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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ZHX3
Full Name:
Zinc fingers and homeoboxes protein 3
Alias:
KIAA0395; TIX1; Triple homeobox 1 protein; Zinc finger and homeodomain protein 3; Zinc fingers and homeoboxes 3
Type:
Transcription protein
Mass (Da):
104658
Number AA:
956
UniProt ID:
Q9H4I2
International Prot ID:
IPI00301844
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0043565
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0045892
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
A
S
K
R
K
S
T
T
P
C
M
I
P
Site 2
T8
M
A
S
K
R
K
S
T
T
P
C
M
I
P
V
Site 3
T9
A
S
K
R
K
S
T
T
P
C
M
I
P
V
K
Site 4
S24
T
V
V
L
Q
D
A
S
M
E
A
Q
P
A
E
Site 5
S46
Q
D
L
P
P
E
A
S
A
A
S
S
E
A
A
Site 6
S50
P
E
A
S
A
A
S
S
E
A
A
Q
N
P
S
Site 7
S57
S
E
A
A
Q
N
P
S
S
T
D
G
S
T
L
Site 8
S58
E
A
A
Q
N
P
S
S
T
D
G
S
T
L
A
Site 9
S62
N
P
S
S
T
D
G
S
T
L
A
N
G
H
R
Site 10
T63
P
S
S
T
D
G
S
T
L
A
N
G
H
R
S
Site 11
T71
L
A
N
G
H
R
S
T
L
D
G
Y
L
Y
S
Site 12
Y75
H
R
S
T
L
D
G
Y
L
Y
S
C
K
Y
C
Site 13
Y77
S
T
L
D
G
Y
L
Y
S
C
K
Y
C
D
F
Site 14
Y81
G
Y
L
Y
S
C
K
Y
C
D
F
R
S
H
D
Site 15
T108
T
D
F
N
K
D
P
T
F
V
C
S
G
C
S
Site 16
S125
A
K
T
P
E
G
L
S
L
H
N
A
T
C
H
Site 17
S154
N
H
V
V
V
E
Q
S
I
P
E
S
T
S
T
Site 18
S158
V
E
Q
S
I
P
E
S
T
S
T
P
D
L
A
Site 19
T161
S
I
P
E
S
T
S
T
P
D
L
A
G
E
P
Site 20
S169
P
D
L
A
G
E
P
S
A
E
G
A
D
G
Q
Site 21
S208
T
L
K
E
N
V
P
S
Q
P
V
G
E
A
L
Site 22
S231
E
V
R
E
G
D
H
S
F
I
N
G
A
V
P
Site 23
S245
P
V
S
Q
A
S
A
S
S
A
K
N
P
H
A
Site 24
Y309
P
L
S
S
I
P
T
Y
N
A
A
M
D
S
N
Site 25
S315
T
Y
N
A
A
M
D
S
N
S
F
L
K
N
S
Site 26
S317
N
A
A
M
D
S
N
S
F
L
K
N
S
F
H
Site 27
S322
S
N
S
F
L
K
N
S
F
H
K
F
P
Y
P
Site 28
Y328
N
S
F
H
K
F
P
Y
P
T
K
A
E
L
C
Site 29
T338
K
A
E
L
C
Y
L
T
V
V
T
K
Y
P
E
Site 30
Y343
Y
L
T
V
V
T
K
Y
P
E
E
Q
L
K
I
Site 31
T353
E
Q
L
K
I
W
F
T
A
Q
R
L
K
Q
G
Site 32
S362
Q
R
L
K
Q
G
I
S
W
S
P
E
E
I
E
Site 33
S364
L
K
Q
G
I
S
W
S
P
E
E
I
E
D
A
Site 34
T378
A
R
K
K
M
F
N
T
V
I
Q
S
V
P
Q
Site 35
T446
T
S
S
P
L
P
L
T
V
T
S
V
P
K
Q
Site 36
T448
S
P
L
P
L
T
V
T
S
V
P
K
Q
P
G
Site 37
S468
T
V
C
S
N
T
T
S
A
V
K
V
V
N
A
Site 38
S495
S
Q
A
F
L
D
A
S
I
Y
K
N
K
K
S
Site 39
Y497
A
F
L
D
A
S
I
Y
K
N
K
K
S
H
E
Site 40
S502
S
I
Y
K
N
K
K
S
H
E
Q
L
S
A
L
Site 41
S507
K
K
S
H
E
Q
L
S
A
L
K
G
S
F
C
Site 42
S512
Q
L
S
A
L
K
G
S
F
C
R
N
Q
F
P
Site 43
T528
Q
S
E
V
E
H
L
T
K
V
T
G
L
S
T
Site 44
S534
L
T
K
V
T
G
L
S
T
R
E
V
R
K
W
Site 45
Y547
K
W
F
S
D
R
R
Y
H
C
R
N
L
K
G
Site 46
S555
H
C
R
N
L
K
G
S
R
A
M
I
P
G
D
Site 47
S575
I
D
S
V
P
E
V
S
F
S
P
S
S
K
V
Site 48
S577
S
V
P
E
V
S
F
S
P
S
S
K
V
P
E
Site 49
S579
P
E
V
S
F
S
P
S
S
K
V
P
E
V
T
Site 50
S580
E
V
S
F
S
P
S
S
K
V
P
E
V
T
C
Site 51
T590
P
E
V
T
C
I
P
T
T
A
T
L
A
T
H
Site 52
T591
E
V
T
C
I
P
T
T
A
T
L
A
T
H
P
Site 53
S599
A
T
L
A
T
H
P
S
A
K
R
Q
S
W
H
Site 54
S604
H
P
S
A
K
R
Q
S
W
H
Q
T
P
D
F
Site 55
T608
K
R
Q
S
W
H
Q
T
P
D
F
T
P
T
K
Site 56
T612
W
H
Q
T
P
D
F
T
P
T
K
Y
K
E
R
Site 57
T614
Q
T
P
D
F
T
P
T
K
Y
K
E
R
A
P
Site 58
Y616
P
D
F
T
P
T
K
Y
K
E
R
A
P
E
Q
Site 59
S629
E
Q
L
R
A
L
E
S
S
F
A
Q
N
P
L
Site 60
S630
Q
L
R
A
L
E
S
S
F
A
Q
N
P
L
P
Site 61
S647
E
E
L
D
R
L
R
S
E
T
K
M
T
R
R
Site 62
T649
L
D
R
L
R
S
E
T
K
M
T
R
R
E
I
Site 63
T652
L
R
S
E
T
K
M
T
R
R
E
I
D
S
W
Site 64
S658
M
T
R
R
E
I
D
S
W
F
S
E
R
R
K
Site 65
S661
R
E
I
D
S
W
F
S
E
R
R
K
K
V
N
Site 66
S680
K
K
A
E
E
N
A
S
Q
E
E
E
E
A
A
Site 67
S698
G
G
E
E
D
L
A
S
E
L
R
V
S
G
E
Site 68
S703
L
A
S
E
L
R
V
S
G
E
N
G
S
L
E
Site 69
S708
R
V
S
G
E
N
G
S
L
E
M
P
S
S
H
Site 70
S713
N
G
S
L
E
M
P
S
S
H
I
L
A
E
R
Site 71
S714
G
S
L
E
M
P
S
S
H
I
L
A
E
R
K
Site 72
S723
I
L
A
E
R
K
V
S
P
I
K
I
N
L
K
Site 73
T735
N
L
K
N
L
R
V
T
E
A
N
G
R
N
E
Site 74
S756
C
D
P
E
D
D
E
S
N
K
L
A
E
Q
L
Site 75
T772
G
K
V
S
C
K
K
T
A
Q
Q
R
H
L
L
Site 76
T786
L
R
Q
L
F
V
Q
T
Q
W
P
S
N
Q
D
Site 77
Y794
Q
W
P
S
N
Q
D
Y
D
S
I
M
A
Q
T
Site 78
S796
P
S
N
Q
D
Y
D
S
I
M
A
Q
T
G
L
Site 79
S815
V
V
R
W
F
G
D
S
R
Y
A
L
K
N
G
Site 80
Y817
R
W
F
G
D
S
R
Y
A
L
K
N
G
Q
L
Site 81
Y827
K
N
G
Q
L
K
W
Y
E
D
Y
K
R
G
N
Site 82
Y830
Q
L
K
W
Y
E
D
Y
K
R
G
N
F
P
P
Site 83
Y853
N
R
E
L
L
Q
D
Y
Y
M
T
H
K
M
L
Site 84
Y854
R
E
L
L
Q
D
Y
Y
M
T
H
K
M
L
Y
Site 85
Y861
Y
M
T
H
K
M
L
Y
E
E
D
L
Q
N
L
Site 86
T872
L
Q
N
L
C
D
K
T
Q
M
S
S
Q
Q
V
Site 87
T897
E
T
R
A
V
A
D
T
G
S
E
D
Q
G
P
Site 88
S899
R
A
V
A
D
T
G
S
E
D
Q
G
P
G
T
Site 89
T910
G
P
G
T
G
E
L
T
A
V
H
K
G
M
G
Site 90
T919
V
H
K
G
M
G
D
T
Y
S
E
V
S
E
N
Site 91
Y920
H
K
G
M
G
D
T
Y
S
E
V
S
E
N
S
Site 92
S921
K
G
M
G
D
T
Y
S
E
V
S
E
N
S
E
Site 93
S924
G
D
T
Y
S
E
V
S
E
N
S
E
S
W
E
Site 94
S927
Y
S
E
V
S
E
N
S
E
S
W
E
P
R
V
Site 95
S929
E
V
S
E
N
S
E
S
W
E
P
R
V
P
E
Site 96
S938
E
P
R
V
P
E
A
S
S
E
P
F
D
T
S
Site 97
S939
P
R
V
P
E
A
S
S
E
P
F
D
T
S
S
Site 98
T944
A
S
S
E
P
F
D
T
S
S
P
Q
A
G
R
Site 99
S945
S
S
E
P
F
D
T
S
S
P
Q
A
G
R
Q
Site 100
S946
S
E
P
F
D
T
S
S
P
Q
A
G
R
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation