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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FZD8
Full Name:
Frizzled-8
Alias:
Type:
Mass (Da):
73300
Number AA:
694
UniProt ID:
Q9H461
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
W
G
Y
L
L
E
V
T
S
L
L
A
A
L
A
Site 2
T61
P
N
Q
F
N
H
D
T
Q
D
E
A
G
L
E
Site 3
Y100
T
P
I
C
L
E
D
Y
K
K
P
L
P
P
C
Site 4
S109
K
P
L
P
P
C
R
S
V
C
E
R
A
K
A
Site 5
Y125
C
A
P
L
M
R
Q
Y
G
F
A
W
P
D
R
Site 6
T146
P
E
Q
G
N
P
D
T
L
C
M
D
Y
N
R
Site 7
Y151
P
D
T
L
C
M
D
Y
N
R
T
D
L
T
T
Site 8
T157
D
Y
N
R
T
D
L
T
T
A
A
P
S
P
P
Site 9
T158
Y
N
R
T
D
L
T
T
A
A
P
S
P
P
R
Site 10
S162
D
L
T
T
A
A
P
S
P
P
R
R
L
P
P
Site 11
S178
P
P
G
E
Q
P
P
S
G
S
G
H
G
R
P
Site 12
S180
G
E
Q
P
P
S
G
S
G
H
G
R
P
P
G
Site 13
S240
Q
C
R
A
P
M
V
S
V
S
S
E
R
H
P
Site 14
S242
R
A
P
M
V
S
V
S
S
E
R
H
P
L
Y
Site 15
S243
A
P
M
V
S
V
S
S
E
R
H
P
L
Y
N
Site 16
Y249
S
S
E
R
H
P
L
Y
N
R
V
K
T
G
Q
Site 17
T254
P
L
Y
N
R
V
K
T
G
Q
I
A
N
C
A
Site 18
Y308
I
D
M
E
R
F
K
Y
P
E
R
P
I
I
F
Site 19
S341
G
H
E
K
V
A
C
S
G
G
A
P
G
A
G
Site 20
Y376
G
P
G
G
R
G
E
Y
E
E
L
G
A
V
E
Site 21
Y388
A
V
E
Q
H
V
R
Y
E
T
T
G
P
A
L
Site 22
T390
E
Q
H
V
R
Y
E
T
T
G
P
A
L
C
T
Site 23
S512
V
S
L
F
R
I
R
S
V
I
K
Q
Q
D
G
Site 24
Y583
D
Q
A
R
R
P
D
Y
A
V
F
M
L
K
Y
Site 25
T609
V
W
V
W
S
G
K
T
L
E
S
W
R
S
L
Site 26
S612
W
S
G
K
T
L
E
S
W
R
S
L
C
T
R
Site 27
S664
G
P
G
G
G
G
G
S
L
Y
S
D
V
S
T
Site 28
Y666
G
G
G
G
G
S
L
Y
S
D
V
S
T
G
L
Site 29
S667
G
G
G
G
S
L
Y
S
D
V
S
T
G
L
T
Site 30
S670
G
S
L
Y
S
D
V
S
T
G
L
T
W
R
S
Site 31
T671
S
L
Y
S
D
V
S
T
G
L
T
W
R
S
G
Site 32
T674
S
D
V
S
T
G
L
T
W
R
S
G
T
A
S
Site 33
S677
S
T
G
L
T
W
R
S
G
T
A
S
S
V
S
Site 34
T679
G
L
T
W
R
S
G
T
A
S
S
V
S
Y
P
Site 35
S681
T
W
R
S
G
T
A
S
S
V
S
Y
P
K
Q
Site 36
S682
W
R
S
G
T
A
S
S
V
S
Y
P
K
Q
M
Site 37
S684
S
G
T
A
S
S
V
S
Y
P
K
Q
M
P
L
Site 38
Y685
G
T
A
S
S
V
S
Y
P
K
Q
M
P
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation