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Updated November 2019
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Protein Info
Short Name:
ZNF335
Full Name:
Zinc finger protein 335
Alias:
BA465L10.2; NIF-1; NRC-interacting factor 1; Z335; ZN335
Type:
Transcription regulation; Nuclear receptor co-regulator; DNA binding protein
Mass (Da):
144893
Number AA:
1342
UniProt ID:
Q9H4Z2
International Prot ID:
IPI00021362
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
E
E
N
E
V
E
S
S
S
D
A
A
P
G
P
Site 2
S10
E
N
E
V
E
S
S
S
D
A
A
P
G
P
G
Site 3
S23
P
G
R
P
E
E
P
S
E
S
G
L
G
V
G
Site 4
S25
R
P
E
E
P
S
E
S
G
L
G
V
G
T
S
Site 5
S32
S
G
L
G
V
G
T
S
E
A
V
S
A
D
S
Site 6
S36
V
G
T
S
E
A
V
S
A
D
S
S
D
A
A
Site 7
S40
E
A
V
S
A
D
S
S
D
A
A
A
A
P
G
Site 8
S54
G
Q
A
E
A
D
D
S
G
V
G
Q
S
S
D
Site 9
S59
D
D
S
G
V
G
Q
S
S
D
R
G
S
R
S
Site 10
S60
D
S
G
V
G
Q
S
S
D
R
G
S
R
S
Q
Site 11
S64
G
Q
S
S
D
R
G
S
R
S
Q
E
E
V
S
Site 12
S66
S
S
D
R
G
S
R
S
Q
E
E
V
S
E
S
Site 13
S71
S
R
S
Q
E
E
V
S
E
S
S
S
S
A
D
Site 14
S73
S
Q
E
E
V
S
E
S
S
S
S
A
D
P
L
Site 15
S75
E
E
V
S
E
S
S
S
S
A
D
P
L
P
N
Site 16
S76
E
V
S
E
S
S
S
S
A
D
P
L
P
N
S
Site 17
S83
S
A
D
P
L
P
N
S
Y
L
P
D
S
S
S
Site 18
Y84
A
D
P
L
P
N
S
Y
L
P
D
S
S
S
V
Site 19
S88
P
N
S
Y
L
P
D
S
S
S
V
S
H
G
P
Site 20
S89
N
S
Y
L
P
D
S
S
S
V
S
H
G
P
V
Site 21
S90
S
Y
L
P
D
S
S
S
V
S
H
G
P
V
A
Site 22
S120
P
D
P
N
M
L
V
S
D
C
T
A
S
S
S
Site 23
T123
N
M
L
V
S
D
C
T
A
S
S
S
D
L
G
Site 24
S127
S
D
C
T
A
S
S
S
D
L
G
S
A
I
D
Site 25
S131
A
S
S
S
D
L
G
S
A
I
D
K
I
I
E
Site 26
T151
D
L
I
Q
N
C
I
T
V
T
S
A
E
D
G
Site 27
Y165
G
G
A
E
T
T
R
Y
L
I
L
Q
G
P
D
Site 28
T178
P
D
D
G
A
P
M
T
S
P
M
S
S
S
T
Site 29
S179
D
D
G
A
P
M
T
S
P
M
S
S
S
T
L
Site 30
S182
A
P
M
T
S
P
M
S
S
S
T
L
A
H
S
Site 31
S183
P
M
T
S
P
M
S
S
S
T
L
A
H
S
L
Site 32
S215
E
A
Q
G
G
P
S
S
P
V
Q
L
P
P
A
Site 33
S223
P
V
Q
L
P
P
A
S
G
A
E
E
P
D
L
Site 34
S232
A
E
E
P
D
L
Q
S
L
E
A
M
M
E
V
Site 35
S255
K
M
C
Q
Y
R
S
S
T
K
A
T
L
L
R
Site 36
T256
M
C
Q
Y
R
S
S
T
K
A
T
L
L
R
H
Site 37
T259
Y
R
S
S
T
K
A
T
L
L
R
H
M
R
E
Site 38
S289
K
G
R
L
R
K
W
S
T
S
T
K
S
Q
E
Site 39
T290
G
R
L
R
K
W
S
T
S
T
K
S
Q
E
E
Site 40
S291
R
L
R
K
W
S
T
S
T
K
S
Q
E
E
E
Site 41
S294
K
W
S
T
S
T
K
S
Q
E
E
E
G
P
E
Site 42
S321
I
D
D
L
E
E
D
S
D
Y
N
P
A
E
D
Site 43
Y323
D
L
E
E
D
S
D
Y
N
P
A
E
D
E
P
Site 44
T341
Q
L
R
L
Q
R
P
T
P
S
T
P
R
P
R
Site 45
S343
R
L
Q
R
P
T
P
S
T
P
R
P
R
R
R
Site 46
T344
L
Q
R
P
T
P
S
T
P
R
P
R
R
R
P
Site 47
S363
K
L
P
R
L
E
I
S
D
L
P
D
G
V
E
Site 48
S376
V
E
G
E
P
L
V
S
S
Q
S
G
Q
S
P
Site 49
S377
E
G
E
P
L
V
S
S
Q
S
G
Q
S
P
P
Site 50
S379
E
P
L
V
S
S
Q
S
G
Q
S
P
P
E
P
Site 51
S382
V
S
S
Q
S
G
Q
S
P
P
E
P
Q
D
P
Site 52
S393
P
Q
D
P
E
A
P
S
S
S
G
P
G
H
L
Site 53
S394
Q
D
P
E
A
P
S
S
S
G
P
G
H
L
V
Site 54
S395
D
P
E
A
P
S
S
S
G
P
G
H
L
V
A
Site 55
T409
A
M
G
K
V
S
R
T
P
V
E
A
G
V
S
Site 56
S416
T
P
V
E
A
G
V
S
Q
S
D
A
E
N
A
Site 57
S418
V
E
A
G
V
S
Q
S
D
A
E
N
A
A
P
Site 58
T433
S
C
P
D
E
H
D
T
L
P
R
R
R
G
R
Site 59
S442
P
R
R
R
G
R
P
S
R
R
F
L
G
K
K
Site 60
Y450
R
R
F
L
G
K
K
Y
R
K
Y
Y
Y
K
S
Site 61
Y453
L
G
K
K
Y
R
K
Y
Y
Y
K
S
P
K
P
Site 62
Y454
G
K
K
Y
R
K
Y
Y
Y
K
S
P
K
P
L
Site 63
Y455
K
K
Y
R
K
Y
Y
Y
K
S
P
K
P
L
L
Site 64
S457
Y
R
K
Y
Y
Y
K
S
P
K
P
L
L
R
P
Site 65
S476
I
C
G
S
R
F
L
S
H
E
D
L
R
F
H
Site 66
S486
D
L
R
F
H
V
N
S
H
E
A
G
D
P
Q
Site 67
Y502
F
K
C
L
Q
C
S
Y
R
S
R
R
W
S
S
Site 68
S504
C
L
Q
C
S
Y
R
S
R
R
W
S
S
L
K
Site 69
S508
S
Y
R
S
R
R
W
S
S
L
K
E
H
M
F
Site 70
S509
Y
R
S
R
R
W
S
S
L
K
E
H
M
F
N
Site 71
Y523
N
H
V
G
S
K
P
Y
K
C
D
E
C
S
Y
Site 72
Y530
Y
K
C
D
E
C
S
Y
T
S
V
Y
R
K
D
Site 73
T531
K
C
D
E
C
S
Y
T
S
V
Y
R
K
D
V
Site 74
S546
I
R
H
A
A
V
H
S
R
D
R
K
K
R
P
Site 75
T556
R
K
K
R
P
D
P
T
P
K
L
S
S
F
P
Site 76
S560
P
D
P
T
P
K
L
S
S
F
P
C
P
V
C
Site 77
S561
D
P
T
P
K
L
S
S
F
P
C
P
V
C
G
Site 78
Y571
C
P
V
C
G
R
V
Y
P
M
Q
K
R
L
T
Site 79
T583
R
L
T
Q
H
M
K
T
H
S
T
E
K
P
H
Site 80
T604
K
S
F
K
K
R
Y
T
F
K
M
H
L
L
T
Site 81
S642
A
L
L
N
H
Q
L
S
H
V
S
D
K
P
F
Site 82
S645
N
H
Q
L
S
H
V
S
D
K
P
F
K
C
S
Site 83
S666
F
R
E
D
F
L
L
S
H
V
A
V
K
H
T
Site 84
S703
H
V
R
C
R
H
A
S
S
F
E
E
W
G
R
Site 85
S704
V
R
C
R
H
A
S
S
F
E
E
W
G
R
R
Site 86
S718
R
H
P
E
E
P
P
S
R
R
R
P
F
F
S
Site 87
S725
S
R
R
R
P
F
F
S
L
Q
Q
I
E
E
L
Site 88
S737
E
E
L
K
Q
Q
H
S
A
A
P
G
P
P
P
Site 89
S745
A
A
P
G
P
P
P
S
S
P
G
P
P
E
I
Site 90
S746
A
P
G
P
P
P
S
S
P
G
P
P
E
I
P
Site 91
T757
P
E
I
P
P
E
A
T
T
F
Q
S
S
E
A
Site 92
T758
E
I
P
P
E
A
T
T
F
Q
S
S
E
A
P
Site 93
S762
E
A
T
T
F
Q
S
S
E
A
P
S
L
L
C
Site 94
S766
F
Q
S
S
E
A
P
S
L
L
C
S
D
T
L
Site 95
Y780
L
G
G
A
T
I
I
Y
Q
Q
G
A
E
E
S
Site 96
S829
D
V
E
A
G
L
A
S
P
G
G
Q
P
S
P
Site 97
S835
A
S
P
G
G
Q
P
S
P
E
G
A
T
P
Q
Site 98
T840
Q
P
S
P
E
G
A
T
P
Q
V
V
T
L
H
Site 99
S859
G
G
G
A
A
A
E
S
Q
L
G
P
P
D
L
Site 100
T870
P
P
D
L
P
Q
I
T
L
A
P
G
P
F
G
Site 101
T885
G
T
G
Y
S
V
I
T
A
P
P
M
E
E
G
Site 102
T893
A
P
P
M
E
E
G
T
S
A
P
G
T
P
Y
Site 103
S894
P
P
M
E
E
G
T
S
A
P
G
T
P
Y
S
Site 104
T898
E
G
T
S
A
P
G
T
P
Y
S
E
E
P
A
Site 105
S901
S
A
P
G
T
P
Y
S
E
E
P
A
G
E
A
Site 106
T917
Q
A
V
V
V
S
D
T
L
K
E
A
G
T
H
Site 107
Y925
L
K
E
A
G
T
H
Y
I
M
A
T
D
G
T
Site 108
T940
Q
L
H
H
I
E
L
T
A
D
G
S
I
S
F
Site 109
S944
I
E
L
T
A
D
G
S
I
S
F
P
S
P
D
Site 110
S949
D
G
S
I
S
F
P
S
P
D
A
L
A
S
G
Site 111
S955
P
S
P
D
A
L
A
S
G
A
K
W
P
L
L
Site 112
S976
R
D
G
P
E
P
P
S
P
A
K
T
H
C
V
Site 113
T980
E
P
P
S
P
A
K
T
H
C
V
G
D
S
Q
Site 114
S986
K
T
H
C
V
G
D
S
Q
S
S
A
S
S
P
Site 115
S988
H
C
V
G
D
S
Q
S
S
A
S
S
P
P
A
Site 116
S989
C
V
G
D
S
Q
S
S
A
S
S
P
P
A
T
Site 117
S991
G
D
S
Q
S
S
A
S
S
P
P
A
T
S
K
Site 118
S992
D
S
Q
S
S
A
S
S
P
P
A
T
S
K
A
Site 119
T996
S
A
S
S
P
P
A
T
S
K
A
L
G
L
A
Site 120
S1007
L
G
L
A
V
P
P
S
P
P
S
A
A
T
A
Site 121
S1010
A
V
P
P
S
P
P
S
A
A
T
A
A
S
K
Site 122
S1016
P
S
A
A
T
A
A
S
K
K
F
S
C
K
I
Site 123
S1020
T
A
A
S
K
K
F
S
C
K
I
C
A
E
A
Site 124
S1036
P
G
R
A
E
M
E
S
H
K
R
A
H
A
G
Site 125
S1071
A
H
M
A
Q
H
S
S
L
R
P
H
Q
C
S
Site 126
S1078
S
L
R
P
H
Q
C
S
Q
C
S
F
A
S
K
Site 127
S1081
P
H
Q
C
S
Q
C
S
F
A
S
K
N
K
K
Site 128
T1096
D
L
R
R
H
M
L
T
H
T
K
E
K
P
F
Site 129
S1127
F
H
I
Q
R
L
H
S
P
D
G
R
K
S
G
Site 130
S1133
H
S
P
D
G
R
K
S
G
T
P
T
A
R
A
Site 131
T1135
P
D
G
R
K
S
G
T
P
T
A
R
A
P
T
Site 132
T1137
G
R
K
S
G
T
P
T
A
R
A
P
T
Q
T
Site 133
T1142
T
P
T
A
R
A
P
T
Q
T
P
T
Q
T
I
Site 134
T1144
T
A
R
A
P
T
Q
T
P
T
Q
T
I
I
L
Site 135
T1146
R
A
P
T
Q
T
P
T
Q
T
I
I
L
N
S
Site 136
S1153
T
Q
T
I
I
L
N
S
D
D
E
T
L
A
T
Site 137
T1157
I
L
N
S
D
D
E
T
L
A
T
L
H
T
A
Site 138
T1160
S
D
D
E
T
L
A
T
L
H
T
A
L
Q
S
Site 139
T1163
E
T
L
A
T
L
H
T
A
L
Q
S
S
H
G
Site 140
S1168
L
H
T
A
L
Q
S
S
H
G
V
L
G
P
E
Site 141
S1182
E
R
L
Q
Q
A
L
S
Q
E
H
I
I
V
A
Site 142
T1195
V
A
Q
E
Q
T
V
T
N
Q
E
E
A
A
Y
Site 143
Y1202
T
N
Q
E
E
A
A
Y
I
Q
E
I
T
T
A
Site 144
T1213
I
T
T
A
D
G
Q
T
V
Q
H
L
V
T
S
Site 145
Y1226
T
S
D
N
Q
V
Q
Y
I
I
S
Q
D
G
V
Site 146
Y1241
Q
H
L
L
P
Q
E
Y
V
V
V
P
E
G
H
Site 147
T1258
Q
V
Q
E
G
Q
I
T
H
I
Q
Y
E
Q
G
Site 148
Y1262
G
Q
I
T
H
I
Q
Y
E
Q
G
A
P
F
L
Site 149
Y1276
L
Q
E
S
Q
I
Q
Y
V
P
V
S
P
G
Q
Site 150
S1280
Q
I
Q
Y
V
P
V
S
P
G
Q
Q
L
V
T
Site 151
T1319
G
L
F
G
T
D
E
T
V
P
E
H
I
Q
Q
Site 152
Y1334
L
Q
H
Q
G
I
E
Y
D
V
I
T
L
A
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation