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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLEKHA4
Full Name:
Pleckstrin homology domain-containing family A member 4
Alias:
Phosphoinositol 3-phosphate-binding protein 1
Type:
Mass (Da):
85401
Number AA:
779
UniProt ID:
Q9H4M7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
E
G
S
R
P
R
S
S
L
S
Site 2
S8
M
E
G
S
R
P
R
S
S
L
S
L
A
S
S
Site 3
S9
E
G
S
R
P
R
S
S
L
S
L
A
S
S
A
Site 4
S11
S
R
P
R
S
S
L
S
L
A
S
S
A
S
T
Site 5
S14
R
S
S
L
S
L
A
S
S
A
S
T
I
S
S
Site 6
S20
A
S
S
A
S
T
I
S
S
L
S
S
L
S
P
Site 7
S21
S
S
A
S
T
I
S
S
L
S
S
L
S
P
K
Site 8
S23
A
S
T
I
S
S
L
S
S
L
S
P
K
K
P
Site 9
S24
S
T
I
S
S
L
S
S
L
S
P
K
K
P
T
Site 10
S26
I
S
S
L
S
S
L
S
P
K
K
P
T
R
A
Site 11
S66
G
W
L
H
K
Q
D
S
S
G
L
R
L
W
K
Site 12
Y86
L
S
G
H
C
L
F
Y
Y
K
D
S
R
E
E
Site 13
Y87
S
G
H
C
L
F
Y
Y
K
D
S
R
E
E
S
Site 14
S90
C
L
F
Y
Y
K
D
S
R
E
E
S
V
L
G
Site 15
S94
Y
K
D
S
R
E
E
S
V
L
G
S
V
L
L
Site 16
S98
R
E
E
S
V
L
G
S
V
L
L
P
S
Y
N
Site 17
S103
L
G
S
V
L
L
P
S
Y
N
I
R
P
D
G
Site 18
Y104
G
S
V
L
L
P
S
Y
N
I
R
P
D
G
P
Site 19
T120
A
P
R
G
R
R
F
T
F
T
A
E
H
P
G
Site 20
T122
R
G
R
R
F
T
F
T
A
E
H
P
G
M
R
Site 21
Y131
E
H
P
G
M
R
T
Y
V
L
A
A
D
T
L
Site 22
T137
T
Y
V
L
A
A
D
T
L
E
D
L
R
G
W
Site 23
S152
L
R
A
L
G
R
A
S
R
A
E
G
D
D
Y
Site 24
Y159
S
R
A
E
G
D
D
Y
G
Q
P
R
S
P
A
Site 25
S164
D
D
Y
G
Q
P
R
S
P
A
R
P
Q
P
G
Site 26
S184
P
G
G
P
P
E
V
S
R
G
E
E
G
R
I
Site 27
S192
R
G
E
E
G
R
I
S
E
S
P
E
V
T
R
Site 28
S194
E
E
G
R
I
S
E
S
P
E
V
T
R
L
S
Site 29
T198
I
S
E
S
P
E
V
T
R
L
S
R
G
R
G
Site 30
S201
S
P
E
V
T
R
L
S
R
G
R
G
R
P
R
Site 31
T211
R
G
R
P
R
L
L
T
P
S
P
T
T
D
L
Site 32
S213
R
P
R
L
L
T
P
S
P
T
T
D
L
H
S
Site 33
T215
R
L
L
T
P
S
P
T
T
D
L
H
S
G
L
Site 34
T216
L
L
T
P
S
P
T
T
D
L
H
S
G
L
Q
Site 35
S220
S
P
T
T
D
L
H
S
G
L
Q
M
R
R
A
Site 36
S229
L
Q
M
R
R
A
R
S
P
D
L
F
T
P
L
Site 37
T234
A
R
S
P
D
L
F
T
P
L
S
R
P
P
S
Site 38
S237
P
D
L
F
T
P
L
S
R
P
P
S
P
L
S
Site 39
S241
T
P
L
S
R
P
P
S
P
L
S
L
P
R
P
Site 40
S244
S
R
P
P
S
P
L
S
L
P
R
P
R
S
A
Site 41
S250
L
S
L
P
R
P
R
S
A
P
A
R
R
P
P
Site 42
S260
A
R
R
P
P
A
P
S
G
D
T
A
P
P
A
Site 43
T263
P
P
A
P
S
G
D
T
A
P
P
A
R
P
H
Site 44
T271
A
P
P
A
R
P
H
T
P
L
S
R
I
D
V
Site 45
S274
A
R
P
H
T
P
L
S
R
I
D
V
R
P
P
Site 46
T290
D
W
G
P
Q
R
Q
T
L
S
R
P
P
T
P
Site 47
S292
G
P
Q
R
Q
T
L
S
R
P
P
T
P
R
R
Site 48
T296
Q
T
L
S
R
P
P
T
P
R
R
G
P
P
S
Site 49
S303
T
P
R
R
G
P
P
S
E
A
G
G
G
K
P
Site 50
S313
G
G
G
K
P
P
R
S
P
Q
H
W
S
Q
E
Site 51
S318
P
R
S
P
Q
H
W
S
Q
E
P
R
T
Q
A
Site 52
T323
H
W
S
Q
E
P
R
T
Q
A
H
S
G
S
P
Site 53
S327
E
P
R
T
Q
A
H
S
G
S
P
T
Y
L
Q
Site 54
S329
R
T
Q
A
H
S
G
S
P
T
Y
L
Q
L
P
Site 55
T331
Q
A
H
S
G
S
P
T
Y
L
Q
L
P
P
R
Site 56
Y332
A
H
S
G
S
P
T
Y
L
Q
L
P
P
R
P
Site 57
S345
R
P
P
G
T
R
A
S
M
V
L
L
P
G
P
Site 58
T357
P
G
P
P
L
E
S
T
F
H
Q
S
L
E
T
Site 59
T366
H
Q
S
L
E
T
D
T
L
L
T
K
L
C
G
Site 60
T441
R
A
T
L
C
H
L
T
Q
E
R
E
R
V
W
Site 61
T450
E
R
E
R
V
W
D
T
Y
S
G
L
E
Q
E
Site 62
Y451
R
E
R
V
W
D
T
Y
S
G
L
E
Q
E
L
Site 63
S452
E
R
V
W
D
T
Y
S
G
L
E
Q
E
L
G
Site 64
T460
G
L
E
Q
E
L
G
T
L
R
E
T
L
E
Y
Site 65
Y467
T
L
R
E
T
L
E
Y
L
L
H
L
G
S
P
Site 66
S473
E
Y
L
L
H
L
G
S
P
Q
D
R
V
S
A
Site 67
S479
G
S
P
Q
D
R
V
S
A
Q
Q
Q
L
W
M
Site 68
T504
P
Q
K
P
P
P
H
T
E
P
D
S
P
S
P
Site 69
S508
P
P
H
T
E
P
D
S
P
S
P
V
L
Q
G
Site 70
S510
H
T
E
P
D
S
P
S
P
V
L
Q
G
E
E
Site 71
S518
P
V
L
Q
G
E
E
S
S
E
R
E
S
L
P
Site 72
S519
V
L
Q
G
E
E
S
S
E
R
E
S
L
P
E
Site 73
S523
E
E
S
S
E
R
E
S
L
P
E
S
L
E
L
Site 74
S527
E
R
E
S
L
P
E
S
L
E
L
S
S
P
R
Site 75
S531
L
P
E
S
L
E
L
S
S
P
R
S
P
E
T
Site 76
S532
P
E
S
L
E
L
S
S
P
R
S
P
E
T
D
Site 77
S535
L
E
L
S
S
P
R
S
P
E
T
D
W
G
R
Site 78
T538
S
S
P
R
S
P
E
T
D
W
G
R
P
P
G
Site 79
S552
G
G
D
K
D
L
A
S
P
H
L
G
L
G
S
Site 80
S559
S
P
H
L
G
L
G
S
P
R
V
S
R
A
S
Site 81
S563
G
L
G
S
P
R
V
S
R
A
S
S
P
E
G
Site 82
S566
S
P
R
V
S
R
A
S
S
P
E
G
R
H
L
Site 83
S567
P
R
V
S
R
A
S
S
P
E
G
R
H
L
P
Site 84
S575
P
E
G
R
H
L
P
S
P
Q
L
G
T
K
A
Site 85
S590
P
V
A
R
P
R
M
S
A
Q
E
Q
L
E
R
Site 86
T612
G
R
P
F
P
R
P
T
S
P
R
L
L
T
L
Site 87
S613
R
P
F
P
R
P
T
S
P
R
L
L
T
L
G
Site 88
T618
P
T
S
P
R
L
L
T
L
G
R
T
L
S
P
Site 89
T622
R
L
L
T
L
G
R
T
L
S
P
A
R
R
Q
Site 90
S624
L
T
L
G
R
T
L
S
P
A
R
R
Q
P
D
Site 91
S649
G
A
Q
K
W
L
R
S
S
G
S
W
S
S
P
Site 92
S650
A
Q
K
W
L
R
S
S
G
S
W
S
S
P
R
Site 93
S652
K
W
L
R
S
S
G
S
W
S
S
P
R
N
T
Site 94
S654
L
R
S
S
G
S
W
S
S
P
R
N
T
T
P
Site 95
S655
R
S
S
G
S
W
S
S
P
R
N
T
T
P
Y
Site 96
T659
S
W
S
S
P
R
N
T
T
P
Y
L
P
T
S
Site 97
T660
W
S
S
P
R
N
T
T
P
Y
L
P
T
S
E
Site 98
Y662
S
P
R
N
T
T
P
Y
L
P
T
S
E
G
H
Site 99
S666
T
T
P
Y
L
P
T
S
E
G
H
R
E
R
V
Site 100
S675
G
H
R
E
R
V
L
S
L
S
Q
A
L
A
T
Site 101
S677
R
E
R
V
L
S
L
S
Q
A
L
A
T
E
A
Site 102
T682
S
L
S
Q
A
L
A
T
E
A
S
Q
W
H
R
Site 103
T692
S
Q
W
H
R
M
M
T
G
G
N
L
D
S
Q
Site 104
S698
M
T
G
G
N
L
D
S
Q
G
D
P
L
P
G
Site 105
S711
P
G
V
P
L
P
P
S
D
P
T
R
Q
E
T
Site 106
T714
P
L
P
P
S
D
P
T
R
Q
E
T
P
P
P
Site 107
T718
S
D
P
T
R
Q
E
T
P
P
P
R
S
P
P
Site 108
S723
Q
E
T
P
P
P
R
S
P
P
V
A
N
S
G
Site 109
S729
R
S
P
P
V
A
N
S
G
S
T
G
F
S
R
Site 110
S731
P
P
V
A
N
S
G
S
T
G
F
S
R
R
G
Site 111
S735
N
S
G
S
T
G
F
S
R
R
G
S
G
R
G
Site 112
S739
T
G
F
S
R
R
G
S
G
R
G
G
G
P
T
Site 113
T746
S
G
R
G
G
G
P
T
P
W
G
P
A
W
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation