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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLK3
Full Name:
Serine/threonine-protein kinase PLK3
Alias:
CNK; Cytokine-inducible serine/threonine-protein kinase; EC 2.7.11.21; FGF-inducible kinase; FNK; Kinase PLK3; PLK-3; Polo-like kinase 3; PRK; Proliferation-related kinase
Type:
Membrane, Dendrite protein
Mass (Da):
71629
Number AA:
646
UniProt ID:
Q9H4B4
International Prot ID:
IPI00304186
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042801
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Polo-like protein-serine kinase 3 (cytokine- inducible kinase (CNK)) pan-specific antibody AB-NK147-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK147-2#Polo-like protein-serine kinase 3 (cytokine- inducible kinase (CNK)) (K357-G374, human) peptide - Powder PE-01BFA75#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BFA75#Plk3Subtide - Plk3 (CNK) protein kinase substrate peptide - Powder PE-01BIZ95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BIZ95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
P
A
A
G
F
L
S
P
R
P
F
Q
R
A
Site 2
S31
A
G
P
G
P
P
P
S
A
L
R
G
P
E
L
Site 3
T54
S
D
P
G
R
L
I
T
D
P
R
S
G
R
T
Site 4
S58
R
L
I
T
D
P
R
S
G
R
T
Y
L
K
G
Site 5
Y62
D
P
R
S
G
R
T
Y
L
K
G
R
L
L
G
Site 6
Y77
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
Site 7
T80
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Site 8
T82
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
Site 9
S96
A
V
K
V
I
P
Q
S
R
V
A
K
P
H
Q
Site 10
Y136
F
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
Site 11
S146
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
Site 12
T156
H
I
W
K
A
R
H
T
L
L
E
P
E
V
R
Site 13
Y164
L
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
Site 14
Y165
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
Site 15
S171
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
Site 16
T194
K
L
G
N
F
F
I
T
E
N
M
E
L
K
V
Site 17
T219
P
P
E
Q
R
K
K
T
I
C
G
T
P
N
Y
Site 18
T223
R
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
Site 19
Y226
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
L
Site 20
Y277
R
C
I
K
Q
V
H
Y
T
L
P
A
S
L
S
Site 21
S282
V
H
Y
T
L
P
A
S
L
S
L
P
A
R
Q
Site 22
S298
L
A
A
I
L
R
A
S
P
R
D
R
P
S
I
Site 23
S304
A
S
P
R
D
R
P
S
I
D
Q
I
L
R
H
Site 24
T315
I
L
R
H
D
F
F
T
K
G
Y
T
P
D
R
Site 25
T319
D
F
F
T
K
G
Y
T
P
D
R
L
P
I
S
Site 26
S326
T
P
D
R
L
P
I
S
S
C
V
T
V
P
D
Site 27
T335
C
V
T
V
P
D
L
T
P
P
N
P
A
R
S
Site 28
S342
T
P
P
N
P
A
R
S
L
F
A
K
V
T
K
Site 29
T348
R
S
L
F
A
K
V
T
K
S
L
F
G
R
K
Site 30
S350
L
F
A
K
V
T
K
S
L
F
G
R
K
K
K
Site 31
S358
L
F
G
R
K
K
K
S
K
N
H
A
Q
E
R
Site 32
S369
A
Q
E
R
D
E
V
S
G
L
V
S
G
L
M
Site 33
S379
V
S
G
L
M
R
T
S
V
G
H
Q
D
A
R
Site 34
T403
A
P
V
S
L
V
E
T
A
P
E
D
S
S
P
Site 35
S408
V
E
T
A
P
E
D
S
S
P
R
G
T
L
A
Site 36
S409
E
T
A
P
E
D
S
S
P
R
G
T
L
A
S
Site 37
T413
E
D
S
S
P
R
G
T
L
A
S
S
G
D
G
Site 38
S416
S
P
R
G
T
L
A
S
S
G
D
G
F
E
E
Site 39
S417
P
R
G
T
L
A
S
S
G
D
G
F
E
E
G
Site 40
Y470
W
V
S
K
W
V
D
Y
S
N
K
F
G
F
G
Site 41
Y478
S
N
K
F
G
F
G
Y
Q
L
S
S
R
R
V
Site 42
S498
D
G
T
H
M
A
L
S
A
N
R
K
T
V
H
Site 43
T503
A
L
S
A
N
R
K
T
V
H
Y
N
P
T
S
Site 44
Y506
A
N
R
K
T
V
H
Y
N
P
T
S
T
K
H
Site 45
T511
V
H
Y
N
P
T
S
T
K
H
F
S
F
S
V
Site 46
S515
P
T
S
T
K
H
F
S
F
S
V
G
A
V
P
Site 47
S517
S
T
K
H
F
S
F
S
V
G
A
V
P
R
A
Site 48
Y534
P
Q
L
G
I
L
R
Y
F
A
S
Y
M
E
Q
Site 49
Y538
I
L
R
Y
F
A
S
Y
M
E
Q
H
L
M
K
Site 50
S551
M
K
G
G
D
L
P
S
V
E
E
V
E
V
P
Site 51
T591
V
N
F
Y
G
D
H
T
K
L
I
L
S
G
W
Site 52
T604
G
W
E
P
L
L
V
T
F
V
A
R
N
R
S
Site 53
S611
T
F
V
A
R
N
R
S
A
C
T
Y
L
A
S
Site 54
Y615
R
N
R
S
A
C
T
Y
L
A
S
H
L
R
Q
Site 55
S626
H
L
R
Q
L
G
C
S
P
D
L
R
Q
R
L
Site 56
Y635
D
L
R
Q
R
L
R
Y
A
L
R
L
L
R
D
Site 57
S644
L
R
L
L
R
D
R
S
P
A
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation