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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
OSBPL3
Full Name:
Oxysterol-binding protein-related protein 3
Alias:
KIAA0704; ORP3; ORP-3; OSBL3; OSBP3; OSBP-related 3; Oxysterol binding protein-like 3; Oxysterol-binding protein-related 3; Oxysterol-binding protein-related protein 3: Oxysterol-binding protein-related protein 3: Oxysterol-binding protein-related protein 3: Oxysterol-binding protein-related protein 3
Type:
Endoplasmic reticulum
Mass (Da):
101224
Number AA:
887
UniProt ID:
Q9H4L5
International Prot ID:
IPI00023555
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006869
GO:0008202
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
D
E
K
N
L
G
V
S
Q
K
L
V
S
P
S
Site 2
S16
G
V
S
Q
K
L
V
S
P
S
R
S
T
S
S
Site 3
S18
S
Q
K
L
V
S
P
S
R
S
T
S
S
C
S
Site 4
S20
K
L
V
S
P
S
R
S
T
S
S
C
S
S
K
Site 5
T21
L
V
S
P
S
R
S
T
S
S
C
S
S
K
Q
Site 6
S22
V
S
P
S
R
S
T
S
S
C
S
S
K
Q
G
Site 7
S23
S
P
S
R
S
T
S
S
C
S
S
K
Q
G
S
Site 8
S25
S
R
S
T
S
S
C
S
S
K
Q
G
S
R
Q
Site 9
S26
R
S
T
S
S
C
S
S
K
Q
G
S
R
Q
D
Site 10
S30
S
C
S
S
K
Q
G
S
R
Q
D
S
W
E
V
Site 11
S34
K
Q
G
S
R
Q
D
S
W
E
V
V
E
G
L
Site 12
Y47
G
L
R
G
E
M
N
Y
T
Q
E
P
P
V
Q
Site 13
T48
L
R
G
E
M
N
Y
T
Q
E
P
P
V
Q
K
Site 14
Y75
G
W
H
K
R
F
F
Y
L
D
K
G
I
L
K
Site 15
S86
G
I
L
K
Y
A
K
S
Q
T
D
I
E
R
E
Site 16
S107
D
V
G
L
S
V
M
S
V
K
K
S
S
K
C
Site 17
S111
S
V
M
S
V
K
K
S
S
K
C
I
D
L
D
Site 18
T119
S
K
C
I
D
L
D
T
E
E
H
I
Y
H
L
Site 19
Y124
L
D
T
E
E
H
I
Y
H
L
K
V
K
S
E
Site 20
Y147
K
L
R
H
H
R
M
Y
R
Q
N
E
I
A
M
Site 21
S166
V
N
H
F
F
S
G
S
T
I
T
D
S
S
S
Site 22
T167
N
H
F
F
S
G
S
T
I
T
D
S
S
S
G
Site 23
S171
S
G
S
T
I
T
D
S
S
S
G
V
F
D
S
Site 24
S172
G
S
T
I
T
D
S
S
S
G
V
F
D
S
I
Site 25
S173
S
T
I
T
D
S
S
S
G
V
F
D
S
I
S
Site 26
S178
S
S
S
G
V
F
D
S
I
S
S
R
K
R
S
Site 27
S180
S
G
V
F
D
S
I
S
S
R
K
R
S
S
I
Site 28
S181
G
V
F
D
S
I
S
S
R
K
R
S
S
I
S
Site 29
S185
S
I
S
S
R
K
R
S
S
I
S
K
Q
N
L
Site 30
S186
I
S
S
R
K
R
S
S
I
S
K
Q
N
L
F
Site 31
S188
S
R
K
R
S
S
I
S
K
Q
N
L
F
Q
T
Site 32
T195
S
K
Q
N
L
F
Q
T
G
S
N
V
S
F
S
Site 33
S197
Q
N
L
F
Q
T
G
S
N
V
S
F
S
C
G
Site 34
S200
F
Q
T
G
S
N
V
S
F
S
C
G
G
E
T
Site 35
S202
T
G
S
N
V
S
F
S
C
G
G
E
T
R
V
Site 36
S215
R
V
P
L
W
L
Q
S
S
E
D
M
E
K
C
Site 37
S216
V
P
L
W
L
Q
S
S
E
D
M
E
K
C
S
Site 38
S237
H
A
Y
L
V
E
M
S
Q
L
L
Q
S
M
D
Site 39
T249
S
M
D
V
L
H
R
T
Y
S
A
P
A
I
N
Site 40
Y250
M
D
V
L
H
R
T
Y
S
A
P
A
I
N
A
Site 41
S251
D
V
L
H
R
T
Y
S
A
P
A
I
N
A
I
Site 42
S262
I
N
A
I
Q
G
G
S
F
E
S
P
K
K
E
Site 43
S265
I
Q
G
G
S
F
E
S
P
K
K
E
K
R
S
Site 44
S272
S
P
K
K
E
K
R
S
H
R
R
W
R
S
R
Site 45
S278
R
S
H
R
R
W
R
S
R
A
I
G
K
D
A
Site 46
S296
L
Q
V
P
K
P
F
S
G
P
V
R
L
H
S
Site 47
S303
S
G
P
V
R
L
H
S
S
N
P
N
L
S
T
Site 48
S304
G
P
V
R
L
H
S
S
N
P
N
L
S
T
L
Site 49
S309
H
S
S
N
P
N
L
S
T
L
D
F
G
E
E
Site 50
T310
S
S
N
P
N
L
S
T
L
D
F
G
E
E
K
Site 51
Y319
D
F
G
E
E
K
N
Y
S
D
G
S
E
T
S
Site 52
S320
F
G
E
E
K
N
Y
S
D
G
S
E
T
S
S
Site 53
S323
E
K
N
Y
S
D
G
S
E
T
S
S
E
F
S
Site 54
S326
Y
S
D
G
S
E
T
S
S
E
F
S
K
M
Q
Site 55
S327
S
D
G
S
E
T
S
S
E
F
S
K
M
Q
E
Site 56
S330
S
E
T
S
S
E
F
S
K
M
Q
E
D
L
C
Site 57
Y344
C
H
I
A
H
K
V
Y
F
T
L
R
S
A
F
Site 58
S355
R
S
A
F
N
I
M
S
A
E
R
E
K
L
K
Site 59
S370
Q
L
M
E
Q
D
A
S
S
S
P
S
A
Q
V
Site 60
S371
L
M
E
Q
D
A
S
S
S
P
S
A
Q
V
I
Site 61
S372
M
E
Q
D
A
S
S
S
P
S
A
Q
V
I
G
Site 62
S374
Q
D
A
S
S
S
P
S
A
Q
V
I
G
L
K
Site 63
S405
L
R
R
I
H
A
E
S
L
L
L
D
S
P
A
Site 64
S410
A
E
S
L
L
L
D
S
P
A
V
A
K
S
G
Site 65
S416
D
S
P
A
V
A
K
S
G
D
N
L
A
E
E
Site 66
S425
D
N
L
A
E
E
N
S
R
D
E
N
R
A
L
Site 67
S437
R
A
L
V
H
Q
L
S
N
E
S
R
L
S
I
Site 68
S443
L
S
N
E
S
R
L
S
I
T
D
S
L
S
E
Site 69
T445
N
E
S
R
L
S
I
T
D
S
L
S
E
F
F
Site 70
S447
S
R
L
S
I
T
D
S
L
S
E
F
F
D
A
Site 71
S449
L
S
I
T
D
S
L
S
E
F
F
D
A
Q
E
Site 72
S460
D
A
Q
E
V
L
L
S
P
S
S
S
E
N
E
Site 73
S463
E
V
L
L
S
P
S
S
S
E
N
E
I
S
D
Site 74
S464
V
L
L
S
P
S
S
S
E
N
E
I
S
D
D
Site 75
S469
S
S
S
E
N
E
I
S
D
D
D
S
Y
V
S
Site 76
S473
N
E
I
S
D
D
D
S
Y
V
S
D
I
S
D
Site 77
Y474
E
I
S
D
D
D
S
Y
V
S
D
I
S
D
N
Site 78
S476
S
D
D
D
S
Y
V
S
D
I
S
D
N
L
S
Site 79
S479
D
S
Y
V
S
D
I
S
D
N
L
S
L
D
N
Site 80
S483
S
D
I
S
D
N
L
S
L
D
N
L
S
N
D
Site 81
T497
D
L
D
N
E
R
Q
T
L
G
P
V
L
D
S
Site 82
S504
T
L
G
P
V
L
D
S
G
R
E
A
K
S
R
Site 83
S510
D
S
G
R
E
A
K
S
R
R
R
T
C
L
P
Site 84
T514
E
A
K
S
R
R
R
T
C
L
P
A
P
C
P
Site 85
S523
L
P
A
P
C
P
S
S
S
N
I
S
L
W
N
Site 86
S524
P
A
P
C
P
S
S
S
N
I
S
L
W
N
I
Site 87
S527
C
P
S
S
S
N
I
S
L
W
N
I
L
R
N
Site 88
S541
N
N
I
G
K
D
L
S
K
V
A
M
P
V
E
Site 89
T555
E
L
N
E
P
L
N
T
L
Q
R
L
C
E
E
Site 90
Y565
R
L
C
E
E
L
E
Y
S
E
L
L
D
K
A
Site 91
S566
L
C
E
E
L
E
Y
S
E
L
L
D
K
A
A
Site 92
S577
D
K
A
A
Q
I
P
S
P
L
E
R
M
V
Y
Site 93
Y593
A
A
F
A
I
S
A
Y
A
S
S
Y
Y
R
A
Site 94
S595
F
A
I
S
A
Y
A
S
S
Y
Y
R
A
G
S
Site 95
S596
A
I
S
A
Y
A
S
S
Y
Y
R
A
G
S
K
Site 96
Y597
I
S
A
Y
A
S
S
Y
Y
R
A
G
S
K
P
Site 97
Y598
S
A
Y
A
S
S
Y
Y
R
A
G
S
K
P
F
Site 98
S602
S
S
Y
Y
R
A
G
S
K
P
F
N
P
V
L
Site 99
Y613
N
P
V
L
G
E
T
Y
E
C
I
R
E
D
K
Site 100
S626
D
K
G
F
Q
F
F
S
E
Q
V
S
H
H
P
Site 101
S630
Q
F
F
S
E
Q
V
S
H
H
P
P
I
S
A
Site 102
S636
V
S
H
H
P
P
I
S
A
C
H
A
E
S
R
Site 103
Y703
G
Q
R
W
I
E
H
Y
G
E
I
V
I
K
N
Site 104
Y717
N
L
H
D
D
S
C
Y
C
K
V
N
F
I
K
Site 105
Y727
V
N
F
I
K
A
K
Y
W
S
T
N
A
H
E
Site 106
T738
N
A
H
E
I
E
G
T
V
F
D
R
S
G
K
Site 107
S743
E
G
T
V
F
D
R
S
G
K
A
V
H
R
L
Site 108
S757
L
F
G
K
W
H
E
S
I
Y
C
G
G
G
S
Site 109
Y759
G
K
W
H
E
S
I
Y
C
G
G
G
S
S
S
Site 110
S764
S
I
Y
C
G
G
G
S
S
S
A
C
V
W
R
Site 111
Y783
P
K
G
Y
E
Q
Y
Y
S
F
T
Q
F
A
L
Site 112
S784
K
G
Y
E
Q
Y
Y
S
F
T
Q
F
A
L
E
Site 113
S798
E
L
N
E
M
D
P
S
S
K
S
L
L
P
P
Site 114
S799
L
N
E
M
D
P
S
S
K
S
L
L
P
P
T
Site 115
S801
E
M
D
P
S
S
K
S
L
L
P
P
T
D
T
Site 116
T806
S
K
S
L
L
P
P
T
D
T
R
F
R
P
D
Site 117
T808
S
L
L
P
P
T
D
T
R
F
R
P
D
Q
R
Site 118
S858
Q
P
R
F
F
R
K
S
D
D
D
S
W
V
S
Site 119
S862
F
R
K
S
D
D
D
S
W
V
S
N
G
T
Y
Site 120
S865
S
D
D
D
S
W
V
S
N
G
T
Y
L
E
L
Site 121
Y869
S
W
V
S
N
G
T
Y
L
E
L
R
K
D
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation