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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SENP3
Full Name:
Sentrin-specific protease 3
Alias:
DKFZP586K0919; DKFZp762A152; Sen3; Sentrin/sumo-specific protease SENP3; Sentrin/SUMO-specific protease SENP3; Sentrin-specific protease 3; SMT3IP1; SSP3; Sumo-1 specific protease 3; SUMO1/sentrin/SMT3 specific peptidase 3; SUSP3
Type:
Protease (non-proteasomal)
Mass (Da):
65010
Number AA:
574
UniProt ID:
Q9H4L4
International Prot ID:
IPI00171525
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004843
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0006511
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
E
T
I
Q
G
T
G
S
W
G
P
E
P
P
G
Site 2
Y24
G
P
G
I
P
P
A
Y
S
S
P
R
R
E
R
Site 3
S25
P
G
I
P
P
A
Y
S
S
P
R
R
E
R
L
Site 4
S26
G
I
P
P
A
Y
S
S
P
R
R
E
R
L
R
Site 5
S44
P
P
K
P
R
L
K
S
G
G
G
F
G
P
D
Site 6
S54
G
F
G
P
D
P
G
S
G
T
T
V
P
A
R
Site 7
T56
G
P
D
P
G
S
G
T
T
V
P
A
R
R
L
Site 8
S69
R
L
P
V
P
R
P
S
F
D
A
S
A
S
E
Site 9
S73
P
R
P
S
F
D
A
S
A
S
E
E
E
E
E
Site 10
S75
P
S
F
D
A
S
A
S
E
E
E
E
E
E
E
Site 11
S103
W
R
L
P
P
R
W
S
Q
L
G
T
S
Q
R
Site 12
T107
P
R
W
S
Q
L
G
T
S
Q
R
P
R
P
S
Site 13
S108
R
W
S
Q
L
G
T
S
Q
R
P
R
P
S
R
Site 14
S114
T
S
Q
R
P
R
P
S
R
P
T
H
R
K
T
Site 15
T117
R
P
R
P
S
R
P
T
H
R
K
T
C
S
Q
Site 16
T121
S
R
P
T
H
R
K
T
C
S
Q
R
R
R
R
Site 17
S123
P
T
H
R
K
T
C
S
Q
R
R
R
R
A
M
Site 18
Y138
R
A
F
R
M
L
L
Y
S
K
S
T
S
L
T
Site 19
S141
R
M
L
L
Y
S
K
S
T
S
L
T
F
H
W
Site 20
S143
L
L
Y
S
K
S
T
S
L
T
F
H
W
K
L
Site 21
S169
A
H
P
K
N
H
L
S
P
Q
Q
G
G
A
T
Site 22
T176
S
P
Q
Q
G
G
A
T
P
Q
V
P
S
P
C
Site 23
S181
G
A
T
P
Q
V
P
S
P
C
C
R
F
D
S
Site 24
S188
S
P
C
C
R
F
D
S
P
R
G
P
P
P
P
Site 25
S212
A
E
D
G
V
R
G
S
P
P
V
P
S
G
P
Site 26
S217
R
G
S
P
P
V
P
S
G
P
P
M
E
E
D
Site 27
T229
E
E
D
G
L
R
W
T
P
K
S
P
L
D
P
Site 28
S232
G
L
R
W
T
P
K
S
P
L
D
P
D
S
G
Site 29
S238
K
S
P
L
D
P
D
S
G
L
L
S
C
T
L
Site 30
S242
D
P
D
S
G
L
L
S
C
T
L
P
N
G
F
Site 31
S260
S
G
P
E
G
E
R
S
L
A
P
P
D
A
S
Site 32
S307
G
E
K
A
G
Q
H
S
P
L
R
E
E
H
V
Site 33
T315
P
L
R
E
E
H
V
T
C
V
Q
S
I
L
D
Site 34
S330
E
F
L
Q
T
Y
G
S
L
I
P
L
S
T
D
Site 35
S335
Y
G
S
L
I
P
L
S
T
D
E
V
V
E
K
Site 36
T353
I
F
Q
Q
E
F
S
T
P
S
R
K
G
L
V
Site 37
S366
L
V
L
Q
L
I
Q
S
Y
Q
R
M
P
G
N
Site 38
Y367
V
L
Q
L
I
Q
S
Y
Q
R
M
P
G
N
A
Site 39
Y383
V
R
G
F
R
V
A
Y
K
R
H
V
L
T
M
Site 40
T389
A
Y
K
R
H
V
L
T
M
D
D
L
G
T
L
Site 41
T395
L
T
M
D
D
L
G
T
L
Y
G
Q
N
W
L
Site 42
Y397
M
D
D
L
G
T
L
Y
G
Q
N
W
L
N
D
Site 43
T417
Y
G
D
L
V
M
D
T
V
P
E
K
V
H
F
Site 44
Y438
D
K
L
R
T
K
G
Y
D
G
V
K
R
W
T
Site 45
T477
S
V
D
V
R
R
R
T
I
T
Y
F
D
S
Q
Site 46
T479
D
V
R
R
R
T
I
T
Y
F
D
S
Q
R
T
Site 47
Y480
V
R
R
R
T
I
T
Y
F
D
S
Q
R
T
L
Site 48
S483
R
T
I
T
Y
F
D
S
Q
R
T
L
N
R
R
Site 49
Y498
C
P
K
H
I
A
K
Y
L
Q
A
E
A
V
K
Site 50
Y518
F
H
Q
G
W
K
G
Y
F
K
M
N
V
A
R
Site 51
S530
V
A
R
Q
N
N
D
S
D
C
G
A
F
V
L
Site 52
S546
Y
C
K
H
L
A
L
S
Q
P
F
S
F
T
Q
Site 53
S550
L
A
L
S
Q
P
F
S
F
T
Q
Q
D
M
P
Site 54
Y564
P
K
L
R
R
Q
I
Y
K
E
L
C
H
C
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation