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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
UNC45A
Full Name:
Protein unc-45 homolog A
Alias:
GC-unc45; GCUNC-45; IRO039700; SMAP1; SMAP-1; Smooth muscle cell associated protein-1; Smooth muscle cell-associated protein 1; UN45A; Unc45 A; Unc-45 A; Unc-45A
Type:
Nuclear receptor co-regulator; Cytoskeletal protein
Mass (Da):
103077
Number AA:
944
UniProt ID:
Q9H3U1
International Prot ID:
IPI00072534
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007517
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
T
V
S
G
P
G
T
P
E
P
Site 2
T8
M
T
V
S
G
P
G
T
P
E
P
R
P
A
T
Site 3
T15
T
P
E
P
R
P
A
T
P
G
A
S
S
V
E
Site 4
S19
R
P
A
T
P
G
A
S
S
V
E
Q
L
R
K
Site 5
S20
P
A
T
P
G
A
S
S
V
E
Q
L
R
K
E
Site 6
Y74
C
H
L
K
L
E
D
Y
D
K
A
E
T
E
A
Site 7
S82
D
K
A
E
T
E
A
S
K
A
I
E
K
D
G
Site 8
Y96
G
G
D
V
K
A
L
Y
R
R
S
Q
A
L
E
Site 9
S99
V
K
A
L
Y
R
R
S
Q
A
L
E
K
L
G
Site 10
S120
L
D
L
Q
R
C
V
S
L
E
P
K
N
K
V
Site 11
Y145
Q
I
Q
E
K
V
R
Y
M
S
S
T
D
A
K
Site 12
S147
Q
E
K
V
R
Y
M
S
S
T
D
A
K
V
E
Site 13
S148
E
K
V
R
Y
M
S
S
T
D
A
K
V
E
Q
Site 14
T149
K
V
R
Y
M
S
S
T
D
A
K
V
E
Q
M
Site 15
T168
L
D
P
E
E
K
G
T
E
K
K
Q
K
A
S
Site 16
S224
R
T
L
V
G
I
C
S
E
H
Q
S
R
T
V
Site 17
S228
G
I
C
S
E
H
Q
S
R
T
V
A
T
L
S
Site 18
T230
C
S
E
H
Q
S
R
T
V
A
T
L
S
I
L
Site 19
S327
I
K
A
V
P
R
K
S
L
K
D
P
N
N
S
Site 20
T336
K
D
P
N
N
S
L
T
L
W
V
I
D
Q
G
Site 21
S353
K
I
L
E
V
G
G
S
L
Q
D
P
P
G
E
Site 22
T364
P
P
G
E
L
A
V
T
A
N
S
R
M
S
A
Site 23
S376
M
S
A
S
I
L
L
S
K
L
F
D
D
L
K
Site 24
Y398
F
H
R
L
C
E
N
Y
I
K
S
W
F
E
G
Site 25
S448
S
V
I
A
L
C
A
S
E
Q
E
E
E
Q
L
Site 26
S472
A
G
K
A
K
R
A
S
F
I
T
A
N
G
V
Site 27
Y486
V
S
L
L
K
D
L
Y
K
C
S
E
K
D
S
Site 28
S489
L
K
D
L
Y
K
C
S
E
K
D
S
I
R
I
Site 29
S493
Y
K
C
S
E
K
D
S
I
R
I
R
A
L
V
Site 30
T511
K
L
G
S
A
G
G
T
D
F
S
M
K
Q
F
Site 31
S514
S
A
G
G
T
D
F
S
M
K
Q
F
A
E
G
Site 32
S578
L
K
A
L
F
Q
L
S
R
L
E
E
R
S
V
Site 33
S599
A
L
V
N
C
T
N
S
Y
D
Y
E
E
P
D
Site 34
Y602
N
C
T
N
S
Y
D
Y
E
E
P
D
P
K
M
Site 35
Y615
K
M
V
E
L
A
K
Y
A
K
Q
H
V
P
E
Site 36
S630
Q
H
P
K
D
K
P
S
F
V
R
A
R
V
K
Site 37
T660
K
T
E
S
P
V
L
T
S
S
C
R
E
L
L
Site 38
S661
T
E
S
P
V
L
T
S
S
C
R
E
L
L
S
Site 39
S662
E
S
P
V
L
T
S
S
C
R
E
L
L
S
R
Site 40
T683
E
E
V
E
D
R
G
T
V
V
A
Q
G
G
G
Site 41
T701
I
P
L
A
L
E
G
T
D
V
G
Q
T
K
A
Site 42
T718
A
L
A
K
L
T
I
T
S
N
P
E
M
T
F
Site 43
T724
I
T
S
N
P
E
M
T
F
P
G
E
R
I
Y
Site 44
Y731
T
F
P
G
E
R
I
Y
E
V
V
R
P
L
V
Site 45
S764
L
T
N
L
A
G
I
S
E
R
L
R
Q
K
I
Site 46
Y783
A
V
P
M
I
E
G
Y
M
F
E
E
H
E
M
Site 47
T851
M
L
T
S
M
R
P
T
L
C
S
R
I
P
Q
Site 48
S854
S
M
R
P
T
L
C
S
R
I
P
Q
V
T
T
Site 49
S898
E
A
S
R
E
I
A
S
T
L
M
E
S
E
M
Site 50
T899
A
S
R
E
I
A
S
T
L
M
E
S
E
M
M
Site 51
S918
V
L
A
K
G
D
H
S
P
V
T
R
A
A
A
Site 52
T921
K
G
D
H
S
P
V
T
R
A
A
A
A
C
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation