
L
D
T
V
W
R
E
L
Q
D
Site 105
S1210
E
H
D
A
R
G
R
S
I
A
I
A
R
C
Y
Site 106
Y1217
S
I
A
I
A
R
C
Y
S
L
K
N
R
H
Q
Site 107
S1218
I
A
I
A
R
C
Y
S
L
K
N
R
H
Q
D
Site 108
Y1229
R
H
Q
D
V
M
P
Y
D
S
N
R
V
V
L
Site 109
S1231
Q
D
V
M
P
Y
D
S
N
R
V
V
L
R
S
Site 110
S1238
S
N
R
V
V
L
R
S
G
K
D
D
Y
I
N
Site 111
Y1243
L
R
S
G
K
D
D
Y
I
N
A
S
C
V
E
Site 112
S1247
K
D
D
Y
I
N
A
S
C
V
E
G
L
S
P
Site 113
S1290
S
V
I
V
M
L
V
S
E
A
E
M
E
K
Q
Site 114
Y1302
E
K
Q
K
V
A
R
Y
F
P
T
E
R
G
Q
Site 115
T1305
K
V
A
R
Y
F
P
T
E
R
G
Q
P
M
V
Site 116
S1322
A
L
S
L
A
L
S
S
V
R
S
T
E
T
H
Site 117
S1325
L
A
L
S
S
V
R
S
T
E
T
H
V
E
R
Site 118
T1326
A
L
S
S
V
R
S
T
E
T
H
V
E
R
V
Site 119
S1335
T
H
V
E
R
V
L
S
L
Q
F
R
D
Q
S
Site 120
S1342
S
L
Q
F
R
D
Q
S
L
K
R
S
L
V
H
Site 121
S1346
R
D
Q
S
L
K
R
S
L
V
H
L
H
F
P
Site 122
S1363
P
E
L
G
L
P
D
S
P
S
N
L
L
R
F
Site 123
Y1378
I
Q
E
V
H
A
H
Y
L
H
Q
R
P
L
H
Site 124
T1386
L
H
Q
R
P
L
H
T
P
I
I
V
H
C
S
Site 125
S1471
P
P
C
K
P
L
A
S
A
S
I
S
Q
K
N
Site 126
S1473
C
K
P
L
A
S
A
S
I
S
Q
K
N
H
L
Site 127
S1475
P
L
A
S
A
S
I
S
Q
K
N
H
L
P
Q
Site 128
S1484
K
N
H
L
P
Q
D
S
Q
D
L
V
L
G
G
Site 129
S1515
R
P
P
G
G
L
E
S
P
V
A
S
L
P
G
Site 130
S1519
G
L
E
S
P
V
A
S
L
P
G
P
A
E
P
Site 131
S1533
P
P
G
L
P
P
A
S
L
P
E
S
T
P
I
Site 132
S1537
P
P
A
S
L
P
E
S
T
P
I
P
S
S
S
Site 133
T1538
P
A
S
L
P
E
S
T
P
I
P
S
S
S
P
Site 134
S1542
P
E
S
T
P
I
P
S
S
S
P
P
P
L
S
Site 135
S1543
E
S
T
P
I
P
S
S
S
P
P
P
L
S
S
Site 136
S1544
S
T
P
I
P
S
S
S
P
P
P
L
S
S
P
Site 137
S1549
S
S
S
P
P
P
L
S
S
P
L
P
E
A
P
Site 138
S1550
S
S
P
P
P
L
S
S
P
L
P
E
A
P
Q
Site 139
S1569
P
P
V
P
E
A
P
S
S
G
P
P
S
S
S
Site 140
S1570
P
V
P
E
A
P
S
S
G
P
P
S
S
S
L
Site 141
S1574
A
P
S
S
G
P
P
S
S
S
L
E
L
L
A
Site 142
S1575
P
S
S
G
P
P
S
S
S
L
E
L
L
A
S
Site 143
S1576
S
S
G
P
P
S
S
S
L
E
L
L
A
S
L
Site 144
S1589
S
L
T
P
E
A
F
S
L
D
S
S
L
R
G
Site 145
S1593
E
A
F
S
L
D
S
S
L
R
G
K
Q
R
M
Site 146
S1601
L
R
G
K
Q
R
M
S
K
H
N
F
L
Q
A
Site 147
T1617
N
G
Q
G
L
R
A
T
R
P
S
D
D
P
L
Site 148
S1620
G
L
R
A
T
R
P
S
D
D
P
L
S
L
L
Site 149
S1625
R
P
S
D
D
P
L
S
L
L
D
P
L
W
T
Site 150
T1632
S
L
L
D
P
L
W
T
L
N
K
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation