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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNPEP
Full Name:
Aminopeptidase B
Alias:
AMPB; APB; Ap-B; Arginine aminopeptidase; Arginyl aminopeptidase
Type:
EC 3.4.11.6; Protease
Mass (Da):
72596
Number AA:
650
UniProt ID:
Q9H4A4
International Prot ID:
IPI00642211
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0004177
GO:0004301
GO:0008235
PhosphoSite+
KinaseNET
Biological Process:
GO:0019370
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
A
S
G
E
H
S
P
G
S
Site 2
S7
_
M
A
S
G
E
H
S
P
G
S
G
A
A
R
Site 3
S10
S
G
E
H
S
P
G
S
G
A
A
R
R
P
L
Site 4
S19
A
A
R
R
P
L
H
S
A
Q
A
V
D
V
A
Site 5
S56
P
P
G
P
G
A
G
S
R
G
L
S
G
T
A
Site 6
S82
A
A
E
L
R
L
D
S
H
P
C
L
E
V
T
Site 7
S100
L
R
R
E
R
P
G
S
E
E
P
P
A
E
P
Site 8
S109
E
P
P
A
E
P
V
S
F
Y
T
Q
P
F
S
Site 9
Y111
P
A
E
P
V
S
F
Y
T
Q
P
F
S
H
Y
Site 10
T112
A
E
P
V
S
F
Y
T
Q
P
F
S
H
Y
G
Site 11
T141
E
R
L
Q
V
L
L
T
Y
R
V
G
E
G
P
Site 12
Y142
R
L
Q
V
L
L
T
Y
R
V
G
E
G
P
G
Site 13
S247
S
A
E
V
G
P
R
S
R
V
W
A
E
P
C
Site 14
Y281
G
E
K
L
F
G
P
Y
V
W
G
R
Y
D
L
Site 15
Y286
G
P
Y
V
W
G
R
Y
D
L
L
F
M
P
P
Site 16
Y353
L
N
E
G
F
T
M
Y
A
Q
R
R
I
S
T
Site 17
T386
L
R
Q
H
M
D
I
T
G
E
E
N
P
L
N
Site 18
T408
P
G
V
D
P
D
D
T
Y
N
E
T
P
Y
E
Site 19
Y409
G
V
D
P
D
D
T
Y
N
E
T
P
Y
E
K
Site 20
T412
P
D
D
T
Y
N
E
T
P
Y
E
K
G
F
C
Site 21
Y414
D
T
Y
N
E
T
P
Y
E
K
G
F
C
F
V
Site 22
S436
G
D
Q
D
Q
F
D
S
F
L
K
A
Y
V
H
Site 23
Y441
F
D
S
F
L
K
A
Y
V
H
E
F
K
F
R
Site 24
Y459
A
D
D
F
L
D
F
Y
L
E
Y
F
P
E
L
Site 25
Y462
F
L
D
F
Y
L
E
Y
F
P
E
L
K
K
K
Site 26
T485
E
F
D
R
W
L
N
T
P
G
W
P
P
Y
L
Site 27
Y491
N
T
P
G
W
P
P
Y
L
P
D
L
S
P
G
Site 28
S496
P
P
Y
L
P
D
L
S
P
G
D
S
L
M
K
Site 29
S500
P
D
L
S
P
G
D
S
L
M
K
P
A
E
E
Site 30
Y537
W
K
T
Y
Q
L
V
Y
F
L
D
K
I
L
Q
Site 31
S546
L
D
K
I
L
Q
K
S
P
L
P
P
G
N
V
Site 32
T559
N
V
K
K
L
G
D
T
Y
P
S
I
S
N
A
Site 33
Y560
V
K
K
L
G
D
T
Y
P
S
I
S
N
A
R
Site 34
Y603
H
N
Q
G
K
Q
K
Y
T
L
P
L
Y
H
A
Site 35
T604
N
Q
G
K
Q
K
Y
T
L
P
L
Y
H
A
M
Site 36
Y608
Q
K
Y
T
L
P
L
Y
H
A
M
M
G
G
S
Site 37
T620
G
G
S
E
V
A
Q
T
L
A
K
E
T
F
A
Site 38
T625
A
Q
T
L
A
K
E
T
F
A
S
T
A
S
Q
Site 39
S628
L
A
K
E
T
F
A
S
T
A
S
Q
L
H
S
Site 40
S631
E
T
F
A
S
T
A
S
Q
L
H
S
N
V
V
Site 41
S635
S
T
A
S
Q
L
H
S
N
V
V
N
Y
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation