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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMARCAD1
Full Name:
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Alias:
DKFZp762K2015; DKFZP762K2015; ETL1; Helicase 1; hHEL1; KIAA1122; SMRCD; SRD1; SWI/SNF-related, matrix associated, actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1; SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
Type:
Adaptor/scaffold; Helicase; EC 3.6.1.-
Mass (Da):
117374
Number AA:
1026
UniProt ID:
Q9H4L7
International Prot ID:
IPI00220119
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016363
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0004386
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0009117
GO:0045941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T24
I
E
E
A
P
E
A
T
P
Q
P
S
Q
P
G
Site 2
S28
P
E
A
T
P
Q
P
S
Q
P
G
P
S
S
P
Site 3
S33
Q
P
S
Q
P
G
P
S
S
P
I
S
L
S
A
Site 4
S34
P
S
Q
P
G
P
S
S
P
I
S
L
S
A
E
Site 5
S37
P
G
P
S
S
P
I
S
L
S
A
E
E
E
N
Site 6
S39
P
S
S
P
I
S
L
S
A
E
E
E
N
A
E
Site 7
S50
E
N
A
E
G
E
V
S
R
A
N
T
P
D
S
Site 8
T54
G
E
V
S
R
A
N
T
P
D
S
D
I
T
E
Site 9
S57
S
R
A
N
T
P
D
S
D
I
T
E
K
T
E
Site 10
T60
N
T
P
D
S
D
I
T
E
K
T
E
D
S
S
Site 11
T63
D
S
D
I
T
E
K
T
E
D
S
S
V
P
E
Site 12
S66
I
T
E
K
T
E
D
S
S
V
P
E
T
P
D
Site 13
S67
T
E
K
T
E
D
S
S
V
P
E
T
P
D
N
Site 14
T71
E
D
S
S
V
P
E
T
P
D
N
E
R
K
A
Site 15
S79
P
D
N
E
R
K
A
S
I
S
Y
F
K
N
Q
Site 16
S81
N
E
R
K
A
S
I
S
Y
F
K
N
Q
R
G
Site 17
Y82
E
R
K
A
S
I
S
Y
F
K
N
Q
R
G
I
Site 18
Y91
K
N
Q
R
G
I
Q
Y
I
D
L
S
S
D
S
Site 19
S95
G
I
Q
Y
I
D
L
S
S
D
S
E
D
V
V
Site 20
S96
I
Q
Y
I
D
L
S
S
D
S
E
D
V
V
S
Site 21
S98
Y
I
D
L
S
S
D
S
E
D
V
V
S
P
N
Site 22
S103
S
D
S
E
D
V
V
S
P
N
C
S
N
T
V
Site 23
S107
D
V
V
S
P
N
C
S
N
T
V
Q
E
K
T
Site 24
T109
V
S
P
N
C
S
N
T
V
Q
E
K
T
F
N
Site 25
T114
S
N
T
V
Q
E
K
T
F
N
K
D
T
V
I
Site 26
T119
E
K
T
F
N
K
D
T
V
I
I
V
S
E
P
Site 27
S124
K
D
T
V
I
I
V
S
E
P
S
E
D
E
E
Site 28
S127
V
I
I
V
S
E
P
S
E
D
E
E
S
Q
G
Site 29
S132
E
P
S
E
D
E
E
S
Q
G
L
P
T
M
A
Site 30
S146
A
R
R
N
D
D
I
S
E
L
E
D
L
S
E
Site 31
S152
I
S
E
L
E
D
L
S
E
L
E
D
L
K
D
Site 32
S173
K
E
L
F
P
Q
R
S
D
N
D
L
L
K
L
Site 33
S211
G
P
R
K
R
K
L
S
S
S
S
E
P
Y
E
Site 34
S212
P
R
K
R
K
L
S
S
S
S
E
P
Y
E
E
Site 35
S213
R
K
R
K
L
S
S
S
S
E
P
Y
E
E
D
Site 36
S214
K
R
K
L
S
S
S
S
E
P
Y
E
E
D
E
Site 37
Y217
L
S
S
S
S
E
P
Y
E
E
D
E
F
N
D
Site 38
S227
D
E
F
N
D
D
Q
S
I
K
K
T
R
L
D
Site 39
T231
D
D
Q
S
I
K
K
T
R
L
D
H
G
E
E
Site 40
S239
R
L
D
H
G
E
E
S
N
E
S
A
E
S
S
Site 41
S242
H
G
E
E
S
N
E
S
A
E
S
S
S
N
W
Site 42
S245
E
S
N
E
S
A
E
S
S
S
N
W
E
K
Q
Site 43
S246
S
N
E
S
A
E
S
S
S
N
W
E
K
Q
E
Site 44
S254
S
N
W
E
K
Q
E
S
I
V
L
K
L
Q
K
Site 45
Y282
L
K
E
H
E
W
M
Y
T
E
A
L
E
S
L
Site 46
T283
K
E
H
E
W
M
Y
T
E
A
L
E
S
L
K
Site 47
S288
M
Y
T
E
A
L
E
S
L
K
V
F
A
E
D
Site 48
Y300
A
E
D
Q
D
M
Q
Y
A
S
Q
S
E
V
P
Site 49
S302
D
Q
D
M
Q
Y
A
S
Q
S
E
V
P
N
G
Site 50
S304
D
M
Q
Y
A
S
Q
S
E
V
P
N
G
K
E
Site 51
S313
V
P
N
G
K
E
V
S
S
R
S
Q
N
Y
P
Site 52
S316
G
K
E
V
S
S
R
S
Q
N
Y
P
K
N
A
Site 53
S333
T
K
L
K
Q
K
F
S
M
K
A
Q
N
G
F
Site 54
S358
P
K
R
V
V
E
D
S
E
Y
D
S
G
S
D
Site 55
Y360
R
V
V
E
D
S
E
Y
D
S
G
S
D
V
G
Site 56
S362
V
E
D
S
E
Y
D
S
G
S
D
V
G
S
S
Site 57
S364
D
S
E
Y
D
S
G
S
D
V
G
S
S
L
D
Site 58
S368
D
S
G
S
D
V
G
S
S
L
D
E
D
Y
S
Site 59
S369
S
G
S
D
V
G
S
S
L
D
E
D
Y
S
S
Site 60
Y374
G
S
S
L
D
E
D
Y
S
S
G
E
E
V
M
Site 61
S375
S
S
L
D
E
D
Y
S
S
G
E
E
V
M
E
Site 62
S376
S
L
D
E
D
Y
S
S
G
E
E
V
M
E
D
Site 63
Y385
E
E
V
M
E
D
G
Y
K
G
K
I
L
H
F
Site 64
S408
L
T
L
I
P
Q
C
S
Q
K
K
A
Q
K
I
Site 65
S423
T
E
L
R
P
F
N
S
W
E
A
L
F
T
K
Site 66
T429
N
S
W
E
A
L
F
T
K
M
S
K
T
N
G
Site 67
S432
E
A
L
F
T
K
M
S
K
T
N
G
L
S
E
Site 68
T434
L
F
T
K
M
S
K
T
N
G
L
S
E
D
L
Site 69
T470
E
D
I
S
N
K
L
T
K
Q
V
T
M
L
T
Site 70
T477
T
K
Q
V
T
M
L
T
G
N
G
G
G
W
N
Site 71
S489
G
W
N
I
E
Q
P
S
I
L
N
Q
S
L
S
Site 72
S494
Q
P
S
I
L
N
Q
S
L
S
L
K
P
Y
Q
Site 73
S496
S
I
L
N
Q
S
L
S
L
K
P
Y
Q
K
V
Site 74
Y500
Q
S
L
S
L
K
P
Y
Q
K
V
G
L
N
W
Site 75
Y538
Q
A
I
A
F
L
A
Y
L
Y
Q
E
G
N
N
Site 76
Y540
I
A
F
L
A
Y
L
Y
Q
E
G
N
N
G
P
Site 77
Y576
P
T
L
K
V
L
C
Y
Y
G
S
Q
E
E
R
Site 78
Y577
T
L
K
V
L
C
Y
Y
G
S
Q
E
E
R
K
Site 79
S579
K
V
L
C
Y
Y
G
S
Q
E
E
R
K
Q
I
Site 80
Y594
R
F
N
I
H
S
R
Y
E
D
Y
N
V
I
V
Site 81
Y597
I
H
S
R
Y
E
D
Y
N
V
I
V
T
T
Y
Site 82
S609
T
T
Y
N
C
A
I
S
S
S
D
D
R
S
L
Site 83
S610
T
Y
N
C
A
I
S
S
S
D
D
R
S
L
F
Site 84
S611
Y
N
C
A
I
S
S
S
D
D
R
S
L
F
R
Site 85
S615
I
S
S
S
D
D
R
S
L
F
R
R
L
K
L
Site 86
Y624
F
R
R
L
K
L
N
Y
A
I
F
D
E
G
H
Site 87
T656
A
N
N
R
L
L
L
T
G
T
P
V
Q
N
N
Site 88
S680
F
V
M
P
H
M
F
S
S
S
T
S
E
I
R
Site 89
S682
M
P
H
M
F
S
S
S
T
S
E
I
R
R
M
Site 90
S684
H
M
F
S
S
S
T
S
E
I
R
R
M
F
S
Site 91
S691
S
E
I
R
R
M
F
S
S
K
T
K
S
A
D
Site 92
S692
E
I
R
R
M
F
S
S
K
T
K
S
A
D
E
Site 93
S696
M
F
S
S
K
T
K
S
A
D
E
Q
S
I
Y
Site 94
S701
T
K
S
A
D
E
Q
S
I
Y
E
K
E
R
I
Site 95
Y703
S
A
D
E
Q
S
I
Y
E
K
E
R
I
A
H
Site 96
Y751
S
E
K
Q
E
Q
L
Y
L
G
L
F
N
R
L
Site 97
S761
L
F
N
R
L
K
K
S
I
N
N
L
E
K
N
Site 98
Y791
H
P
L
L
H
R
Q
Y
Y
T
A
E
K
L
K
Site 99
Y792
P
L
L
H
R
Q
Y
Y
T
A
E
K
L
K
E
Site 100
T826
F
E
D
M
E
V
M
T
D
F
E
L
H
V
L
Site 101
S853
D
M
D
L
I
L
D
S
G
K
F
R
V
L
G
Site 102
S864
R
V
L
G
C
I
L
S
E
L
K
Q
K
G
D
Site 103
T880
V
V
L
F
S
Q
F
T
M
M
L
D
I
L
E
Site 104
Y897
L
K
H
H
Q
H
R
Y
L
R
L
D
G
K
T
Site 105
T904
Y
L
R
L
D
G
K
T
Q
I
S
E
R
I
H
Site 106
S907
L
D
G
K
T
Q
I
S
E
R
I
H
L
I
D
Site 107
S986
S
Q
G
T
I
E
E
S
M
L
K
I
N
Q
Q
Site 108
T1002
L
K
L
E
Q
D
M
T
T
V
D
E
G
D
E
Site 109
T1003
K
L
E
Q
D
M
T
T
V
D
E
G
D
E
G
Site 110
S1011
V
D
E
G
D
E
G
S
M
P
A
D
I
A
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation